Search Results (83)

Biothiols, including cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), are crucial for physiological regulation and their imbalance poses severe health risks. Herein, we developed a pH-responsive liquid crystal (LC)-based sensing platform for detection of biothiols by doping 4-n-pentylbiphenyl-4-carboxylic acid (PBA) into 4-n-pentyl-4-cyanobiphenyl (5CB). Urease catalyzed urea hydrolysis to produce OH⁻, triggering the deprotonation of PBA, thereby inducing a vertical alignment of LC molecules at the interface corresponding to dark optical appearances. Heavy metal ions (e.g., Hg²⁺) could inhibit urease activity, under which condition LC presents bright optical images and LC molecules maintain a state of tilted arrangement. However, biothiols competitively bind to Hg²⁺, the activity of urease is maintained which enables the occurrence of urea hydrolysis. This case triggers LC molecules to align in a vertical orientation, resulting in bright optical images. This pH-driven reorientation of LCs provides a visual readout (bright-to-dark transition) correlated with biothiol concentration. The detection limits of Cys/Hcy and GSH for the PBA-doped LC platform are 0.1 μM and 0.5 μM, respectively. Overall, this study provides a simple, label-free and low-cost strategy that has a broad application prospect for the detection of biothiols. Full article

The chiral nonlinear Schrödinger equation (CNLSE) serves as a simplified model for characterizing edge states in the fractional quantum Hall effect. In this paper, we leverage the generalization and parameter inversion capabilities of physics-informed neural networks (PINNs) to investigate both forward and inverse problems of 1D and 2D CNLSEs. Specifically, a hybrid optimization strategy incorporating exponential learning rate decay is proposed to reconstruct data-driven solutions, including bright soliton for the 1D case and bright, dark soliton as well as periodic solutions for the 2D case. Moreover, we conduct a comprehensive discussion on varying parameter configurations derived from the equations and their corresponding solutions to evaluate the adaptability of the PINNs framework. The effects of residual points, network architectures, and weight settings are additionally examined. For the inverse problems, the coefficients of 1D and 2D CNLSEs are successfully identified using soliton solution data, and several factors that can impact the robustness of the proposed model, such as noise interference, time range, and observation moment are explored as well. Numerical experiments highlight the remarkable efficacy of PINNs in solution reconstruction and coefficient identification while revealing that observational noise exerts a more pronounced influence on accuracy compared to boundary perturbations. Our research offers new insights into simulating dynamics and discovering parameters of nonlinear chiral systems with deep learning. Full article

BOPAM exhibits high fluorescence quantum yields, along with exceptional photostability, rendering it a promising platform for applications as fluorescence sensors. However, the development of BOPAM-based fluorophores with extended emission wavelengths remains limited, and the underlying mechanisms of fluorescence quenching via the population of dark twisted intramolecular charge transfer (¹TICT) excited states are not yet fully understood. To address these gaps, we synthesized a series of BOPAM derivatives by incorporating electron-donating groups at the boron atoms and the phenyl rings of the BOPAM core. The introduction of bromide, phenyl, and naphthyl groups preserved the intrinsic locally excited (¹LE) emission of BOPAM. In contrast, the incorporation of diphenylamine (BP-DA) and triphenylamine (BP-TA) moieties resulted in a red-shifted emission, attributed to an enhanced intramolecular charge transfer (ICT) process. Notably, in acetonitrile, BP-DA exhibited weak fluorescence originating from a ¹TICT state, which was populated via the S₂ → ¹TICT transition. Furthermore, the emission observed from BP-TA was associated with a higher-lying excited state, likely the initially populated S₂ state possessing a ¹LE character. These findings not only introduce novel red-emissive BOPAM-based fluorophores, but also offer valuable insights into the role of the S₂ state in governing fluorescence quenching mechanisms in BOPAM derivatives. Full article

