Search Results (5,654)

Background: Type 2 inflammatory diseases are among the most common chronic inflammatory conditions in childhood and represent a growing global health burden. Increasing evidence suggests that early-life nutritional exposures may influence immune programming and allergic disease development. This Position Paper aims to summarize the current evidence regarding the immunomodulatory role of polyunsaturated fatty acids (PUFAs), particularly omega-3 long-chain fatty acids, in the prevention of allergic diseases during early life. Methods: A scoping literature review and consensus process were conducted to map biological mechanisms and clinical evidence linking omega-3 PUFAs with allergic disease prevention. This document analyzed experimental, observational, and randomized controlled studies evaluating maternal prenatal/lactational omega-3 exposure. The clinical evidence was qualitatively appraised using study-design-specific Joanna Briggs Institute (JBI) Critical Appraisal Tools. Particular attention was given to immune modulation, inflammatory pathways, epithelial barrier function, gut microbiota interactions, and the ferroptosis–immune–metabolic axis. Results: Omega-3 PUFAs, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), exert immunomodulatory and anti-inflammatory effects through multiple mechanisms, including specialized pro-resolving mediator production, regulation of T-helper cell responses, cytokine modulation, maintenance of epithelial barrier integrity, and microbiota interaction. Emerging evidence also supports their involvement in oxidative stress and ferroptosis regulation. Current clinical evidence, particularly from higher-quality prenatal randomized trials and evidence syntheses, suggests that adequate maternal omega-3 intake during pregnancy and lactation may reduce the risk of respiratory allergic outcomes, especially wheezing and asthma, in selected offspring. Conclusions: Adequate omega-3 PUFA intake, such as 2 g/die, during critical windows of immune maturation may represent a valuable strategy for the primary prevention of allergic diseases. Current evidence most strongly supports supplementation during pregnancy and lactation, particularly in populations with low dietary omega-3 intake or increased allergic risk. Omega-3 supplementation should be considered within a broader multifactorial preventive approach aimed at promoting immune tolerance and reducing the future burden of allergic diseases. Full article

Alfalfa densification is a critical step in feed utilization and biomass energy conversion because it directly affects the transport efficiency, storage stability, and energy consumption of biomass processing systems. However, the thermodynamic behavior of the densification process remains poorly understood, especially under open-die conditions without external heating. This study investigated the thermo-mechanical characteristics of alfalfa pellet open-die densification without external heating by combining experimental measurements with ANSYS macro-continuum simulation. Stress transmission and temperature field distributions were analyzed. The results showed that the pellet quality index under different process conditions remained above 800, meeting the requirements for pelleted feed. Moisture content had a more significant effect on forming pressure than other factors; as moisture content increased, the forming pressure decreased. At an aspect ratio of 5.0, the forming pressure was below 45 kN. Simulation results further indicated that aspect ratio had a stronger influence on frictional behavior during densification. Under an aspect ratio of 5.0, the energy consumption was 888.53 J, and the heat flux reached 0.0062 W/mm². These results indicate that frictional dissipation driven by radial force is the dominant mechanism governing thermo-mechanical coupling. Moisture content and aspect ratio significantly affected both peak compression force and coupling intensity. Although reducing moisture content or increasing aspect ratio improved pellet quality, it also increased die load due to enhanced radial force. The coupling intensity followed the order: peak pressure stage > moving stage > compression stage. These findings reveal the evolution of stress and temperature fields during alfalfa densification, offering critical theoretical guidance for optimizing densification process parameters. Full article

