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Search Results (745)

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Keywords = cultural memories

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21 pages, 961 KiB  
Article
A Mixed-Method Assessment of Drivers and Barriers for Substituting Dairy with Plant-Based Alternatives by Danish Adults
by Beatriz Philippi Rosane, Lise Tjørring, Annika Ley, Derek Victor Byrne, Barbara Vad Andersen, Susanne Gjedsted Bügel and Sophie Wennerscheid
Foods 2025, 14(15), 2755; https://doi.org/10.3390/foods14152755 - 7 Aug 2025
Abstract
The market for plant-based alternatives to animal foods has increased rapidly in the past decade, mainly due to consumer demand. Little evidence is available regarding nutritional impacts, drivers, and barriers to using these products as substitutes for animal foods in real-life conditions. This [...] Read more.
The market for plant-based alternatives to animal foods has increased rapidly in the past decade, mainly due to consumer demand. Little evidence is available regarding nutritional impacts, drivers, and barriers to using these products as substitutes for animal foods in real-life conditions. This pilot study followed 16 Danish adults (30 ± 11 years old; 11 females) for 4 weeks with substituting milk, cheese, and yogurt with plant-based analogues to dairy (PBADs) and assessed their drivers and barriers to applying the intervention with a mixed-method approach. PBADs are constantly compared to their animal counterparts, both regarding product characteristics, such as price and sensory properties, as well as cultural roles and subjective memories. The mixed methods showed dairy attachment, price, and taste were the main barriers to consuming PBAD, while changes in life and social circles were drivers (qualitative data). As for the liking of PBADs, plant-based yoghurt was the preferred intervention product (73.5/100, p < 0.05), followed by plant-based drinks (65.9/100), while plant-based cheese was the lowest rated (47.9/100, p < 0.05). As for dietary changes, a lower average intake of sugars, saturated fatty acids, cholesterol, calcium, phosphorus, and zinc was observed after the intervention. Additionally, this study describes the attachment of the study population to milk and dairy products. It shows that choosing dairy is beyond nourishment but is connected to tradition, culture, pleasure, memories, and a sense of belonging. In contrast, there is no history or attachment to PBADs. Full article
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17 pages, 1766 KiB  
Article
The Effects of the Red River Jig on the Wholistic Health of Adults in Saskatchewan
by Nisha K. Mainra, Samantha J. Moore, Jamie LaFleur, Alison R. Oates, Gavin Selinger, Tayha Theresia Rolfes, Hanna Sullivan, Muqtasida Fatima and Heather J. A. Foulds
Int. J. Environ. Res. Public Health 2025, 22(8), 1225; https://doi.org/10.3390/ijerph22081225 - 6 Aug 2025
Abstract
The Red River Jig is a traditional Métis dance practiced among Indigenous and non-Indigenous Peoples. While exercise improves physical health and fitness, the impacts of cultural dances on wholistic health are less clear. This study aimed to investigate the psychosocial (cultural and mental), [...] Read more.
