Search Results (383)

Background/Objectives: Nanotechnology has become a transformative area in modern dentistry, providing new opportunities for better diagnosis, targeted drug delivery, improved restorative materials, antimicrobial treatments, and tissue regeneration. This scoping review outlines the scope, key developments, and future directions of nanotechnology use across all dental specialties, highlights emerging innovations, and identifies major translational challenges and research priorities. Methods: This review followed the Joanna Briggs Institute (JBI) methodology for scoping reviews and adhered to the PRISMA-ScR guidelines. These guidelines, originally by Arksey and O’Malley (2005) and later updated by Levac et al. (2010) and Peters et al. (2020, 2021), guided the process. The Population, Concept, and Context (PCC) framework guided the eligibility criteria. Included studies were primary research or reviews reporting nanotechnology applications in any dental specialty, published in English, with no date restriction. Excluded were non-peer-reviewed sources, conference abstracts without full text, studies unrelated to dental applications, and non-English publications. A comprehensive literature search was conducted across PubMed/MEDLINE, Scopus, and Web of Science. After screening titles and abstracts and reviewing full texts, 133 studies were included. Results: The included studies covered a wide range of fields such as restorative dentistry, implantology, periodontology, endodontics, drug delivery, tissue regeneration, oral diagnostics, antimicrobial applications, prosthodontics, orthodontics, and emerging technologies like nanorobotics and graphene-based systems. The most commonly reported nanomaterials were silver nanoparticles (AgNPs), calcium phosphate nanoparticles (CaP NPs), and polymeric nanoparticles such as PLGA and chitosan. Additionally, there was a notable increase in publications starting from 2019. Conclusions: Nanotechnology offers transformative possibilities in every area of dentistry. Nonetheless, challenges such as nanotoxicology safety, regulatory alignment, and effective clinical application need resolution. Essential steps include standardized characterization, gathering long-term safety data, and establishing international regulatory standards to ensure safe adoption of nano dentistry. Full article

Background: Accurate three-dimensional positioning of dental implants is fundamental for long-term prosthetic success. While static guided surgery and traditional dynamic navigation present intrinsic limitations related to physical bulk or hand–eye coordination (the “look-away” phenomenon), Augmented Reality (AR) via Head-Mounted Displays (HMDs) promises to overcome these barriers by superimposing virtual holograms directly onto the surgical field. Objectives: The aim of this scoping review is to map the existing literature to evaluate the positioning accuracy, workflow efficiency, and ergonomic/technical barriers of HMD-based AR navigation systems in implant dentistry. Methods: A systematic search was conducted across the PubMed, Scopus, Web of Science, and Cochrane Library databases, following the PRISMA-ScR guidelines. In vitro, ex vivo, and clinical studies utilizing AR headsets (e.g., HoloLens) for implant guidance, reporting quantitative data on accuracy and/or qualitative data on usability issues, were included. Results: Eleven studies were included (7 in vitro, 1 ex vivo, 3 clinical). Accuracy showed a strong dependence on case complexity: for standard implants, the mean error at the entry point ranged between 0.33 and 1.51 mm, which is comparable to s-CAIS techniques. However, in complex scenarios (zygomatic implants), significant deviations were reported (up to 5.64 mm and 9.60°). The main barriers to routine adoption identified include tracking instability due to line-of-sight interruption, device weight, and the vergence–accommodation conflict. Conclusions: AR dynamic navigation demonstrates promising potential. Nevertheless, current evidence relies predominantly on in vitro studies that fail to fully replicate real-world surgical complexities. Persistent technical and ergonomic barriers, such as tracking instability and hardware limitations, indicate that the technology remains largely in a preclinical phase and is not yet suitable for routine clinical application. Further advancements toward markerless tracking systems, lighter headsets, and rigorous in vivo trials are required. Full article

Introduction: One of the fundamental principles of modern medicine, including dentistry, is prevention. However, if treatment is not initiated, tooth loss can occur, necessitating the use of dental prostheses to restore the function and aesthetics of the stomatognathic system. The oral microbiome is a complex ecosystem that is sensitive to external factors, including the biomaterials used to manufacture dental prostheses. Objectives: This narrative literature review aims to identify and compare the effects of various metal alloys used in dentistry, specifically high-precious (gold), precious (silver–palladium) and base (cobalt–chromium and nickel–chromium) alloys, as well as titanium, on the balance of the oral microbiome and biofilm formation. Results: The analysis indicates that gold, silver and palladium alloys demonstrate the most favourable biocompatibility and antibacterial properties, significantly reducing biofilm accumulation. Titanium and titanium-based alloys generally exhibit neutral properties under healthy conditions, although their biocorrosion products can alter the microbial environment in pathological states such as peri-implantitis. In contrast, base metal alloys (cobalt–chromium and nickel–chromium) are highly susceptible to biocorrosion in acidic environments, which can encourage the growth of bacteria that cause tooth decay and inflammation, potentially exacerbating oral dysbiosis. Conclusions: The selection of materials plays a critical role in maintaining oral microbial homeostasis and preventing plaque-related diseases. High-noble alloys and titanium are more biocompatible than base metal alloys. However, further long-term clinical trials and multi-species biofilm models are needed to fully understand these interactions between materials and microbes. Full article

