Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (108)

Search Parameters:
Keywords = delayed perforation

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
10 pages, 2316 KB  
Case Report
Successful Staged Surgery for Esophagopulmonary Fistula with Lung Abscess During Neoadjuvant Chemoradiotherapy
by Mu-Chou Lin, Wei-Lun Chang and Ying-Yuan Chen
J. Clin. Med. 2026, 15(10), 3852; https://doi.org/10.3390/jcm15103852 - 16 May 2026
Viewed by 239
Abstract
Esophagopulmonary fistula (EPF) with lung abscess is a rare but serious complication during neoadjuvant chemoradiotherapy (nCRT) for esophageal squamous cell carcinoma and is often associated with poor prognosis. We report a 52-year-old man with cT3N3M0 esophageal squamous cell carcinoma who developed fever and [...] Read more.
Esophagopulmonary fistula (EPF) with lung abscess is a rare but serious complication during neoadjuvant chemoradiotherapy (nCRT) for esophageal squamous cell carcinoma and is often associated with poor prognosis. We report a 52-year-old man with cT3N3M0 esophageal squamous cell carcinoma who developed fever and hemoptysis during the third week of nCRT. Computed tomography showed a newly developed right lower lobe lung abscess adjacent to the primary tumor, suspicious for esophageal perforation with fistulous communication. Because the lesion and infection appeared localized, staged aggressive surgery was undertaken. The patient underwent en bloc esophagectomy and right lower lobectomy with cervical esophagostomy, followed by delayed reconstruction using a laparoscopically created gastric conduit. Final pathology showed marked treatment response with ypT1bN0 disease, and the resected lung showed no malignant involvement. R0 resection was achieved, and the patient remains disease-free at 28 months. This case illustrates a possible management pathway in a highly selected patient with localized EPF and lung abscess during nCRT, suggesting that early staged source control may preserve reconstructive options when systemic deterioration has not yet occurred. Full article
(This article belongs to the Section General Surgery)
Show Figures

Graphical abstract

10 pages, 9429 KB  
Review
Exophiala dermatitidis Eye Infection: Case Report and Literature Review
by Suzana Otašević, Marija Trenkić, Marko Stalević, Marina Ranđelović, Slavica Stojnev, Milica Đorđević, Jana Pešić Stanković, Goran Koraćević and Roberta Iatta
J. Fungi 2026, 12(5), 368; https://doi.org/10.3390/jof12050368 - 16 May 2026
Viewed by 409
Abstract
Exophiala endophthalmitis of exogenous origin is an exceptionally rare but severe ocular infection, characterized by diagnostic delays, limited therapeutic guidance, and frequently poor outcomes. Herein, we report one new case of an 80-year-old woman who presented with severe fungal keratitis progressing to endophthalmitis [...] Read more.
Exophiala endophthalmitis of exogenous origin is an exceptionally rare but severe ocular infection, characterized by diagnostic delays, limited therapeutic guidance, and frequently poor outcomes. Herein, we report one new case of an 80-year-old woman who presented with severe fungal keratitis progressing to endophthalmitis two years after an uncomplicated cataract surgery. The condition was initially misdiagnosed and treated with topical antibiotics and corticosteroids. By cultivation, microscopy, histopathological, and PCR analysis of the samples, Exophiala dermatitidis was identified as the causative agent. Despite targeted antifungal therapy with voriconazole, the disease rapidly progressed, resulting in corneal perforation and evisceration of the affected eye. The number of confirmed cases of this infection remains very limited. To address this gap, we conducted a structured review of all reported instances of exogenous Exophiala endophthalmitis, in which Exophiala dermatitidis emerged as the predominant causative species. Common predisposing factors included corneal barrier disruption, ocular surgery, diabetes mellitus, and corticosteroid use. Diagnostic confirmation was frequently delayed, and treatment outcomes varied. Amphotericin B-based regimens were associated with poor results, whereas voriconazole, particularly when combined with surgical intervention, demonstrated more favorable outcomes. Exogenous Exophiala endophthalmitis remains underrecognized, with limited evidence to guide management. This entity should be considered in postoperative or trauma-associated intraocular inflammation, and current evidence supports azole-based therapy combined with surgical intervention when indicated. Full article
(This article belongs to the Special Issue Diagnosis and Management of Human Mold Infections, 2nd Edition)
Show Figures

