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311 Results Found

  • Review
  • Open Access
32 Citations
5,601 Views
14 Pages

Estimation of Reduction in Influenza Vaccine Effectiveness Due to Egg-Adaptation Changes—Systematic Literature Review and Expert Consensus

  • Raul Ortiz de Lejarazu-Leonardo,
  • Emanuele Montomoli,
  • Radek Wojcik,
  • Solomon Christopher,
  • Anne Mosnier,
  • Elena Pariani,
  • Antoni Trilla Garcia,
  • Helmut Fickenscher,
  • Barbara C. Gärtner and
  • Ravi Jandhyala
  • + 2 authors

29 October 2021

Background: Influenza vaccines are the main tool to prevent morbidity and mortality of the disease; however, egg adaptations associated with the choice of the manufacturing process may reduce their effectiveness. This study aimed to estimate the impa...

  • Article
  • Open Access
2 Citations
3,012 Views
10 Pages

MADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Eggs

  • Hui Chen,
  • Junqiu Wang,
  • Yunsong Liu,
  • Ivy Quek Ee Ling,
  • Chih Chuan Shih,
  • Dafei Wu,
  • Zhiyan Fu,
  • Raphael Tze Chuen Lee,
  • Miao Xu and
  • Vincent T. Chow
  • + 4 authors

Seasonal Influenza H3N2 virus poses a great threat to public health, but its vaccine efficacy remains suboptimal. One critical step in influenza vaccine production is the viral passage in embryonated eggs. Recently, the strength of egg passage adapta...

  • Article
  • Open Access
4 Citations
3,437 Views
13 Pages

Expanding Mouse-Adapted Yamagata-like Influenza B Viruses in Eggs Enhances In Vivo Lethality in BALB/c Mice

  • Matthew J. Pekarek,
  • Erika M. Petro-Turnquist,
  • Adam Rubrum,
  • Richard J. Webby and
  • Eric A. Weaver

14 June 2022

Despite the yearly global impact of influenza B viruses (IBVs), limited host range has been a hurdle to developing a readily accessible small animal disease model for vaccine studies. Mouse-adapting IBV can produce highly pathogenic viruses through s...

  • Article
  • Open Access
9 Citations
7,512 Views
20 Pages

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus

  • Vincenzo Carbone,
  • Elena K. Schneider,
  • Steve Rockman,
  • Mark Baker,
  • Johnny X. Huang,
  • Chi Ong,
  • Matthew A. Cooper,
  • Elizabeth Yuriev,
  • Jian Li and
  • Tony Velkov

5 June 2015

The haemagglutinin (HA) glycan binding selectivity of H1N1 influenza viruses is an important determinant for the host range of the virus and egg-adaption during vaccine production. This study integrates glycan binding data with structure-recognition...

  • Review
  • Open Access
27 Citations
6,106 Views
13 Pages

Cell-Based Manufacturing Technology Increases Antigenic Match of Influenza Vaccine and Results in Improved Effectiveness

  • Steven Rockman,
  • Karen Laurie,
  • Chi Ong,
  • Sankarasubramanian Rajaram,
  • Ian McGovern,
  • Vy Tran and
  • John Youhanna

26 December 2022

To ensure that vaccination offers the best protection against an infectious disease, sequence identity between the vaccine and the circulating strain is paramount. During replication of nucleic acid, random mutations occur due to the level of polymer...

  • Article
  • Open Access
9 Citations
4,112 Views
13 Pages

Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina

  • Analía Urueña,
  • Paula Micone,
  • María Cecilia Magneres,
  • Ian McGovern,
  • Joaquin Mould-Quevedo,
  • Túlio Tadeu Rocha Sarmento and
  • Norberto Giglio

28 September 2022

Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in...

