Search Results (50,844)

This study investigates the forecast bust of Typhoon SHANSHAN (2024) characterized by large track errors using the four major interactive grand global operational ensemble data and the atmospheric reanalysis data. Ensemble space empirical orthogonal function (EOF) analysis is applied to 850, 500, and 300 hPa geopotential heights at three target times to diagnose how synoptic-scale uncertainty contributed to the erroneous motions of SHANSHAN. We align the multi-level EOF bases to a reference-time basis via a weighted Procrustes rotation and evaluate similarity to the atmospheric reanalysis data in the aligned principal component (PC) space, enabling robust, distance-based conditioning of ensemble members. Results show that ensemble spread is consistently larger in the mid-latitudes, with relatively large uncertainty concentrated around the upper-tropospheric trough and lower-tropospheric structure near SHANSHAN. The dominant EOF modes differ by phase of SHANSHAN: lower-tropospheric modes govern the westward-moving stage, whereas mid- and upper-tropospheric modes dominate after recurvature. Selecting members whose EOF-based PC structures most closely match the atmospheric reanalysis effectively suppresses large-error outliers and yields improved conditional track predictions. These findings highlight phase-dependent synoptic controls and demonstrate that adaptive, reference-consistent conditioning can enhance the track guidance of tropical cyclones during difficult forecast situations. Full article

Baseflow separation was performed for 42 small catchments completely built up of either crystalline rocks or folded/unfolded Paleogene flysch rocks. Three different methods were applied—Local minimum (BFI), Kille’s and Rambert’s. Mean total annual runoff in individual catchments varied from 179 to 1132 mm, with an average of 498 mm. Taking into account results for the whole dataset, baseflow participated in 45% ± 15% ratio of the total runoff. Local minimum and Kille’s method results were quite similar: both showed average baseflow participating on 39%/40% of total runoff in unfolded Paleogene catchments, on 29%/29% in folded flysch and 44%/45% in catchments with crystalline basement. Rambert’s method results were 10% to 12% higher from the previous two, reaching 50% in unfolded flysch Paleogene catchments, 41% in folded flysch and 56% in crystalline catchments. Differences might be caused by the nature of Rambert’s method, which is based on recession curves analyses, while the previous two result from discharge statistics. Still, usually only less than 50% of unevaporated precipitation is able to infiltrate and recharge groundwater resources in crystalline rocks and flysch sediments, and folded flysch rocks are sometimes able to absorb only 10–20% of unevaporated precipitation. Full article

Background/Objectives: Sex differences in ST-elevation myocardial infarction (STEMI) outcomes persist despite advances in primary percutaneous coronary intervention (PCI), but whether female sex independently influences early mortality remains unclear. study aimed to assess sex-based differences in clinical characteristics, management, in-hospital outcomes and to determine whether female sex independently predicts in-hospital mortality. Methods: This retrospective observational study included 512 consecutive patients with STEMI presenting within 6 h of symptom onset and treated with primary PCI. Clinical, laboratory, echocardiographic and angiographic data were analyzed. The primary endpoint was in-hospital mortality. Multivariable logistic regression identified independent predictors of mortality. Results: Women comprised 32.0% of the cohort and were older than men (median 69 vs. 59 years, p < 0.001), with a higher prevalence of diabetes and hypertension, but lower rates of smoking (all p < 0.001). Women had lower hemoglobin levels and a higher prevalence of moderate-to-severe mitral regurgitation (17.1% vs. 8.0%, p = 0.004). Procedural characteristics, including door-to-balloon time and complete revascularization, were similar between sexes. Crude in-hospital mortality was higher in women (13.4% vs. 7.5%, p = 0.047); however, female sex was not independently associated with mortality after adjustment (adjusted OR 1.07, 95% CI 0.48–2.41; p = 0.864). Lower LVEF and reduced GFR were the strongest independent predictors of death. Conclusions: Higher mortality in women is primarily driven by a more adverse clinical profile rather than sex itself, emphasizing the importance of early risk stratification and management. Full article

