Search Results (2,998)

The sustainable stabilization of clayey soils has become a critical strategy for improving their mechanical performance while reducing environmental impact. This study compares two distinct stabilization systems applied to the same low-plasticity clay (CL) from Cartagena de Indias, Colombia: (i) lime catalyzed with sodium chloride (NaCl) and (ii) xanthan gum (XG) reinforced with polypropylene fibers (PPF). A series of laboratory tests was performed to evaluate the unconfined compressive strength (q_u) and small-strain stiffness (G_o) of both systems under controlled compaction and curing conditions. The lime–NaCl system demonstrated accelerated early-age strength and stiffness development, reaching q_u values above 2.5 MPa and G_o exceeding 10 GPa after 28 days of curing, mainly attributed to enhanced pozzolanic reactions catalyzed by NaCl. Conversely, the XG–PPF blends exhibited progressive improvements in mechanical performance, achieving notable gains after 90 days due to the polymeric bonding of XG and the fiber–matrix reinforcement that enhanced ductility and post-peak behavior. When normalized through the porosity–binder index, both systems exhibited power-law trends, with the lime–NaCl mixtures displaying higher exponents indicative of cementation-controlled behavior, while the XG–PPF mixtures showed lower exponents consistent with interparticle bonding and network formation. These results highlight the complementary mechanisms of chemical and biopolymeric stabilization, providing insights into the selection of sustainable binders tailored to specific design requirements in tropical clays. This research demonstrated that the implementation of machine learning models enhanced the fitting accuracy of the two soil stabilization methods when compared with traditional mathematical regression models commonly used in geotechnical engineering. Among the tested approaches, the neural network and Gaussian process regression models exhibited the best performance, achieving R² values ranging from 0.917 to 0.980 during the validation stage. Full article

Background: In triple-negative breast cancer (TNBC), the addition of immunotherapy has significantly improved outcomes. Immune-related adverse events (irAEs) can be accelerated in patients with pre-existing autoimmune (AI) conditions. The treatment-response standardized protocol used in clinical care raises concerns about the need for right-sizing strategies. As the use of immunotherapy expands, recognizing toxicity from recurrence and optimizing response-adapted approaches are essential to balance cure with quality of survival. Case Presentation: A 38-year-old pregnant woman with a distant history of uveitis and psoriasis was discovered to have pregnancy-associated TNBC. Postnatally, she was treated with neoadjuvant chemotherapy and pembrolizumab, followed by wire-guided left breast wide local excision and sentinel lymph node biopsy of the left axilla. After surgery, residual cancer was noted. She continued adjuvant pembrolizumab and adjuvant radiotherapy 40.05 Gy/15 fr to the breast and nodes, followed by a 13.35 Gy/5 fr boost to the tumour bed (breast). Despite a persistent residual tumour, pembrolizumab was continued as per protocol in a response-agnostic manner. At the end of one year of adjuvant pembrolizumab, she developed progressive numbness and weakness in the ipsilateral arm, initially raising suspicion for local recurrence. Comprehensive MRI and PET-CT imaging did not identify recurrent tumour or new metastatic disease. Electromyography confirmed a lower-trunk brachial plexopathy without a structural cause. An immune-mediated process was diagnosed by a process of elimination. Despite treatment with 1st-line high-dose corticosteroids and 2nd-line intravenous immunoglobulin (IVIG), improvement was limited. Therapeutic plasmapheresis led to marked functional recovery and symptom resolution 20 months later. Discussion: Four main challenges are identified: (1) the diagnostic difficulty in identifying local recurrence or radiation injury from immune-related neuropathy; (2) the emerging therapeutic role of plasmapheresis in steroid-refractory irAEs; (3) the possible inconsistencies between rare toxicities observed in clinical trials vs. clinical practice; and (4) the limitations in response in adjuvant therapy, particularly in patients with coexisting AI conditions. Conclusions: Early recognition and accurate distinction from tumour recurrence, as well as support for plasmapheresis as a potential option in steroid-refractory presentations, have been shown to improve patient survival and symptom reduction. With increasing use of immunotherapy, real-world toxicity data, predictive biomarkers, and personalized treatment strategies are urgently needed to balance cure with long-term functional outcomes. Full article

