Search Results (12,865)

This study aimed to investigate the production of nanoemulgels structured with flaxseed fiber, designed to simulate salad dressings. For this purpose, the influence of microfluidizer passes (from one to four) on physicochemical and rheological properties was determined, followed by an assessment of thermal behavior. Rotor–stator homogenization followed by microfluidization were employed to produce nanoemulgels, which were characterized using laser diffraction, multiple light scattering, and rheological measurements. The resulting systems exhibited monomodal particle size distributions with mean diameters below 220 nm. Increasing the number of microfluidizer passes from one to four led to slight reductions in particle size, although they were not statistically significant. The formulation with two passes demonstrated superior physical stability during aging studies. Rheological evaluation indicated enhanced gel-like behavior with up to three passes, whereas excessive energy input (four passes) slightly compromised structural integrity. The linear viscoelastic region decreased notably after the first pass but remained relatively stable thereafter. The two-pass nanoemulgel, identified as the optimal formulation, was further tested for thermal stability. Temperature increases (5–20 °C) led to minor decreases in viscosity and firmness, yet the structure remained thermally stable. These findings support microfluidization as an effective strategy for developing stable flaxseed fiber-based nanoemulgels, with potential applications in functional food systems. Full article

Biomolecular condensates (BCs), formed through liquid–liquid phase separation (LLPS), are membraneless compartments that dynamically regulate key cellular processes. Beyond their canonical roles in energy metabolism and apoptosis, Mitochondria harbor distinct BCs, including mitochondrial RNA granules (MRGs), nucleoids, and degradasomes, that coordinate RNA processing, genome maintenance, and protein homeostasis. These structures rely heavily on proteins with intrinsically disordered regions (IDRs), which facilitate the transient and multivalent interactions necessary for LLPS. In this review, we explore the composition and function of mitochondrial BCs and their emerging involvement in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis, and Huntington’s disease. We provide computational evidence identifying IDR-containing proteins within the mitochondrial proteome and demonstrate their enrichment in BC-related functions. Many of these proteins are also implicated in mitochondrial stress responses, apoptosis, and pathways associated with neurodegeneration. Moreover, the evolutionary conservation of phase-separating proteins from bacteria to mitochondria underscores the ancient origin of LLPS-mediated compartmentalization. Comparative analysis reveals functional parallels between mitochondrial and prokaryotic IDPs, supporting the use of bacterial models to study mitochondrial condensates. Overall, this review underscores the critical role of mitochondrial BCs in health and disease and highlights the potential of targeting LLPS mechanisms in the development of therapeutic strategies. Full article

Proton-exchange membranes (PEMs) are the pivotal components of vanadium redox flow batteries (VRFBs) and play a critical role in the comprehensive output performance of VRFB systems. Currently, the most widely commercialized membranes are Nafion series membranes produced by DuPont, Wilmington, DE, USA, but the high vanadium permeability and cost hinder their large-scale promotion. Hence, there is an active demand for developing a low-cost, high-performance, and energy-efficient PEM to promote the commercialization of VRFB systems. In this paper, sulfonated poly(ether ether ketone) (SPEEK) as matrix and zirconia nanoparticles as inorganic filler were used for composite modification to prepare a series of SPEEK–ZrO₂ organic–inorganic hybrid membranes for VRFBs. The thickness of these membranes was 50–100 μm. Compared with Nafion 115 (thickness 128 μm), composite membranes demonstrated obvious cost advantages. The results showed that the SP–Z-X series membranes had higher water uptake (53.26–71.1%) and proton conductivity (0.11–0.24 S cm⁻¹). SP–Z-5 displayed the best comprehensive output performance at 200 mA cm⁻² (CE: 99.01%, VE: 81.95%, EE: 81.11%). These hybrid membranes are very cost-effective and exhibit high potential for application in VRFB applications, and are expected to lead to the industrial application of VRFBs on a large scale. Full article

