Search Results (7,768)

Background: Type 2 diabetes is characterized by substantial interindividual variability in postprandial glucose responses, yet continuous glucose monitoring (CGM)-derived glucose patterns are commonly described using quantitative metrics without sufficient consideration of the physiological mechanisms that generate them. Objective: To develop a physiology-based framework for interpreting CGM-derived glycemic phenotypes in relation to dietary exposures and individual metabolic characteristics, thereby supporting precision nutrition in adults with type 2 diabetes. Methods: A structured narrative review of the literature was conducted using PubMed to identify studies examining CGM, postprandial glucose regulation, dietary exposures, metabolic physiology, and precision nutrition. Evidence was synthesized within a predefined conceptual framework linking dietary exposures, underlying physiology, individual metabolic characteristics, CGM-derived glycemic phenotypes, and their clinical interpretation. Results: Postprandial glucose responses reflect coordinated interactions among nutrient digestion and absorption, hormonal regulation, hepatic glucose production, peripheral glucose disposal, and individual metabolic characteristics rather than dietary carbohydrate exposure alone. The proposed framework interprets recurring CGM-derived glucose patterns as physiologically meaningful glycemic phenotypes, including characteristic patterns of postprandial excursion, recovery, baseline glycemia, and glycemic variability. This framework provides a structured approach for physiology-informed interpretation of CGM observations and individualized nutritional assessment. Although direct evidence supporting phenotype-guided nutritional interventions and long-term clinical benefit remains limited, emerging computational approaches may further strengthen this interpretive process by integrating CGM with complementary biological and behavioral data. Conclusions: Rather than viewing CGM solely as a technology for measuring glucose, the proposed framework positions it as a physiological lens through which dietary exposures, metabolic regulation, and individual metabolic characteristics can be integrated to support precision nutrition in type 2 diabetes. Full article

Background: In phenylketonuria (PKU), the lifelong phenylalanine (Phe)-restricted diet may contribute to altered feeding behaviours and disordered eating. The true prevalence of disordered eating and eating disorders remains uncertain, partly because validated PKU-specific assessment tools are lacking. This systematic review aimed to identify, appraise, and synthesise the evidence on disordered eating and eating disorders in PKU. Methods: Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane) were searched from inception to 24 February 2026. English-language studies reporting disordered eating or eating disorders in early-diagnosed individuals with PKU managed with a Phe-restricted diet, with or without drug therapy, were included. Studies of late- or never-treated patients, pregnancy, lactation, reviews, and preclinical studies were excluded. Two independent reviewers conducted study selection and data extraction. Outcomes included the prevalence of eating disorders, disordered eating behaviours and attitudes, associated factors, and the influence of drug treatment. Findings were synthesised qualitatively, and risk of bias was assessed using the NIH Study Quality Assessment Tools. Results: Twenty-four studies (2928 individuals with PKU) met the inclusion criteria. Most were observational or survey-based. Eating disorders were reported more frequently in PKU (3–13%) than in the general population (n = 4 studies). Common disordered eating features included food neophobia (n = 5 studies), limited food variety (n = 9), food aversion or refusal (n = 5), poor appetite (n = 5), prolonged mealtimes (n = 3), negative parent–child mealtime interactions (n = 6), and specific taste preferences (n = 5). Delayed feeding skill development (n = 6 studies), reduced social eating (n = 6), gastrointestinal symptoms (n = 8), and psychological or neurodevelopmental difficulties (n = 7) were also associated with disordered eating. Early feeding difficulties frequently persisted into adulthood, and longstanding eating behaviours did not consistently improve with pharmaceutical treatment (n = 6 studies). Most studies were rated as fair quality (19/24), with common limitations including small sample sizes, lack of sample-size justification, non-validated assessment tools, and absence of randomised controlled trials. Conclusions: Current evidence suggests that people with PKU experience a greater burden of eating-related difficulties than the general population, although robust estimates of eating disorder prevalence remain lacking. Existing screening tools may misclassify treatment-related dietary behaviours as pathological or fail to identify PKU-specific eating concerns. Development of PKU-specific screening tools could support routine clinical discussions about eating behaviours and the psychosocial impact of dietary treatment, facilitating earlier identification of individuals requiring specialist eating disorder assessment. (Prospero registration: CRD42024539600). Full article

