Search Results (20,315)

Cystic fibrosis (CF) is caused by loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride and bicarbonate channel and affects multiple organs, with pancreatic involvement showing very high penetrance. In pancreatic ducts, CFTR drives secretion of alkaline, bicarbonate-rich fluid that maintains intraductal patency, neutralises gastric acid and permits safe delivery of digestive enzymes. Selective impairment of CFTR-dependent bicarbonate transport, even in the presence of residual chloride conductance, is strongly associated with exocrine pancreatic insufficiency, recurrent pancreatitis and cystic-fibrosis-related diabetes. These clinical manifestations are captured by pharmacodynamic anchors such as faecal elastase-1, steatorrhoea, pancreatitis burden and glycaemic control, providing clinically meaningful benchmarks for CFTR-targeted therapies. In this review, we summarise the principal mechanisms underlying pancreatic pathophysiology and the current approaches to clinical management. We then examine in vitro pancreatic duct models that are used to evaluate small molecules and emerging therapeutics targeting CFTR. These experimental systems include native tissue, primary cultures, organoids, co-cultures and microfluidic devices, each of which has its own advantages and limitations. Intact micro-perfused ducts provide the physiological benchmark for studying luminal pH control and bicarbonate (HCO₃⁻) secretion. Primary pancreatic duct epithelial cells (PDECs) and pancreatic ductal organoids (PDO) preserve ductal identity, patient-specific genotype and key regulatory networks. Immortalised ductal cell lines grown on permeable supports enable scalable screening and structure activity analyses. Co-culture models and organ-on-chip devices incorporate inflammatory, stromal and endocrine components together with flow and shear and provide system-level readouts, including duct-islet communication. Across this complementary toolkit, we prioritise bicarbonate-relevant endpoints, including luminal and intracellular pH and direct measures of HCO₃⁻ flux, to improve alignment between in vitro pharmacology and clinical pancreatic outcomes. The systematic use of complementary models should facilitate the discovery of next-generation CFTR modulators and adjunctive strategies with the greatest potential to protect both exocrine and endocrine pancreatic function in people with CF. Full article

Surface electromyography (sEMG) is widely used for neuromuscular assessment, but the high cost of commercial systems limits accessibility in sports and rehabilitation settings. This study validated a low-cost open-source sEMG device (OLI) against a commercial field reference (SHI) during dynamic and isometric knee extensions in 36 healthy adults. Three preprocessing pipelines were tested for OLI signals: RAW, global root mean square (RMS), and cycle-centered RMS. Waveform similarity was assessed using the coefficient of multiple correlation (CMC), retaining repetitions with CMC ≥ 0.80. For valid repetitions, a calibration model (SHI = a + b × OLI) and Bland–Altman analysis were applied to min–max normalized RMS and area-under-the-curve (AUC) metrics. The global RMS pipeline showed the best overall performance, retaining 81.9% of repetitions with high shape similarity (CMC = 0.92 ± 0.04). It exhibited minimal bias in RMS (−0.69; 95% CI −1.11 to −0.27), limits of agreement of approximately ±10 normalized units, and a moderate-to-high correlation (r = 0.73; 95% CI 0.69–0.77). The calibration slope (b = 0.16; 95% CI 0.15–0.17) showed moderate within-session consistency (ICC(2,1) = 0.45). These findings indicate that, with appropriate preprocessing, the open-source system provides practically acceptable agreement with a commercial reference for characterizing relative muscle activation patterns, supporting its use in applied sports and rehabilitation contexts. Full article