The steel industry is currently grappling with the dual environmental challenges of massive steel slag accumulation and carbon emissions. To address the limitations of traditional carbonation processes—namely slow reaction kinetics and insufficient mechanical properties—this study proposes a novel rapid carbonation enhancement method coupling microwave thermal field intensification, silicon carbide (SiC) physical absorption, and potassium silicate chemical activation. The effects of microwave heating parameters on the performance of carbonated steel slag blocks were systematically investigated. The results indicate a significant synergistic effect between the microwave thermal effect and the alkali-activated system. Under the conditions of a 0.14 liquid-to-solid ratio and microwave heating at 90 °C for 45 min, the compressive strength reached a peak of 48.82 MPa (a 44.7% increase over the conventional treatment group). Microstructural characterization revealed the reinforcement mechanism: the introduction of SiC and potassium silicate solution (K₂SiO₃) under microwave heating promotes a denser distribution of carbonation products. Synchronized with alkali activation, this effect promotes the in-situ growth of dense calcite crystals within a gel network, thereby significantly optimizing the pore structure (e.g., reducing the average pore size to 43 nm), and enhancing strength through synergistic effects. This research is subject to further energy and life-cycle assessments, and this approach holds potential for CO₂ mineralization and the recycling of steel slag. Full article

In the Lutheran church music tradition, the placement of pre-existing chorale melodies as cantus firmus in new compositions constitutes a stable compositional practice extending from the sixteenth through the eighteenth century. Musicological literature has generally treated this practice as a formal technique or theological reference; however, neither its authoritative function nor its embedding within the auditory body of the congregation has been systematically examined within a theoretical framework. This study addresses this gap by taking Johann Sebastian Bach’s use of Philipp Nicolai’s 1599 chorale as cantus firmus in the opening chorale fantasia of Wachet auf, ruft uns die Stimme BWV 140, 1731 (Wake, Awake, for Night is Flying) as a two-layered analytical case. The study adopts Catherine Bell’s concept of ritualization as developed in Ritual Theory, Ritual Practice (1992) as its theoretical framework, operationalizing two specific analytical concepts from within this framework: traditionalization (the strategy of legitimizing the new by binding it to the authority of the old) and ritualized body (the embodied internalization of ritual practice). The first concept is employed to analyze the hierarchical contrast between the fixed cantus firmus position of Nicolai’s chorale and the mobility of the surrounding polyphony; the second is developed as an original analytical proposal examining how the chorale may function as a structural spine within the auditory body of the congregation. The article argues that Bach’s gesture of chorale placement can be understood not only as a musical technique or theological reminder, but as both a traditionalization act that strategically invokes inherited authority and a ritual structuring that may have been collectively experienced within the auditory body of the listening congregation. This reading proposes a new perspective on the cultural-strategic and embodied dimensions of compositional practices in Lutheran liturgical music research, and aims to contribute methodologically to the analytical study of Bach’s chorale cantatas at the intersection of ritual theory and musicology. Full article

Magnesium-based alloys remain poorly researched, particularly regarding their behavior and resistance under hydrodynamic loading conditions. Interest in these materials is driven by their low density, lower even than that of aluminum alloys, and their excellent pressure die-casting capability, leading to manufacturing components with high geometric accuracy and structural homogeneity. Due to their biodegradability and biocompatibility, recent research has focused on using them in reconstructive surgery devices, similar to Zn-Mg alloys. As the blood circulatory system can, at certain stages, be considered similar to a hydraulic system, it is subjected to hydrodynamic flow regimes, including cavitation erosion. In this context, the current research, conducted on the AM50 magnesium-based alloy, provides new insights into its behavior and structural resistance exposed to shock waves and microjets generated by cavitation. Cavitation tests were performed using a standard 20 kHz vibratory device on three material conditions: one semi-finished (initial) state and two aged, heat-treated states at 200 °C for 12 and 24 h. Analyses of the characteristic erosion curves, cavitation resistance parameters, and macro- and microstructural examinations of the eroded surfaces revealed that, compared with the semi-finished condition, the applied heat-treatment regimes increased the HV₅ hardness by 6.8–17% and the cavitation resistance by 27–61%. Full article

