The use of waste materials in road construction is becoming widely spread due to economic and environmental needs. Construction and demolition waste materials and mining residues have been studied for a long time. However, the use of fine materials,...
Techniques of the design of experiments (DOE) and computational fluid dynamics (CFD) were applied for improving the bow shape of a tanker hull. Through this, a hull that could reduce the added resistance in waves was derived. The key design elements...
A methodology for the design of an experiment is proposed in order to find asmany schemes as possible with the maximum number of factors with different levels for thesmallest number of experimental runs. An algorithm was developed and homemadesoftwar...
Statistical experimental designs such as factorial, optimal, or definitive screening designs represent the state of the art in biopharmaceutical process characterization. However, such methods alone do not leverage the fact that processes operate as...
During multidisciplinary design of welded aircraft components, designs are principally optimized upon component performance, employing well-established modelling and simulation techniques. On the contrary, because of the complexity of modelling weldi...
Biological products are increasingly important, and therefore the industry has begun to adopt quality by design, as recommended by the ICH and the U.S. FDA. Smaller companies, however, have faced difficulties in employing full-scale experiments or th...
Liquid–liquid equilibria (LLE) characterization is a task requiring considerable work and appreciable financial resources. Notable savings in time and effort can be achieved when the experimental plans use the methods of the optimal design of e...
A systematic method to identify key factors that control the synthesis of Physical Vapor Deposition (PVD)-based graphene on copper is necessary for engineering graphene growth. The statistical design-of-experiments method is employed and demonstrated...
Interoperability is a challenge for the realisation of smart grids. In this work, we apply the methodology for interoperability testing and the design of experiments developed at the Smart Grids Interoperability Laboratory of the Joint Research Centr...
This research focuses on the optimization of the thermofusion process in the construction of biodigesters as it has a direct influence on their quality and durability. The study utilizes factorial experiments and statistical analysis, with particular...
The coating design of machine tools refers to the exterior appearance of a machine tool and is an important method for improving the user experience and brand image. In this study, we studied and optimized the coating design of serial CNC cylindrical...
Design of experiments (DOE) methodology was used to identify and optimize factors that influence the degree of functionalization (polycarboxylation) of WS2 INTs via a modified acidic Vilsmeier–Haack reagent. The six factors investigated were reaction...
Background: The Box–Behnken design of experiments (BBD) is a statistical modelling technique that allows the determination of the significant factors in developing nanoparticles (NPs) using a limited number of runs. It also allows the predictio...
Oral delivery has become the route of choice among all other types of drug administrations. However, typical chronic disease drugs are often poorly water-soluble, have low dissolution rates, and undergo first-pass metabolism, ultimately leading to lo...
The production of high yields of soluble recombinant protein is one of the main objectives of protein biotechnology. Several factors, such as expression system, vector, host, media composition and induction conditions can influence recombinant protei...
Cardiac catheter ablation (CCA) is a common method used to correct cardiac arrhythmia. Pulsed Field Ablation (PFA) is a recently-adapted CCA technology whose ablation is dependent on electrode and waveform parameters (factors). In this work, the use...
Global warming is predominantly caused by methane (CH4) and carbon dioxide (CO2) emissions. CH4 is estimated to have a global warming potential (GWP) of 28–36 over 100 years. Its impact on the greenhouse effect cannot be overstated. In this report, a...
One of the basic components of Industry 4.0 is the design of a flexible manufacturing system (FMS), which involves the choice of parameters to optimize its performance. Discrete event simulation (DES) models allow the user to understand the operation...
This paper deals with the dielectric and mechanical characterizations of polyacrylonitrile (PAN)-aligned electrospun nanofiber mats. A two factor three level full factorial experiment is conducted to understand the effect of various parameters on die...
In a Kubernetes environment, the resource allocation for Pods has a direct impact on both performance and cost. When resource sizes are determined based on user experience, under-provisioning can lead to performance degradation and execution instabil...
This paper proposes an original approach to investigate the influence of the geometry of Francis turbines draft tube on pressure fluctuations and energy losses in off-design conditions. It is based on Design of Experiments (DOE) of the draft tube geo...
Self-emulsifying drug delivery systems (SEDDS) consist of isotropic mixtures of oils, surfactants, and solvents that after dispersion emulsify in the aqueous media of the gastrointestinal tract (GIT). SEDDS can deliver hydrophobic drugs, which could...
This paper deals with the redesign of an aircraft passenger seat, placed at the first seat row, which was not compliant with Federal Aviation Regulations FAR 25.562 “Emergency landing dynamic conditions” regulation (due to a high value for the Head I...
This paper presents the results of a numerical investigation by design of experiments of the thermal management of a symmetrical rectangular heat sink for LED lighting placed in a cavity with asymmetrical conditions at its opening. Our mathematical m...