Smartphone-based augmented reality (AR) may help dentists visualize an implant axis during treatment or training. Before a virtual overlay can be displayed, however, the application must first recognize the real target reliably. This in vitro study tested how five lighting conditions affected recognition of a two-colored, 3D-printed polylactic acid (PLA) dental model by a Unity/Vuforia smartphone application. The application ran on a Samsung Galaxy S22. A GoPro HERO10 recorded the smartphone display at 240 frames per second, and the videos were evaluated frame by frame. Red, green, blue, daylight-like light-emitting diode (LED) and halogen illumination were tested at a central and an eccentric model position, with ten repetitions per condition and position. The model was not recognized under red or blue illumination within the predefined observation interval. Recognition was successful in all repetitions under green, daylight-like and halogen illumination. Recognition speed differed among these successful conditions, and the eccentric position delayed recognition under daylight-like and halogen illumination. A supplementary region-of-interest analysis also showed lighting-dependent differences in image brightness and contrast. These findings indicate that lighting should be standardized and documented when smartphone-based dental AR systems are developed and tested. Full article

Titanium remains the gold standard in dental implantology; however, its clinical drawbacks, such as hypersensitivity reactions, metallic particle release, and aesthetically compromising discoloration, have driven interest in metal-free alternatives. Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) has emerged as a promising bioceramic candidate, offering favorable aesthetics, mechanical strength, and reduced bacterial plaque affinity. Its pristine surface is nonetheless bioinert, prompting extensive research into surface modification strategies, including sandblasting, acid-etching, femtosecond laser texturing, and bioactive coatings, to enhance osteoconductivity. This comprehensive narrative review synthesizes in vitro evidence on the behavior of key host cell populations—macrophages, mesenchymal stem cells, osteoblasts, fibroblasts, and epithelial cells in response to Y-TZP surface and its modifications, relevant to osseointegration and soft-tissue sealing. A literature search was conducted across PubMed, Scopus, Web of Science, and the Cochrane Library, supplemented by Google Scholar, concluding in March 2026. By integrating findings across multiple cell lineages, this review aims to clarify how engineered zirconia topographies modulate cell-specific pathways, thereby informing the development of next-generation implants optimized for biological integration. Full article

Background/Objectives: Thermal injury during implant osteotomy is a recognized complication of guided surgery. Closed guide architectures and metallic sleeves restrict coolant access to the drill–bone interface, reducing the effectiveness of conventional external irrigation. This study aimed to describe the design and fabrication of a 3D-printed surgical guide system with integrated internal irrigation channels and to evaluate its technical and clinical feasibility in guided implant surgery. Methods: The system was developed by integrating CBCT and IOS data into BlueSky Bio planning software. Irrigation channels were generated by CAD subtraction. Guides were fabricated by additive manufacturing—digital light processing (DLP) in biocompatible Asiga DentaGuide resin and, in one case, selective laser melting (SLM) in Mediloy metal—with metal auxiliary components incorporated where required. Channel patency was confirmed by flow equivalence testing and visual inspection. The design was evaluated for compatibility with the BioHorizons Pro Surgical Guide Kit and the Ticare Fidelis Kit. Clinical feasibility was assessed in two cases: maxillary All-on-6 rehabilitation and immediate implant placement in the esthetic zone. Results: Both guides were successfully fabricated with confirmed patent irrigation channels. Guide seating was verified through occlusal fenestrations and secured with fixation pins. Irrigation flow remained unobstructed throughout all osteotomy steps, and no guide-related or irrigation-related complications were observed. The system was integrated into standard drilling protocols without modification for either implant platform. Conclusions: This proof-of-concept study demonstrates the technical feasibility of an internally irrigated surgical guide across two implant systems and distinct clinical scenarios. The proposed design was successfully integrated into standard guided surgery workflows and maintained functional irrigation. Further in vitro thermal studies and prospective clinical investigations are required to evaluate its effect on temperature control. Full article