Plastic shrinkage and self-desiccation, along with the associated early-age cracking, are still among the most important factors that influence long-term performance of concrete structures, including durability. Superabsorbent polymers (SAPs) have been widely researched for application in concrete to mitigate shrinkage through facilitating effective internal curing by releasing water into the mixture to promote continuous hydration of cement. The acoustic emission (AE) monitoring technique, due to its high sensitivity, has proven very effective in tracking the process of water release by SAPs in concrete during early-stage curing. Typically, AE parameters such as cumulative activity, amplitude and energy are utilized to characterize the kinetics of curing processes. While these parameters indicate well the internal activity of SAPs in time, they do not offer information on the precise location of the active sources within the material’s volume, leaving a crucial gap in the understanding of the ongoing microstructural changes caused by internal water distribution and cement hydration. In this sense, AE event source localization can offer information about the active zones of water hydration activity in the material 3D domain, allowing detection of their evolution during concrete curing. Meanwhile, Acoustic Emission Tomography (AET) computes ultrasonic velocity distributions in different periods of monitoring, which are governed by acoustic characteristics of the concrete mixtures, to visualize material stiffness development spatially and temporally. This level of insight is particularly important for SAP concrete, where uniformity of internal water curing is essential for ensuring long-term durability and material soundness. By visualizing how the hydration sources evolve in real time, these methods offer an effective, non-destructive, and cost-effective solution for early-age concrete quality control, which would be challenging to achieve through other techniques. Full article

Alzheimer’s disease (AD) is the most common neurodegenerative disorder worldwide, for which aging represents the main risk factor. As the global elderly population expands, the prevalence of Alzheimer’s disease escalates rapidly. Notably, as AD brain lesions may start 15–20 years before the appearance of the first symptoms, early diagnosis or prognosis of AD is of paramount importance for better patient treatment. Based on the absence of effective cure or early diagnosis of AD, this meta-analysis investigates the differentially expressed genes between Alzheimer’s and a healthy brain and identifies genes that can serve as risk factors for the disease or biomarkers of diagnostic, prognostic, or pharmacological value. Microarray datasets were collected from public repositories, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) guidelines. Quality control and data normalization were performed. Differentially expressed gene (DEG) lists were created for each study and combined through a Mosteller–Bush meta-analysis, resulting in a final list of DEGs. This list was filtered using an adjusted p-value cut-off of 0.001, and the included statistically significant DEGs were subjected to enrichment analyses. A total of eight microarray studies were identified, producing a combined list of 4218 DEGs, of which 1944 were up-regulated and enriched for immune response processes, and 2274 were down-regulated and enriched for synapse-related pathways. This meta-analysis reveals a distinct transcriptomic profile in Alzheimer’s disease characterized by the prevalence of immune response and inflammation alongside the collapse of essential synaptic and neuronal signaling. Full article

Hypersonic vehicles impose stringent requirements on lightweight structures to maintain mechanical integrity under extreme thermal environments. Bismaleimide (BMI)-based carbon fiber-reinforced polymer (CFRP) composites, featuring a high glass transition temperature and excellent thermal stability, are regarded as promising candidates for such applications. However, the high curing temperature and narrow processing window of BMI resins make it challenging to manufacture stiffened-shell structures with low defect levels and high fiber volume fractions. In this study, an integrated manufacturing route—hot-melt prepregging–filament winding–matched-metal mold forming—is proposed, and the key processing parameters are optimized via single-factor experiments and the Box–Behnken response surface methodology. The tensile strength of the laminate is selected as the response variable to evaluate the effects of the compression displacement (A), thermal consolidation/bonding temperature (B), heating rate (C), and cooling rate (D). The results reveal a unimodal dependence of the tensile strength on each parameter, with the significance ranking B > D > A > C; moreover, the A–B and A–D interactions are significant (p < 0.01). The established quadratic regression model exhibits good agreement with experimental data (R² = 0.974; R²_adj = 0.949). The predicted optimum conditions are A = 0.07 mm, B = 114.93 °C, C = 1.35 °C·min⁻¹, and D = 4.58 °C·min⁻¹, corresponding to a predicted tensile strength of approximately 2287 MPa. Validation experiments yielded 2291 MPa, in excellent agreement with the prediction. Microstructural observations indicate tight interlaminar bonding and a pronounced reduction in voids under the optimized conditions. Applying the optimized process to fabricate stiffened-shell demonstrators achieves a fiber volume fraction of >60% and a void content of <1%. This work provides a quantitatively defined processing window and parameter optimization basis for the high-quality manufacturing of BMI-CFRP stiffened-shell structures, with significant engineering relevance. Full article