Figure 1

10 pages, 7022 KB  
Case Report
Total Reconstruction of the Donor Site After Toe-to-Thumb Transfer: Introducing a Novel Technique
by Pierfrancesco Pugliese, Serafina Pepe, Mara Franza and Adriana Cordova
Surgeries 2026, 7(2), 59; https://doi.org/10.3390/surgeries7020059 - 8 May 2026
Viewed by 231
Abstract
Traumatic thumb loss causes severe functional impairment, as the thumb provides approximately 40% of total hand function. Toe-to-thumb transfer remains the gold standard for thumb reconstruction, yet donor site morbidity represents a significant functional and aesthetic limitation. A total thumb reconstruction using a [...] Read more.
Traumatic thumb loss causes severe functional impairment, as the thumb provides approximately 40% of total hand function. Toe-to-thumb transfer remains the gold standard for thumb reconstruction, yet donor site morbidity represents a significant functional and aesthetic limitation. A total thumb reconstruction using a “trimmed” right great toe transfer, combined with immediate donor site reconstruction using a free SCIP (superficial circumflex iliac perforator) flap and iliac crest bone graft. The flap was designed as a tubular skin island to create a neo-hallux with optimal contour and volume, minimizing visible scarring and avoiding microcirculatory compression. The patient, a 33-year-old man with post-traumatic thumb avulsion, underwent delayed reconstruction three months after injury. The postoperative course was uneventful, with no vascular or wound complications. At 12 months, he resumed full ambulation and manual activities, including motorcycle driving and work tasks. Baropodometric analysis demonstrated symmetric load distribution and gait dynamics. Thumb opposition was satisfactory (Kapandji score: seven); the patient rated the aesthetic results as excellent. This case demonstrates that SCIP flap reconstruction with iliac crest bone graft enables complete functional and aesthetic restoration of the great toe donor site after total toe transfer. Compared to previous techniques using cross-flaps, skin grafts, or peroneal flaps, this approach minimizes morbidity, optimizes cosmetic outcomes, and preserves gait. Although representing a single case, this constitutes the first documented instance of total hallux reconstruction following toe-to-thumb transfer, emphasizing the importance of the foot as a functional and aesthetic unit and the need for donor-site preservation in microsurgical reconstructive planning. Full article
(This article belongs to the Section Hand Surgery and Research)
Show Figures

Figure 1

24 pages, 3556 KB  
Review
An Integrated Review of Conventional and Emerging Diagnostic and Therapeutic Modalities to Reduce the Risk of Surgical Resections in Intestinal Tuberculosis
by Khalid Alyahyawi
Diagnostics 2026, 16(9), 1332; https://doi.org/10.3390/diagnostics16091332 - 29 Apr 2026
Viewed by 426
Abstract
Intestinal tuberculosis (ITB) is a complex form of extrapulmonary tuberculosis characterized by nonspecific gastrointestinal symptoms and substantial overlap with conditions such as Crohn’s disease and gastrointestinal malignancies. These similarities frequently lead to diagnostic uncertainty, delayed diagnosis, and inappropriate management. This systematic review summarizes [...] Read more.
Intestinal tuberculosis (ITB) is a complex form of extrapulmonary tuberculosis characterized by nonspecific gastrointestinal symptoms and substantial overlap with conditions such as Crohn’s disease and gastrointestinal malignancies. These similarities frequently lead to diagnostic uncertainty, delayed diagnosis, and inappropriate management. This systematic review summarizes current evidence on the clinical presentation, diagnostic approaches, and therapeutic strategies for ITB, with particular emphasis on emerging diagnostic technologies and their role in reducing surgical interventions. A systematic literature search was conducted using PubMed, Scopus, and Google Scholar following PRISMA guidelines to identify relevant studies published from 2000 to 2025. The review focused on clinical manifestations, imaging findings, endoscopic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopathological confirmation. Molecular techniques such as GeneXpert MTB/RIF and GeneXpert MTB/RIF Ultra and multiplex polymerase chain reaction assays improve diagnostic accuracy and shorten detection time. Emerging technologies including artificial intelligence-assisted radiologic interpretation and CRISPR-based stool sequencing platforms show promise for earlier detection. Standard anti-tubercular therapy remains the cornerstone of treatment, while minimally invasive endoscopic and surgical procedures are effective for managing complications such as strictures, obstruction, and perforation. Early and precise diagnosis of intestinal tuberculosis is essential to prevent complications and optimize patient outcomes. Integrating conventional diagnostic approaches with emerging molecular and artificial intelligence-based technologies may enhance diagnostic precision and support individualized treatment strategies. Further ITB-specific clinical studies are needed to validate novel diagnostic tools and refine therapeutic approaches for improved patient care. Full article
(This article belongs to the Special Issue Abdominal Diseases: Diagnosis, Treatment and Management—2nd Edition)
Show Figures