Background: The aim of this ex vivo study was to compare the resistance to lateral wall failure during sequential implant site preparation using osseodensification (OD) burs and conventional rotary drills in a standardized narrow ridge model. The primary outcome was the drill diameter at first lateral wall perforation. Secondary outcomes included paired perforation occurrence at a clinically relevant diameter (4.0 mm) and perforation morphology (length and width). Methods: Twenty standardized trabecular bone blocks were prepared in a paired within-specimen design, with each block receiving two osteotomies: one prepared using conventional rotary drills and the other using OD burs. Osteotomy diameter was sequentially increased according to the manufacturers’ protocols until lateral wall perforation occurred. The drill diameter at first perforation was recorded. Perforation morphology (length and width) was quantified using high-resolution extraoral digital scanning and software-based measurements. Statistical analysis was performed using paired non-parametric tests (α = 0.05). Results: OD burs significantly delayed lateral wall perforation compared with conventional drills (median 4.30 vs. 4.00 mm; p = 0.0000171). At the 4.0 mm drill step, perforation occurred in 16/20 (80%) conventional versus 2/20 (10%) OD preparations (p = 0.0013). Perforation length was significantly greater with conventional drilling (p = 0.000681), while no significant difference was observed for perforation width (p = 0.073). Conclusions: Within the limits of this decorticated trabecular ex vivo model, OD increased resistance to lateral wall failure, delayed perforation onset, and reduced perforation length compared with conventional drilling. Full article

Objectives: Patient safety is central to healthcare quality, yet dental practice also involves occupational risks for professionals. This study examined the lifetime prevalence and types of patient- and staff-safety incidents among Korean dental professionals and explored associated demographic, professional, and institutional factors. Methods: A cross-sectional survey was conducted among 439 dental professionals in South Korea. Participants reported lifetime experience of predefined safety incidents, institutional safety factors, and demographic and occupational characteristics. Descriptive statistics, profession-based comparisons, and multivariable logistic regression were applied. Results: Overall, 89.1% of respondents reported at least one safety incident. The most common patient-safety events were aspiration or ingestion of teeth or prosthetic materials and instrument-related injury, whereas sharps injuries and verbal abuse were the leading staff-safety issues. Dentists and dental hygienists differed significantly in response knowledge, liability insurance coverage, and safety education. The presence of institutional safety protocols was associated with higher reported incident experience, which may reflect greater recognition and reporting rather than a causal increase in harm. Conclusions: Safety incidents are highly prevalent in Korean dental practice and represent an underrecognized quality-of-care and workforce-safety issue. Integrated strategies including occupational-hygiene measures, structured safety education, non-punitive reporting, and stronger organizational preparedness are needed to improve dental healthcare delivery. Full article

This research reports on the properties of oxide-ceramic coatings produced by plasma electrolytic oxidation in novel electrolyte solutions for implantology applications. A series of bioactive calcium-phosphate coatings was synthesized on medical-grade Ti-13Zr-13Nb alloy using the plasma electrolytic oxidation (PEO) method. Novel electrolytes enriched with calcium and phosphorus were developed, enabling the formation of coatings with tailored physicochemical and structural characteristics. A correlation was established between the electrolyte composition and the phase composition, thickness, morphology, porosity, and microhardness of the resulting coatings. The optimum coatings exhibited a Ca/P ratio close to that of natural human bone tissue, homogeneity, a well-developed porous surface topography, and controlled resorption behavior. For the first time, a mechanism of calcium-phosphate coating resorption in a biologically active environment has been proposed. It involves partial dissolution, the formation of apatite-like surface structures, and the subsequent controlled release of Ca and P ions. In vitro testing in simulated body fluid indicated the potential bioactivity of the synthesized coatings. The proposed calcium-phosphate coatings may be considered promising candidates for future implant surface modification. The results obtained are significant for the development of advanced orthopedic and dental implants, including those fabricated using additive manufacturing technologies. Full article

