In the recent consumer market, eyewear has gone beyond the improvement of visual function and is used for the individual style and the symbolization of social standing. Consequently, the aesthetic design of eyewear influences consumer purchasing deci...
Built environment and infrastructure designs are produced in complex information systems. Managing this complexity poses a significant challenge; data scarcity and bias are substantial obstacles. This paper addresses the gap in data availability by m...
The design of experiments (DoE) is one of the quality-by-design tools valued in analytical method development, not only for cost reduction and time effectiveness, but also for enabling analytical method control and understanding via a systematic work...
It is generally acknowledged that good-quality design is a prerequisite for good quality and productive construction work. One proposed measure to improve the quality of construction has been contractors’ involvement in the design phase, and this phe...
The quality of educational multimedia edition design is determined by a set of characteristics that affect perception, readability and communication efficiency. Quality assessment of multimedia edition design is based on a comprehensive analysis of c...
The classical dependency structure matrix (DSM) can effectively deal with iterative schedules that are highly coupled and interdependent, such as the design process and the concurrent process. Classical DSM generally follows the assumption that the l...
Cosmeceuticals are cosmetic formulations that are intended to alleviate skin conditions that affect its appearance and functionality. They are not considered medications but contain molecules that exert biological action on the skin beyond traditiona...
In recent years, the “quality by design” (QbD) approach has been used for developing pharmaceutical formulations. This is particularly important for complex dosage forms such as topical semisolid products. The first step for developing a...
Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives to develop and optimize chitosan-based mucoadhesive buccal films by relying on qualit...
Background/Objectives: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been widely applied in oral drug delivery, particularly for poorly water-soluble compounds. The successful development of SNEDDS largely depends on the precise composit...
Nanoparticles can be used as drug carriers in various applications (e.g., in pulmonary drug delivery and mucosal vaccination). For further investigations, such as drug release studies, as well as for cell and tissue targeting, particles with defined...
The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical fact...
The pursuit of sustainable design has made strides in improving building practices, yet traditional approaches often fall short in addressing the holistic needs of both the environment and human well-being. This research delves into the emerging fiel...
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In t...
Background/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies. Rooted in ICH Q8–Q11 guidelines, QbD emphasizes defining Cri...
In the analytical quality by design (AQbD) framework, the design of experiments (DOE) plays a very important role, as it provides information about how experimental input variables influence critical method attributes. Based on the information obtain...
Buildings exert a profound influence on the environment, with the design phase recognized as the pivotal determinant of a building’s overall performance. Green building design, in particular, introduces heightened complexity, where the attribut...
For business-to-business (B2B) companies, selecting new product concepts is vital to new product development (NPD), since it significantly contributes to the ultimate success and reputation of the product in terms of quality and function. The researc...
Designing and delivering outcome-based courses that emphasize learner-centric educational discourse and active learning is challenging, especially in online learning environments. Ensuring quality in the design and delivery of such courses in the vir...
Nanomedicine is an emerging field with continuous growth and differentiation. Liposomal formulations are a major platform in nanomedicine, with more than fifteen FDA-approved liposomal products in the market. However, as is the case for other types o...
Design quality considers the extent to which the owner’s requirements are accurately synthesized into conformance specifications and drawings for the construction team to execute. Expected superior performance and sustainability of a green building r...
This comprehensive review of the synergistic use of Quality by Design (QbD) and the Pi–Buckingham theorem explores an innovative approach to enhancing product development and process optimization within the pharmaceutical industry. QbD is a sys...
A pediatric dosage form for crizotinib (Xalkori) was commercialized using quality-by-design principles in a material-sparing fashion. The dosage form consists of spherical multiparticulates (microspheres or pellets) that are coated and encapsulated i...
Design for longevity is known as an eco-design opportunity and could help to reduce the environmental footprint of energy-free items. However, extending the lifespan of products is not always desirable and the focus should be on achieving an optimal...
Nanogel is administered via various routes to overcome physiological barriers and achieve the desired therapeutic effect in vivo. However, developing a stable nanogel system is required to retain its therapeutic efficacy after storage. Therefore, a n...