Objectives: Volleyball playing positions are associated with different functional demands. This study compared postural control, jump performance, and upper-limb mobility across playing roles in competitive male volleyball players. Methods: Fifty male volleyball players competing in the Italian Serie C championship were equally distributed across five roles: middle blockers (MB), liberos (LIB), opposite hitters (OH), setters (SET), and outside hitters (HIT). Using a wearable inertial sensor, athletes performed bipodalic balance tasks with eyes open and closed, dominant- and non-dominant-leg single-leg balance, squat jump (SJ), countermovement jump (CMJ), and bilateral upper-limb flexion and extension tests. Results: Significant role-related differences emerged in balance and jump performance. In bipodalic balance, the eyes-open condition showed a mixed pattern, with HIT displaying the largest ellipse area and SET showing the highest path-related values, whereas in the eyes-closed condition, HIT showed the highest values across all stabilometric parameters. In the single-leg stance, OH showed the largest postural excursions on the dominant side, while LIB stood out on the non-dominant side. In jump tests, MB showed the best vertical performance in both SJ and CMJ, whereas LIB and SET generally showed the lowest outputs. Temporal differences also emerged across roles. Upper-limb mobility was similar across roles in flexion, while extension showed a role-specific pattern, with SET displaying greater ROM than LIB, HIT, and OH. Conclusions: Volleyball roles are associated with distinct functional profiles in balance, jump mechanics, and upper-limb mobility. This integrated assessment may support more specific training, monitoring, and injury-prevention strategies. Full article

Greece and the eastern Mediterranean are among the regions that are most exposed to climate-driven natural hazards, with wildfires, floods, and extreme rainfall events consistently producing significant socioeconomic and environmental impacts. Although previous literature has addressed each hazard type individually, a systematic, comparative analysis of the atmospheric circulation regimes associated with all three hazard categories within a unified Lagrangian framework has not yet been conducted for Greece. In this study, a 96 h HYSPLIT back-trajectory analysis driven by ERA5 reanalysis data, combined with k-means clustering, is employed to characterise the air mass origins associated with extreme events in Greece from 2000 to 2020 at two atmospheric levels: 750 m and 3000 m above sea level. Wildfire events are predominantly linked to short-distance northeast airflow at 750 m, and are directly associated with the Etesian wind system and to a coherent northwest-west Mediterranean signal at 3000 m, reflecting the influence of the summer blocking anticyclone over Europe. Conversely, flood events are dominated by northerly flow at 750 m, driven by the eastern flank of Mediterranean depressions. These results indicate that flooding in Greece is primarily conditioned by surface cyclogenesis, regardless of the upper-level flow geometry. Extreme rainfall events exhibit the most complex structure, with a dominant upper-level cluster that describes a recurving trajectory consistent with cut-off low dynamics. Cross-hazard comparisons demonstrate that similar near-surface trajectory patterns may arise from different atmospheric drivers, underscoring the necessity of integrating Lagrangian trajectory classification with additional context, such as thermodynamic and seasonal, to enable robust multi-hazard attribution and enhance early warning capabilities in the eastern Mediterranean. Full article

Magnetic anomaly detection is vulnerable to environmental noise and insufficient prior target information, making non-periodic anomaly signals difficult to detect at low-signal-to-noise-ratio (SNR) conditions. This paper proposes a detection method based on a multi-parameter-constrained mirror dual-branch biased monostable stochastic resonance (SR) system. Nonlinear odd-order bias terms are introduced into the conventional biased monostable potential function to build a multi-parameter-controllable SR model. This improves regulation of potential-well width, depth, and wall morphology, enhancing noise-energy utilization and responses to non-periodic features. Considering peak-type, valley-type, and bipolar anomaly morphologies, a mirror dual-branch SR structure is developed to cooperatively detect features with different polarities. To preserve temporal waveforms and time–frequency structures during parameter optimization, a composite metric combining the correlation coefficient and wavelet-domain image structural similarity index is constructed. Multi-fidelity robust Bayesian optimization is used to obtain a unified robust parameter set for the magnetic anomaly signal family. Experiments with simulated colored noise and measured geomagnetic noise show that the proposed method effectively recovers magnetic anomaly features under strong noise. At −19 dB SNR, its detection probability remains above 80%. Compared with orthogonal basis function decomposition, empirical mode decomposition, and complete ensemble empirical mode decomposition with adaptive noise, the method achieves better noise suppression, feature preservation, and detection performance under low-SNR conditions. Full article