Due to its relatively low apparent density, as well as high water absorption and crushing value, recycled aggregate (RA) is difficult to directly apply in practical concrete production. Existing studies have proposed a variety of pretreatment methods for RA. To further deepen the understanding of their effectiveness in improving the properties of RA and to provide guidance for its practical application, a comprehensive investigation is necessary. The pretreatment methods of RA can be classified into three main categories: physical strengthening, chemical enhancement, and bio-deposition. In this study, physical strengthening includes mechanical grinding and microwave heating, chemical strengthening includes acid treatment, polymer treatment, and carbonation curing, and biological strengthening refers to biological strengthening techniques. Different strengthening methods improve the properties of RA and the corresponding recycled aggregate concrete (RAC) to varying degrees. However, it is essential to control the external treatment conditions appropriately during the strengthening process. In addition, the source of RA and its inherent physical characteristics also have a significant influence on the treatment outcomes. Therefore, the optimal strengthening conditions should be determined based on the specific properties of each type of RA. This study systematically summarizes and discusses the influencing factors associated with each strengthening method, and the discussion section compares the pros and cons from different perspectives. Furthermore, within the context of engineering decision-making for sustainable and durable construction materials, the study also addresses the limitations of current strengthening technologies and proposes potential directions for future research. Full article

Epoxy resins with excellent overall performance, are widely used in aerospace, automotive, and related fields, frequently in combination with reinforcing fibers to fabricate composites. To enable controllable epoxy processing for prepreg fabrication and composite forming, a rheological model and a curing kinetics model were developed and experimentally validated for an epoxy resin. Rotational rheometry was conducted to quantify the viscosity evolution with temperature and time, enabling construction of a corresponding rheological model. Comparison between model predictions and experimental measurements exhibited a high level of consistency across a wide temperature range. Furthermore, differential scanning calorimetry (DSC) was employed to measure heat-flow curves at different heating rates. The degree of curing was calculated from the heat-flow data, and an autocatalytic curing kinetics model was established based on a reaction kinetics formulation. And the accuracy of the model was verified by isothermal experiments. The developed rheological model provides a theoretical basis and practical guidance for resin processing and prepreg fabrication, whereas the curing kinetics model supports the design and control of curing and forming schedules for epoxy-matrix composites. Full article

Meat and meat products are integral components of various diets and provide many macro- and micronutrients. However, concerns over their potential adverse health effects remain pressing. This study employed a semi-quantitative Risk–Benefit Assessment (RBA) methodology to compare both beneficial and adverse health impacts of various meat products, i.e., fermented (Salame and Chouriço), dry-cured (Presunto), and heat-treated (Fiambre), with unprocessed grilled pork meat as a reference. Nutritional composition and microbiological and toxicological hazards were assessed using data acquired from national and international databases and the literature. In the end, a heatmap approach was used to summarize and compare product profiles. While grilled pork offered the most favorable profile, processed products showed high levels of sodium, nitrites, and contaminants, such as polycyclic aromatic hydrocarbons and ochratoxin A. Notably, Salame exhibited the most concerning risk profile, including high levels of histamine and ochratoxin A, whereas Fiambre, despite the high nitrite content, showed the lowest microbial and toxicological risks. These findings highlight significant variability in health-related impacts among meat products, caused mainly by processing technologies. The results can improve dietary guidance and regulations and encourage innovations, especially by indicating the potential of using engineered fermentation techniques and novel additives for improved meat products. Full article

Microcontact stamping is a promising microfabrication technique for producing functional patterned thin films on flexible substrates; however, systematic optimization of its process parameters for thermochromic applications remains limited. In this study, we present a comprehensive parametric optimization of the microcontact stamping process to fabricate thermochromic pigment-coated thin films with rapid and reversible color responses. The effects of liquid resin type, SU-8 mold thickness, polydimethylsiloxane (PDMS) mixing ratio, and pattern size on pattern fidelity and thermochromic performance were systematically investigated. The optimal conditions were identified as a UV-curable resin, a 600 µm-thick SU-8 mold, a PDMS base-to-curing-agent ratio of 5:1, and a pattern size of 125 × 125 µm². Under these conditions, the stamped thermochromic films exhibited uniform micro-patterns, rapid response and recovery behavior, and stable reversible color changes over 20 consecutive thermal cycles. This work provides practical guidelines for parameter-controlled microcontact stamping of functional thin films and demonstrates its potential for scalable fabrication of thermochromic micro-patterns. The proposed approach is expected to contribute to the development of flexible and wearable electronic devices, smart displays, and thermally responsive sensing platforms. Full article