The Hubble constant is of paramount importance in astrophysics and cosmology. A large number of methods have been developed with different electromagnetic probes to estimate its value. The most recent results show a tension between values obtained from Cosmic Microwave Background observations and supernovae. The simultaneous detection of gravitational waves and electromagnetic radiation from GW170817 provided a direct estimation of the Hubble constant that did not depend on the astronomical distance ladder. This concise review will present the methods to estimate the Hubble constant with the gravitational observations of compact binary mergers, discussing both bright and dark sirens and reporting the state of the art of the results. Full article

This study aimed to address the unexplored relaxing effects of stargazing with different night sky darknesses in a planetarium by conducting an experiment to investigate the physiological effects of the relaxation/stress state on brain and autonomic nervous system activity, as well as the psychological healing effects. Five healthy young women participated in our experiment. We conducted physiological measurements of oxygenated hemoglobin (OxyHb) concentration in the left and right prefrontal cortices by near-infrared spectroscopy, heart rate variability as a measure of the relaxation/stress state, and a psychological assessment of healing on an 11-point Likert scale. We used 9 types of stimuli: 6-star image stimuli that imitated dark star fields (low light pollution) to bright night sky (high light pollution), and movie stimuli that were viewed daily. The results showed that (1) visual stimulation with images of dark night sky significantly reduced the concentration of OxyHb in the right prefrontal cortex and (2) the psychological rating of healing was significantly higher compared to bright night sky. The results of this study will help solve the problems of the mental and physical effects of light pollution on astronomical observations and the reproduction of star images in planetariums. Full article

This paper deals with the exact wave results of the (1+1)-dimensional nonlinear compound Korteweg–De Vries and Burgers (KdVB) equation with a truncated M-fractional derivative. This model represents the generalization of Korteweg–De Vries-modified Korteweg–De Vries and Burgers equations. We obtained periodic, combo singular, dark–bright, and other wave results with the use of the extended sinh-Gordon equation expansion (EShGEE) and modified $(G^{\prime }/G^2)$-expansion techniques. The use of the effective fractional derivative makes our results much better than the existing results. The obtained solutions are useful as well as applicable in various fields, including mathematical physics, plasma physics, ocean engineering, optics, etc. The obtained solutions are demonstrated by 2D, 3D, and contour plots. The achieved results will be fruitful for future research on this equation. Stability analysis is used to check that the results are precise as well as exact. Modulation instability (MI) analysis is performed to find stable steady-state solutions of the abovementioned model. In the end, it is concluded that the methods used are easy and reliable. Full article

According to some theoretical models, primordial black holes with masses of more than 10⁸ solar masses could be born in the early universe, and their possible observational manifestations have been investigated in a number of works. Dense dark matter and baryon halos could form around such primordial black holes even at the pre-galactic stage (in the cosmological Dark Ages epoch). In this paper, the distribution and physical state of the gas in the halo are calculated, taking into account the radiation transfer from the central accreting primordial black hole. This made it possible to find the ionization radius, outside of which there are regions of neutral hydrogen absorption in the 21 cm line. The detection of annular absorption regions at high redshifts in combination with a central bright source may provide evidence of the existence of supermassive primordial black holes. We also point out the fundamental possibility of observing absorption rings with strong gravitational lensing on galaxy clusters, which weakens the requirements for the angular resolution of radio telescopes. Full article

Background: Adolescence is a period of significant psychological, physical, and social changes. During this time, adolescents face increasing responsibilities, such as making educational and career decisions, managing peer relationships, and becoming more independent from their families. These changes are often accompanied by mood fluctuations and altered sleep patterns. This study aimed to explore the relationships between bright- and dark-side hypomania, insomnia, and various dimensions of health-related quality of life (HRQOL), such as self-esteem, family and peer relationships, social acceptance, and autonomy. Methods: A total of 1475 participants in mid-adolescence (mean age: 13.4 years; range: 11–16 years; 48.8% males) completed a series of self-reported questionnaires covering sociodemographic information, hypomania, including dark and bright-side hypomania, insomnia, and HRQOL. Results: Compared to participants with no or dark-side hypomania, participants with bright-side hypomania reported better HRQOL. Bright-side hypomania was significantly associated with favorable relationships with parents and home, peer relationships, and the school environment and with less insomnia. In contrast, dark-side hypomania showed significant associations with lower scores for self-esteem, moods and emotional states, peer relationships, social acceptance, the school environment, and more insomnia. Conclusions: Among a larger sample of adolescents, bright- and dark-side hypomania were associated with a broad, though specific variety of aspects of HRQOL and insomnia. Given that standardized programs are available to improve insomnia and resilience as a proxy of psychological well-being, such interventions may have the potential to improve adolescents’ psychological well-being and sleep quality concomitantly. Full article

