Search Results (10,982)

Selenium (Se) is an antioxidant essential trace element influencing inflammatory and immune pathways. This systematic review aimed to evaluate the role of maternal Se status during pregnancy in miscarriage risk. A systematic search of PubMed and Embase up to July 2024 was conducted to identify relevant original research studies in English. Available evidence was qualitatively synthesized and predefined sources of bias were assessed. Of 2345 studies identified, 421 full texts were assessed and 14 were included, encompassing 2309 pregnancies. Despite notable methodological limitations across several studies, current evidence indicates that maternal blood Se concentrations are lower among women who experience miscarriage compared to those with uncomplicated pregnancies. Findings regarding placental Se levels were inconsistent, but important methodological issues were noted. Environmental Se exposure was investigated in a single low-powered study, which did not demonstrate a statistically significant association. Potential interactions between Se status, co-exposure to other environmental or lifestyle factors, and effect modification remain insufficiently explored. Adequate maternal Se status during early gestation may reduce miscarriage risk by mitigating oxidative stress and ferroptosis, supporting immune regulation, and modulating thyroid autoimmunity and function. However, causal inference cannot be established due to the absence of randomized interventional evidence. Full article

Aramid-based polymeric fabrics are increasingly employed in lightweight protective and structural applications where high strength, flexibility, and impact resistance are required. Their response under high-velocity impact is governed by complex interactions among fiber properties, inter-yarn friction, and the mechanical behavior of the impacting body. In this work, three-dimensional finite element simulations were conducted in ANSYS Explicit Dynamics to investigate the coupled effects of the interfacial friction coefficient (μ= coefficient of friction = 0.0–0.5) and impactor material on the dynamic response of 24-layer plain-weave aramid panels. The numerical results reveal that low friction facilitates yarn mobility and localized penetration, whereas moderate friction enhances stress-wave dispersion and enables a more uniform activation of multiple fabric layers. At higher friction levels, penetration is further reduced, but localized stress concentrations may emerge due to constrained yarn movement. The constitutive properties of the impactor strongly influenced deformation modes and the efficiency of kinetic energy transfer to the composite structure. The simulated results are consistent with experimental data reported in the literature, confirming the predictive capability of the model. The study provides quantitative insight into the role of frictional interactions and impactor characteristics in optimizing the energy absorption and structural integrity of aramid-based polymeric fabrics subjected to high-velocity loading, contributing to the development of advanced lightweight protective materials. Full article

To improve the computational efficiency of complex fatigue assessments, this study proposes a framework that integrates high-fidelity finite element analysis (FEA)with ensemble learning for evaluating the fatigue performance of weathering steel welded joints. First, a three-dimensional crack propagation model for cruciform fillet welds was developed on the ABAQUS-FRANC3D platform, with a validation error of less than 20%. Subsequently, a large-scale parametric analysis was conducted. The results indicate that as the stress amplitude increases from 67.5 MPa to 99 MPa, the fatigue life decreases to 40.29% of the baseline value. When the stress amplitude reaches 180 MPa, the fatigue life drops sharply to 14.28% of the baseline. Within the stress ratio range of 0.1 to 0.7, increasing the initial crack size from 0.075 mm to 0.5 mm reduces the fatigue life to between 85.78% and 86.48% of the baseline. Edge cracks, influenced by stress concentration, exhibit approximately 15.2% shorter fatigue life compared to central cracks, while the maximum variation in fatigue life due to crack geometry is only 10.25%. Second, an Extremely Randomized Trees surrogate model constructed based on the simulation data demonstrates excellent performance. Finally, by integrating this model with Paris’s law, the developed prediction framework achieves high consistency with numerical simulation results, with all predicted values falling within the two-standard-deviation interval. This data-driven approach can effectively replace computationally intensive finite element analysis, enabling efficient structural safety assessments. Full article