Akkermansia muciniphila is regarded as a beneficial mucin-degrading commensal, yet in Japanese populations the genus Akkermansia occurs at low abundance and is frequently undetectable. We examined its dietary correlates and its relationship with physical function in 786 community-dwelling older Japanese adults (age ≥ 65 years). Dietary patterns were derived from 31 food groups by principal component analysis (PCA) with varimax rotation, and Akkermansia was quantified by 16S rRNA gene sequencing and expressed as centered log-ratio (CLR)-transformed z-scores. Akkermansia was undetectable in 356 participants (45.3%) and of low abundance among carriers (median ≈ 0.35%). A noodle-based dietary pattern (principal component [PC] 4) was inversely associated with Akkermansia after adjustment for age, sex, body mass index, and lifestyle/comorbidity covariates (β = −0.125; p = 0.0007), with a dose–response across quartiles (p for trend = 0.004). In a two-part model, this association was confined to detection (adjusted odds ratio per 1 standard deviation = 0.80; 95% confidence interval, 0.69–0.93) and was absent among carriers (p = 0.25), indicating that diet was related to whether Akkermansia was present rather than to its abundance. Akkermansia was unrelated to grip strength, muscle mass, and frailty; weak carrier-restricted associations did not survive false discovery rate correction (p = 0.056) and are considered exploratory. These findings provide limited evidence for a role of Akkermansia in physical function in this low-abundance population. Full article

Obesity is a major health concern within the United States. Previous studies have shown that a diet high in monounsaturated fatty acids (MUFA) may help combat metabolic disease by improving cardiometabolic and inflammatory status. Pecans have high MUFA content and the highest antioxidant capacity of any nut. The aim of this preliminary study is to determine if a diet supplemented with 1.5 ounces of pecans daily for eight weeks could improve blood glucose, lipid panel, inflammatory markers, and body composition in individuals with overweight and obesity as compared to a control group who maintained their normal diet. Post-intervention measurements showed no significant difference from baseline values for either the experimental or the control group. Data acquired using the Vioscreen Food Frequency Questionnaire found negative correlations were present between LDL cholesterol and dietary intake of iron, selenium, zinc, MUFA, polyunsaturated fatty acids, saturated fatty acids, and dietary cholesterol. Furthermore, there were negative correlations determined between fasting blood glucose and dietary intake of magnesium, MUFA, and SFA. Regarding inflammatory markers, no detectable levels of IL-10 nor TNF-α were found in the majority of samples. IL-6 was detectable in all samples, but showed no statistical difference between any of the groups in the study. Thus, an intervention of 1.5 oz of pecans for eight weeks did not significantly change measured metabolic parameters nor levels of serum IL-6. However, due to the sample size limitations of this hypothesis-generating preliminary study, further research is needed. Further studies should include a longer intervention period, a larger cohort, and potentially a larger dosage of pecans to increase the amount of MUFA in the diet to determine if such interventions may influence cardiometabolic and inflammatory parameters. Full article

Global agricultural productivity is increasingly threatened by climate change, soil salinization, and freshwater scarcity. In response, edible halophytes such as Crambe maritima L. (sea kale) are emerging as resilient, promising alternative crops for biosaline agriculture. This review comprehensively evaluates the agronomic, phytochemical, and commercial potential of C. maritima and related Crambe species. We examine current propagation protocols and highlight the application of controlled-environment agriculture (CEA) to leverage “saline eustress,” strategically enhancing secondary metabolite biosynthesis without penalizing harvestable biomass. Nutritionally, Crambe species exhibit a highly favorable profile, selectively accumulating essential macro- and micro-minerals alongside potent bioactive compounds, particularly characteristic glucosinolates, including sinigrin, together with diverse phenolic acids. These specific secondary metabolites confer antioxidant defense system and antimicrobial properties, positioning the genus as an unexploited resource for functional foods, nutraceuticals, and cosmeceuticals. However, successfully transitioning C. maritima from a wild coastal halophyte into a reliable horticultural crop necessitates overcoming critical domestication bottlenecks, including mechanical seed dormancy, polygenic salinity tolerance, and a scarcity of long-term field data. By addressing these multidisciplinary challenges through targeted breeding and advanced agronomy, C. maritima represents a highly promising candidate for dietary diversification and the advancement of climate-resilient agricultural systems. Full article