Florid cemento-osseous dysplasia (FCOD) is a benign fibro-osseous condition typically presenting as multifocal, sclerotic masses throughout the jaws. While often asymptomatic, the hypovascular nature of the dysplastic bone predisposes it to secondary infection, which can mimic more aggressive pathologies. We present a complex diagnostic challenge involving a 76-year-old female with a history of intravenous ibandronic acid therapy for 18 months. The patient presented with a purulent mandibular fistula and exposed bone, leading to an initial clinical suspicion of Stage 2 Medication-Related Osteonecrosis of the Jaw (MRONJ). Radiographic evaluation, however, revealed generalized “cotton-wool” opacities across all four quadrants, characteristic of FCOD, with multifocal mixed radiolucent–radiopaque changes and a localized demarcated sequestrum in the symptomatic area. Accordingly, the diagnostic reasoning progressed from an initial clinical suspicion of MRONJ, to radiologic consideration of infected FCOD, and finally to exclusion of plasma cell neoplasia by immunohistochemical evaluation. The diagnostic dilemma intensified during histopathological analysis, which revealed an unusually dense, sheet-like infiltration of plasma cells within the fibro-osseous stroma. This striking plasmacytosis initially raised suspicion for a plasma cell neoplasm, such as plasmacytoma or multiple myeloma. To differentiate reactive inflammation from malignancy, immunohistochemical staining for kappa and lambda light chains was performed, demonstrating a polyclonal pattern that confirmed a reactive process. The final diagnosis was determined as FCOD with superimposed secondary osteomyelitis. Following conservative surgical debridement and targeted antibiotic therapy, the patient showed clinical resolution and remained stable at a 6-month follow-up. Recognizing these overlaps is essential for preventing over-treatment and ensuring appropriate management in elderly patients with complex medical backgrounds. Full article

Background: Er:YAG laser (λ = 2940 nm) biomodification of the implant osteotomy site removes the smear layer after rotary preparation and may enhance bone-implant contact. This randomized controlled clinical study evaluated implant stability dynamics following Er:YAG laser biomodification using resonance frequency analysis (RFA). Methods: Ninety patients were randomized 1:1 into a case group (n = 45; rotary osteotomy + Er:YAG biomodification; 400 mJ, 17 Hz) and a control group (n = 45; rotary osteotomy alone). Implant stability quotient (ISQ) was measured by RFA in vestibulo-oral (VO) and mesiodistal (MD) directions at placement, days 10, 20, 30, and month 3. Results: The case group showed significantly higher ISQ values at all time points in both directions (t-test, p < 0.05). Repeated measures ANOVA revealed a significant time × group interaction in the MD direction (F = 14.461, p < 0.001, partial η² = 0.341). Primary VO ISQ: 75.04 ± 4.27 (cases) vs. 72.29 ± 3.38 (controls); primary MD ISQ: 76.49 ± 4.29 vs. 72.89 ± 2.29. The proportion achieving ISQ ≥ 70 was consistently higher in the case group. Conclusions: Er:YAG laser biomodification combined with rotary osteotomy yields higher, more stable ISQ values throughout early healing in mandibular D2/D3 bone, potentially supporting shorter healing intervals and early loading in selected clinical situations. Full article

Background/Objectives: Titanium alloy Ti₆Al₄V remains the gold standard in dental implantology due to its excellent mechanical properties, corrosion resistance, and biocompatibility. However, implant-associated infections and insufficient osseointegration continue to represent major clinical challenges, mainly related to bacterial biofilm formation and suboptimal surface–tissue interactions. Biofilm formation refers to the adhesion, accumulation, and growth of microbial communities embedded within a self-produced extracellular polymeric matrix on implant surfaces, which contributes to bacterial persistence and resistance to host defense mechanisms. This review aims to critically evaluate recent advances in multifunctional bioceramic coatings for dental implants, with a particular focus on zirconia (ZrO₂)-based systems and their antibacterial mechanisms. Methods: A structured literature analysis was conducted using major scientific databases including PubMed, Scopus, and Web of Science, focusing mainly on studies published between 2015 and 2025 related to CaP, Ag, and ZrO₂-based coatings for dental implants. The review examines their physicochemical properties, antibacterial strategies, ion release behavior, and biological responses, including osteogenic activity and biofilm inhibition. Particular attention is given to hybrid systems integrating multiple functional phases. Results: CaP coatings exhibit excellent osteoconductivity and promote early osseointegration but show limited intrinsic antibacterial activity. Ag-based coatings provide strong broad-spectrum antimicrobial effects through controlled Ag⁺ ion release, although concerns regarding cytotoxicity and dose-dependent responses remain. ZrO₂ coatings significantly enhance corrosion resistance and surface stability, while their antibacterial performance can be improved through nanostructuring, laser surface modification, and ionic doping. Hybrid Ag–CaP–ZrO₂ coatings demonstrate improved antibacterial activity, enhanced corrosion resistance, and better regulation of ion release kinetics and osteogenic response compared with single-component coating systems. Conclusions: Multifunctional bioceramic coatings represent a promising strategy for improving the performance of dental implants and addressing the dual challenge of infection control and tissue integration. However, challenges remain regarding long-term stability, controlled ion release, and limited clinical validation. Future research should focus on the development of smart, stimuli-responsive coatings and standardized evaluation protocols to facilitate clinical translation. Full article