Numerous factors influence the formation of blasting craters in engineering blasting. Based on the actual parameters of the Daye Iron Mine, this study established six sets of single-hole blasting crater numerical models with different borehole diameters using ANSYS(19.0)/LS-DYNA(R13) software. The variation in blasting crater volume with the scaled depth was analyzed to determine the optimum scaled depth for each borehole diameter, and a functional relationship between the optimum scaled depth and borehole diameter was derived through curve fitting. Furthermore, using a borehole diameter of 0.076 m as a case study, a double-hole blasting crater was developed to investigate the effect of varying hole spacing on blasting crater volume and to determine the optimal hole spacing. The blasting parameters were optimized based on the numerical simulation results. The results show that within the range of borehole diameters considered, the blasting crater volume initially increases and then decreases with increasing scaled depth of the explosive charge. The fitted relationship between the optimum scaled depth and borehole diameter is y = −180.7197x³ + 86.3754x² − 9.5504x + 1.0782. For a borehole diameter of 0.076 m, the optimum scaled depth is 0.7278 m/kg^1/3, and the optimal hole spacing is 0.52 m. Based on blasting similarity theory, the calculated optimum burial depth of the explosive charge is 0.59 m, the critical burial depth is 1.1 m, and the recommended row spacing ranges from 0.95 m to 1.18 m. The findings of this study provide a theoretical basis for optimizing blasting parameters at the Daye Iron Mine and similar mining operations. Full article

Raman spectroscopic analysis of fluorite was conducted in a diamond anvil cell (DAC) over a pressure range of 0.5–20.5 GPa under different hydrostatic environments, whereas the electrical conductivity was measured at 298–873 K and 1.2–19.6 GPa. High-resolution transmission electron microscopy (HRTEM) observations were performed on both the initial and recovered samples after recovery to ambient conditions. Three representative pressure-transmitting media (PTMs), including silicone oil, the mixture of methanol and ethanol (4:1 volume ratio, ME), and helium, were employed to control the degree of hydrostaticity within the DAC sample chamber. Experimental results indicate that the pressure-induced abrupt change in A_1g, A_3g, B_1g and B_2g Raman modes, together with the discontinuities in pressure-dependent Raman shifts, Grüneisen parameters, and electrical conductivity, can efficiently characterize the α (cubic structure, space group $Fm\overline{3}m$, No 225)-to-γ (cotunnite structure, PbCl₂-type, space group Pnma, No 62) phase transition in fluorite. The transition pressures are determined to be 10.4, 9.6, 8.9 and 7.5 GPa under conditions of no PTM, silicone oil, ME and helium, respectively, demonstrating that the structural phase transition of fluorite is highly sensitive to hydrostaticity. Raman spectroscopy and electrical conductivity measurements upon decompression reveal that the phase transition is reversible, which is further confirmed by the HRTEM microstructural observation on both the initial and recovered samples. The linear relationships between electrical current and sinusoidal voltage, with the nonlinearity factors close to 1.00, manifest the Ohmic response of fluorite under high pressure. Finally, our high-temperature and high-pressure electrical conductivity results revealed the negative dependence of transition temperature on pressure, and the phase boundary between cubic and PbCl₂-type fluorite was determined as: P (GPa) = 13.057 (±1.008) − 0.008 (±0.001) T (K). The obtained phase diagram of fluorite can be employed to deeply explore the high-pressure phase stability and structural transitions of other similar binary halide family minerals. Full article

Background/Objectives: Spinal ependymoma is the most common intramedullary spinal cord tumor in adults, and maximal safe resection is the cornerstone of treatment. Patients aged 75 years and older are underrepresented in surgical neuro-oncology cohorts. We sought to characterize treatment patterns and identify predictors of overall survival in very elderly patients with spinal ependymoma. Methods: We performed a retrospective cohort study of patients aged 65 years or older with spinal ependymoma using the National Cancer Database. The primary cohort was patients aged 75 years or older (very elderly); patients aged 65–74 years served as a comparison cohort. Multivariable Cox proportional-hazards models were fit within each cohort, and a surgery-by-age-cohort interaction was tested. Results: Of 1497 eligible patients aged 65 years or older with spinal ependymoma, 422 patients (28.2%) met criteria for the final analytic cohort. Intramedullary versus extramedullary tumor status was not available in the NCDB PUF and therefore could not be characterized. Very elderly patients were less likely to undergo surgery than the comparison cohort (70% vs. 85%; p < 0.001) despite similar tumor characteristics. Among very elderly patients, median overall survival was 59.7 months without surgery and 106.0 months with surgery, an approximately 46-month difference favoring surgery. Surgery was independently associated with lower mortality (HR 0.46; 95% CI, 0.24–0.89; p = 0.021). Increasing age (HR 1.15 per year; 95% CI, 1.07–1.22; p < 0.001), Charlson–Deyo score ≥ 2 (HR 4.41; 95% CI, 1.65–11.79; p = 0.003), and increasing tumor size (HR 1.02 per mm; 95% CI, 1.01–1.04; p < 0.001) were also independently associated with worse survival. In the 65–74 cohort, no significant association between surgery and overall survival was detected (HR 1.23; 95% CI, 0.54–2.81; p = 0.623), though statistical power was limited by only 7 deaths in the no-surgery arm. The surgery-by-age-cohort interaction was significant (HR 0.37; p = 0.043). Conclusions: Surgical resection was independently associated with improved overall survival in very elderly patients with spinal ependymoma despite lower utilization. Chronological age alone may be an imperfect basis for excluding older adults from surgical consideration. Full article