Figure 1

29 pages, 425 KB  
Review
Rare and Unusual Consequences of Blunt Abdominal Trauma—The Significance of Anatomical Anomalies
by Maciej Rybicki, Bartłomiej Białas, Wiktoria Jachymczak, Igor Karolczak, Julia Kot, Klaudia Dobrowolska, Bartosz Marek Czyżewski, Joanna Czyżewska, Kamil Paszowski and Karol Kamil Kłosińki
J. Clin. Med. 2026, 15(8), 2842; https://doi.org/10.3390/jcm15082842 - 9 Apr 2026
Viewed by 495
Abstract
Background/Objectives: Blunt abdominal trauma is a frequent challenge in emergency medicine, but its diagnosis and treatment become significantly more complex when rare anatomical anomalies are present. Atypical anatomy may mask symptoms or mimic other acute abdominal conditions, causing delays in treatment. The [...] Read more.
Background/Objectives: Blunt abdominal trauma is a frequent challenge in emergency medicine, but its diagnosis and treatment become significantly more complex when rare anatomical anomalies are present. Atypical anatomy may mask symptoms or mimic other acute abdominal conditions, causing delays in treatment. The aim of this paper is to review the literature on six rare anatomical anomalies and their impact on the consequences of blunt abdominal trauma. Methods: A Narrative literature review was undertaken, covering PubMed, Scopus, Web of Science and Google Scholar databases, analysing publications from 1960 to 2025. Case reports and case series (91 patients in total) with confirmed organ damage following blunt trauma in the course of: duodenal diverticulum, Meckel’s diverticulum, splenic torsion, rupture or torsion of the accessory spleen, visceral inversion (situs inversus) and horseshoe kidney. Results: Demographic analysis revealed a predominance of perforations of the duodenal diverticulum in older women (mean age 62 years), while younger men predominated in all other groups. The clinical picture was often non-specific or misleading, especially in situs inversus, where the location of pain did not correlate with the typical topography of organs. Contrast-enhanced computed tomography (CECT) has proved to be a key diagnostic tool, surpassing ultrasound/FAST scans due to its ability to provide precise anatomical imaging. Surgical treatment was predominant (100% in Meckel’s diverticulum, 95% in duodenal diverticulum), while conservative treatment was effective in horseshoe kidney injuries (94.8%). Mortality was highest in situs inversus (29%) and duodenal diverticulum perforation (20%). The vast majority of these fatal cases occurred in the era of modern computed tomography, suggesting that the therapeutic challenges stem directly from the specific nature of these anomalies, rather than from past diagnostic limitations. Conclusions: Anatomical anomalies significantly modulate the clinical manifestations of blunt abdominal trauma, increasing the risk of diagnostic errors. Early contrast-enhanced computed tomography and awareness of these rare pathologies are crucial for appropriate management and improved prognosis. Full article
(This article belongs to the Special Issue Acute Care for Traumatic Injuries and Surgical Outcomes: 2nd Edition)
8 pages, 727 KB  
Case Report
Unveiling Uncommon: Perforated Peptic Ulcer Mimicking Post-Cesarean Complications—A Case Report
by Samantha Davis, Samie A. Rizvi, Moosa Malik, Mostafa E. Nagy and Hani Serag
Reports 2026, 9(1), 92; https://doi.org/10.3390/reports9010092 - 22 Mar 2026
Viewed by 657
Abstract
Background and Clinical Significance: Peptic ulcer perforation is a severe complication of peptic ulcer disease, resulting from erosion of the upper gastrointestinal mucosa. While uncommon in post-cesarean patients, its symptoms can resemble post-operative complications, risking delayed diagnosis and adverse outcomes. This case [...] Read more.
Background and Clinical Significance: Peptic ulcer perforation is a severe complication of peptic ulcer disease, resulting from erosion of the upper gastrointestinal mucosa. While uncommon in post-cesarean patients, its symptoms can resemble post-operative complications, risking delayed diagnosis and adverse outcomes. This case highlights the need for an expanded diagnostic approach in post-cesarean patients with atypical abdominal symptoms. Case Presentation: A 27-year-old West African woman presented to Ain Shams University Hospital in Cairo, Egypt, with worsening abdominal pain, vomiting, fever, and tachycardia three weeks post-cesarean. Initially misdiagnosed with gastroenteritis, she underwent emergency laparotomy due to persistent symptoms, which revealed a 3 cm perforated peptic ulcer. An omental patch repair was performed, and she was discharged in stable condition seven days later. Peptic ulcer perforation, although rare post-cesarean, can mimic common post-operative symptoms, leading to diagnostic delays. A thorough evaluation of abdominal symptoms unresponsive to standard post-operative care is essential, as misdiagnosis increases risks of morbidity. Non-gynecologic causes should be considered, particularly with persistent symptoms. Conclusions: Physicians should consider peptic ulcer perforation in post-cesarean patients presenting with sustained abdominal pain, fever, or gastrointestinal distress. Recognizing atypical complications early allows timely intervention, improving outcomes and reducing mortality. This case underscores the value of broad differential diagnoses in post-operative care. Full article
(This article belongs to the Section Surgery)
Show Figures