Background/Objectives: Immediate-loading interim implant-supported complete-arch fixed dental prostheses (ISCFDPs) are widely used for immediate loading in edentulous patients. Although traditional denture conversion techniques are well established, newer systems aim to improve efficiency and prosthesis integrity. This clinical report aims to describe and compare four chairside conversion techniques for immediate-loading interim ISCFDPs. Methods: Four clinical cases were treated using different conversion techniques, including conventional denture conversion, guided conversion with static computer-assisted implant surgery (s-CAIS), and two closed-mouth pickup systems (SMART Denture Conversion and EasyPro). Clinical workflows, procedural characteristics, and prosthetic considerations were evaluated. Results: All techniques enabled the successful fabrication of immediate-loaded interim ISCFDPs. Conventional conversion was flexible and cost-effective but technique-sensitive and associated with increased risk of prosthesis weakening. Guided conversion improved structural integrity and reduced intraoral adjustment but required precise planning and higher costs. Closed-mouth systems preserved occlusion, minimized denture modification, and reduced chairside time, though they relied on proprietary components and had limited clinical evidence. Conclusions: Each conversion technique presents distinct advantages and limitations. Selection should be based on clinical conditions, available resources, and clinician experience. Further studies are needed to validate the long-term outcomes of emerging conversion systems. Full article

Background/Objectives: Osteoporosis is highly relevant to dentistry, oral surgery, and implantology. Because panoramic radiographs are routinely acquired in dental practice, they may enable opportunistic pre-screening. This pilot study evaluated established radiomorphometric indices on orthopantomograms (OPGs) and introduced a new qualitative index, the Mini Osteoporosis Pre-Screening (MOPS) index, based on the appearance of the cervical vertebral bodies visible on panoramic radiographs. Methods: This retrospective study analyzed 40 pseudonymized patient datasets, each including both OPG and dual-energy X-ray absorptiometry (DXA) examinations. DXA findings served as the reference standard in the study group. In addition 80 OPG scans from a control group of young adults without clinical or anamnestic evidence of osteoporosis were assessed. Two independent examiners with backgrounds in radiology and dentistry evaluated four indices: mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and MOPS. Results: Relative to the reference standard, MOPS demonstrated diagnostic accuracy ranging from 83% to 100% across selected groups. In women, accuracy ranged from 90% to 100%, with a sensitivity of 1.0 and specificity of 0.9. MCI and MOPS were more robust than MCW, whereas PMI showed limited applicability in routine clinical images. Conclusions: Panoramic radiographs can show osteoporosis-related changes in the mandible and cervical spine. MOPS offers a rapid, cost-neutral pre-screening method and may help dentists identify patients who warrant DXA referral. Larger prospective studies are needed to confirm its clinical utility. Full article

Background: Despite the widespread clinical use of dental implants, research in implant dentistry remains active, aiming to develop new materials, designs, and surface morphologies, as well as to better understand the biological mechanisms underlying the pathophysiology of certain diseases to improve patient outcomes. In this context, preclinical animal models provide an essential opportunity to explore and validate new technologies and protocols before their application in humans. Although large vertebrate species have historically been preferred due to their biological similarity to humans, small animal models such as rats offer significant advantages. Additionally, they allow researchers to work with larger sample sizes, improving the statistical power of experimental outcomes. This scoping review aimed to analyze the current literature on intraoral rat surgical models in the field of implant dentistry. Methods: We included the preclinical studies using rat models focused on implant placement in the oral cavity and published in English. We excluded all studies that involved animal models other than rats or used implant placements in anatomical sites different from the target region. An electronic search was conducted in the PubMed and Scopus databases. From an initial 1032 results, 680 articles remained after duplicate removal. A first screening retained 191 articles, and after full-text review, 98 studies were ultimately included. The selection process was conducted using the software Rayyan. Data were extracted and analyzed across nine domains: Publication metadata, Focused Research Questions, Animal specificities, Study Design, Surgical Protocol Features, Medications Administered to Establish the Experimental Model, Timing of Euthanasia, Characterization methods, and Drop-Out Information. Results: The evaluation of the selected literature revealed a lack of standardization in study design. There is no consensus regarding the rat species used, the age at the time of implant placement, the anatomical site, or the implant morphology. Even more concerning is the presence of methodological deficiencies in the reporting of study design and outcome measures. Conclusions: By summarizing the available data, this review proposes the most commonly used features across preclinical trials in rats. Moreover, it offers a comprehensive overview of the current scientific landscape in this field, enabling researchers to compare different study designs and more easily access relevant information. Full article