This study investigates the effect of repeated exposure to optic flow in virtual reality (VR) on postural control in upright standing in older adults. Eighteen participants (>60 years) completed pre/post assessments consisting of quiet standing in a real environment (eyes open/closed), postural responses to simulated forward and backward self-motion in VR, and proprioceptive perturbations induced by bilateral Achilles and tibialis anterior tendon vibration. Intra- (within similar sensory modality) and inter-modal correlations (within different sensory modalities inducing similar directional postural response) were also investigated to provide insight into sensory integration strategies. The intervention consisted of six 100-s VR bouts alternating simulated forward and backward self-motion. Postural outcomes were quantified from force platform recordings as center of pressure (CoP) velocity and excursion. Repeated VR exposure reduced CoP velocity during simulated forward and backward self-motion (p < 0.05). After the intervention, CoP velocity decreased when standing with eyes closed (p < 0.05) but not when eyes were open. Postural response to tendon vibration was not modified by the intervention (p > 0.05). After the intervention, intra-modal correlation for postural responses to optic flow appeared, whereas a pre-existing inter-modal association between Achilles vibration and forward optic flow disappeared. These results indicate that the postural control system remains adaptable in older adults and highlight the potential of VR environments to improve balance in older adults. Full article

This study examined how duct inclination influences particle removal in a hybrid acoustic–electrostatic filtration system operating at low airflow velocities. The experiments were carried out in a 150 mm diameter air duct at airflow speeds of 0.50 and 0.75 m/s, with duct inclinations of 45° and 90°. Aerosol particles with properties similar to marine diesel exhaust, spanning a size range of 0.2–10 µm, were introduced at stable concentrations. Electrostatic voltages of 17.5 and 20 kV were applied, together with acoustic voltages between 100 and 200 V. Particle removal was evaluated using both size-resolved and overall collection efficiencies. The results show that duct inclination mainly affects the removal of fine and medium-sized particles. The largest differences were observed for particles around 1 µm in diameter, where the vertical duct increased collection efficiency by up to 27 percentage points at an airflow speed of 0.75 m/s. For larger particles in the 5–10 µm size range, high removal efficiency was achieved under all tested conditions, and duct orientation had a smaller influence on collection performance. Overall, the results confirm that duct inclination has a clear and measurable effect on the performance of hybrid acoustic–electrostatic filtration systems operating at low airflow velocities. Full article

Background: Rare diseases are associated with chronic progression, functional impairment, and complex care needs, requiring long-term and coordinated rehabilitation. Physical and Rehabilitation Medicine (PRM) plays a key role in maintaining functional capacity and improving quality of life; however, access to rehabilitation services remains uneven across regions. Aim: This study aims to assess the regional structural availability of PRM services across Bulgaria and to identify territorial differences in the organizational profile of rehabilitation services that may influence the potential availability of rehabilitation care for patients with rare diseases. Methods: A descriptive cross-sectional study was conducted using publicly available aggregated data from the NHIF and the National Statistical Institute as of 31 December 2024. Structural indicators included the number of outpatient and inpatient PRM healthcare facilities and PRM specialists, standardized per 100,000 population, as well as the outpatient-to-inpatient facility ratio (OFs/IFs). Hierarchical cluster analysis (Ward’s method, Euclidean distance) was applied as an exploratory tool to identify similarities in regional service availability profiles. Results: Substantial regional differences in the structural availability of PRM services were identified. Outpatient facilities ranged from 4.46 to 6.74 per 100,000 population, while inpatient facilities ranged from 2.30 to 3.42 per 100,000 population. The OFs/IFs ratio varied between 1.30 and 2.26, indicating different organizational profiles of PRM service provision. Exploratory hierarchical clustering suggested two broad regional service profiles: one characterized by a relatively balanced distribution of outpatient and inpatient structures and another characterized by a predominance of outpatient-oriented rehabilitation services. Conclusion: The findings reveal substantial regional differences in the organization of PRM services in Bulgaria. Regions with a predominance of outpatient structures may demonstrate different capacities for delivering comprehensive rehabilitation services, particularly for patients with complex long-term needs, including rare diseases. The results highlight the need for targeted regional planning, improved integration of rehabilitation services, and policy measures aimed at ensuring equitable access to care. Full article