Quantifying e-waste in Sub-Saharan Africa remains constrained by scarce data, weak institutional reporting, and the dominance of informal sector activity. We present the first nationwide assessment of e-waste generation and Random Forest-based national forecasting in Sierra Leone. A mixed-methods survey administered 6000 questionnaires across all 16 districts, targeting households, institutions, enterprises, and informal actors. The study documented devices in use, storage, and disposal across the following six categories: ICT, appliances, lighting, batteries, medical, and other electronics. Population growth and device adoption simulations were combined with lifespan distributions and a Random Forest model trained on survey and simulated historical data to construct e-waste flows and forecast quantities through to 2050, including disposal fate probabilities for repurposing versus discarding. The results showed sharp spatial disparities, with Western Urban (Freetown) averaging about 10 kg per capita compared to 1.8 kg per capita in rural areas. Long-term district patterns were highly concentrated: 50-year annual averages indicated that Western Area Urban contributes 15.3% of national totals, followed by Bo (12.7%) and Western Area Rural (12.1%), with the top five districts contributing 59.1%. By 2050, total national e-waste entering reuse and disposal pathways was projected to reach 23.4 kilo tons per year (kt yr⁻¹) with a 95% uncertainty interval (UI) of 11–42 kt yr⁻¹ (and a 99% interval extending to 50 kt yr⁻¹), corresponding to 0.9–3.4 kg/capita/year. Household appliances dominated total mass, ICT devices exhibited high reuse rates, and batteries showed minimal reuse despite high hazard potential. These findings provide critical evidence for e-waste policy, regulation, and infrastructure planning in data-scarce regions. Full article

The integration of extended reality (XR) into industrial robotics requires robust middleware solutions capable of bridging heterogeneous systems, protocols, and user interactions. This paper presents a novel middleware framework designed to connect industrial robots with XR devices such as the HoloLens. The architecture employs a hybrid communication layer that combines MQTT (Message Queuing Telemetry Transport) and ØMQ (Zero Message Queue), leveraging the Sparkplug Robotics API model for robot data and publisher–subscriber streaming for XR camera feeds. A Redis cache database is introduced to ensure efficient data handling and prevent data corruption. On the robot side, the system is built on ROS 2 (Robot Operating System) and connects to proprietary industrial protocols through dedicated bridges, enabling seamless interoperability. Spatial alignment between physical robots and XR overlays is achieved using ArUco marker-based synchronization, while real-time kinematic and process data are visualized directly in XR. The middleware further supports bidirectional interaction, allowing users to adjust parameters and issue commands through XR devices. Beyond functionality, safety considerations are incorporated by integrating human–robot interaction safeguards and ensuring compliance with industrial communication standards. The proposed solution demonstrates how middleware-driven XR integration enhances transparency, control, and safety in robotic manufacturing processes, laying the foundation for greater efficiency and adaptability in Industry 4.0 environments. Full article

The extraction of land gas resources requires efficient methods to address the issue of pipeline obstruction due to the accumulation of natural gas hydrates. The existing ground heating, downhole throttling, and decompression measures are energy-intensive. The metal-reinforced composite heat-insulation pipe serves as the production string for terrestrial natural gas wells, effectively minimizing temperature loss of natural gas within the wellbore. This innovation eliminates the need for ground heating equipment and downhole throttling devices in large-scale gas well production, thereby fundamentally achieving environmentally sustainable natural gas extraction, energy conservation, and cost reduction. This research simulates the operational circumstances and environmental characteristics of the Sulige gas field. Utilizing predictions and analyses of the formation characteristics of natural gas hydrate, the gas–solid two-phase flow DPM model, RNG k-ε turbulence model, heat transfer characteristics, and population balance model are employed to examine the concentration distribution, pressure distribution, velocity distribution, and heat transfer characteristics of natural gas hydrate within the vertical tube of the structure. The findings indicate that a reduction in natural gas production or an increase in hydrate volume fraction leads to significant accumulation of hydrate adjacent to the tube wall, while the concentration distribution of hydrate is more uniform at elevated production conditions. The pressure distribution of hydrate under each operational state exhibits a pattern characterized by a high central concentration that progressively diminishes towards the periphery. The unit pressure drop of hydrate markedly escalates with an increase in flow rate. As the ambient temperature of the formation rises or the flow rate escalates, the thermal loss of the hydrate along the pipeline diminishes, resulting in an elevated exit temperature. Minimizing the thermal conductivity of the composite pipe can significantly decrease the temperature loss of the hydrate along the pipeline, greatly aiding in hydrate inhibition during the extraction of natural gas from terrestrial wells. This paper’s research offers theoretical backing for the enduring technical application of metal-reinforced composite insulating pipes in terrestrial gas fields, including the Sulige gas field. Full article