Saline–alkaline water resources are globally widespread, and their rational development offers significant potential to alleviate freshwater scarcity. Saline–alkaline water aquaculture farming not only affects fish growth and survival but also impairs reproductive and developmental functions. Largemouth bass (Micropterus salmoides), an economically important fish, has demonstrated excellent high tolerance to such environments, in order to investigate the effects of alkaline water aquaculture environments on its growth performance, sex hormone levels, gonadal development, and molecular adaptation mechanisms. In this study, largemouth bass were chronically exposed to freshwater (0.55 mmol/L), low alkalinity (10 mmol/L), or high alkalinity (25 mmol/L) and cultured for 80 days. Alkalinity exposure more severely impacted the growth rate of females. High alkalinity significantly increased the hepatosomatic index and decreased the gonadosomatic index in both sexes; moreover, it induced oxidative stress in both sexes, evidenced by reduced superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (TAOC) levels and elevated malondialdehyde (MDA) content. Furthermore, the levels of sex hormones Serum estradiol (E2), 11-ketotestosterone (11-KT), and testosterone were significantly reduced, accompanied by either an elevated ratio of primary oocytes and follicular atresia, or by reduced spermatogenesis. Apoptotic signals appeared in gonadal interstitial cells, with upregulated expression of genes P53, Bax, Casp3, and Casp8. Ultrastructural damage included fewer mitochondria and cristae blurring, further indicating tissue damage causing dysfunction. Transcriptome results showed that oxidative stress damage and energy metabolism imbalance caused by carbonate alkalinity were key to the delayed gonadal development, which was mainly manifested in enrichment of the ECM–receptor interaction and PI3K-Akt signaling pathways in females exposed to low alkalinity, and the GnRH secretion and chemokine signaling pathways in males. Glycosphingolipid biosynthesis and Ferroptosis pathway were enriched in females exposed to high alkalinity, and the Cortisol synthesis and secretion pathway were enriched in males. Overall, high-alkalinity exposure significantly delayed gonadal development in both sexes of largemouth bass, leading to reproductive impairment. Full article

Petrochemicals currently represent the predominant global source of energy and consumer products, including the starting materials used in the platform chemical, plastic polymer, and pharmaceutical industries. However, in recent years, the world’s approaches have shifted towards green chemistry and bio-based chemical production in an effort to reduce CO₂ emissions and mitigate climate change. Over the past few decades, researchers have discovered that marine metabolites, primarily sourced from invertebrates, can be utilized to create sustainable and renewable chemicals. This review highlights the significance of advancing marine microorganism-based biotechnology and biochemistry in developing effective conversion systems to enhance the biological production of key platform chemicals, including those utilized as biomaterials and for energy. A background in marine metabolite biochemistry lays the groundwork for potential strategies to mitigate dependence on petroleum for consumer products. This is followed by a discussion of petroleum product replacement technologies, green chemistry alternatives, and CO₂ mitigation efforts for the production of sustainable and renewable key platform chemicals. Full article

Actions related to reducing CO₂ emissions have led to the development of technologies using raw materials in the form of broadly understood biomass as CO₂-neutral fuels. There has been a rapid development of pyrolysis processes (carbonization, dry distillation) of various types of biomass toward the production of biochar for industrial applications. Particularly high hopes are associated with the use of biochar as a substitute for fossil fuel in energy-intensive sectors of the economy, especially the metallurgical and steel industries. This paper characterizes the current state and potential for biochar application, using the iron and steel industry as a case study. The analysis focuses primarily on the characteristics of biochar production and its industrial application potential. The characterization includes the diversity of biomass feedstocks, processing methods, and reactor types, the influence of operational parameters on biochar yield, as well as the properties and applications of biochar. As part of the analysis of biomass use potential in the iron and steel industry, the study reviews the current levels of coal substitution achieved at the laboratory scale and presents examples of biochar implementation in existing industrial facilities. In addition, key factors limiting the feasibility of coal substitution in the iron and steel industry are identified. The summary includes the main directions for further research aimed at increasing the use of biochar in industry. Full article