Background/Objectives: Transcranial direct current stimulation (tDCS) has been explored as a strategy for pain management, but no study has investigated its use in Greater Trochanteric Pain Syndrome (GTPS). This study evaluated the effects of the combination of resistance exercises (REs) with tDCS on pain, functionality, and quality of life in patients with GTPS. Methods: In this randomized, double-blind trial, adults with GTPS were allocated to receive tDCS with RE (intervention group, IG) or sham tDCS with RE (control group, CG). Supervised 20 min sessions occurred on four consecutive days. Anodal tDCS (2 mA) was applied over the primary motor cortex. The primary outcome was the VISA-G.BR score at day thirty. Secondary outcomes included pain, functionality, and quality of life at multiple time points, assessed by HAGOS, PQAS, McGill Pain Questionnaire, and SF-36. Results: Thirty patients were included. Both groups improved, but between-group differences were nonsignificant for the primary outcome (VISA-G.BR effect size, −0.16; 95% CI, −0.54 to 0.27; p = 0.460). Secondary outcomes followed a similar pattern. Conclusions: These findings reinforce the value of RE in GTPS while suggesting a limited role for short-term tDCS protocols. Future studies should investigate whether protocols involving a greater number of stimulation sessions may produce superior clinical effects. Full article

Background/Objective: Highly palatable foods are pleasurable and motivational stimuli that activate the brain’s reward system and can induce overeating in the absence of physiological needs. This study investigated how different access patterns to a cafeteria diet influence food intake, body weight-related parameters, and metabolic and neurobehavioral outcomes. Methods: At postnatal day 31, forty male Wistar rats were assigned to a standard diet or a cafeteria diet with continuous, predictable intermittent, or unpredictable intermittent access. After 10 weeks, the open-field and sucrose-preference tests assessed exploratory and anxiety-like behaviors and reward-related responses, respectively. Body composition, serum biochemical parameters, neurotransmitter content, and mRNA and protein levels were analyzed in reward-related brain regions. Results: Intermittent access increased food intake on cafeteria days compared with continuous access, with unpredictable access yielding the highest intake. Continuous-access rats exhibited higher final body weight and fat accumulation than chow-fed Control rats. Despite similar body weight, both intermittent-access groups had higher visceral adiposity, obesity indices, and adverse metabolic outcomes than the Control group. All cafeteria-fed rats displayed anxiety-like behavior, and all groups preferred sucrose except the continuous-access group. Molecular analyses revealed region-specific differences in gene expression related to neuroplasticity, stress response, and epigenetic regulation that varied with access pattern and predictability. Conclusions: Our results suggest that, beyond diet composition, the pattern and predictability of food access are key determinants of feeding behavior. Intermittent access increases the motivational value of the cafeteria diet, promoting overeating and driving reward- and stress-related neuroadaptations with potential metabolic and mental health implications. Full article

We document and illustrate Primula xideensis, a new species collected from Xide County, Sichuan Province, China. Morphologically, it resembles P. stenocalyx, P. farinosa s.l., and P. pulchella, but differs by its roots densely covered with multicellular hairs; elliptic to obovate leaves with non-revolute, irregularly and deeply dentate margins, both surfaces efarinose, shortly hairy, and scabrous; tubular calyx parted to the middle; corolla mouth densely white-farinose; stamens positioned at mid-corolla tube in pin flowers and near the throat in thrum flowers; styles reciprocally placed; and an oblong capsule shorter than the persistent calyx. To clarify its phylogenetic placement, we constructed phylogenetic trees using two datasets: 63 complete chloroplast genome sequences and 75 nuclear ribosomal DNA internal transcribed spacer (nrITS) sequences. Both trees showed similar topologies, consistently placing the new species within a monophyletic group of Sect. Aleuritia, supporting its assignment to this section. For a deeper comparison between the new species and other members of Sect. Aleuritia, we incorporated chloroplast genomes of seven additional species from this section. The results revealed highly conserved chloroplast genomes among all eight species, with only minor differences between the new species and the others. Primula xideensis is currently known only from its type locality. Based on IUCN Red List criteria, its conservation status is assessed as Data Deficient (DD). Full article