The cement industry is a major source of anthropogenic CO₂ emissions due to its energy-intensive production process and calcination of limestone. Producing one ton of cement emits approximately one ton of CO₂, and cement accounts for about 5% to 8% of global CO₂ emissions. In this context, cement-less one-part (“just-add-water”) ambient-cured geopolymer concrete (GPC) has gained attention due to its environmental friendliness and practicality for large-scale cast-in-situ construction. However, field adoption remains limited, mainly due to the scarcity of data on mechanical properties and durability, as well as the lack of widely accepted standards and specifications. This paper is part of the larger research on tensile performance of anchors embedded in GPC. It is well understood that the tensile performance of anchors installed in concrete substrate is largely influenced by their effective embedment depth and the substrate’s mechanical properties, particularly the fracture energy and modulus of elasticity. Therefore, prior to the investigation of the tensile performance of anchors in GPC, it is crucial to understand the mechanical behaviour of the GPC substrate itself. This study examined key parameters that influence the compressive strength of one-part ambient-cured slag/fly ash-based GPC. The alkali content, slag content, water-to-solid (W/S) ratio, and aggregate content were investigated. Additionally, various mechanical properties such as uniaxial tensile strength, splitting tensile strength, elastic modulus, and fracture energy of the hardened GPC are presented. The test results revealed that higher slag and activator content enhanced compressive strength, whereas a higher aggregate content reduced the strength. The strength gain was also attributed to higher alkali content, lower W/S ratio, and increased binder content; however, excessive alkali and an overly low W/S ratio caused rapid setting due to accelerated reaction kinetics. The 7-day compressive strength ranged from 62% to 78% of the 28-day strength, while there was no notable strength gain after 28 days of curing. The developed GPC attained compressive strengths of over 40 MPa at 28 days and 50 MPa at 56 days. The uniaxial tensile strength test demonstrated a ratio of 0.87 relative to splitting tensile strength. The findings also indicated that the aggregate conditions and curing regimes (whether using as-is aggregates with moisture curing or oven-dried aggregates with sealed curing) had no meaningful effect on the mean compressive strength of GPC and its reproducibility. Full article

The interplay between curing conditions and performance in superhydrophobic cementitious materials remains a critical challenge, wherein hydrophobic agent incorporation enhances hydrophobicity but often compromises mechanical strength. This study aimed to investigate the effects of curing humidity and temperature on compressive strength and contact angle and clarify the influence of surface texture on hydrophobicity. SEM–EDS, FTIR, XRD, TG, and AFM were employed to analyze the specimens. Our results showed that curing temperature positively impacts material properties, whereas excessive curing humidity enhances compressive strength but negatively affects superhydrophobicity. Additionally, micro- and nanoscale coarse structures were found to be beneficial for improving superhydrophobicity. This study offers valuable insights into the most efficient mechanism through which to optimize the preparation process for desirable properties in superhydrophobic cementitious materials. Full article

In the extreme high-temperature (up to 150 °C) and high-pressure (up to 140 MPa) conditions of deep in situ condition-preserved coring devices, high-strength epoxy resin was selected as the insulation layer. The non-isothermal DSC method was employed at heating rates of 2.5, 5, 10, 15, and 20 °C/min, revealing that increasing the heating rate elevates curing temperatures, expands the curing range, and enhances curing rate and heat release. The curing kinetics were modeled using n-order and autocatalytic approaches, with the latter accurately describing the behavior. Optimized integration process conditions (80 °C/4 h + 150 °C/2 h + 180 °C/3 h) yielded epoxy with compressive strength of 204.47 MPa, initial thermal decomposition temperature of 345.9 °C, thermal conductivity of 0.246 W/m·K, and T_g of 193.04 °C (storage modulus 2.41 GPa at 150 °C). As insulation, it reduces rock core heat loss by 32.38% (8.78 × 10⁴ J) and active heating demand by 44 W, enhancing system stability for in situ temperature preservation. Full article