With the popularization of nuclear energy in the field of energy application, the effective removal of radioactive iodine isotopes is crucial for the long-term development of nuclear energy. In this paper, bimetallic MOFs with different Cu/Bi ratios were synthesized by a simple solvothermal method, and a bimetallic nano-adsorbent Cu_x/Bi_10−x-NC was prepared by one-step calcination. Adsorption experiments show that Cu_x/Bi_10−x-NC exhibits excellent adsorption performance for iodide ions, gaseous iodine, and I₂ in cyclohexane solution, with the maximum adsorption capacities reaching up to 484.08 and 233.11 mg g⁻¹, respectively. Through the characterization of the material system before and after adsorption, this excellent adsorption performance is attributed to the synergistic effect between Cu and Bi, as well as the highly dispersed adsorption active sites derived from the MOF template. Therefore, the prepared Cu_x/Bi_10−x-NC has great potential in the efficient and stable capture of various forms of iodine. Full article

Obesity (lipotoxicity) results from a chronic imbalance between energy intake and expenditure. It is strongly associated with type 2 diabetes mellitus (T2DM, glucotoxicity) and considered a major risk factor for the development of metabolic complications. Their convergence constitutes “diabesity”, representing a major challenge for public health worldwide. Limited treatment efficacy highlights the need for novel, multi-targeted therapies. Non-shivering thermogenesis (NST), mediated by brown and beige adipose tissue and skeletal muscle, has emerged as a promising therapy due to its capacity to increase energy expenditure and improve metabolic health. Also, skeletal muscle plays a central role in glucose uptake and lipid oxidation, further highlighting its relevance in diabesity. This review explores current and emerging knowledge on physiological stimuli, including cold exposure, physical activity, and fasting, as well as bioactive ingredients and drugs that stimulate NST in thermogenic tissues. Special emphasis is placed on melatonin as a potential regulator of mitochondrial function and energy balance. The literature search was conducted using MEDLINE and Web of Science. Studies were selected based on scientific relevance, novelty, and mechanistic insight; prioritizing human and high-quality rodent research published in peer-reviewed journals. Evidence shows that multiple interventions enhance NST, leading to improved glucose metabolism, reduced fat accumulation, and increased energy expenditure in humans and/or rodents. Melatonin, in particular, shows promise in modulating thermogenesis through organelle-molecular pathways and mitochondrial protective effects. In conclusion, a multi-target approach through the activation of NST by physiological, nutritional, and pharmacological agents offers an effective and safe treatment for diabesity. Further research is needed to confirm these effects in clinical practice and support their use as effective therapeutic strategies. Full article

In recent years, recovering critical elements from coal has attracted considerable interest due to their significant potential and resulting advantages. A prime example is the coal-hosted Al-Ga-Li-REE deposit within the Jungar Coalfield of Inner Mongolia, northern China, where lithium (Li), gallium (Ga), and aluminum (Al) are successfully extracted from coal ash. However, the specific forms in which these elements exist, crucial for developing effective extraction methods, remain unquantified. This research investigated the distribution of Li, Ga, Nb, Zr, and rare earth elements (REEs) within the coal. The study employed a combination of analytical techniques, including inductively coupled plasma mass spectrometry (ICP-MS), sequential chemical extraction (SCE), scanning electron microscopy coupled with energy-dispersive X-ray spectrometry (SEM-EDS), and X-ray powder diffraction analysis (XRD). The analyzed coals exhibited enriched levels of Li, Ga, Zr, Nb, and REEs. Kaolinite and boehmite were the primary mineral constituents, along with minor amounts of calcite, pyrite, rutile, goyazite, and chlorite. Sequential chemical extraction revealed that Li and Ga are primarily associated with aluminosilicate phases (71.84%–84.39%) and, to a lesser degree, organic matter (12.15%–25.09%). Zirconium and Nb were also predominantly found within aluminosilicates (68.53%–95.96%). REEs occur mainly in carbonate (28.28%–60.78%), aluminosilicate (11.6%–33.08%), and organic (22.04%–29.42%) fractions. Full article

