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PLGA Microspheres with Alginate-Coated Large Pores for the Formulation of an Injectable Depot of Donepezil Hydrochloride
- Dohyun Kim,
- Tae Hee Han,
- Seong-Chul Hong,
- Sun Jae Park,
- Yong Hak Lee,
- Hyeongmin Kim,
- Minwoo Park and
- Jaehwi Lee
As the main symptom of Alzheimer’s disease-related dementia is memory loss, patient compliance for donepezil hydrochloride (donepezil), administered as once-daily oral formulations, is poor. Thus, we aimed to design poly(lactic-co-glycolic acid...