The interpretation and diagnosis of central sleep apnea in pediatrics by nocturnal polysomnography is challenging due to its technical complexity, which involves the simultaneous recording of multiple physiological parameters related to sleep and wakefulness. Furthermore, the unfamiliar environment of a sleep laboratory can hinder sleep evaluation, and diagnostic backlogs are common due to restricted capacity at specialist tertiary centers. The ability to undertake home sleep studies in a familiar environment using simple, robust, and low-cost technology is attractive. The potential to repurpose the PneumoWave biosensor, a UKCA Class 1 device, registered as an accelerometer-based monitoring device that is intended to capture and store chest motion data continuously over a period of time for retrospective analysis, was explored in an in vitro model of central sleep apnea. The PneumoWave system contains a biosensor (PW010), which was able to record simulated apnea episodes of 5 to 20 s across physiologically relevant pediatric breathing rates using an in vitro manikin model and manual annotation. The findings confirm that the PneumoWave biosensor could be a useful technology to support home sleep apnea testing and warrant further exploration. Full article

The Social Internet of Things (SIoT) enables collaborative service provisioning among interconnected devices by leveraging socially inspired trust relationships. This paper proposes a socially driven SIoT protocol for trust-aware service selection, enabling dynamic friendship formation and ranking among distributed service-providing devices based on observed execution behavior. The protocol integrates detection accuracy, round-trip time (RTT), processing time, and device characteristics within a graph-based friendship model and employs PageRank-based scoring to guide service selection. Industrial computer vision workloads are used as a representative testbed to evaluate the proposed SIoT trust-evaluation framework under realistic execution and network constraints. In homogeneous environments with comparable service-provider capabilities, friendship scores consistently favor higher-accuracy detection pipelines, with F1-scores in the range of approximately 0.25–0.28, while latency and processing-time variations remain limited. In heterogeneous environments comprising resource-diverse devices, trust differentiation reflects the combined influence of algorithm accuracy and execution feasibility, resulting in clear service-provider ranking under high-resolution and high-frame-rate workloads. Experimental results further show that reducing available network bandwidth from 100 Mbps to 10 Mbps increases round-trip communication latency by approximately one order of magnitude, while detection accuracy remains largely invariant. The evaluation is conducted on a physical SIoT testbed with three interconnected devices, forming an 11-node, 22-edge logical trust graph, and on synthetic trust graphs with up to 50 service-providing nodes. Across all settings, service-selection decisions remain stable, and PageRank-based friendship scoring is completed in approximately 20 ms, incurring negligible overhead relative to inference and communication latency. Full article

The efficient and timely management of human evacuation during emergency events is an important area of research where the Internet of Things (IoT) can be of great value. Significant areas of application for optimum evacuation strategies include buildings, sports arenas, cultural venues, such as museums and concert halls, and ships that carry passengers, such as cruise ships. In many cases, the evacuation process is complicated by constraints on space and movement, such as corridors, staircases, and passageways, that can cause congestion and slow the evacuation process. In such circumstances, the Internet of Things (IoT) can be used to sense the presence of evacuees in different locations, to sense hazards and congestion, to assist in making decisions based on sensing to guide the evacuees dynamically in the most effective direction to limit or eliminate congestion and maximize safety, and notify to the passengers the directions they should take or whether they should stop and wait, through signaling with active IoT devices that can include voice and visual indications and signposts. This paper uses an analytical queueing network approach to analyze an emergency evacuation system, and suggests the use of the Pull Policy, which employs the IoT to direct evacuees in a manner that reduces downstream congestion by signalling them to move forward when the preceding evacuees exit the system. The IoT-based Pull Policy is analyzed using a realistic representation of evacuation from an existing commercial cruise ship, with a queueing network model that also allows for a computationally very efficient comparison of different routing rules with wide-ranging variations in speed parameters of each of the individual evacuees.Numerical examples are used to demonstrate its value for the timely evacuation of passengers within the confined space of a cruise ship. Full article