The Red River Jig is a traditional Métis dance practiced among Indigenous and non-Indigenous Peoples. While exercise improves physical health and fitness, the impacts of cultural dances on wholistic health are less clear. This study aimed to investigate the psychosocial (cultural and mental), social, physical function, and physical fitness benefits of a Red River Jig intervention. In partnership with Li Toneur Nimiyitoohk Métis Dance Group, Indigenous and non-Indigenous adults (N = 40, 39 ± 15 years, 32 females) completed an 8-week Red River Jig intervention. Social support, cultural identity, memory, and mental wellbeing questionnaires, seated blood pressure and heart rate, weight, pulse-wave velocity, heart rate variability, baroreceptor sensitivity, jump height, sit-and-reach flexibility, one-leg and tandem balance, and six-minute walk test were assessed pre- and post-intervention. Community, family, and friend support scores, six-minute walk distance (553.0 ± 88.7 m vs. 602.2 ± 138.6 m, p = 0.002), jump, leg power, and systolic blood pressure low-to-high-frequency ratio increased after the intervention. Ethnic identity remained the same while affirmation and belonging declined, leading to declines in overall cultural identity, as learning about Métis culture through the Red River Jig may highlight gaps in cultural knowledge. Seated systolic blood pressure (116.5 ± 7.3 mmHg vs. 112.5 ± 10.7 mmHg, p = 0.01) and lower peripheral pulse-wave velocity (10.0 ± 2.0 m·s−1 vs. 9.4 ± 1.9 m·s−1, p = 0.04) decreased after the intervention. Red River Jig dance training can improve social support, physical function, and physical fitness for Indigenous and non-Indigenous adults. Full article
(This article belongs to the Special Issue Improving Health and Mental Wellness in Indigenous Communities)
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10 pages, 174 KiB  
Article
Between Place and Identity: Spatial Production and the Poetics of Liminality in Jeffrey Eugenides’ Fiction
by Maria Miruna Ciocoi-Pop
Literature 2025, 5(3), 19; https://doi.org/10.3390/literature5030019 - 4 Aug 2025
Viewed by 116
Abstract
This article investigates the role of space in the fiction of Jeffrey Eugenides, focusing on The Virgin Suicides (1993) and Middlesex (2002) through the lens of spatial theory. Drawing on key thinkers such as Henri Lefebvre, Michel Foucault, Edward Soja, Yi-Fu Tuan, and [...] Read more.
This article investigates the role of space in the fiction of Jeffrey Eugenides, focusing on The Virgin Suicides (1993) and Middlesex (2002) through the lens of spatial theory. Drawing on key thinkers such as Henri Lefebvre, Michel Foucault, Edward Soja, Yi-Fu Tuan, and Doreen Massey, the study explores how Eugenides constructs spatial environments that not only frame but actively shape the identities, desires, and traumas of his characters. In The Virgin Suicides, suburban domestic spaces are shown to function as heterotopias—sites of surveillance, repression, and mythologized femininity—while Middlesex engages with transnational and urban spaces to narrate diasporic and intersex identity as dynamic, embodied, and liminal. The analysis reveals that Eugenides uses space as both a narrative device and a thematic concern to interrogate gender, memory, and power. Rather than passive backdrops, the novelistic spaces become charged arenas of conflict and transformation, reflecting and resisting dominant socio-cultural discourses. This study argues that space in Eugenides’ fiction operates as a critical register for understanding the politics of belonging and the production of subjectivity. By situating Eugenides within the broader field of literary spatiality, this article contributes to contemporary debates in literary geography, gender studies, and American fiction. Full article
26 pages, 4349 KiB  
Article
Palazzo Farnese and Dong’s Fortified Compound: An Art-Anthropological Cross-Cultural Analysis of Architectural Form, Symbolic Ornamentation, and Public Perception
by Liyue Wu, Qinchuan Zhan, Yanjun Li and Chen Chen
Buildings 2025, 15(15), 2720; https://doi.org/10.3390/buildings15152720 - 1 Aug 2025
Viewed by 156
Abstract
This study presents a cross-cultural comparison of two fortified residences—Palazzo Farnese in Italy and Dong’s Fortified Compound in China—through a triadic analytical framework encompassing architectural form, symbolic ornamentation, and public perception. By combining field observation, iconographic interpretation, and digital ethnography, the research investigates [...] Read more.