Figure 1

35 pages, 778 KB  
Review
Surgical Necrotising Enterocolitis (S-NEC): Where We Stand Today: A Narrative Review
by Maria Manousi, Dionysios Dellaportas, Konstantinos Nastos, Christina Siouli, Yvelise De Verney, Anastasia Dimopoulou and Nikolaos Zavras
J. Clin. Med. 2026, 15(6), 2236; https://doi.org/10.3390/jcm15062236 - 15 Mar 2026
Viewed by 1000
Abstract
Surgical necrotising enterocolitis (NEC) continues to carry significant morbidity and mortality in preterm and very-low-birth-weight infants. This review presents up-to-date evidence to guide the shift from medical to surgical treatment and to improve management during and after surgery. Need for surgery is best [...] Read more.
Surgical necrotising enterocolitis (NEC) continues to carry significant morbidity and mortality in preterm and very-low-birth-weight infants. This review presents up-to-date evidence to guide the shift from medical to surgical treatment and to improve management during and after surgery. Need for surgery is best anticipated through dynamic clinical assessment, supported by laboratory markers of systemic inflammation or ischemia and targeted imaging, while pneumoperitoneum remains the sole absolute indication for immediate intervention. In infants without perforation, the timing of surgery remains challenging: delayed surgery after clinical deterioration worsens long-term outcomes, whereas very early surgery often reflects severe disease leading to greater bowel loss, highlighting the need for carefully timed intervention after brief stabilisation. Laparotomy remains the cornerstone of surgical management, with peritoneal drainage serving as a temporising option for the most unstable infants and laparoscopy emerging as a feasible adjunct. Long-term complications, including strictures, short bowel syndrome, neurodevelopmental impairment, bronchopulmonary dysplasia and severe retinopathy of prematurity highlight the need for better predictive tools, enhanced imaging of bowel viability, and rigorous nutritional support, while long-term quality-of-life outcomes remain insufficiently studied. Full article
(This article belongs to the Section Clinical Pediatrics)
Show Figures

Figure 1

15 pages, 981 KB  
Article
Risk Factors of Adverse Outcomes for Colorectal ESD After Generalization of the Technique—A Multi-Centre Retrospective Study in Hong Kong
by Sophie Sok Fei Hon, Michael Chi Ming Poon, Louis Ho Shing Lau, Henry Kin Ming Joeng, Kong Ling Ting, Po Yan Wong, Lok Ping Si, Michelle Hau Ching Lo, Wing Fung Ng, Wing Yan Chan, Cherry Yee Ni Wong, Philip Ching Tak Ip, Simon Siu Man Ng and Philip Wai Yan Chiu
Gastroenterol. Insights 2026, 17(1), 18; https://doi.org/10.3390/gastroent17010018 - 3 Mar 2026
Viewed by 669
Abstract
Background: Most of the public hospitals in Hong Kong provide a regular colorectal endoscopic submucosal dissection (ESD) service. The current retrospective study aims to review the long- and short-term outcomes of these services, so as to identify areas for improvement. Method and Results: [...] Read more.
Background: Most of the public hospitals in Hong Kong provide a regular colorectal endoscopic submucosal dissection (ESD) service. The current retrospective study aims to review the long- and short-term outcomes of these services, so as to identify areas for improvement. Method and Results: From January 2017 to March 2020, 634 lesions in 623 patients were removed by an ESD technique in seven endoscopic units. The mean lesion size was 31 mm (SD 13 mm, range 10–95 mm), and the mean procedure time was 121 min (SD 67 min). En bloc resection and R0 resection could be achieved in 91.3% and 79.3% of the lesions, respectively. The intra-procedure perforation rate was 12.3%. The delayed bleeding rate was 2.1%, and the delayed perforation rate was 0.8%. Only 0.9% (6/634) of the procedures needed emergency surgical salvage due to complications. Most of the lesions were adenomas (564/634), and 55 of them were adenocarcinomas. The cumulative local recurrence rate was 4.0% at a mean follow-up of 34 months. In multivariate analysis, longer procedure time, submucosal fibrosis, hybrid ESD and piecemeal removal were associated with intra-procedure perforation. Risk factors for failed en bloc resection included non-granular and polypoid morphology, colonic location, longer procedure time and low centre volume. Malignant pathology without salvage surgery was the only independent risk factor for local recurrence. Conclusions: Colorectal ESD has been carried out in Hong Kong with acceptable short-and long-term outcomes despite the technique still being in the learning phase in some centres. Potential areas for improvement should include targeted training to speed up the procedure and enable better handling of difficult cases, aiming to decrease the perforation rate and local recurrence. Full article
(This article belongs to the Special Issue Novelties in Colorectal Surgery and Proctology)
Show Figures