Gold nanoparticles (Au-NP) are frequently used as model nanomaterials to study nanoparticle behavior in plants due to their analytical detectability and negligible natural background in plant tissues. However, the feasibility of visualizing the spatial distribution of foliar-applied Au-NP at low exposure levels using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) remains insufficiently explored. In this study, commercially sourced Au-NP were applied to lentil leaves (Lens culinaris var. Beluga) at a low concentration of 0.5 mg·L⁻¹ using a controlled leaf submersion approach. Leaves were sampled at 1 h, 24 h, and 96 h post-exposure and analyzed by LA-ICP-MS imaging to assess time-dependent changes in gold-associated spatial signals, and to compare elemental distribution patterns with non-exposed controls. Untreated control leaves showed no detectable gold at any sampling time point, confirming negligible native Au background. In treated leaves, LA-ICP-MS imaging revealed an initially localized Au hotspot at 1 h, followed by progressive Au redistribution toward the leaf margins and petiole region by 24 h and 96 h. Gold signals persisted over the full 96 h period, indicating stable association of Au-NP with leaf tissue. Comparative elemental mapping of Ca, Mg, K, P, Fe, Zn, and Cu showed no persistent differences in spatial distribution patterns between treated and control leaves as detectable by LA-ICP-MS. This study demonstrates the feasibility of LA-ICP-MS imaging for visualizing the deposition and temporal spatial redistribution of low-dose foliar-applied nanoparticles in intact leaves. The results provide a methodological reference for future hypothesis-driven studies that apply nanoparticles under more controlled conditions, include increased replication, and combine multiple analytical techniques. Full article

To achieve global carbon-neutrality goals, magnetic levitation (maglev) technologies offer a promising pathway toward sustainable, energy-efficient transportation systems. In this study, a comprehensive methodology was developed to analyse and optimise the levitation performance of high-temperature superconducting (HTS) maglev systems. Several permanent magnet guideway (PMG) configurations were compared, and an optimised PMG Halbach array design was identified that enhances flux concentration and significantly improves levitation performance. To accurately model the electromagnetic interaction between the HTS bulk and the external magnetic field, finite element models based on the H-formulation were established in both two dimensions (2D) and three dimensions (3D). An HTS maglev demonstrator was built using YBCO bulks, and an experimental platform was constructed to measure levitation force. While the 2D model offers fast computation, it shows deviations from the measurements due to geometric simplifications, whereas the 3D model predicts levitation forces for the cylindrical bulk with much higher accuracy, with errors remaining below 10%. The strong agreement between experimental measurements and the 3D simulation across the entire force–height cycle confirms that the proposed model reliably reproduces the electromagnetic coupling and resulting levitation forces in HTS maglev systems. The paper provides a practical and systematic reference for the optimal design and experimental validation of HTS bulk-based maglev systems. Full article

The accumulation of heavy metals in fish tissues is widely recognized as an indicator of aquatic environmental pollution, and the analysis of their content provides a basis for assessing ecological risk and the safety of aquatic food. The European eel (Anguilla anguilla) is a species frequently used as a bioindicator in environmental studies due to its wide geographic distribution, long life cycle, and high capacity for bioaccumulation of heavy metals in various tissues. The aim of this study was to assess the variation in the accumulation of heavy metals, i.e., mercury (Hg), lead (Pb), arsenic (As), and cadmium (Cd), in the tissues (muscle, liver, gonads, and gills) of European eels caught in two locations in Polish inland waters. The obtained results showed significant differences both in the concentration levels of individual elements and in their co-occurrence in the examined tissues. The statistical methods used, including correlation analysis, heat maps, and principal component analysis (PCA), allowed for a comprehensive assessment of the relationships between metals and the identification of factors differentiating the studied populations. The obtained results clearly indicate that fish residing in similar environments for long periods exhibit significant differences in heavy metal content in various fish tissues. Fish obtained from environments with potentially higher levels of heavy metal inputs, such as the Oder River EMU compared with the Vistula River EMU, showed higher levels of heavy metal accumulation in tissues. This study also found that the concentration of heavy metals tested did not exceed the safe standards for human fish consumption. Full article

Geometric discontinuities are unavoidable in additively manufactured polymer components and can significantly alter their mechanical response; however, their effects are rarely quantified in a systematic and geometry-comparative manner. In this study, the tensile behavior of FDM-printed PLA+ specimens with three different geometries—dog-bone, circular-hole, and U-notched (manufactured and tested in accordance with ASTM D638 (Type IV))—was experimentally and numerically investigated. Tensile tests were conducted using a universal testing machine equipped with an extensometer, while finite element simulations were performed using an experimentally calibrated Ramberg–Osgood-based elastic–plastic material model. The dog-bone specimens exhibited an ultimate tensile strength (UTS) of 41–43 MPa and a Young’s modulus of 3.06 GPa, representing the intrinsic material response under nearly homogeneous stress conditions. Circular-hole specimens maintained comparable strength (38–42 MPa) but showed reduced ductility (1.4–1.6%) and a slightly increased apparent modulus of 3.17 GPa due to localized deformation. In contrast, U-notched specimens displayed the highest apparent modulus (≈5.30 GPa) and nominal UTS (46–49 MPa), accompanied by a pronounced reduction in ductility (0.9–1.0%), indicating severe stress concentration and predominantly brittle fracture behavior. Finite element analysis showed excellent agreement with experimental results, with peak von Mises stresses reaching approximately 42 MPa for all geometries, corresponding closely to the experimentally measured tensile strength. These results demonstrate that geometric discontinuities strongly govern stress localization, apparent stiffness, and fracture initiation in FDM-printed PLA+ components. The validated Ramberg–Osgood-based modeling framework provides a reliable tool for predicting geometry-dependent mechanical behavior under quasi-static loading and supports geometry-aware design of additively manufactured polymer structures. Full article