  • Article
  • Open Access
26 Citations
3,664 Views
13 Pages

Retrospective Assessment of the Antigenic Similarity of Egg-Propagated and Cell Culture-Propagated Reference Influenza Viruses as Compared with Circulating Viruses across Influenza Seasons 2002–2003 to 2017–2018

  • Sankarasubramanian Rajaram,
  • Pirada Suphaphiphat,
  • Josephine van Boxmeer,
  • Mendel Haag,
  • Brett Leav,
  • Ike Iheanacho,
  • Kristin Kistler and
  • Raúl Ortiz de Lejarazu

Suboptimal vaccine effectiveness against seasonal influenza is a significant public health concern, partly explained by antigenic differences between vaccine viruses and viruses circulating in the environment. Haemagglutinin mutations within vaccine...

  • Review
  • Open Access
16 Citations
7,130 Views
16 Pages

12 January 2022

Subtype H3N2 influenza A viruses (A(H3N2)) have been the dominant strain in some countries in the Western Pacific region since the 2009 influenza A(H1N1) pandemic. Vaccination is the most effective way to prevent influenza; however, low vaccine effec...

  • Article
  • Open Access
3 Citations
3,896 Views
16 Pages

Predicting Egg Passage Adaptations to Design Better Vaccines for the H3N2 Influenza Virus

  • Yunsong Liu,
  • Hui Chen,
  • Wenyuan Duan,
  • Xinyi Zhang,
  • Xionglei He,
  • Rasmus Nielsen,
  • Liang Ma and
  • Weiwei Zhai

17 September 2022

Seasonal H3N2 influenza evolves rapidly, leading to an extremely poor vaccine efficacy. Substitutions employed during vaccine production using embryonated eggs (i.e., egg passage adaptation) contribute to the poor vaccine efficacy (VE), but the evolu...

  • Article
  • Open Access
1,231 Views
21 Pages

Duck Egg Crack Detection Using an Adaptive CNN Ensemble with Multi-Light Channels and Image Processing

  • Vasutorn Chaowalittawin,
  • Woranidtha Krungseanmuang,
  • Posathip Sathaporn and
  • Boonchana Purahong

17 July 2025

Duck egg quality classification is critical in farms, hatcheries, and salted egg processing plants, where cracked eggs must be identified before further processing or distribution. However, duck eggs present a unique challenge due to their white eggs...

  • Article
  • Open Access
8 Citations
2,163 Views
16 Pages

24 February 2024

Partial least-squares (PLS) regression is a well known chemometric method used for predictive modelling, especially in the presence of many variables. Although PLS was not initially developed as a technique for classification tasks, scientists have r...

  • Article
  • Open Access
14 Citations
3,505 Views
21 Pages

21 December 2021

This paper presents the Hybrid and Self-Adaptive Differential Evolution algorithms (HSADE) to solve an egg distribution problem in Thailand. We introduce and formalize a model for a multi-product, multi-depot vehicle routing problem with a time windo...

  • Article
  • Open Access
7 Citations
2,565 Views
16 Pages

Enhanced Microvascular Adaptation to Acute Physical Stress and Reduced Oxidative Stress in Male Athletes Who Consumed Chicken Eggs Enriched with n-3 Polyunsaturated Fatty Acids and Antioxidants—Randomized Clinical Trial

  • Luka Kolar,
  • Petar Šušnjara,
  • Marko Stupin,
  • Ana Stupin,
  • Ivana Jukić,
  • Zrinka Mihaljević,
  • Nikolina Kolobarić,
  • Iva Bebek,
  • Diana Nejašmić and
  • Marija Lovrić
  • + 1 author

31 October 2023

This randomized interventional study aimed to determine the effects of n-3 polyunsaturated fatty acids, selenium, vitamin E, and lutein supplementation in the form of enriched chicken egg consumption on microvascular endothelium-dependent vasodilatio...

  • Article
  • Open Access
68 Citations
15,845 Views
14 Pages

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

  • Weina Sun,
  • Stephen McCroskery,
  • Wen-Chun Liu,
  • Sarah R. Leist,
  • Yonghong Liu,
  • Randy A. Albrecht,
  • Stefan Slamanig,
  • Justine Oliva,
  • Fatima Amanat and
  • Alexandra Schäfer
  • + 6 authors

17 December 2020

A successful severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine must not only be safe and protective, but must also meet the demand on a global scale at a low cost. Using the current influenza virus vaccine production capacity to ma...