The present article exemplifies the application of the concept of quality by design (QbD) for the systematic development of a nanoparticulate imiquimod (IMQ) emulsion gel formulation as an investigational medicinal product (IMP) for evaluation in an...
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as contr...
In Ecuador, 30% of the population does not consume drinking water of good quality. One of the causes is related to the deficiency in the technical skills of water operators because some have not had access to elementary, high school or higher educati...
Logging residues, which refer to the unused portions of trees cut during logging, are important sources of biomass for the emerging biofuel industry and are critical feedstocks for the first-type biofuel facilities (e.g., corn-ethanol facilities). Lo...
Research on the influence of packaging on consumer perception of beer and other alcoholic beverages suggest an important role in capturing consumers’ attention and generating expectations on perceived product quality, and in particular that col...
Capsule-based dry powder inhalers (cDPIs) are widely utilized in the delivery of pharmaceutical powders to the lungs. In these systems, the fundamental nature of the interactions between the drug/formulation powder, the capsules, the inhaler device,...
This review aims to present the Quality by Design (QbD) model as a suitable methodology to perform research in the academic Costa Rican institutions that teach Pharmacy. Pubmed, Science Direct, and Google Scholar databases were screened for original...
Quality management in the design phase is crucial for determining the overall quality of prefabricated buildings. However, traditional design methods can no longer meet the complex design, component, and nodal requirements of prefabricated buildings....
The purpose of this study was to apply the Quality by Design (QbD) approach to the electrospinning of fibres loaded with the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin (INDO) and diclofenac sodium (DICLO). A Quality Target Product Pro...
The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA are lipid nanoparticles (LNPs). Many...
Scientific regulatory systems with suitable analytical methods for monitoring quality, safety, and efficacy are essential in medicinal plant drug discovery. There have been only few attempts to adopt the analytical quality by design (AQbD) strategy i...
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Affected by regular tides, bidirectional water flows play a crucial role in surface river systems. Using optimization theory to design a water quality monitoring network can reduce the redundant monitoring nodes as well as save the costs for building...
In engineering design, the decision-making process holds significant importance as it plays an important role in determining the outcomes of a task. The decision-making process is notably influenced by various factors, with particular focus on the pe...
The strategic relevance of innovation and scientific research has amplified the attention towards the definition of quality in research practice. However, despite the proliferation of evaluation metrics and procedures, there is a need to go beyond bi...
Nanoparticle research and development for pharmaceuticals is a challenging task in the era of personalized medicine. Specialized and increased patient expectations and requirements for proper therapy adherence, as well as sustainable environment safe...
This paper mainly studies the influence of tractor parameters on shift quality. The kinetic theoretical model of the powertrain system was deduced, and then the simulation model was established by using AMESim simulation software. The acceptable jerk...
Public technology innovation procurement plays an essential role in alleviating current major social challenges. In the process of government procurement, the hidden adverse selection and moral hazard caused by the unobservable technology types and e...
In the comprehensive development and utilization of crop straw, it is key to separate the fibers in the straw through a certain process or equipment. In order to obtain rice straw fiber material, the straw fiber crusher was designed using SOLIDWORKS...
As the industry shifts to automated manufacturing and the assembly of parts in smaller batches, there is a clear need for an efficient design of grippers. This paper presents a method for automated grasp planning and finger design for multiple parts...
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is commonly used in the enantioseparation and chiral purity control of pharmaceuticals from different matrices. The adoption of Quality by Design (QbD) concepts in...
COVID-19 lockdowns led to a reassessment of housing conditions and created greater awareness of their impact on wellbeing and inequalities. Changes in home use and lived experience during the pandemic were studied through a survey of London residents...
This study addresses the limited research on examining comfort levels among architecture students. Specifically, it seeks to evaluate indoor environmental quality (IEQ) within design studios to investigate the occurrence of health symptoms and ascert...
Sustainability in the built environment seeks to balance ecological responsibility with human health and well-being. Biophilic design, a key strategy within sustainable architecture that emphasizes connections with nature, has emerged as a promising...
As the population ages, the demand for suitable rental housing will increase. Suitable housing means housing that can accommodate those impairments that typically correspond with ageing. This paper explores the quality of life (QoL) requirements of t...
Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side effect profile that includes hepato- and haema-toxicity. A novel pse...
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