Figure 1

7 pages, 1098 KB  
Case Report
Tracheal Rupture Secondary to an Iatrogenic Esophageal Perforation Presenting with Neck Insufflation on Valsalva: A Case Report
by Lomesh Choudhary, Sophia Werden Abrams and Benjamin van der Woerd
J. Otorhinolaryngol. Hear. Balance Med. 2026, 7(1), 13; https://doi.org/10.3390/ohbm7010013 - 2 Mar 2026
Viewed by 534
Abstract
Background: Tracheal rupture is a rare, life-threatening condition that may follow blunt trauma, intubation, and, less commonly, esophageal instrumentation. The diagnosis may be challenging due to the subtle, delayed, and wide variety of symptoms. We present a unique case of delayed tracheal rupture [...] Read more.
Background: Tracheal rupture is a rare, life-threatening condition that may follow blunt trauma, intubation, and, less commonly, esophageal instrumentation. The diagnosis may be challenging due to the subtle, delayed, and wide variety of symptoms. We present a unique case of delayed tracheal rupture secondary to iatrogenic esophageal perforation, presenting months later with a cervical neck insufflation on Valsalva, a novel clinical sign that has not been previously described in the literature. Case Presentation: A 44-year-old male initially presented with esophageal food impactation. Following endoscopic removal attempts, he developed signs consistent with esophageal perforation and was managed conservatively. In follow-up, he reported persistent neck discomfort, facial numbness, and the ability to insufflate the right side of his neck while doing a Valsalva. Flexible bronchoscopy and retrospective review of imaging revealed a proximal posterior tracheal defect, initially misinterpreted as a tracheal diverticulum. Surgical exploration confirmed a 6 cm dehiscence between the membranous trachea and the anterior wall of the esophagus. The defect was repaired using regional muscle flaps with tissue sealant reinforcement. Postoperatively, the patient had complete symptom resolution and no recurrence of neck insufflation. Conclusions: The case underscores the importance of maintaining a high index of suspicion for tracheal injury in patients with persistent or atypical symptoms following esophageal perforation or instrumentation. To our knowledge, we have described a novel clinical finding of neck insufflation upon Valsalva for diagnosing tracheal rupture. Full article
(This article belongs to the Section Laryngology and Rhinology)
Show Figures

Figure 1

8 pages, 2335 KB  
Case Report
Critical Intestinal Perforations in Pediatric Immunocompromised Patients: A Case-Based Review
by William Hunt Stafford, Jennifer McArthur and Saad Ghafoor
Pediatr. Rep. 2026, 18(1), 30; https://doi.org/10.3390/pediatric18010030 - 14 Feb 2026
Viewed by 854
Abstract
As survival rates for children with cancer and immune disorders have improved, clinical focus has shifted toward managing serious treatment-related complications. Intestinal perforation remains life-threatening and is typically diagnosed by signs of peritonitis and inflammation. This report presents three high-risk pediatric patients who [...] Read more.
As survival rates for children with cancer and immune disorders have improved, clinical focus has shifted toward managing serious treatment-related complications. Intestinal perforation remains life-threatening and is typically diagnosed by signs of peritonitis and inflammation. This report presents three high-risk pediatric patients who developed severe intestinal perforation without the usual clinical symptoms. Each patient was receiving high-dose corticosteroids and/or targeted biologic immunomodulators (ruxolitinib, anakinra, tocilizumab, eculizumab). Classic indicators such as fever, leukocytosis, hemodynamic instability, and abdominal pain were absent, despite surgical findings of fecal contamination and bowel necrosis. All three patients survived to hospital discharge. These cases demonstrate that potent immunomodulatory therapies can mask the physiological response to perforation. Relying solely on traditional clinical signs may delay diagnosis. In this population, subtle findings such as persistent gastrointestinal bleeding, feeding intolerance, or minor imaging abnormalities should prompt consideration of perforation. Early imaging and multidisciplinary review are essential for timely intervention and improved outcomes. Full article
Show Figures

Figure 1

15 pages, 665 KB  
Review
Duodenal Trauma: Mechanisms of Injury, Diagnosis, and Management
by Raffaele Bova, Giulia Griggio, Serena Scilletta, Federica Leone, Carlo Vallicelli, Vanni Agnoletti and Fausto Catena
J. Clin. Med. 2026, 15(2), 567; https://doi.org/10.3390/jcm15020567 - 10 Jan 2026
Cited by 1 | Viewed by 2294
Abstract
Background: Traumatic injuries of the duodenum are generally rare but when they occur, they can result in serious complications. Inaccurate injury classification, delayed diagnosis, or late treatment can significantly raise morbidity and mortality. A multidisciplinary approach is often necessary. Mechanisms of injury [...] Read more.
Background: Traumatic injuries of the duodenum are generally rare but when they occur, they can result in serious complications. Inaccurate injury classification, delayed diagnosis, or late treatment can significantly raise morbidity and mortality. A multidisciplinary approach is often necessary. Mechanisms of injury: Isolated duodenal injuries are relatively uncommon due to the duodenum’s proximity to pancreas and major vascular structures. Duodenal injuries can result from blunt or penetrating trauma. Classification: The 2019 World Society of Emergency Surgery (WSES)-American Association for the Surgery of Trauma (AAST) guidelines recommend incorporating both the AAST-OIS grading and the patient’s hemodynamic status to stratify duodenal injuries into four categories: Minor injuries WSES class I, Moderate injuries WSES class II, Severe injuries WSES class III, and WSES class IV. Diagnosis: The diagnostic approach involves a combination of clinical assessment, laboratory investigations, radiological imaging and, in particular situations, surgery. Prompt diagnosis is critical because delays exceeding 24 h are associated with a higher incidence of postoperative complications and a significant rise in mortality. Contrast-enhanced abdominal computed tomography (CT) represents the gold standard for diagnosis in patients who are hemodynamically stable. Management: Duodenal trauma requires a multimodal approach that considers hemodynamic stability, the severity of the injury and the presence of associated lesions. Non-operative management (NOM) is reserved for hemodynamically stable patients with minor duodenal injuries without perforation (AAST I/WSES I), as well as all duodenal hematomas (WSES I–II/AAST I–II) in the absence of associated abdominal organ injuries requiring surgical intervention. All hemodynamically unstable patients, those with peritonitis, or with CT findings consistent with duodenal perforations or AAST grade III or higher injuries are candidates for emergency surgery. If intervention is required, primary repair should be the preferred option whenever feasible, while damage control surgery is the best choice in cases of hemodynamic instability, severe associated injuries, or complex duodenal lesions. Definitive reconstructive surgery should be postponed until the patient has been adequately resuscitated. The role of endoscopic techniques in the treatment of duodenal injuries and their complications is expanding. Conclusions: Duodenal trauma is burdened by potentially high mortality. Among the possible complications, duodenal fistula is the most common, followed by duodenal obstruction, bile duct fistula, abscess, and pancreatitis. The overall mortality rate for duodenal trauma persists to be significant with an average rate of 17%. Future prospective research needed to reduce the risk of complications following duodenal trauma. Full article
Show Figures