  • Editorial
  • Open Access
8 Citations
3,089 Views
5 Pages

21 August 2020

Influenza infections are responsible for significant number of deaths and overwhelming costs worldwide every year. Vaccination represents the only cost-efficient alternative to address this major problem in human health. However, current vaccines are...

  • Review
  • Open Access
106 Citations
20,170 Views
12 Pages

Efforts to Improve the Seasonal Influenza Vaccine

  • Alfred T. Harding and
  • Nicholas S. Heaton

Influenza viruses infect approximately 20% of the global population annually, resulting in hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) approved antiviral drugs for combating the disease, vaccination remains the...

  • Feature Paper
  • Article
  • Open Access
2 Citations
3,507 Views
16 Pages

Evaluation of the Egg Bank of Two Small Himalayan Lakes

  • Roberta Piscia,
  • Sara Bovio,
  • Marina Manca,
  • Andrea Lami and
  • Piero Guilizzoni

11 February 2020

High mountain lakes are biodiversity treasures. They host endemic taxa, adapted to live in extreme environments. Among adaptations, production of diapausing eggs allows for overcoming the cold season. These diapausing eggs can rest in the sediments,...

  • Article
  • Open Access
14 Citations
10,660 Views
20 Pages

28 June 2020

Leaf insects (Phasmatodea: Phylliidae) exhibit perfect crypsis imitating leaves. Although the special appearance of the eggs of the species Phyllium philippinicum, which imitate plant seeds, has received attention in different taxonomic studies, the...

  • Article
  • Open Access
18 Citations
6,196 Views
13 Pages

Review of Analyses Estimating Relative Vaccine Effectiveness of Cell-Based Quadrivalent Influenza Vaccine in Three Consecutive US Influenza Seasons

  • Constantina Boikos,
  • Ian McGovern,
  • Deborah Molrine,
  • Justin R. Ortiz,
  • Joan Puig-Barberà and
  • Mendel Haag

The adaptation of influenza seed viruses in egg culture can result in a variable antigenic vaccine match each season. The cell-based quadrivalent inactivated influenza vaccine (IIV4c) contains viruses grown in mammalian cell lines rather than eggs. I...

  • Article
  • Open Access
236 Views
20 Pages

Using an Optoelectronic Method for the Non-Destructive Sorting of Hatching Duck Eggs

  • Shokhan Alpeisov,
  • Aidar Moldazhanov,
  • Akmaral Kulmakhambetova,
  • Azimjan Azizov,
  • Zhassulan Otebayev and
  • Dmitriy Zinchenko

The efficient pre-incubation selection of duck eggs is essential to ensuring stable hatchability, but most existing optoelectronic and machine vision systems have been calibrated for chicken eggs and cannot be directly used for duck eggs because of t...

  • Article
  • Open Access
4 Citations
3,897 Views
10 Pages

3 November 2022

Bird nests function as vessels for eggs and nestlings, and an environment for rearing offspring. However, foreign objects falling into bird nests and nestling eggshells may be harmful. Moreover, the smell of fecal sacs increases the risk of detection...

  • Article
  • Open Access
5 Citations
2,626 Views
12 Pages

30 June 2023

The increasing atmospheric CO2 concentrations and warming of marine waters have encouraged experiments on multi-stressor interactions in marine organisms. We conducted a multigenerational experiment to assess reproductive capacities regarding egg pro...

  • Article
  • Open Access
8 Citations
5,084 Views
9 Pages

10 January 2019

Parasitoidism is one of the main causes of insect egg mortality. Parasitoids are often able to detect eggs using semiochemicals released from eggs and disturbed plants. In response, female insects adopt a wide variety of oviposition strategies to red...

  • Feature Paper
  • Review
  • Open Access
1 Citations
1,533 Views
16 Pages

26 May 2025

Eggs are good sources of animal proteins. Methods for creating designer eggs are attractive to scientists and producers of the eggs, in order to fulfill customers’ demands. We review and summarize the current understanding of how genetic and en...