Background/Objectives: Recent advancements in innovative drug delivery nanosystems have significantly impacted wound healing, particularly through the incorporation of natural products. This study aimed to develop and characterize a Phlomis crinita extract-loaded nanostructured formulation (PCE-NF) as a topical therapy for skin wounds. Methods: This study involved the incorporation of P. crinita extract in a nanoemulsion by the high-energy emulsification method. This formulation was subjected to physicochemical and biopharmaceutical characterization, and a physical stability study over 30 days. Biocompatibility, tolerability, and irritant effects were assessed, while the wound healing potential was evaluated using in vitro skin models of fibroblasts and keratinocytes. Results: PCE-NF showed a homogeneous appearance with nanometric-sized spherical droplets of 212.27 nm and Newtonian behavior. This formulation showed a sustained release of its majority component (luteonin 7-(6″-acetylglucoside)), which followed a hyperbolic kinetic while showing high permeation, through healthy human skin, with 22.01 µg after 27 h. There were no cytotoxic effects of PCE-NF with improvements in skin barrier function and hydration levels. The wound healing potential of PCE-NF at 3.125 µg/mL was evidenced by enhanced cell migration and accelerated wound closure in 3T3-L1 and HaCaT cells, with values of 94.24 and 92.41%, respectively. Conclusions: These results suggest that this formulation could be used as an effective wound healing treatment. Full article

Community-scale biomass power plants (CSBPPs) offer a decentralized approach for electricity generation by utilizing locally available biomass while delivering socioeconomic benefits. Site selection plays a critical role in the success of CSBPPs and requires the consideration of diverse spatial and non-spatial factors. This study presents a spatial decision-support tool for identifying suitable CSBPP sites in Thailand’s Eastern Economic Corridor (EEC), which comprises the Chachoengsao, Chonburi, and Rayong provinces. A geoprocessing workflow integrating Geographic Information Systems (GISs), Multi-Criteria Decision-Making (MCDM), and the Analytic Hierarchy Process (AHP) was developed using ModelBuilder tools in ArcGIS Pro (version 3.0.2). Thirteen sub-criteria related to geographical, infrastructural, and socioeconomic–cultural dimensions, along with exclusion zones, were evaluated by 15 experts from diverse stakeholder groups. Biomass availability from five major economic crops was combined with other spatial data layers, incorporating expert-assigned weights and suitability scores. The findings indicated a remaining biomass energy potential was 34,156 TJ, with sugarcane residues contributing over 80%. Approximately 20% of the EEC area (about 0.262 million hectares) was classified as highly suitable for CSBPP development, revealing several viable site options. The proposed model offers a flexible and replicable framework for regional biomass planning and can be adapted to other locations by adjusting the criteria and integrating optimization techniques. Full article

Lanthanide hydrogen-bonded organic frameworks (Ln-HOFs) integrating luminescent and proton-conductive properties hold significant promise for multifunctional sensing and energy applications, yet their development remains challenging due to the difficulty of balancing structural stability and functional diversity. In this context, this study successfully synthesized a novel neodymium(III)-based hydrogen-bonded framework material, formulated as {Nd(H₂O)₃(4-CPCA)[H(4-CPCA)]∙H₂O}ₙ (SNUT-15), via hydrothermal assembly using 1-(4-carboxyphenyl)-4-oxo-1,4-dihydropyridazine-3-carboxylic acid (H₂(4-CPCA)) as the ligand. Single-crystal X-ray diffraction analysis revealed a rare two-dimensional hydrogen-bonded bilayer structure stabilized by π-π stacking interactions and intermolecular hydrogen bonds. Hirshfeld surface analysis further corroborated the structural characteristics of this material. Moreover, leveraging the superior luminescent properties of lanthanide elements, this crystalline material exhibits dual functionality: selective fluorescence quenching toward Fe³⁺, La³⁺, and Mn²⁺ (with detection limits of 1.74 × 10⁻⁴, 1.88 × 10⁻⁴, and 3.57 × 10⁻⁴ mol·L⁻¹, respectively), as well as excellent proton conductivity reaching 7.92 × 10⁻³ S cm⁻¹ under conditions of 98% relative humidity and 353 K (80 °C). As a multifunctional neodymium(III)-based HOF material, SNUT-15 demonstrates its potential for applications in environmental monitoring and solid-state electrolytes, providing valuable insights into the rational design of lanthanide-containing frameworks. Full article