Figure 1

8 pages, 2417 KB  
Case Report
Amniotic Membrane-Assisted Corneal Transplantation in Ocular Perforation Due to GVHD: A Case Report
by Nicola Cardascia, Maria Gabriella La Tegola, Francesco D’Oria, Giacomo Boscia, Francesco Boscia and Giovanni Alessio
J. Clin. Med. 2026, 15(2), 548; https://doi.org/10.3390/jcm15020548 - 9 Jan 2026
Viewed by 648
Abstract
Background/Objectives: Ocular graft-versus-host disease (oGVHD) is a chronic, immune-mediated complication of allogeneic hematopoietic stem cell transplantation that can progress to corneal ulceration or perforation. These cases are often refractory to standard therapy and present a high risk of graft failure after keratoplasty. We [...] Read more.
Background/Objectives: Ocular graft-versus-host disease (oGVHD) is a chronic, immune-mediated complication of allogeneic hematopoietic stem cell transplantation that can progress to corneal ulceration or perforation. These cases are often refractory to standard therapy and present a high risk of graft failure after keratoplasty. We report a case of oGVHD-related corneal perforation successfully managed with a novel amniotic membrane-assisted “envelope” technique during corneal transplantation. Case Report: A 42-year-old man with chronic oGVHD and a full-thickness corneal perforation underwent urgent repair with a lamellar patch graft completely wrapped in cryopreserved amniotic membrane, followed by penetrating keratoplasty (PKP) using an amniotic membrane envelope surrounding the donor lenticule. Results: The amniotic membrane provided a 360° biological barrier that isolated graft antigens from the inflammatory environment while supporting epithelial healing and stromal remodeling. Despite recurrent inflammatory episodes and multiple procedures—including cataract extraction, pars plana vitrectomy, and multilayer amniotic membrane transplantation—the graft remained clear and stable at 12-month follow-up, achieving a best-corrected visual acuity of 20/40. Conclusions: The amniotic membrane envelope technique may represent a valuable adjunct in managing high-risk corneal perforations secondary to oGVHD. By combining immune modulation and regenerative support, this approach can enhance tectonic stability, reduce rejection risk, and promote durable surface recovery, potentially delaying or avoiding keratoprosthesis in refractory cases. Full article
(This article belongs to the Special Issue Diagnosis and Management of Corneal Diseases)
Show Figures