  • Article
  • Open Access
2,207 Views
14 Pages

The Prevalence of Egg Parasitoids of Two Cobweb Spiders in a Tropical Urban Gradient

  • Natalia Jiménez-Conejo,
  • Paul E. Hanson,
  • Eduardo Chacón-Madrigal and
  • Geovanna Rojas-Malavasi

27 November 2024

Parasitoidism strongly influences the structure of the spiders’ populations, and it can be affected by environmental factors such as those caused by anthropogenic actions. We studied the prevalence of parasitoids in egg sacs and the proportion...

  • Article
  • Open Access
38 Citations
8,388 Views
10 Pages

Vibrio spp. are major causes of mortality in white shrimp (Litopenaeus vannamei) which is lacking adaptive immunity. Passive immunization with a specific egg yolk antibody (IgY) is a potential method for the protection of shrimp against vibriosis. In...

  • Review
  • Open Access
3 Citations
3,728 Views
16 Pages

Listeria Occurrence in Conventional and Alternative Egg Production Systems

  • Steven C. Ricke,
  • Corliss A. O’Bryan and
  • Michael J. Rothrock

Listeria continues to be a persistent foodborne pathogen that is responsible for human cases of listeriosis when contaminated food products are consumed. Human subjects considered to be most susceptible include the elderly, immunocompromised, and pre...

  • Feature Paper
  • Opinion
  • Open Access
9 Citations
2,936 Views
7 Pages

4 January 2021

Calanoida have the highest number of species among Copepoda in marine plankton, but not in fresh water, where the greatest number are Cyclopoida. Freshwater Cyclopoida also live in more freshwater sites than Calanoida. This could be a consequence of...

  • Article
  • Open Access
12 Citations
3,229 Views
15 Pages

Bone Health or Performance? Adaptation Response of Genetically Divergent Chicken Layer Lines to a Nutritive Calcium Depletion

  • Simon Jansen,
  • Mara Bues,
  • Ulrich Baulain,
  • Christin Habig,
  • Ingrid Halle,
  • Stefanie Petow,
  • Ahmad Reza Sharifi,
  • Annett Weigend,
  • Mirja Rosmarie Wilkens and
  • Steffen Weigend

14 September 2020

In modern laying hybrids, calcium (Ca) homeostasis is immensely challenged by daily eggshell calcification. However, excessive mobilization of Ca from bones may lead to osteoporosis, which then manifests in a high incidence of poor bone quality. The...

  • Review
  • Open Access
21 Citations
3,789 Views
8 Pages

During a schistosome infection, the interactions that occur between the mammalian host and the parasite change rapidly once egg laying begins. Both juvenile and adult schistosomes adapt to indefinitely avoid the host immune system. In contrast, the s...

  • Article
  • Open Access
1 Citations
702 Views
16 Pages

3 August 2025

Spawning diversity plays an essential role in fish survival and reproduction, which contributes to the exceptional diversity of teleosts among vertebrates. Different zona radiata structures reflect the adaptability of fish to the environment of spawn...

  • Communication
  • Open Access
1 Citations
1,750 Views
9 Pages

Influence of Salinity on the Survival Rate of Fertilized Chum Salmon (Oncorhynchus keta) Eggs

  • Jong Won Park,
  • Beom Sik Kim,
  • Ju Kyoung Kim,
  • Hae Kun Jung,
  • Hyun Je Park and
  • Chung Il Lee

Chum salmon (Oncorhynchus keta) exhibit a remarkable ability to adapt to changes in salinity during their life cycle. However, the fertilized egg stages are sensitive to salinity, affecting ontogeny and hatching. This study investigated the effect of...

  • Article
  • Open Access
5 Citations
2,947 Views
14 Pages

4 August 2022

In Canada, approximately 12,000 people annually are hospitalized with influenza. While vaccination is the most effective method for reducing the burden of seasonal influenza, the propagation of vaccine virus strains in eggs can result in egg adaption...