This study presents a cross-cultural comparison of two fortified residences—Palazzo Farnese in Italy and Dong’s Fortified Compound in China—through a triadic analytical framework encompassing architectural form, symbolic ornamentation, and public perception. By combining field observation, iconographic interpretation, and digital ethnography, the research investigates how heritage meaning is constructed, encoded, and reinterpreted across distinct sociocultural contexts. Empirical materials include architectural documentation, decorative analysis, and a curated dataset of 4947 user-generated images and 1467 textual comments collected from Chinese and international platforms between 2020 and 2024. Methods such as CLIP-based visual clustering and BERTopic-enabled sentiment modelling were applied to extract patterns of perception and symbolic emphasis. The findings reveal contrasting representational logics: Palazzo Farnese encodes dynastic authority and Renaissance cosmology through geometric order and immersive frescoes, while Dong’s Compound conveys Confucian ethics and frontier identity via nested courtyards and traditional ornamentation. Digital responses diverge accordingly: international users highlight formal aesthetics and photogenic elements; Chinese users engage with symbolic motifs, family memory, and ritual significance. This study illustrates how historically fortified residences are reinterpreted through culturally specific digital practices, offering an interdisciplinary approach that bridges architectural history, symbolic analysis, and digital heritage studies. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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30 pages, 427 KiB  
Article
From The Demon to the Secret Voice: Archetypal Echoes and Oral Culture in 19th Century Romantic Poetry
by Gül Mükerrem Öztürk
Humanities 2025, 14(8), 160; https://doi.org/10.3390/h14080160 - 31 Jul 2025
Viewed by 160
Abstract
The first half of the 19th century witnessed the rise of Romantic poetry, which focused in depth on individual consciousness, inner worlds, and metaphysical inquiries. This poetic orientation became particularly evident in works centred on themes such as solitude, alienation, and existential quests. [...] Read more.
The first half of the 19th century witnessed the rise of Romantic poetry, which focused in depth on individual consciousness, inner worlds, and metaphysical inquiries. This poetic orientation became particularly evident in works centred on themes such as solitude, alienation, and existential quests. Within this context, the present study aims to examine the archetypal and poetic resonances of the poetic voice in Mihail Lermontov’s poem The Demon, based on its sixth and final version dated 1841, in relation to Nikoloz Baratashvili’s poem Secret Voice. Lermontov’s poem is analyzed through the English translation by Charles Johnston, published in 1983, while Baratashvili’s poem is discussed based on the 24-line version included in the fifth edition (1895) of the anthology Poems and Letters (Leksebi da Tserilebi). This study explores the thematic and structural similarities between the two poems within the framework of comparative literature and psychoanalytic criticism, focusing on Romantic archetypes, the uncanny, the shadow figure, and ontological solitude. Furthermore, the dialogue established between Lermontov’s demonic narrator and Baratashvili’s introspective poetic voice reopens discussions on the boundaries of cultural memory, oral narrative patterns, and poetic identity. Ultimately, this comparative analysis reveals the implicit influences of The Demon on Georgian poetry and discusses the intercultural resonances of themes such as voice, self, and archetype in Romantic poetry. Full article
(This article belongs to the Section Literature in the Humanities)
15 pages, 1173 KiB  
Article
Examining the Potential Benefits of Affirming Values on Memory for Educational Information
by Karen Arcos, Rebecca Covarrubias and Benjamin C. Storm
Behav. Sci. 2025, 15(8), 1033; https://doi.org/10.3390/bs15081033 - 30 Jul 2025
Viewed by 275
Abstract
First-generation students can experience a cultural mismatch between their values and those that colleges and universities tend to prioritize. This mismatch can increase cognitive load, leaving fewer resources available for learning. Effective and long-lasting learning requires actively processing new information and connecting it [...] Read more.
First-generation students can experience a cultural mismatch between their values and those that colleges and universities tend to prioritize. This mismatch can increase cognitive load, leaving fewer resources available for learning. Effective and long-lasting learning requires actively processing new information and connecting it to existing knowledge—an effort that demands significant cognitive resources. Value affirmation exercises, where students select and reflect upon values that are important to them, have shown promise in reducing cultural mismatch and improving performance on cognitive tasks. However, the impact of these exercises on the learning and recall of new information is less clear. The current study investigated whether a value affirmation exercise, completed before reading an educational passage, would improve memory recall for that passage in a sample of 400 first-generation and continuing-generation young adults, as compared to not affirming. Our results failed to provide evidence that value affirmation exercises impacted recall performance, regardless of whether participants affirmed independent values, interdependent values, or both. Given the importance and implications of this outcome for student learning, we discuss possible explanations for these null findings and suggest future directions in affirmation research. Full article
(This article belongs to the Special Issue Educational Applications of Cognitive Psychology)
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17 pages, 11812 KiB  
Article
Heritage GIS: Deep Mapping, Preserving, and Sustaining the Intangibility of Cultures and the Palimpsests of Landscape in the West of Ireland
by Charles Travis
Sustainability 2025, 17(15), 6870; https://doi.org/10.3390/su17156870 - 29 Jul 2025
Viewed by 369
Abstract
This paper presents a conceptual and methodological framework for using Geographical Information Systems (GIS) to “deep map” cultural heritage sites along Ireland’s Wild Atlantic Way, with a focus on the 1588 Spanish Armada wrecks in County Kerry and archaeological landscapes in County Sligo’s [...] Read more.