Phosphate accounts for about 0.6% of body weight at birth and about 1% of body weight in adults. This anion is essential for the performance of many essential human cellular processes, including energy metabolism and cell signaling; it is also a key component of the phospholipid bilayer and nucleic acids structure. In addition, phosphate is responsible for maintaining acid-base balance within the cells, functioning of the nervous system and preserving bone integrity. Normal serum phosphate levels change throughout life, varying from the neonatal period, through adolescence, and stabilizing at adult values by the end of puberty. Serum phosphate homeostasis is maintained through dietary intake, intra- and intercellular shifts, and excretion/absorption/reabsorption processes mediated by Fibroblast Growth Factor 23, parathyroid hormone, and 1,25-(OH)₂D₃. Within this homeostatic network, dietary sources and current population-based intake data highlight a widespread oversupply in modern diets that can influence chronic disease outcomes. Ultimately, alterations in serum phosphate concentrations lead to numerous pathological conditions, both congenital and acquired. These conditions may involve either hypo- or hyperphosphatemia, each characterized by a wide spectrum of clinical manifestations, some of which primarily affect the musculoskeletal system. Starting from this evidence, the primary purpose of this review is to examine the phosphate-related pathological conditions from biological-molecular and clinical perspectives, while also considering targeted nutritional and clinical strategies for managing phosphate balance. Algorithms for management and differential diagnosis are also considered, thus providing a recent overview of a medical field that is becoming increasingly important for clinicians. Full article

Cancer remains a leading global cause of morbidity and mortality, with oxidative stress playing a central role in its pathogenesis, progression, and response to therapy. Nutrition has emerged as a modifiable factor capable of influencing redox homeostasis, thereby contributing to both cancer prevention and therapeutic outcomes. This narrative review summarizes current evidence on dietary patterns, specific nutrients, and bioactive compounds that modulate oxidative stress and are associated with reduced cancer risk and improved response to treatment. A literature search was conducted using PubMed, Scopus, and Google Scholar, covering the period from 2002 to 2025 to capture contemporary dietary approaches and clinical evidence. Eligible studies addressed nutrient compounds, dietary strategies, obesity, gut microbiota, conventional cancer therapies, and clinical outcomes, with particular emphasis on mechanisms related to oxidative stress, inflammation, and immune modulation. Epidemiological evidence consistently supports the protective role of plant-based dietary patterns and reduced intake of red and processed meat, partly due to their antioxidant and anti-inflammatory properties. Nutrients such as dietary fiber, polyphenols, and omega-3 fatty acids are associated with decreased oxidative damage, improved immune responses, and enhanced therapeutic efficacy across multiple tumor types, including colorectal, breast, lung, and ovarian cancers, as well as glioblastoma. Emerging data also suggest that dietary interventions, including ketogenic diets and fasting, may influence tumor metabolism and redox balance, potentially increasing sensitivity to conventional therapies. The gut microbiota has been identified as a key mediator linking diet, oxidative stress, and cancer-related pathways. Although current evidence supports the role of nutritional strategies in targeting oxidative stress for cancer prevention and treatment, further large-scale randomized clinical trials are required to clarify their impact on survival and treatment efficacy. The integration of nutritional counseling into oncology practice represents a cost-effective, accessible, and patient-centered approach with the potential to modulate oxidative stress and improve clinical outcomes. Full article

The main objective of this study is to assess the level of sustainable supply chain management implementation in enterprises offering homogenized food products and dietary foods in the Polish FMCG market, as well as to evaluate their strategic orientation toward sustainability, with particular emphasis on the extent of implementation of sustainable transportation and distribution-related logistics practices. The study employed a quantitative research design based on a census survey of all enterprises operating in this market segment in Poland (84 firms classified under PKD 10.86.Z). After data verification, 80 valid questionnaires were included in the analysis, representing an effective response rate of 95.24%. Data were collected using a structured questionnaire comprising 17 items organized into two dimensions: strategic sustainability orientation and sustainable logistics practices. Responses were measured on a seven-point Likert scale. The research instrument was refined through expert evaluation and pilot tested, and demonstrated satisfactory internal consistency (Cronbach’s α = 0.74). The empirical data were analyzed using the Development Index calculated with the gradient method, which measures deviations from an ideal reference value and enables quantitative assessment of the maturity of sustainable supply chain management practices. The findings indicate that the implementation of SSCM among the surveyed enterprises remains selective rather than comprehensive. Companies demonstrate relatively strong performance in employee-related social practices, digital supply chain transparency, and delivery route optimization. In contrast, environmental initiatives, particularly the adoption of low-emission transportation solutions, replacement of environmentally harmful transport assets, and broader integration of environmental and economic objectives, remain insufficiently developed. The study highlights the need for a more balanced integration of the environmental, social, and economic dimensions of sustainability within supply chain management. The results provide practical guidance for enterprises seeking to improve the sustainability of their logistics operations while strengthening long-term competitiveness and creating value for stakeholders. Full article