We investigate a quantum walk on a ring represented by a directed triangle graph with complex edge weights and monitored at a constant rate until the quantum walker is detected. To this end, the first hitting time statistics are recorded using unitary dynamics interspersed stroboscopically by measurements, which are implemented on IBM quantum computers with a midcircuit readout option. Unlike classical hitting times, the statistical aspect of the problem depends on the way we construct the measured path, an effect that we quantify experimentally. First, we experimentally verify the theoretical prediction that the mean return time to a target state is quantized, with abrupt discontinuities found for specific sampling times and other control parameters, which has a well-known topological interpretation. Second, depending on the initial state, system parameters, and measurement protocol, the detection probability can be less than one or even zero, which is related to dark-state physics. Both return-time quantization and the appearance of the dark states are related to degeneracies in the eigenvalues of the unitary time evolution operator. We conclude that, for the IBM quantum computer under study, the first hitting times of monitored quantum walks are resilient to noise. However, a finite number of measurements leads to broadening effects, which modify the topological quantization and chiral effects of the asymptotic theory with an infinite number of measurements. Full article

Vision-based forest fire detection systems have significantly advanced through Deep Learning (DL) applications. However, DL-based models typically require large-scale labeled datasets for effective training, where the quality of data annotation is crucial to their performance. To address challenges related to the quality and quantity of labeling, a domain adaptation-based approach called FireDA is proposed for forest fire recognition in scenarios with limited labels. Domain adaptation, a subfield of transfer learning, facilitates the transfer of knowledge from a labeled source domain to an unlabeled target domain. The construction of the source domain FBD is initiated, which includes three common fire scenarios: forest (F), brightness (B), and darkness (D), utilizing publicly available labeled data. Subsequently, a novel algorithm called Neighborhood Aggregation-based 2-Stage Domain Adaptation (NA2SDA) is proposed. This method integrates feature distribution alignment with target domain Proxy Classification Loss (PCL), leveraging a neighborhood aggregation mechanism and a memory bank designed for the unlabeled samples in the target domain. This mechanism calibrates the source classifier and generates more accurate pseudo-labels for the unlabeled sample. Consequently, based on these pseudo-labels, the Local Maximum Mean Discrepancy (LMMD) and the Proxy Classification Loss (PCL) are computed. To validate the efficacy of the proposed method, the publicly available forest fire dataset, FLAME, is employed as the target domain for constructing a transfer learning task. The results demonstrate that our method achieves performance comparable to the supervised Convolutional Neural Network (CNN)-based state-of-the-art (SOTA) method, without requiring access to labels from the FLAME training set. Therefore, our study presents a viable solution for forest fire recognition in scenarios with limited labeling and establishes a high-accuracy benchmark for future research. Full article

This paper is concerned with the novel exact solitons for the truncated M-fractional (1+1)-dimensional nonlinear generalized Bretherton model with arbitrary constants. This model is used to explain the resonant nonlinear interaction between the waves in different phenomena, including fluid dynamics, plasma physics, ocean waves, and many others. A series of exact solitons, including bright, dark, periodic, singular, singular–bright, singular–dark, and other solitons are obtained by applying the extended sinh-Gordon equation expansion (EShGEE) and the modified $(G^{\prime }/G^2)$-expansion techniques. A novel definition of fractional derivative provides solutions that are distinct from previous solutions. Mathematica software was used to obtain and verify the solutions. The solutions are shown through 2D, 3D, and density plots. A stability process was conducted to verify that the solutions are exact and accurate. Modulation instability was used to determine the steady-state results for the corresponding equation. Full article