The ecological network serves as a vital spatial strategy for addressing climate change, biodiversity loss, and habitat fragmentation. Addressing limitations in existing ecological network studies—such as strong subjectivity and insufficient accuracy in structural element identification, cross-regional integration, and resistance surface weighting—this research uses the Zhengzhou–Kaifeng–Luoyang region (ZKLR) as a case study. It introduces the self-organizing map (SOM) model to identify ecological sources and employs the XGBoost-SHAP model to optimize resistance surface weights, thereby reducing subjective weighting biases. Subsequently, the Linkage Mapper tool is utilized to construct the regional ecological network. The superiority of the SOM model for identifying ecological sources was confirmed by comparison with a traditional network based on morphological spatial pattern analysis (MSPA). Further integrating complex network topology theory, nodes attack the simulations-assessed network resilience and proposed optimization strategies. The results indicate the following: (1) The area of ecological sources identified by the SOM model is three times that of the MSPA model; (2) SHAP feature importance analysis revealed that elevation (DEM) exerted the greatest influence on the composite resistance surface, contributing over 40%, followed by land use and slope, with each contributing approximately 15%. High-resistance areas were primarily distributed in western and central mountainous regions and built-up urban areas, while low-resistance areas were concentrated in the central and eastern plains; (3) topological analysis indicates that the integrated ecological network (IEN) exhibits superior robustness compared to the structural ecological network (SEN). The edge-adding strategy generated 22 additional ecological corridors, significantly enhancing the overall resilience of the integrated ecological network; and (4) based on ecological network construction and optimization results, a territorial spatial protection strategy of “one belt, two cores, two zones, and three corridors” is proposed. This study provides a novel methodological framework for ecological network construction, with findings offering reference for ecological conservation and spatial planning in the ZKLR and similar areas. Full article

The impacts of land use on stormwater runoff quality and Best Management Practices to mitigate these impacts have been investigated since the 1970s, yet challenges remain in providing a modeling approach that concomitantly considers contributions from different land use types. In densely developed urban areas, a buildup/washoff approach is often applied, while in rural areas, some type of erosion modeling is employed, as the processes of detachment, entrainment, and transport are fundamentally different. This study presents a coupled modeling approach within PCSWMM, integrating exponential buildup/washoff for impervious surfaces with the Modified Universal Soil Loss Equation (MUSLE) for pervious areas, including construction sites, to characterize water quality in the large mixed urban–rural Sparrovale catchment in Geelong, Australia. The watershed includes an innovative cascading system of 12 online NbS wetlands along one of the main tributaries, Armstrong Creek, to manage runoff quantity and quality, as well as 16 offline NbS wetlands that are tributary to the online system. A total of 78 samples for Total Suspended Solids (TSS), Total Phosphorus (TP), and Total Nitrogen (TN) were collected from six monitoring sites along Armstrong Creek during wet- and dry-weather events between May and July 2024 for model validation. The data were supplemented with six other catchment stormwater quality datasets collected during earlier studies, which provided an understanding of water quality status for the broader Geelong region. Results showed that average nutrient concentrations across all the sites ranged from 0.44 to 2.66 mg/L for TP and 0.69 to 5.7 mg/L for TN, spanning from within to above the ecological threshold ranges for eutrophication risk (TP: 0.042 to 1 mg/L, TN: 0.3 to 1.5 mg/L). In the study catchment, upstream wetlands reduced pollutant levels; however, downstream wetlands that received runoff from agriculture, residential areas, and, importantly, construction sites, showed a substantial increase in sediment and nutrient concentration. Water quality modeling revealed washoff parameters primarily influenced concentrations from established urban neighborhoods, whereas erosion parameters substantially impacted total pollutant loads for the larger system, demonstrating the importance of integrated modeling for capturing pollutant dynamics in heterogeneous, urbanizing catchments. The study results emphasize the need for spatially targeted management strategies to improve stormwater runoff quality and also show the potential for cascading wetlands to be an important element of the Nature-based Solution (NbS) runoff management system. Full article