In image super-resolution tasks, methods based on Generative Adversarial Networks (GANs), Transformer models, and diffusion models demonstrate robust global modeling capabilities and outstanding performance. However, their computational costs remain prohibitively high, limiting deployment on resource-constrained devices. Meanwhile, frequency-domain approaches based on convolutional neural networks (CNNs) capture complementary structural information but lack long-range dependencies, resulting in suboptimal perceptual image quality. To overcome these limitations, we propose a micro-Transformer-based architecture. This framework enriches high-frequency image information through wavelet transform-based frequency-domain features, integrates spatio-temporal and frequency-domain cross-feature fusion, and incorporates a discriminator constraint to achieve image super-resolution. Extensive experiments demonstrate that this approach achieves competitive PSNR/SSIM performance while maintaining reasonable computational complexity. Its visual quality and efficiency outperform most existing SR methods. Full article

The construction industry is undergoing a rapid digital transformation, with Digital Twins (DTs) and Extended Reality (XR) as two emerging technologies with great potential. Despite their potential, there are several challenges regarding DT and XR use in construction projects, including implementation barriers, interoperability issues, system complexity, and a lack of standardized frameworks. This study presents a systematic literature review (SLR) of DT and XR technologies—including Virtual Reality (VR), Augmented Reality (AR), and Mixed Reality (MR)—in the construction industry. The study analyzes 52 peer-reviewed articles identified using the Web of Science database to explore thematic findings. Key findings highlight DT and XR applications for safety training, real-time monitoring, predictive maintenance, lifecycle management, renovation or demolition, scenario risk assessment, and education. The SLR also identifies core enabling technologies such as Building Information Modeling (BIM), Internet of Things (IoT), Big Data, and XR devices, while uncovering persistent challenges including interoperability, high implementation costs, and lack of standardization. The study highlights how integrating DTs and XR can improve construction by making it smarter, safer, and more efficient. It also suggests areas for future research to overcome current challenges and help increase the use of these technologies. The primary contribution of this study lies in deepening the understanding of DT and XR technologies by examining them through the lenses of their benefits as well as drivers for and challenges to their adoption. This enhanced understanding provides a foundation for exploring integrated DT and XR applications to advance innovation and efficiency in the construction sector. Full article

Mobile authentication is crucial for device security; however, conventional techniques such as PINs and swipe patterns are susceptible to social engineering attacks. This work explores the integration of touch stroke analysis and Explainable AI (xAI) to address these vulnerabilities. Unlike static methods that require intervention at specific intervals, continuous authentication offers dynamic security by utilizing distinct user touch dynamics. This study aggregates touch stroke data from 150 participants to create comprehensive user profiles, incorporating novel biometric features such as mid-stroke pressure and mid-stroke area. These profiles are analyzed using machine learning methods, where the Random Tree classifier achieved the highest accuracy of 97.07%. To enhance interpretability and user trust, xAI methods such as SHAP and LIME are employed to provide transparency into the models’ decision-making processes, demonstrating how integrating touch stroke dynamics with xAI produces a visible, trustworthy, and continuous authentication system. Full article