Persistent luminescence nanoparticles (PLNPs) represent a unique class of optical materials. They possess the ability to absorb and store energy from external excitation sources and emit light persistently once excitation terminates. Because of this distinctive property, PLNPs have attracted considerable attention in various areas. Especially in recent years, PLNPs have revealed marked benefits and extensive application potential in fields such as biological detection, imaging, targeted delivery, as well as integrated diagnosis and treatment. Not only do they potently attenuate autofluorescence interference arising from biological tissues, but they also demonstrate superior signal-to-noise ratio and sensitivity in in vivo imaging scenarios. Therefore, regarding the current research, this paper firstly introduces the classification, synthesis methods, and luminescence mechanism of the materials. Subsequently, the research progress of PLNPs in biological detection and imaging and medical treatment in recent years is reviewed. The challenges faced by materials in biomedical applications and the outlook of future development trends are further discussed, which delivers an innovative thought pattern for developing and designing new PLNPs to cater to more practical requirements. Full article

Permian shale gas is a kind of energy resource with commercial development potential. The characteristics of its organic source and enrichment have received extensive attention in recent years. This study systematically analyzed the variations in types and assemblages of hydrocarbon-forming organisms across different stratigraphic layers of Permian shale in western Hubei through scanning electron microscopy (SEM) and microscopic observations. Moreover, the source characteristics and enrichment mechanisms of organic matter in Permian shale were identified. Hydrocarbon generation in Permian shale is primarily attributed to planktonic algae-derived acritarchs, supplemented by higher plants and green algae, based on the observation under the SEM and microscope. The hydrocarbon-forming microorganisms in the Gufeng Formation are predominantly characterized by acritarchs. A notable decrease in acritarch content is observed at the bottom of the Wujiaping Formation, accompanied by a significant increase in higher plant constituents and a slight rise in green algae abundance. Subsequently, from the middle-upper members of the Wujiaping Formation through the Dalong Formation, acritarch concentrations rebound while higher plants and green algae contributions diminish. The organic matter in the studied layer is predominantly generated from planktonic algae (acritarchs and green algae), with subordinate contributions from terrestrial higher plants. During the sedimentary stage of the Gufeng Formation, rising sea levels sustained a deep siliceous shelf environment in the E’xi Trough, where organic matter was primarily sourced from acritarchs, with limited terrigenous input. The regressive phase at the bottom of the Wujiaping Formation resulted in coastal marsh throughout the E’xi Trough, creating a mixed organic matter assemblage of aquatic planktonic algae and enhanced terrestrial higher plant material. As sedimentation progressed into the middle-upper Wujiaping Formation and Dalong Formation, the E’xi Trough evolved into a deep siliceous shelf and platform-margin slope environment. During this stage, organic matter was again predominantly supplied by planktonic algae (mainly acritarchs), with reduced terrestrial organic input. These findings provide valuable theoretical insights for guiding Permian shale gas exploration and development strategies. Full article

Cemented paste backfill (CPB) gains strength through the hydration of the binder constituent of the CPB, where mix temperature is a key influencing factor. Both rate of strength development and ultimate strength are influenced by the overarching temperature conditions in which the binder hydration occurs. This study investigates the influence of mixing water temperature on the thermal behaviour, hydration kinetics, and microstructural development of CPB using a combination of thermal finite element modelling, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Five CPB mixtures were prepared, with water temperatures ranging from 5 °C to 50 °C, and tested under controlled conditions to isolate the effects of the initial thermal input. Results show that moderate mixing water temperatures (20–35 °C) optimize hydration and mechanical strength, while excessive temperatures (≥50 °C) increase the risk of thermal cracking due to generation of excessive heat. The thermal modelling results demonstrated that the highest temperatures were observed in the bottom section of the fill mass, in contact with the surrounding rock, where the combined effects of mix-generated heat and rock conduction were most pronounced. The 50 °C mix reached a peak internal temperature of 85.6 °C with a thermal gradient of 40.5 °C, while the 5 °C mix recorded a much lower peak of 55.7 °C and a gradient of 16.8 °C. These results highlight that higher mixing water temperatures accelerate early hydration reactions and significantly influence the internal thermal profile during the first 21 days of curing. Based on these findings, the design of paste plants can be improved by incorporating a heating/cooling system for the mixing water tank—firstly, to ensure the water temperature does not exceed 50 °C and secondly, to maintain water within an optimal temperature range, potentially reducing binder consumption. Full article