Background: Adult patients with a thin buccal cortical plate and fragile periodontal phenotype are at high risk of dehiscence, fenestration and recession during transverse orthodontic expansion. Conventional mechanics often create a cervical compression-dominant environment that exceeds the adaptive capacity of the periodontal ligament (PDL)–bone complex. Objectives: This study proposes an integrative mechanobiological model in which a skeletal-anchorage-assisted loading protocol (Bone Protection System, BPS) transforms expansion into a tension-dominant regime that favours buccal phenotype preservation. Methods: Patient-specific finite element models were used to compare conventional expansion with a BPS-modified force system. Regional PDL stress patterns and crown/apex displacement vectors were analysed to distinguish tipping-dominant from translation-dominated mechanics. A pilot CBCT proof-of-concept (n = 1 thin-phenotype adult) with voxel-based registration quantified changes in maxillary and mandibular alveolar ridge width and buccal cortical plate thickness before and after BPS-assisted expansion. The mechanical findings were integrated with current evidence on compression- versus tension-driven inflammatory and osteogenic pathways in the PDL and cortical bone. Results: FEM demonstrated that conventional expansion concentrates high cervical compressive stress along the buccal PDL and cortical surface, accompanied by bending-like crown–root divergence. In contrast, the BPS protocol redirected forces to create a buccal tensile-favourable region and a more parallel crown–apex displacement pattern, indicative of translation-dominated movement. In the proof-of-concept (n = 1) CBCT case, BPS-assisted expansion was associated with preservation or increase of buccal ridge dimensions without radiographic signs of cortical breakdown. Conclusions: A tension-dominant orthodontic loading environment generated by a skeletal-anchorage-assisted force system may support buccal cortical preservation and vestibular phenotype reinforcement in thin-phenotype patients. The proposed mechanobiological model links these imaging and FEM findings to known molecular pathways of inflammation, angiogenesis and osteogenesis. It suggests a functional biomaterial-based strategy for widening the biological envelope of safe tooth movement. Full article

Panax notoginseng, a high-value medicinal crop, suffers substantial yield losses due to Fusarium oxysporum-mediated root rot, for which no molecularly defined control targets are currently available. Histone acetyltransferases (HATs) serve as crucial epigenetic regulators of fungal development and stress responses; however, their functional roles in F. oxysporum remain largely unexplored. In this study, we systematically identified six FoHAT genes via genome-wide analysis and classified them into evolutionarily conserved subfamilies through phylogenetic comparison with orthologs from Saccharomyces cerevisiae, Homo sapiens, and Arabidopsis thaliana. Structural analyses revealed distinct motif compositions and domain architectures among FoHAT members, while promoter cis-element profiling suggested potential subfunctionalization via stress-responsive regulatory mechanisms. Functional investigations demonstrated that major notoginsenosides present in P. notoginseng root exudates—R₁, Rg₁, Rg₂, Re, and Rd—dynamically influenced both spore germination and FoHAT expression profiles. Intriguingly, each notoginsenoside exerted concentration-dependent non-linear effects on spore germination, either inhibiting or promoting the process. Concurrently, notoginsenoside exposure triggered compensatory transcriptional responses, most notably a rebound in Fo-Hat1_N expression from 9% to 112% under Rd treatment. This work establishes an initial epigenetic framework for combating Fusarium root rot in medicinal plants and offers a foundation for developing HAT-targeted small-molecule inhibitors. Full article

This study explores the viability of ultra-high-performance concrete (UHPC) as a structural material for compressed air storage (CAES) systems, combining comprehensive experimental testing and numerical simulations. Scaled (1:20) CAES tanks were designed and tested experimentally under controlled pressure conditions up to 4 MPa (580 psi), employing strain gauges to measure strains in steel cylinders both with and without UHPC confinement. Finite element models (FEMs) developed using ANSYS Workbench 2024 simulated experimental conditions, enabling detailed analysis of strain distribution and structural behavior. Experimental and numerical results agreed closely, with hoop strain relative errors between 0.9% (UHPC-confined) and 1.9% (unconfined), confirming the numerical model’s accuracy. Additionally, the study investigated the role of a rubber interface layer integrated between the steel and UHPC, revealing its effectiveness in mitigating localized stress concentrations and enhancing strain distribution. Failure analyses conducted using the von Mises criterion for steel and the Drucker–Prager criterion for UHPC confirmed adequate safety factors, validating the structural integrity under anticipated operational pressures. Principal stresses from numerical analyses were scaled to real-world operational pressures. These thorough results highlight that incorporating rubber enhances the system’s structural performance. Full article