Introduction: Asthma is the most common chronic inflammatory disease in childhood, with complex pathogenesis and heterogeneous clinical manifestations. Current efforts are focused on achieving remission through phenotyping and personalized therapy. Micronutrient deficiency is commonly observed in both children and adults, and current evidence points to their role in the pathogenesis of numerous acute and chronic conditions. Method: In this narrative review, we analyzed current information regarding the influence of micronutrient deficiencies on asthma control. The aim was to clarify the extent to which current knowledge provides evidence for implementing specific dietary measures in children with asthma to achieve disease control. We conducted a review of the literature covering the past 20 years to assess the impact of iron, vitamin D, and folic acid deficiency on asthma control. The research was performed in PubMed, Web of Science, Cochrane Library and Embase. Results: Vitamin D deficiency is associated with the frequency of asthma exacerbations in children. However, data regarding the severity of exacerbations, hospitalizations, or emergency department visits are not consistent across different studies. Vitamin D supplementation has controversial effects on disease control. Iron deficiency may contribute to the development of asthma, but there is no clear evidence. Observational studies have reported associations between iron deficiency, poorer asthma control, frequent exacerbations, and impaired lung function. An association between low folate levels and increased asthma risk and poorer asthma control was also reported. Conclusions: Assessing micronutrient status in children with asthma and the effect of correcting deficiencies as part of a personalized treatment plan to achieve symptom control remains a topic that requires further research. Full article

Objective: Our objective was to determine the salivary levels of cobalt, nickel, chromium, and titanium ions at the end of fixed orthodontic treatment and during the post-removal period (1 and 3 months after removal of the fixed appliance). Methods: This pilot longitudinal study included fifteen individuals (10 females and 5 males). Five milliliters of saliva was collected at three time points: T1 (before withdrawal of orthodontic appliances), T2 (one month post-withdrawal), and T3 (three months post-withdrawal). The concentrations of nickel (Ni), titanium (Ti), chromium (Cr), and cobalt (Co) in the samples were analyzed using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). All samples were analyzed in triplicate. The data were analyzed by repeated-measures ANOVA, and differences were considered significant if the p-value was ≤0.05. Results: The concentrations of Co, Cr, and Ti at the three time points were low and decreased after the removal of the orthodontic appliance, while Ni showed an increase at T3. Co and Ni showed significant differences between T3 and T1 (p = 0.016 and p = 0.029, respectively). There was also significantly increased Ni ion release at T3 compared to T2 (p = 0.010). The Cr and Ti levels at all three time points were significantly different (Cr: p = 0.001; Ti: p = 0.001 and p = 0.005). Conclusions: The levels of cobalt, chromium, and titanium in saliva decreased after removal of the orthodontic appliance, whereas nickel increased at T3. However, the levels were below the mean dietary intake levels; therefore, these concentrations can be considered non-toxic. This study has limitations that should be considered when interpreting the results. Full article