Bound states in the continuum (BICs), which are characterized by their high-quality factor, have become a focal point in modern optical research. This study investigates BICs within a periodic array of dielectric resonators, specifically composed of a silicon rectangular bar coupled with four silicon rectangular blocks. Through the analysis of mode coupling, we demonstrate that the interaction between the blocks significantly modulates the eigenmodes of the bar, causing a redshift in all modes and enabling the formation of electromagnetically induced transparency based on BICs (EIT-BIC). Unlike typical EIT mechanisms, this EIT-BIC arises from the coupling of “bright” and “dark” modes both from the rectangular bar, offering novel insights for nanophotonic and photonic device design. Further, our systematic exploration of BIC formation mechanisms and their sensing properties by breaking structural symmetries and changing environmental refractive indices has shed light on the underlying physics. This research not only consolidates a robust theoretical framework for understanding BIC behavior but also paves the way for high-quality factor resonator and sensor development, as well as the precise control of photonic states. The findings significantly deepen our understanding of these phenomena and hold substantial promise for future photonic applications. Full article

This study reports new types of passive mode-locked Er-doped fiber laser (EDFL) based on a segment of doped fiber saturable absorber (DFSA) with Tm/Ho-doped fiber (THDF), Yb-doped fiber (YDF), and Er-doped fiber (EDF). By employing THDF-SA, a bright pulse sequence with a fundamental repetition rate of 17.86 MHz was obtained. In addition, various mode-locked output states, including dark pulses, dark–bright pulse pairs, bright–dark pulse pairs, and second-harmonic pulses, were obtained through polarization modulation and gain modulation, and the orthogonality of dark–bright pulses in both polarization directions was verified. Furthermore, using EDF-SA and YDF-SA, dark pulses and dark–bright pulses were obtained. A comparison of the three experiments revealed that THDF-SA effectively reduces the mode-locked threshold and improves the average output power. Compared with bright pulses, dark pulses offer several advantages such as resisting noise, increasing propagation speed, and suppressing nonlinear scattering (such as pulse-intrinsic Raman scattering); thus, the EDFL can find broad application in long-distance transmission, precision measurement, and other fields. Full article

The objective of infrared and visual image fusion is to amalgamate the salient and complementary features of the infrared and visual images into a singular informative image. To accomplish this, we introduce a novel local-extrema-driven image filter designed to effectively smooth images by reconstructing pixel intensities based on their local extrema. This filter is iteratively applied to the input infrared and visual images, extracting multiple scales of bright and dark feature maps from the differences between continuously filtered images. Subsequently, the bright and dark feature maps of the infrared and visual images at each scale are fused using elementwise-maximum and elementwise-minimum strategies, respectively. The two base images, representing the final-scale smoothed images of the infrared and visual images, are fused using a novel structural similarity- and intensity-based strategy. Finally, our fusion image can be straightforwardly produced by combining the fused bright feature map, dark feature map, and base image together. Rigorous experimentation conducted on the widely used TNO dataset underscores the superiority of our method in fusing infrared and visual images. Our approach consistently performs on par or surpasses eleven state-of-the-art image-fusion methods, showcasing compelling results in both qualitative and quantitative assessments. Full article

In view of the lack of high-precision optical simulation equipment for dim space targets at present, in this study, a simulation method for dim space targets based on polarization stray light suppression is proposed, the overall optical system architecture of the optical engine for depolarization stray light suppression is constructed, the mechanism of stray light generation is explored, and the dark state light leakage suppression method is presented by compensating the phase of LCOS reflected light with wave plate; a high-image quality collimating optical system with large field of view and flat aberration is designed based on the illumination system optimization method of the critical angle matching of the spectroscopic film; and the polarization stray light suppression effect and star position simulation error of the dim target simulator are tested. The test results show that the illumination of the simulated dim target is ≮10⁻¹⁰ lx, the contrast is 6.96, the non-uniformity of the bright state is only 5.88%, and the simulation error of the star position is 9.9″. This research can make some contributions to enhancing the observability of detecting dim targets, breaking through the detection technology of extremely dark targets in space, developing advanced deep space detection capabilities, and improving the engineering technology system of deep space exploration. Full article