Figure 1

19 pages, 1019 KB  
Article
First Clinical Application and Validation of the Romanian BREAST-Q in Immediate and Delayed Breast Reconstruction: A Prospective Study
by Andrada-Elena Ţigăran, Adelaida Avino, Abdalah Abu-Baker, Teodora Timofan, Daniela-Elena Ion, Daniela-Elena Gheoca-Mutu, Radu-Cristian Jecan, Erick George Neștianu and Laura Raducu
Cancers 2026, 18(1), 168; https://doi.org/10.3390/cancers18010168 - 3 Jan 2026
Cited by 1 | Viewed by 799
Abstract
Objectives: Breast cancer treatment has increasingly shifted toward integrating patient-reported outcomes into surgical decision-making. However, Romania has lacked a validated instrument to evaluate quality of life (QoL) after breast reconstruction. This study aimed to translate, culturally adapt, and clinically validate the Romanian version [...] Read more.
Objectives: Breast cancer treatment has increasingly shifted toward integrating patient-reported outcomes into surgical decision-making. However, Romania has lacked a validated instrument to evaluate quality of life (QoL) after breast reconstruction. This study aimed to translate, culturally adapt, and clinically validate the Romanian version of the BREAST-Q Reconstruction Module, and to assess postoperative changes in QoL following immediate and delayed breast reconstruction. Methods: A prospective observational study enrolled 116 patients undergoing immediate or delayed implant-based or autologous reconstruction between June 2023 and June 2024. The BREAST-Q was translated using standardized forward–backward methodology, followed by expert review, pilot testing, and psychometric validation. Patients completed preoperative and 1-year postoperative BREAST-Q questionnaires. Statistical analyses included Cronbach’s α, intraclass correlation coefficients, paired and independent t-tests, Pearson correlations, and ANCOVA to assess the impact of radiotherapy and other clinical factors on postoperative outcomes. Results: The Romanian BREAST-Q showed excellent internal consistency (α = 0.947) and strong test–retest reliability (ICC = 0.81–0.92). Both immediate and delayed reconstruction significantly improved psychosocial well-being and breast symptoms (p < 0.001). Immediate reconstruction produced modest gains in physical well-being, whereas delayed reconstruction yielded a substantial increase in breast satisfaction (effect size d = 1.33). Breast sensation significantly decreased in both cohorts. Within delayed reconstructions, deep inferior epigastric perforator (DIEP) flaps were associated with higher physical well-being, whereas latissimus dorsi (LD) flaps demonstrated slightly better sensory outcomes. Radiotherapy had a strong negative effect on postoperative breast satisfaction (p < 0.001) after adjusting for covariates. Conclusions: The Romanian BREAST-Q is a valid, reliable instrument for evaluating QoL after breast reconstruction. Reconstruction improved multiple QoL domains, although sensory decline persisted across techniques. Symmetrization and DIEP reconstruction enhanced postoperative comfort, while radiotherapy remained a major predictor of lower satisfaction. These findings support the need for integrative reconstructive strategies that address aesthetic, functional, and sensory outcomes. Full article
(This article belongs to the Special Issue New Perspectives in the Management of Breast Cancer)
Show Figures

Figure 1

17 pages, 3407 KB  
Case Report
An Anatomy-Guided, Stepwise Microsurgical Reconstruction of a Posteriorly Projecting ICA–PCoA Aneurysm Beneath the Optic Apparatus: A Detailed Operative Sequence
by Matei Șerban, Corneliu Toader and Răzvan-Adrian Covache-Busuioc
Diagnostics 2026, 16(1), 124; https://doi.org/10.3390/diagnostics16010124 - 1 Jan 2026
Viewed by 720
Abstract
Background: Posteriorly directed aneurysms at the internal carotid–posterior communicating artery (ICA–PCoA) junction concentrate technical risk at the posteromedial neck where the PCoA origin and perforators exist beneath the optic apparatus. Our aim was to describe, in a reproducible fashion, an anatomy-driven sequence [...] Read more.
Background: Posteriorly directed aneurysms at the internal carotid–posterior communicating artery (ICA–PCoA) junction concentrate technical risk at the posteromedial neck where the PCoA origin and perforators exist beneath the optic apparatus. Our aim was to describe, in a reproducible fashion, an anatomy-driven sequence in the management of a ruptured ICA–PCoA aneurysm that visualized the posterior wall and a closing line parallel to the PCoA axis and which is placed within contemporary practice. Case Presentation: This is a single case study employing predetermined surgical techniques demonstrating a reproducible method of anatomical microsurgery applied to a posterior projecting ICA-PCoA aneurysm. The authors describe a 62-year-old female who was stabilized by nimodipine and aggressive blood pressure control in the systolic range 140–160 mmHg after an aneurysmal subarachnoid hemorrhage. Diagnostic contrast catheter angiography showed a left ICA-PCoA aneurysm of 13.1 × 10.0 mm at the base with a neck of 4.3 mm projecting posteriorly into the carotid–optic cistern. Complete adherence to a protocol of staged techniques was employed for the operation, as detailed below. Step 1: Early cisternal decompression requiring total and immediate relaxation of the temporal lobe, rapidly opening up the carotid–optic anatomical window. Step 2: Circumferential dissection about the neck of the aneurysm permitting definition of the true posteromedial wall and definition of the perforator territories and anterior choroidal territories. Step 3: Brief but effective ICA proximal quiescence (58 s) permitting clipping under direct vision. Step 4: Staged closure of two clips with the closing line of the clips orientated parallel to the axis of the PCoA with maintenance of the diameter of all parent vessels, the origin of the PCoA and the integrity of the perforators. Urgent postoperative digital subtraction angiography (DSA) study showed complete exclusion of the aneurysm with no alteration in flow characteristics, and 3 months later DSA studies again showed permanent obliteration and patency of those branches. The immediate DSA demonstrated complete exclusion of the aneurysm with patent supraclinoid ICA caliber and PCoA ostium, the anterior choroidal artery was preserved; no angiographic vasospasm was identified. The postoperative course was uncomplicated; there was no hydrocephalus, seizure disorder or delayed ischemia. At discharge and three months postprocedure the patient was neurologically intact (Modified Rankin Scale 0). Non-contrast cranial CT (three months) demonstrated stable clip position and no hemorrhagic or ischemic sequelae. Conclusions: In posteriorly projecting ICA–PCoA aneurysms that are disturbed beneath the optic apparatus, an anatomy-guided strategy—early cisternal decompression, true posteromedial neck exposure, brief purposeful quieting of the proximal ICA and two-clip closure parallel to the PCoA in selected cases—may provide the opportunity for durable occlusion whilst the physiology of branching is preserved. We intend for this transparent description to be adopted, refined or discarded based on local anatomy and practice. Full article
(This article belongs to the Special Issue Cerebrovascular Lesions: Diagnosis and Management, 2nd Edition)
Show Figures