The use of plant-based fermentation products as substitutes for costly feed ingredients like fishmeal and soybean meal has been at the forefront of aquaculture research. This study investigated the effects of dietary fermented mulberry leaf powder (FMLP) on grass carp (0.86 ± 0.07 kg). Fish were fed a basal diet supplemented with 0%, 5%, 10%, or 15% FMLP for 70 days to assess impacts on growth, muscle quality, antioxidant status, and lipid metabolism. Results indicated that FMLP did not significantly affect growth performance (p > 0.05). However, it reduced the hepatosomatic index, viscerosomatic index, condition factor, and intraperitoneal fat ratio (p < 0.05). While muscle basic nutrition was unchanged, FMLP improved post-mortem muscle water-holding capacity, drip loss, cooking yield, and texture (p < 0.05). FMLP lowered malondialdehyde and elevated glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities in grass carp (p < 0.05). Concurrently, the gene expression of GSH-Px, Nrf2, and SOD was upregulated in the liver (p < 0.05). Regarding lipid metabolism, FMLP increased serum high-density lipoprotein cholesterol and decreased hepatic total cholesterol and triacylglycerol (p < 0.05). It promoted gene expression related to fatty acid oxidation (PPARα, CPT-1a, CPT-1b) while inhibiting the genes involved in lipogenesis (SREBP, FAS). Quadratic regression analysis determined that an inclusion level of approximately 7.55% to 11.40% (with the data suggesting an optimal range near 8–10%) improves muscle quality, enhances antioxidant defenses, and promotes healthier lipid metabolism in grass carp. Full article

In population health the highly cited Atherosclerosis Risk in Communities study indicated a U-shaped association between carbohydrate intake and mortality, whilst the Prospective Urban Rural Epidemiology study linked higher fat intake to lower mortality risks. The Malaysia Lipid Study reported high-fat and high-carbohydrate dietary patterns were associated with increased cardiometabolic risks, including insulin resistance and small dense LDL particles generation. This animal model study therefore was purposely designed to evaluate metabolic outcomes of carbohydrate–fat permutations in Zucker diabetic fatty (ZDF) and Zucker lean (Z_lean) rats by using ¹H Nuclear Magnetic Resonance (NMR) metabolomics. Twenty-four ZDF rats were randomly divided into four groups (n = 6 per group): control (standard diet), Diet A (54%-energy carbohydrate, 32%-energy fat, 14%-energy protein) mimicking a recommended adult Malaysian diet, Diet B (49%-energy carbohydrate, 37%-energy fat, 14%-energy protein) mimicking a low-carbohydrate, moderate high-fat diet, and metformin treatment (100 mg/kg), which effectively represents a 5%-energy exchange in isocaloric meals. An additional six Z_lean were given Diet A (n = 3) and Diet B (n = 3). The intervention lasted eight weeks. Using log-transformed data, analysis of variance (ANOVA) revealed significant differences between the groups for eleven metabolites (1,6-anhydro-β-D-glucose, 2-hydroxyvalerate, acetate, 3-aminoisobutyrate, 3-hydroxybutyrate, carnitine, choline, citrate, creatine, lactate, and N-methylhydantoin) (all p < 0.05) which remained significant even after false discovery rate (FDR) correction. Majorly elevated metabolites in both ZDF and Z_lean rats were 3-hydroxybutyrate, N-methylhydantoin, 3-aminoisobutyrate, and carnitine, indicating dietary influences independent of diabetes status. Conversely, citrate and 1,6-anhydro-β-D-glucose levels showed distinct patterns across the groups, with Z_lean rats exhibiting lower levels and ZDF rats showing higher levels compared to healthy controls, suggesting potential genetic or physiological influences. Other metabolites such as creatine, acetate, choline and 2-hydroxyvalerate showed varied trends, highlighting metabolic complexities. Compared to the control group, metformin treatment generally resulted in lower levels of metabolites, except for acetate, which was higher, indicating improved insulin sensitivity. The findings indicated moderate high-fat diets may exacerbate metabolic disturbances as seen in both ZDF and Z_lean rats, while metformin treatment generally improved metabolic profiles. Full article