This paper presents a conceptual and methodological framework for using Geographical Information Systems (GIS) to “deep map” cultural heritage sites along Ireland’s Wild Atlantic Way, with a focus on the 1588 Spanish Armada wrecks in County Kerry and archaeological landscapes in County Sligo’s “Yeats Country.” Drawing on interdisciplinary dialogues from the humanities, social sciences, and geospatial sciences, it illustrates how digital spatial technologies can excavate, preserve, and sustain intangible cultural knowledge embedded within such palimpsestic landscapes. Using MAXQDA 24 software to mine and code historical, literary, folkloric, and environmental texts, the study constructed bespoke GIS attribute tables and visualizations integrated with elevation models and open-source archaeological data. The result is a richly layered cartographic method that reveals the spectral and affective dimensions of heritage landscapes through climate, memory, literature, and spatial storytelling. By engaging with “deep mapping” and theories such as “Spectral Geography,” the research offers new avenues for sustainable heritage conservation, cultural tourism, and public education that are sensitive to both ecological and cultural resilience in the West of Ireland. Full article
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11 pages, 226 KiB  
Opinion
Sexuality and Stroke: The Importance of Considering Cognitive and Perceptual Impairments in Post-Stroke Sexual Functioning
by Daniel Geller and Samantha Wong
Brain Sci. 2025, 15(8), 797; https://doi.org/10.3390/brainsci15080797 - 26 Jul 2025
Viewed by 456
Abstract
Sexuality and intimacy are essential aspects of the human experience for all people, contributing significantly to physical and emotional connections, well-being, and quality of life. Despite their importance, these topics are frequently overlooked in stroke rehabilitation, especially for those with cognitive and perceptual [...] Read more.
Sexuality and intimacy are essential aspects of the human experience for all people, contributing significantly to physical and emotional connections, well-being, and quality of life. Despite their importance, these topics are frequently overlooked in stroke rehabilitation, especially for those with cognitive and perceptual impairments. Existing research on post-stroke sexual rehabilitation tends to focus on sexual dysfunction and the secondary physical and psychological stroke symptoms, with little attention to cognitive and perceptual impairments. Cognitive deficits, such as decreased memory, generalized attention, and executive function not only can hinder sexual participation but also raise the complex issue of capacity to consent. This paper argues that it is imperative for researchers and healthcare practitioners to address cognitive and perceptual challenges, understand consent laws in their respective regions, and consider the influence of culture and social norms in order to support the sexual rights and well-being of all stroke survivors. Furthermore, this article provides some practical recommendations, from an occupational therapy perspective, that healthcare practitioners can provide to clients and their partners. Full article
16 pages, 5151 KiB  
Article
Design and Characterization of Curcumin-Modified Polyurethane Material with Good Mechanical, Shape-Memory, pH-Responsive, and Biocompatible Properties
by Man Wang, Hongying Liu, Wei Zhao, Huafen Wang, Yuwei Zhuang, Jie Yang, Zhaohui Liu, Jing Zhu, Sichong Chen and Jinghui Cheng
Biomolecules 2025, 15(8), 1070; https://doi.org/10.3390/biom15081070 - 24 Jul 2025
Viewed by 268
Abstract
In the context of critical challenges in curcumin-modified polyurethane synthesis—including limited curcumin bioavailability and suboptimal biodegradability/biocompatibility—a novel polyurethane material (Cur-PU) with good mechanical, shape memory, pH-responsive, and biocompatibility was synthesized via a one-pot, two-step synthetic protocol in which HO-PCL-OH served as the soft [...] Read more.