  • Communication
  • Open Access
2 Citations
2,877 Views
11 Pages

An Algorithm for Obtaining 3D Egg Models from Visual Images

  • Zlatin Zlatev,
  • Mariya Georgieva-Nikolova and
  • Hristo Lukanov

31 December 2021

Mathematical models for describing the shape of eggs find application in various fields of practice. The article proposes a method and tools for a detailed study of the shape and peripheral contours of digital images of eggs that are suitable for gro...

  • Article
  • Open Access
23 Citations
3,775 Views
10 Pages

Development of a Novel Acoustic Spectroscopy Method for Detection of Eggshell Cracks

  • István Kertész,
  • Viktória Zsom-Muha,
  • Rebeka András,
  • Ferenc Horváth,
  • Csaba Németh and
  • József Felföldi

3 August 2021

Non-destructive testing (NDT) for eggshell faults is highly important for the egg industry, as cracked eggs account for around 3% of total production. The most commonly used method at present, candling, is labor intensive, while computer vision syste...

  • Article
  • Open Access
4 Citations
7,492 Views
13 Pages

Small Scale Egg Production: The Challenge of Portuguese Autochthonous Chicken Breeds

  • Nuno V. Brito,
  • Júlio Cesar Lopes,
  • Virgínia Ribeiro,
  • Rui Dantas and
  • José V. Leite

Biodiversity concerns and the sustainability of agroecological systems, together with consumer demand for higher quality products from alternative and extensive farming methods, have reinforced interest in local breeds that are well adapted to low-in...

  • Article
  • Open Access
4 Citations
5,037 Views
11 Pages

Modification and Clinical Application of the Inner Perivitelline Membrane Test in Different Avian Species

  • Judith Krohn,
  • Dominik Fischer,
  • Helena Schneider,
  • Klaus Failing,
  • Michael Lierz,
  • Christine Ehling and
  • Axel Wehrend

12 April 2019

The aim of this study was to adapt an inner perivitelline membrane (IPVM) test as an interspecies penetration assay for avian spermatozoa. The IPVM of different bird species was evaluated to test the penetrating ability of avian spermatozoa in an int...

  • Article
  • Open Access
498 Views
16 Pages

28 October 2025

This study investigates spongy moth (Lymantria dispar) infestation patterns in Whirlpool Forest, Ontario, offering a region-specific perspective while largely corroborating existing findings. We analyzed egg mass distribution across 43 sampling plots...

  • Article
  • Open Access
837 Views
16 Pages

24 March 2025

The predatory function and numerical responses of natural enemy insects are critical for evaluating their biological control potential, particularly in understanding pest suppression mechanisms and ecological adaptability. Here, we examined the preda...

  • Article
  • Open Access
5 Citations
3,823 Views
18 Pages

8 September 2020

The most important exotic leafhopper pests currently affecting the Italian vineyards are the leafhoppers Scaphoideus titanus, Orientus ishidae and the planthopper Metcalfa pruinosa. Their highest population density is detected in the uncultivated are...

  • Article
  • Open Access
21 Citations
6,630 Views
12 Pages

Mass-Rearing of Drosophila suzukii for Sterile Insect Technique Application: Evaluation of Two Oviposition Systems

  • Fabiana Sassù,
  • Katerina Nikolouli,
  • Silvana Caravantes,
  • Gustavo Taret,
  • Rui Pereira,
  • Marc J. B. Vreysen,
  • Christian Stauffer and
  • Carlos Cáceres

12 December 2019

Drosophila suzukii (Diptera: Drosophilidae) is an invasive pest of a wide range of commercial soft-skinned fruits. To date, most management tactics are based on spraying of conventional and/or organic insecticides, baited traps, and netting exclusion...

  • Article
  • Open Access
1,605 Views
13 Pages

19 June 2024

Insect pheromones have been intensively studied with respect to their role in insect communication. However, scarce knowledge is available on the impact of pheromones on plant responses, and how these in turn affect herbivorous insects. A previous st...