Background/Objectives: Alcohol-associated liver disease (ALD) is driven by gut-liver axis dysfunction, including intestinal barrier disruption, dysbiosis, microbial translocation, inflammation, metabolic dysfunction, and malnutrition. Fermented dairy foods may modulate several of these domains, yet whether sheep yogurt, as an intact fermented dairy matrix, is relevant in ALD is unknown. This scoping review mapped evidence relevant to sheep yogurt, ALD, and gut-liver axis biology. Methods: A PRISMA-ScR-guided scoping review searched PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar from January 2006 to February 2026. Eligible sources were charted using a prespecified framework classifying evidence as direct, indirect, or mechanistic inference. Mapped domains included ALD pathophysiology; intestinal barrier integrity; bacterial and fungal microbial ecology; bile acid and tryptophan-aryl hydrocarbon receptor signaling; nutritional vulnerability; fermented dairy interventions; and ovine dairy-matrix characteristics. Results: Of 1388 records identified, 121 sources were included after duplication and screening. No eligible study directly tested sheep yogurt or a defined sheep yogurt preparation in ALD-relevant experimental or clinical settings. Indirect evidence supported the relevance of gut-liver axis dysfunction to ALD and indicated that selected fermented dairy products, probiotics, postbiotics, and microbial preparations may influence intestinal permeability, inflammatory signaling, microbial ecology, oxidative stress, and liver-injury outcomes. Compositional data supported sheep yogurt as a distinct food matrix. However, findings from isolated components, probiotic-only interventions, and non-ALD models could not be interpreted as evidence of sheep yogurt efficacy in ALD. Conclusions: The current literature supports a hypothesis-driven research framework rather than any therapeutic claim for sheep yogurt in ALD. Any potential benefit of sheep yogurt in ALD remains hypothetical and cannot support clinical or dietary recommendations until validated experimentally. Future direct, comparator-controlled studies of intact sheep yogurt should assess liver injury, barrier integrity, microbial translocation, relevant metabolites, and nutrition-related outcomes. Full article

Background: Iron deficiency anemia (IDA) is among the most prevalent nutritional disorders worldwide and a growing public health concern among women in Saudi Arabia. Available Saudi evidence remains fragmented, with single-center studies that vary by population, region, and diagnostic criteria. This review evaluated the prevalence of anemia in Saudi Arabia, assessed gender-related differences across the lifespan, and highlighted local determinants and prevention strategies relevant to women. Methods: Eight cross-sectional studies (26,412 participants) reporting anemia prevalence in Saudi individuals aged ≥13 with both-sex data were identified across five databases (2007–2024), excluding chronic-disease and under-13 studies. Quality was appraised with the JBI checklist, and because of substantial heterogeneity, findings were synthesized narratively by population group (SWiM guideline) rather than pooled. Results: Anemia was consistently more prevalent in women than men across all population groups and regions. Female prevalence ranged from about 18–22% in older and community adults to over 65% in female university students, whereas male prevalence ranged from none detected to 28% in a hospital-based sample. The lowest mean hemoglobin (10.4 g/dL) occurred in young women. Between study heterogeneity was considerable (I² > 99%) and persisted within sex subgroups, so findings were synthesized by population group rather than pooled into a single estimate. Conclusions: Anemia remains a significant public health challenge among women in Saudi Arabia, shaped by an interacting set of dietary, sociocultural, hereditary, and health-system determinants specific to the local context. Beyond confirming the female burden, this review consolidates fragmented national evidence, appraises its quality, and translates the findings into targeted recommendations: dietary counseling to address local inhibitors of iron absorption, screening during peak-risk periods, and integration with existing premarital screening and food-fortification infrastructure. Full article

This study aimed to evaluate the effects of dietary supplementation with guanidinoacetic acid (GAA) on growth performance, antioxidant status, nutrient digestibility, ruminal fermentation, and meat quality in lambs through a meta-analysis. The electronic databases Scopus, Web of Science, ScienceDirect, and Google Scholar were used to identify the articles required for the meta-analysis using the Preferred Reporting Elements for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The data used in this meta-analysis were obtained from 12 peer-reviewed English-language articles published in the last decade (January 2016 to April 2026). All data were analyzed using random-effects models. Dietary supplementation with GAA decreased the feed conversion ratio (p < 0.05) and increased (p < 0.05) dry matter intake, average daily gain, carcass weight and yield, and Longissimus dorsi muscle area. Dietary supplementation with GAA decreased (p < 0.001) serum malondialdehyde concentration and increased (p ≤ 0.05) serum concentrations of superoxide dismutase, catalase, glutathione peroxidase, and total antioxidant capacity. Dietary supplementation with GAA decreased (p < 0.001) ruminal pH and increased (p < 0.05) the digestibility of dry matter, organic matter, neutral detergent fiber, and acid detergent fiber, as well as the ruminal concentrations of total volatile fatty acids, acetate, and butyrate. Dietary supplementation with GAA decreased (p < 0.001) drip loss in meat and increased (p < 0.001) meat pH and meat protein content. In conclusion, guanidinoacetic acid can be used as a dietary additive to improve growth performance, antioxidant status, nutrient digestibility, ruminal fermentation, and meat quality in lambs. Full article