Recently, the EU approved RENURE-criteria materials to be used as substitutes for synthetic N fertilisers. Several studies have been performed on the agronomic efficacy and potential environmental impacts of different bio-based fertilisers (BBFs) from biomass recovery, including the RENURE-criteria materials. But information is lacking about their effectiveness under abiotic stress conditions like salinity and drought. The predictions for climate change-induced increased drought and soil salinisation for the European soils have also increased, making it inevitable to understand BBF performance in these impending situations. Two RENURE-criteria top-priority materials (ammonium nitrate (AN) and ammonium sulphate (AS) and another commercially used BBF—an evaporator concentrate (CaE)) were evaluated in a pot trial growing spinach under salinity and drought stress with a reference ‘no stress’ condition to examine crop growth, nutrient uptake, and nitrogen fertiliser replacement value (NFRV). Agronomically, BBFs performed at par with the synthetic fertiliser (SF) under unstressed and salt-stressed conditions, whereas, under drought stress, BBFs outperformed the SF treatment. AS exhibited the highest yield and nutrient uptake, displaying an NFRV of 3.1 and 1.8 under no-stress and salt-stress conditions, respectively. Salt stress did not negatively impact the crops grown in this trial, potentially due to the higher potassium content in the system, which alleviated the possible negative impacts of high sodium. This study delves into the agronomic response, without evaluating crop physiological changes, and, hence, should be taken as a preliminary step into further investigation of observed elemental interactions (that could be potentially driving stress mitigation) while also examining the crop physiology during the duration of stress. Full article

Among corrosive environments, Cl⁻ is one of the most aggressive anions which can cause electrochemical corrosion and the resultant failures of alloys, and the increase in Cl⁻ concentration will further deteriorate the passive film in many conventional alloys. Here, we report single-phase Nb₂₅Mo₂₅Ta₂₅Ti₂₀W₅C_x (x = 0.1, 0.3, 0.8 at.%) refractory high-entropy alloys (RHEAs) with excellent corrosion resistance in high-concentration NaCl solutions. According to potentiodynamic polarization, electrochemical impedance spectroscopy, corroded morphology and the current–time results, the RHEAs demonstrate even better corrosion resistance with the increase in NaCl concentration to 23.5 wt.%, significantly superior to 304 L stainless steel. Typically, the corrosion current density (i_corr) and over-passivation potential (E_t) reached the lowest and highest value, respectively, in the 23.5 wt.% NaCl solution, and the i_corr (2.36 × 10⁻⁷ A/cm²) of Nb₂₅Mo₂₅Ta₂₅Ti₂₀W₅C_0.1 alloy is nearly two orders lower than that of 304 L stainless steel (1.75 × 10⁻⁵ A/cm²). The excellent corrosion resistance results from the formation of passive films with fewer defects and more stable oxides. Moreover, with the addition of the appropriate C element, the RHEAs also demonstrated improved strength and plasticity simultaneously, for example, the Nb₂₅Mo₂₅Ta₂₅Ti₂₀W₅C_0.3 alloy exhibited an average yield strength of 1368 MPa and a plastic strain of 19.7%. The present findings provide useful guidance to address the conflict between the excellent corrosion resistance and high strength of advanced alloys. Full article

This paper systematically investigated the mechanical behavior of welded-plate lifting lugs subjected to dynamic and eccentric loadings in steel structure hoisting applications. By integrating on-site stress monitoring throughout the hoisting process with finite element numerical simulations, the dynamic response characteristics of the lugs were comprehensively analyzed. The results indicated that the stress response followed a three-stage evolution comprising elastic growth stage, peak fluctuation stage, and gradual decay stage. Non-uniform loading significantly intensified stress concentrations at the edges of the lifting holes and in the lug–stiffener transition region, with local impact parameters ranging from 1.02 to 1.12 and exhibiting a distinctly non-uniform spatial distribution. A refined finite element model was established, and comparisons with experimental data confirmed that static and dynamic prediction errors were controlled within 5 MPa and 5%, respectively. The optimal lifting angle of 75° was identified, resulting in a significant reduction in dynamic amplification. Furthermore, a small-sample Bootstrap method was introduced to probabilistically correct the dynamic parameter, enhancing design reliability by approximately 10%. Overall, this research provided a more rigorous theoretical foundation and practical design tool for evaluating the safety of lifting lugs subjected to dynamic loading. Full article