Mangrove forests in northern Mozambique were impacted by human and natural pressures, causing channel blockage, permanent flooding, and tree die back. To address the issue, hydrological restoration was carried out in August 2024, excavating 6.88 km of channels, with impact in 38 ha of degraded mangrove. The intervention area was divided into three zones, upper, middle, and lower, based on ecological and environmental characteristics. This study reports on the monitoring carried out 4 and 10 months later. Site salinity approached optimal levels for mangrove growth, dropping by 56% in high-salinity zones, and increasing above 100% in freshwater-invaded zones. The intervention also homogenized the previously distinct upper, middle, and lower zones to more statistically similar groups (Dunn post hoc: p > 0.05). Moreover, seedling density increased from 57.1 ± 44.1 to 4864 ± 1778.6 seedlings/ha; additionally, regenerating species increased in numbers (1 to 3 mangrove species in middle zone; and 0 to 3 mangrove species in lower zone). The study also reports the dieback of competing species, Juncus kraussii and Cyperus articulates. These changes result from the improved tidal flow and general habitat conditions in the restored site. This restoration offers a model for scaling up restoration efforts across the region, where ecological restoration remains underrepresented in many mangrove restoration initiatives. Full article

Reuse of human excreta and derivatives is becoming a common practice in areas with agricultural predominance. While in situ treated faeces through ecological sanitation (Ecosan), known as “faecal by-products” are being used to sustain soil nutrients and improve on-site sanitation, the concern remains about the health risks related to the survival of pathogens in these by-products in the community of farmers. This study assessed the survival of faecal pathogens and estimated microbial risks associated with the use of Ecosan faecal by-products in agriculture. The quantitative microbial risks assessment (QMRA) framework was used to estimate the risks posed by each faecal pathogen in solid and semi-solid faecal by-products under the probabilistic model of Monte Carlo simulation. Ascaris lumbricoides (6.5 eggs/gr), Taenia species (0.3 egg/gr), Schistosoma species (9.3 cercariae/gr), Entamoeba species (4.4 cysts/gr), and Escherichia coli (451 Cfu/gr) were detected in semi-solid faecal products. Exposure scenarios were observed throughout four critical points: vault faecal by-products removal/unloading, transport, collection, and application of faecal by-products in the gardens. Due to the presence of eggs and cysts, an estimated annual risk of infections was found in semi-solid faecal by-products with Schistosoma species (88%) and Ascaris lumbricoides (90%). Both concentrations were above World Health organisation (WHO) standards of associated infective risks of 0–10% of helminths in faecal sludge applied in the gardens. The users of faecal by-products, particularly farmers are exposed not only to high concentrations of helminth eggs but also to protozoa and bacteria with infective risks of Entamoeba species (99%) and E. coli species (62%). A stepwise implementation of faecal pathogens die-off during treatment of faecal by-products in compliance with the WHO’s 2018 guidelines can prevent the use of unsanitary faecal by-products. According to these findings, the proper control of intestinal protozoa and soil-transmitted helminths (STHs) should be enforced through personal protective measures in Burera district, Rwanda. Full article

Sauce-aroma Baijiu is produced through a one-year cyclic process involving multiple fermentations and distillations. However, the dynamic changes and correlations among fermented grains (FG), distilled fermented grains (DG), heart liquor (HL) and tail liquor (TL) remain unclear. In this study, the physicochemical indicators and volatile compounds (VCs) from the 3rd to 6th distillation rounds were systematically analyzed. Across successive rounds, FG and DG exhibited similar trends in key physicochemical indicators, as did HL and TL. Headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME/GC-MS) identified 76, 73, 80 and 93 VCs in FG, DG, HL and TL, respectively. Multivariate statistical analyses revealed significant inter-round differences in volatile profiles, and further indicated that total acids and water contents in FG were positively correlated with the majority of VCs in liquor. These results clarify the dynamic change of physicochemical and flavor components during Baijiu production and provide a basis for quality evaluation. Full article