Bone conduction hearing implant systems (BCHIs) are established treatments for patients with conductive or mixed hearing loss or single-sided deafness when conventional hearing aids are unsuitable. This study evaluated the cost-effectiveness of the active transcutaneous system Sentio versus a similar system, i.e., Osia in an Australian setting. Scenario analyses also compared Sentio to other systems, i.e., Ponto and Baha Attract. A Markov cohort model was adapted from a previously published source to reflect Australian practice, incorporating device acquisition, surgery, maintenance, battery replacement and adverse event management over a 15-year horizon from a healthcare perspective. Effectiveness inputs were derived from published evidence using a naïve indirect comparison. Extensive sensitivity analyses and external validation tested robustness. In the base case, Sentio was associated with lower costs and a small modelled incremental quality-adjusted life years (QALYs) gain versus Osia. Scenario analyses confirmed cost-effectiveness relative to Ponto and Baha Attract, with outcomes below the Australian willingness-to-pay threshold. Health state utility, device price and reimplantation assumptions were the most influential drivers, yet Sentio remained cost-effective in over 95% of simulations. These findings support Sentio as a clinically and economically efficient BCHI in Australia and highlight the need for direct utility and long-term durability data. Full article

The growing penetration of power electronics and nonlinear loads in industrial electrical networks has increased the dynamic complexity of these systems, exceeding the analysis capabilities of traditional approaches based on quasi-stationary models. In this context, this paper presents a methodology for the dynamic characterization of an industrial electrical network based on high-resolution synchrophasor measurements obtained using a microPMU. The proposed approach is based on the identification of a linear dynamic model in state space using subspace techniques based on real data recorded during a short-duration transient event. The results show that the identified model is capable of adequately capturing local underdamped dynamics and reproducing the temporal response observed in the measurements. This evidences the presence of dynamic modes associated with the interaction between the network and power electronics-based devices. Similarly, the stability analysis of the identified model demonstrates its consistency and robust gains in temporal variations within the analysis window. Overall, the results confirm that the combination of microPMU and data-based modeling techniques is an effective tool for improving dynamic observability and understanding the transient behavior of industrial power grids, complementing classical analysis and simulation methods. Full article

This paper presents a 2D micro-conveyance device based on a 3 × 3 electromagnetic digital actuator array. This device allows the conveyed object to be moved between several discrete positions distributed in the xy-plane through a collaborative actuation of the digital actuators. Each digital actuator includes a mobile permanent magnet placed in a square cavity and can be moved between four discrete positions. An analytical model of the digital actuators was proposed and used to design the conveyance device. Then, a prototype was built using rapid prototyping techniques and was experimentally characterized. The reachable workspace of the conveyance device is 56 mm × 56 mm in the xy-plane, and the proposed architecture enables the workspace to be easily enlarged by adding elementary modules. The distance between two discrete positions is 4 mm, and the positioning repeatability was measured as 5.5 µm. The maximum conveyance velocity and transportable mass were found to be up to 16 mm.s⁻¹ and 15 g, respectively. Full article

Millimeter-wave (mmWave)/terahertz (THz) devices relying on conventional semiconductor technologies face significant performance bottlenecks, constraining their use in next-generation electronic systems. To address these challenges, this work demonstrates high-performance THz Schottky barrier diodes (SBDs) based on aligned carbon nanotube (ACNT) arrays, and the realization of a D-band second-harmonic frequency multiplier. The ACNT-SBDs exhibit superior electrical and radio-frequency (RF) characteristics, achieving a forward current density of 0.14 mA·μm⁻¹ at −1.3 V and an intrinsic cutoff frequency (f_C) of 506 GHz. The developed small-signal model of diodes shows close agreement with measurements, with S-parameter relative errors below 0.7% from 100 MHz to 67 GHz. The implemented 154 GHz D-band multiplier achieved a maximum output power of −18.97 dBm and a minimum conversion loss of 27.92 dB, outperforming previously reported frequency multipliers based on carbon nanotubes or two-dimensional (2D) materials. This study not only establishes the outstanding high-frequency response, nonlinear efficiency, and integration potential of ACNT-based devices but also provides a promising technical pathway for future THz communication and sensing applications. Full article