  • Article
  • Open Access
1,609 Views
22 Pages

4 March 2025

Egg-carrying ectothermic planktonic organisms in stressed conditions adapt diverse reproductive trade-off strategies, which are denoted by markers of stress, either in their physiology, morphology or reproductive characteristics. This is the first st...

  • Article
  • Open Access
21 Citations
2,858 Views
12 Pages

8 July 2022

S-ovalbumin content is an indicator of egg freshness and has an important impact on the quality of processed foods. The objective of this study is to develop simplified models for monitoring the S-ovalbumin content of eggs during storage using hypers...

  • Article
  • Open Access
5 Citations
1,713 Views
18 Pages

Genome-Assisted Probiotic Characterization and Application of Lactiplantibacillus plantarum 18 as a Candidate Probiotic for Laying Hen Production

  • Guoqing Zhang,
  • Ning Yang,
  • Zhongyuan Liu,
  • Xinyu Chen,
  • Mengjiao Li,
  • Tongyu Fu,
  • Donghong Zhang and
  • Cuiqing Zhao

Probiotics gained significant attention for their potential to improve gut health and enhance productivity in animals, including poultry. This comprehensive study focused on the genetic analysis of Lactiplantibacillus plantarum 18 (LP18) to understan...

  • Article
  • Open Access
417 Views
17 Pages

Genetic Basis of Egg Production in Baicheng-You Chickens: A Genome-Wide Association Study

  • Gaoyun You,
  • Tinghao Jiang,
  • Haiying Li,
  • Wei Dong,
  • Xiaoyu Zhao,
  • Shihao Zhang,
  • Zhuocheng Hou,
  • Herong Liao and
  • Zhongtao Yin

21 November 2025

The Baicheng-You chicken is a valuable local breed in Xinjiang, China, known for its strong disease and stress resistance and excellent meat quality. However, it has not been scientifically bred or protected, leading to low production performance, pa...

  • Article
  • Open Access
1,041 Views
19 Pages

Assessing the Productivity of Colonies Headed by Preheated Honeybee Queens

  • Abd Al-Majeed Al-Ghzawi,
  • Shahera Talat Zaitoun,
  • Mohammad Nafi Solaiman Al-Sabi,
  • Salem Saleh Mazari,
  • Ilham Mustafa Al-Omari and
  • Maqbool Saed Altalhi

18 August 2025

This study investigated the effects of preheat hardening on the egg-laying capacity of honeybee queens and the flight performance of their daughter workers. A honeybee queen was confined in a cage with a two-section frame for 12 h. Then, 48 h old egg...

  • Article
  • Open Access
7 Citations
4,364 Views
15 Pages

Pathobiological and Genomic Characterization of a Cold-Adapted Infectious Bronchitis Virus (BP-caKII)

  • Seung-Min Hong,
  • Se-Hee An,
  • Chung-Young Lee,
  • Chang-Seon Song,
  • Kang-Seuk Choi,
  • Jae-Hong Kim and
  • Hyuk-Joon Kwon

19 November 2018

We established a cold-adapted infectious bronchitis virus (BP-caKII) by passaging a field virus through specific pathogen-free embryonated eggs 20 times at 32 °C. We characterized its growth kinetics and pathogenicity in embryonated eggs, and its...

  • Article
  • Open Access
611 Views
16 Pages

30 October 2025

Changes in food consumption are closely related to food production, loss, and waste. Few studies focused on people’s adaptation to climate warming through changes in food consumption quantity. This study examined how climate warming in the curr...

  • Communication
  • Open Access
5 Citations
2,357 Views
13 Pages

Fatty Acids in the Eggs of Red King Crabs from the Barents Sea

  • Alexander G. Dvoretsky,
  • Fatima A. Bichkaeva,
  • Nina F. Baranova and
  • Vladimir G. Dvoretsky

22 January 2024

The red king crab, Paralithodes camtschaticus, was introduced into the Barents Sea where, after a period of 30 years of adaptation, it has established a new population. This population has been commercially exploited over the past two decades, suppor...

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