Figure 1

13 pages, 1801 KB  
Case Report
A Ruptured Tri-Lobulated ICA–PCom Aneurysm Presenting with Preserved Neurological Function: Case Report and Clinical–Anatomical Analysis
by Stefan Oprea, Cosmin Pantu, Alexandru Breazu, Octavian Munteanu, Adrian Vasile Dumitru, Mugurel Petrinel Radoi, Daniel Costea and Andra Ioana Baloiu
Diagnostics 2026, 16(1), 73; https://doi.org/10.3390/diagnostics16010073 - 25 Dec 2025
Cited by 1 | Viewed by 993
Abstract
Background and Clinical Significance: Although rupture of aneurysms at the internal carotid-posterior communicating artery (ICA-PCom) junction accounts for a small percentage of all ruptured intracranial aneurysms, they are clinically relevant due to their proximity to perforator-rich cisterns, the optic-carotid-oculomotor pathways and flow-diverting zones, [...] Read more.
Background and Clinical Significance: Although rupture of aneurysms at the internal carotid-posterior communicating artery (ICA-PCom) junction accounts for a small percentage of all ruptured intracranial aneurysms, they are clinically relevant due to their proximity to perforator-rich cisterns, the optic-carotid-oculomotor pathways and flow-diverting zones, as well as their high likelihood for causing early neurological instability. Additionally, ruptured ICA-PCom aneurysms that have multiple lobulations are associated with increased variability in wall shear stress, local inflammatory remodeling and higher propensity for rupture at smaller sizes compared to other types of aneurysms. Due to the rapidity of early physiological destabilization in most patients with ruptured ICA-PCom aneurysms, clinical–anatomical correlations in these cases are often obscured by neurological deterioration; therefore, the presentation of this patient provides a unique opportunity to correlate the minimal early symptoms, tri-lobulation of the aneurysm and confined cisternal hemorrhage, to better understand rupture behavior, surgical decision-making in an anatomically challenging area, and postoperative recovery. Case Presentation: A 48-year-old hypertensive female experienced an acute “thunderclap” headache accompanied by intense photophobia and focal meningeal irritation, but, unexpectedly, retained a normal neurologic examination. She did exhibit some minor ocular motor micro-latencies, early cortical attentional strain and lateralized pain sensation that suggested localized cisternal involvement despite lack of generalized neurologic impairment. Digital subtraction angiography and three-dimensional CT angiography revealed a ruptured, tri-lobulated aneurysm originating from the communicating portion of the left internal carotid artery proximal to its origin from the posterior communicating artery, oriented toward the perimesencephalic cisterns. The aneurysm was surgically clipped using a standard left pterional craniotomy with direct visualization, after careful dissection through the carotid and optic windows to preserve the anterior choroidal artery, oculomotor nerve, and surrounding perforators. The neck of the aneurysm was reconstructed with a single straight clip, without compromise to the parent vessel lumen. The patient had an uneventful postoperative course without vasospasm or neurologic deficit. At both 3 and 9 months postoperatively the patient remained free of clinical neurologic deficit, and imaging demonstrated continued aneurysm exclusion, preserved ICA-PCom anatomy, and no evidence of delayed ischemic injury or hydrocephalus. Conclusions: The goal of this report is to demonstrate how a ruptured, morphologically complex ICA-PCom aneurysm may present with preserved neurologic function, thereby enabling the study of clinical–anatomical associations before secondary injury mechanisms intervene. The relationship between the configuration of the patient’s symptoms, geometry of the aneurysm and pattern of hemorrhage within the cisterns offers insight into a rare rupture pattern observed during routine clinical experience. Through complete anatomical analysis, timely microsurgical reconstruction and consistent follow-up, the authors were able to achieve long-term recovery of this particular patient. Continued advancements in vascular imaging techniques, aneurysmal wall modeling, and postoperative monitoring will likely help clarify the underlying mechanism(s) responsible for such presentations. Full article
(This article belongs to the Special Issue Cerebrovascular Lesions: Diagnosis and Management, 2nd Edition)
Show Figures

Figure 1

Back to TopTop