Isoflavones are the main phenolic compounds of soybean that affect its biological activity. The quantity of these valuable compounds extracted from plant material can significantly vary, influenced by the chosen extraction method and the specific ext...
An accurate and computationally efficient lithium-ion battery model is beneficial when developing state-of-charge (SOC) and state-of-health (SOH) algorithms for battery management systems (BMS). These models allow for software-in-the-loop (SIL) and h...
Lattice-based workpieces contain patterned repetition of individuals of a basic topology (Schwarz, ortho-walls, gyroid, etc.) with each individual having distinct geometric grading. In the context of the design, analysis and manufacturing of lattice...
Glycans carry a vast range of functions in nature. Utilizing their properties and functions in form of polymers, coatings or glycan derivatives for various applications makes the synthesis of modified glycans crucial. Since amines are easy to modify...
Hand, foot, and mouth disease (HFMD) represents an emerging health concern whose main causative agents are Coxsackievirus A6 (CVA6) and enterovirus A71 (EV71). The lack of a CVA6 vaccine and the rise of new HFMD-causing strains due to the containment...
In structural engineering, thin-walled structures play an important role in the design of the lightweight structural model. It carries different loading conditions when it exists in any model, and it is designed with thin plates or thin shells. Penet...
In this study, material and dynamic stress experiments are combined with finite element (FE) simulations to reveal the fracture mechanism of the wheelset lifting apparatus, and a structural design optimization scheme based on the double-layer Kriging...
Despite the great potential of design of experiments (DoE) for efficiency and plannability in academic research, it remains a method predominantly used in industrial processes. From our perspective though, DoE additionally provides greater informatio...
According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch. Full factorial design was employed to increase...
A new framework for optimal design based on the information-theoretic measures of mutual information, conditional mutual information and their combination is proposed. The framework is tested on the analysis of protocols—a combination of angles along...
Optimisation of tissue engineering (TE) processes requires models that can identify relationships between the parameters to be optimised and predict structural and performance outcomes from both physical and chemical processes. Currently, Design of E...
The base-catalyzed ethanolysis of soybean oil and waste cooking oil (WCO) was investigated in two types of continuous reactors (microreactor and T-mixer) and in a batch reactor. Flow rate, ethanol/oil ratio and concentration of catalyst were varied a...
The rapid growth of tourism on Jeju Island has led to an increase in traffic volume, causing accelerated ground subsidence at the intersections between natural caves and roads. Natural phenomena are not caused by a single specific factor, but rather...
The effectiveness of model-based multivariable controllers depends on the quality of the model used. In addition to satisfying standard accuracy requirements for model structure and parameter estimates, a model to be used in a controller must also sa...
The rapid increase in the use and development of statistical design of experiments (DoE), particularly in pharmaceutical process development, has become increasingly important over the last decades. This rise aligns with Green Chemistry Principles, s...
Single-lip deep hole drilling (SLD) is characterized by a high surface quality and compressive residual stress in the subsurface of the drill hole. These properties are strongly dependent on the cutting parameters of the SLD process and the actual ge...
Wind energy is a vital renewable resource with substantial economic and environmental benefits, yet its spatial variability poses significant optimization challenges. This study advances wind farm layout optimization by employing a systematic genetic...
In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE® Pro 13 (Sartorius) was used to develop a full-factorial design of experi...
This study presents a comprehensive investigation into the design and optimization of capacitive pressure sensors (CPSs) for their integration into capacitive touch buttons in electronic applications. Using the Finite Element Method (FEM), various ge...
In current times, DNA vaccines are seen as a promising approach to treat and prevent diseases, such as virus infections and cancer. Aiming at the production of a functional and effective plasmid DNA (pDNA) delivery system, four chitosan polymers, dif...
The focus of the experimental work was on shallow spiral geothermal heat exchanger configurations. Real-scale experiments were carried out for vertically oriented spiral collectors (helix) in sand and soil. One objective was to develop a measurement...
In this study, the design of mixture experiments was used to find empirical models that could predict, for a first approximation, the relative density, flexural strength, Vickers hardness and fracture toughness of sintered composites in order to iden...
Alkali-activated aluminosilicate matrices are increasingly studied for their ability to stabilize hazardous metal contaminants via alkali activation at room temperature. In this study, metakaolin-based geopolymers were used to immobilize chromium and...
In data centers, heating, ventilation, and air-conditioning (HVAC) consumes 30–40% of total energy consumption. Of that portion, 26% is attributed to fan power, the ventilation efficiency of which should thus be improved. As an alternative meth...
To improve collision safety in robot–human collaborative applications, increasing attention has been paid to rotational variable stiffness actuators. A new rotational variable stiffness actuator, which works in two stages, is proposed for hybri...
In this study, sustainable technology microwave-assisted extraction (MAE) in association with green solvents was applied to recover phenolic compounds from spent coffee grounds (SCGs). A design of experiments (DOE) was used for process optimization....
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