In the context of critical challenges in curcumin-modified polyurethane synthesis—including limited curcumin bioavailability and suboptimal biodegradability/biocompatibility—a novel polyurethane material (Cur-PU) with good mechanical, shape memory, pH-responsive, and biocompatibility was synthesized via a one-pot, two-step synthetic protocol in which HO-PCL-OH served as the soft segment and curcumin was employed as the chain extender. The experimental results demonstrate that with the increase in Cur units, the crystallinity of the Cur-PU material decreases from 32.6% to 5.3% and that the intensities of the diffraction peaks at 2θ = 21.36°, 21.97°, and 23.72° in the XRD pattern gradually diminish. Concomitantly, tensile strength decreased from 35.5 MPa to 19.3 MPa, and Shore A hardness declined from 88 HA to 65 HA. These observations indicate that the sterically hindered benzene ring structure of Cur imposes restrictions on HO-PCL-OH crystallization, leading to lower crystallinity and retarded crystallization kinetics in Cur-PU. As a consequence, the material’s tensile strength and hardness are diminished. Except for the Cur-PU-3 sample, all other variants exhibited exceptional shape-memory functionality, with Rf and Rr exceeding 95%, as determined by three-point bending method. Analogous to pure curcumin solutions, Cur-PU solutions demonstrated pH-responsive chromatic transitions: upon addition of hydroxide ion (OH) solutions at increasing concentrations, the solutions shifted from yellow-green to dark green and finally to orange-yellow, enabling sensitive pH detection across alkaline gradients. Hydrolytic degradation studies conducted over 15 weeks in air, UPW, and pH 6.0/8.0 phosphate buffer solutions revealed mass loss <2% for Cur-PU films. Surface morphological analysis showed progressive etching with the formation of micro-to-nano-scale pores, indicative of a surface-erosion degradation mechanism consistent with pure PCL. Biocompatibility assessments via L929 mouse fibroblast co-culture experiments demonstrated ≥90% cell viability after 72 h, while relative red blood cell hemolysis rates remained below 5%. Collectively, these findings establish Cur-PU as a biocompatible material with tunable mechanical properties, and pH responsiveness, underscoring its translational potential for biomedical applications such as drug delivery systems and tissue engineering scaffolds. Full article
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28 pages, 20978 KiB  
Article
From Painting to Cinema: Archetypes of the European Woman as a Cultural Mediator in the Western genre
by Olga Kosachova
Arts 2025, 14(4), 83; https://doi.org/10.3390/arts14040083 - 23 Jul 2025
Viewed by 450
Abstract
The Western genre has traditionally been associated with American identity and male-dominated narratives. However, recent decades have seen increasing attention to female protagonists, particularly the European woman as a cultural mediator within the frontier context. This study aims to identify the archetypes of [...] Read more.
The Western genre has traditionally been associated with American identity and male-dominated narratives. However, recent decades have seen increasing attention to female protagonists, particularly the European woman as a cultural mediator within the frontier context. This study aims to identify the archetypes of the European woman in the Western genre through a diachronic and comparative analysis of the visual language found in European painting from the late 17th to early 19th centuries and in 20th–21st century cinema. The research methodology combines narrative, visual, and semiotic analysis, with a focus on intermedial and intertextual parallels between visual art and film. The study identifies nine archetypal models corresponding to goddesses of the Greek pantheon and traces their transformation across different aesthetic systems. These archetypes, rooted in artistic traditions such as Baroque, Classicism, Romanticism, and others, reappear in Western films through compositional, symbolic, and iconographic strategies, demonstrating their persistence and ability to transcend temporal, medial, and geographical boundaries. The findings suggest that the woman in the Western genre is not merely a central character, but a visual sign that activates cultural memory and engages with deep archetypal structures embedded in the collective unconscious. Full article
(This article belongs to the Special Issue What is ‘Art’ Cinema?)