Aridification and hotter droughts are triggering forest die-off events characterized by high mortality rates and declines in forest productivity. The western Mediterranean Basin is a climate change hotspot where many of these die-off events have affected several tree and shrub species in recent decades. Yet, the responses of canopy greenness and cover, radial growth, and gross primary productivity (GPP) to climate in these die-off sites remain poorly understood across species and biomes. Here, we examined 44 sites across Spain, covering humid, dry sub-humid, and semi-arid biomes, and including nine tree and one shrub species. We obtained and correlated monthly climate data, satellite-derived vegetation indices (Normalized Difference Vegetation Index, Enhanced Vegetation Index), tree-ring metrics (basal area increment, ring-width indices), and GPP. We assessed climate trends and relationships between climate, vegetation indices, growth, GPP, and resilience after five extreme drought years in the period 1984–2023. Climate warming impacted all sites, increasing vapor pressure deficit and reducing soil moisture availability, with semi-arid sites warming the most. Vegetation indices and growth showed the largest declines during extreme droughts in dry sub-humid and semi-arid sites. Correlations with climate variables highlighted strong sensitivity to drought stress, particularly regarding growth metrics. During die-off events, GPP significantly declined in the growing season, but no legacy effects were observed afterwards. Vegetation indices and growth partially recovered one year after drought, with resilience peaking for GPP in semi-arid sites. Hotter droughts constrain GPP and growth, especially in dry sub-humid and semi-arid forests. Forests and shrublands experiencing die-off are diagnostic monitors of drought-induced thresholds in ecosystem productivity. Full article

Background: Chronic kidney disease presents a significant health challenge among the elderly, with recent data indicating a 13.9% prevalence for early stages (1–3) and a lower 0.6% prevalence for advanced stages. Notably, many geriatric patients die from cardiovascular complications before reaching end-stage kidney disease, highlighting the critical interplay between renal and cardiovascular health. Central to this connection is endothelial dysfunction, considered the initial trigger for cardiovascular mortality. We aimed to investigate the correlation between different measurement methods demonstrating endothelial dysfunction and sVE-cadherin levels. Another objective was to examine the relationship between decreased glomerular filtration rate (GFR) and sVE-cadherin levels. We hypothesized an inverse relationship between impaired renal function, endothelial dysfunction, and sVE-cadherin. Methods: The study included geriatric patients with CKD who were not receiving RRT. Non-geriatric patients, those with cardiovascular disease, atrial fibrillation, heart failure, active immunosuppressive use, active infection, history of active malignancy, Raynaud’s phenomenon, and renal transplantation patients were excluded. Demographic data of the patients, nailfold capillary measurements, carotid intima-media thickness, flow-mediated dilatation, sVE-cadherin, and serum fibroblast growth factor 23 (FGF23) levels were measured. Results: We analyzed 96 patients. Key findings revealed a significant inverse correlation between serum sVE-cadherin levels and glomerular filtration rate (GFR), suggesting that, as kidney function declines, endothelial integrity is compromised. Interestingly, patients treated with sodium–glucose co-transporter-2 inhibitors had notably lower sVE-cadherin levels, indicating the possible modulatory effect of these drugs on endothelial function. Additional correlations were observed: fibroblast growth factor 23 levels were positively related to capillary diameter, and carotid intima-media thickness was associated with mean platelet volume. Declining GFR corresponded to reductions in capillary count, while use of dipeptidyl peptidase-4 inhibitors was linked to higher capillary density. Over a 2.3-year follow-up, survivors had higher lymphocyte counts (p = 0.088, not statistically significant) and baseline sVE-cadherin levels tended to be higher in those who died, although this was not statistically significant. Conclusions: These findings suggest that uremic toxins may worsen endothelial injury by disrupting intercellular connections, highlighting the complex pathogenic environment in CKD. Given these insights, the need for standardized diagnostic thresholds for endothelial dysfunction in geriatric CKD patients is clear. Serum sVE-cadherin emerges as a promising novel biomarker for assessing endothelial health, offering potential for earlier intervention and improved cardiovascular outcomes. It may be a potent indicator of endothelial dysfunction and should be featured in future studies of elderly CKD patients. Full article