Valorizing construction and demolition waste (CDW) via alkaline activation enables low-carbon binders. This study assesses binary geopolymers formulated with recycled brick powder (PLR) and recycled concrete powder (PCR) in seven precursor ratios (0–100% PCR), activated with a ternary NaOH/Na₂SiO₃/KOH solution (silicate modulus M_s ≈ 3.2) at L/B = 0.15, and cured for 7, 14, and 28 days. Compressive strength (fc), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS) were used to link microstructure–phases–properties. A local maximum in fc at ~30% PCR (16.2 MPa at 28 d) was observed versus 0% PCR (14.2 MPa) and ≥50% PCR (13.8 → 10.1 MPa at 28 d). XRD indicated a reduction in inherited crystalline phases and an increased amorphous fraction at ~30% PCR; FTIR (normalized peak position and FWHM of the T–O–Si band, not absolute intensity) suggested higher network extension; SEM-EDS (local/semiquantitative) showed a moderate rise in Ca that supports C-A-S-H domains bridging the N-A-S-H network. At a high PCR, excess Ca simplified mineralogy (quartz/portlandite dominance), promoted competitive routes (C-S-H/carbonation), reintroduced microdefects, and reduced fc. A theoretical oxide balance per mix identified a compositional window where Ca/(Si + Al) ≈ 0.35–0.45 coincides with the mechanical optimum and with XRD/FTIR tracers. Overall, a ~30% PCR window maximizes co-reticulation of N-A-S-H/C-A-S-H and densification without compromising aluminosilicate continuity, providing transferrable design and process-control criteria for CDW-based geopolymer binders. Full article

The study investigated whether the full replacement of chemically solvent-extracted soybean meal (SM) with mechanically extracted soybean press cake (SC) could be carried out in pigs intended for dry-cured ham production. Eighty Italian heavy pigs were fattened and finished up to a body weight of 165 kg, with half being fed a commercial diet containing SM and the other half fed an isoenergetic and isonitrogenous diet in which SC fully replaced SM. Growth parameters, carcass traits, fresh meat and cured ham quality, and fatty acid composition were analyzed. Thighs were processed according to the Parma ham production rules, which require a long curing period. The only noteworthy differences observed concerned an increase in polyunsaturated fatty acid levels in the subcutaneous fat of the SC group compared with the SM group (17.26 vs. 14.58%, p < 0.05, in fresh thighs and 15.83 vs. 12.14%, p < 0.01, in cured hams), and particularly in linoleic acid (14.85 vs. 13.01%, p < 0.01 in fresh thighs and 13.72 vs. 10.64%, p < 0.01 in cured hams), which is consistent with general nutritional recommendations favoring unsaturated over saturated fatty acids. These modifications did not affect the final quality, oxidative stability, or visual appearance of the long-cured hams. In conclusion, soybean cake–based diets can be applied throughout the production cycle of heavy pigs; however, higher inclusion levels should be carefully managed, as they may affect parameters related to suitability for dry curing. Full article

This paper provides a systematic review of urushiol-based antibacterial coatings for lacquer art applications, focusing on three key dimensions: molecular mechanisms, durability, and safety. Natural lacquer films form a dense three-dimensional network through laccase-catalyzed oxidative cross-linking, endowing them with excellent mechanical properties and corrosion resistance, while the catechol structure in urushiol confers broad-spectrum antibacterial potential. The article elaborates on the synergistic antibacterial mechanisms of urushiol, including covalent reactions with bacterial proteins via quinone intermediates, induction of oxidative stress, and metal ion chelation. It also reveals the dynamic change pattern of coating antibacterial activity over time, characterized by “high initial efficiency- gradual mid-term decline—long-term stabilization,” a process influenced collectively by side-chain unsaturation, degree of curing, and environmental factors such as temperature, humidity, and light exposure. From an application perspective, this review examines modification approaches such as silver/titanium dioxide composite systems, structurally regulated sustained-release strategies, and anti-adhesion surface designs, while pointing out current limitations in artistic compatibility, long-term durability, and safety assessment. Particularly in scenarios involving food contact and cultural heritage preservation, migration risks from unreacted urushiol monomers and metal nanoparticles, as well as the inherent sensitization potential of urushiol, remain critical challenges for safe application. Accordingly, this paper proposes the establishment of a holistic research framework covering “material design–process control–performance evaluation” and advocates for the development of functional coating systems with low migration, high biocompatibility, and preserved aesthetic value. Such advances are essential to promote the sustainable development and safe application of urushiol-based antibacterial coatings in fields such as cultural heritage conservation, daily-use utensils, and high-end decorative arts. Full article