With the expansion of modern protected agriculture, the amount of post-harvest tomato biomass has increased sharply. Conventional unmanaged disposal practices disrupt carbon flows and cause substantial environmental emissions. Tomato plant residues (TPRs), which are rich in lignocellulose and selected high-value secondary metabolites, have considerable potential as feedstocks for green industrial materials. However, their complex biophysical properties, high physiological moisture content, and recalcitrant cell-wall barriers hinder large-scale processing. This review systematically examines the mechanisms and process architectures for converting TPRs into macromolecular products. First, it analyzes cross-scale anatomical heterogeneity and dynamic rheological properties of TPRs, defining their physicochemical boundaries as industrial precursors. Second, it summarizes the development of physical field-coupled equipment, ranging from anti-tangling harvest-shredding to die-roller densification. Furthermore, it examines the core mechanisms of multi-field-coupled pretreatment technologies, including steam explosion, deep eutectic solvents (DES), and mechanochemistry, in deconstructing vascular skeletons and reducing multiphase mass-transfer resistance. Finally, this review discusses reconstruction pathways for TPR-derived components in advanced polymer materials, including biodegradable nanocellulose films, bio-based composites, aerogels, and lignin-based polyurethane networks. Overall, it links microscopic reaction kinetics with macroscopic equipment engineering, proposes a closed-loop material conversion system from in-field volume reduction to cascaded biorefinery, and provides an engineering framework for future multi-machine intelligent collaboration and continuous production across the industrial chain. Full article

Contemporary English speakers often make a distinction between things that are artificial and those that are deemed natural. On the one hand are places, things, and situations that humans have altered, and on the other those that are free (or relatively free) of human influence. This concept of “nature” is an important, if problematic, one: it influences much of the modern environmental movement, where nature often has positive connotations while the artificial is valued negatively. In this paper I will be focusing on an idea found in Tibetan anti-meat literature: that there is a moral difference between eating the meat of animals that “die as a result of their karma” and animals that are slaughtered. This idea, I argue, parallels the distinction between the natural and artificial found in many English language discussions about the environment. As such, my suggestion is that this idea could, with some development, help support dialogue over environmental issues between Western and Buddhist philosophers and communities. Full article

The German author Hans Erich Nossack (1901–1977) wrote the novel “On Call: A Report on the Epidemic” four years before his death. This fascinating novel has yet to be translated into English. It depicts a bleak future in which a mysterious global epidemic erupts. The focus is on an unnamed first-person narrator, a chemist in a so-called on-call unit. His task is to recover the numerous bodies left behind by the epidemic. In a matter-of-fact, almost emotionless tone, he reconstructs the course of the catastrophe in retrospect. The disease is an anomaly: it is a kind of ‘suicide epidemic’ in which people apparently die or take their own lives for no apparent reason. The reasons for this remain unclear, intensifying uncertainty and a sense of helplessness within society. The novel describes in great detail fundamental changes in individual psychology and global society, revealing striking parallels nearly 50 years later during the worldwide COVID-19 pandemic. This paper seeks to compare the suicide pandemic described in the novel with today’s COVID-19 pandemic. To the best of my knowledge, this association has not been previously described. Similarities between the novel and the pandemic will be analysed. Nevertheless, there are also fundamental differences between the novel’s plot and the COVID-19 pandemic. In addition, some basic information about the author Nossack (a rather complex personality), likely not well-known to non-German-speaking readers, will be provided. The goal of this contribution is to familiarise non-German-speaking readers with this novel and its author. Finally, I will briefly mention Aaron Antonovsky’s concept of salutogenesis, which focuses on building resilience, resources, and supportive environments to manage disease. Nossack’s “Bereitschaftsdienst” anticipates key questions in salutogenesis—particularly the importance of finding meaning, comprehensibility, and coping strategies in the face of existential threats—but explores them within a far darker and more sceptical framework. Full article