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49 pages, 21554 KiB  
Article
A Disappearing Cultural Landscape: The Heritage of German-Style Land Use and Pug-And-Pine Architecture in Australia
by Dirk H. R. Spennemann
Land 2025, 14(8), 1517; https://doi.org/10.3390/land14081517 - 23 Jul 2025
Viewed by 282
Abstract
This paper investigates the cultural landscapes established by nineteenth-century German immigrants in South Australia and the southern Riverina of New South Wales, with particular attention to settlement patterns, architectural traditions and toponymic transformation. German immigration to Australia, though numerically modest compared to the [...] Read more.
This paper investigates the cultural landscapes established by nineteenth-century German immigrants in South Australia and the southern Riverina of New South Wales, with particular attention to settlement patterns, architectural traditions and toponymic transformation. German immigration to Australia, though numerically modest compared to the Americas, significantly shaped local communities, especially due to religious cohesion among Lutheran migrants. These settlers established distinct, enduring rural enclaves characterized by linguistic, religious and architectural continuity. The paper examines three manifestations of these cultural landscapes. A rich toponymic landscape was created by imposing on natural landscape features and newly founded settlements the names of the communities from which the German settlers originated. It discusses the erosion of German toponyms under wartime nationalist pressures, the subsequent partial reinstatement and the implications for cultural memory. The study traces the second manifestation of a cultural landscapes in the form of nucleated villages such as Hahndorf, Bethanien and Lobethal, which often followed the Hufendorf or Straßendorf layout, integrating Silesian land-use principles into the Australian context. Intensification of land use through housing subdivisions in two communities as well as agricultural intensification through broad acre farming has led to the fragmentation (town) and obliteration (rural) of the uniquely German form of land use. The final focus is the material expression of cultural identity through architecture, particularly the use of traditional Fachwerk (half-timbered) construction and adaptations such as pug-and-pine walling suited to local materials and climate. The paper examines domestic forms, including the distinctive black kitchen, and highlights how environmental and functional adaptation reshaped German building traditions in the antipodes. Despite a conservation movement and despite considerable documentation research in the late twentieth century, the paper shows that most German rural structures remain unlisted and vulnerable. Heritage neglect, rural depopulation, economic rationalization, lack of commercial relevance and local government policy have accelerated the decline of many of these vernacular buildings. The study concludes by problematizing the sustainability of conserving German Australian rural heritage in the face of regulatory, economic and demographic pressures. With its layering of intangible (toponymic), structural (buildings) and land use (cadastral) features, the examination of the cultural landscape established by nineteenth-century German immigrants adds to the body of literature on immigrant communities, settler colonialism and landscape research. Full article
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10 pages, 700 KiB  
Article
Neurocognitive Foundations of Memory Retention in AR and VR Cultural Heritage Experiences
by Paula Srdanović, Tibor Skala and Marko Maričević
Electronics 2025, 14(15), 2920; https://doi.org/10.3390/electronics14152920 - 22 Jul 2025
Viewed by 265
Abstract
Immersive technologies such as augmented reality (AR) and virtual reality (VR) have emerged as powerful tools in cultural heritage education and preservation. Building on prior work that demonstrated the effectiveness of gamified XR applications in engaging users with heritage content and drawing on [...] Read more.
Immersive technologies such as augmented reality (AR) and virtual reality (VR) have emerged as powerful tools in cultural heritage education and preservation. Building on prior work that demonstrated the effectiveness of gamified XR applications in engaging users with heritage content and drawing on existing studies in neuroscience and cognitive psychology, this study explores how immersive experiences support multisensory integration, emotional engagement, and spatial presence—all of which contribute to the deeper encoding and recall of heritage narratives. Through a theoretical lens supported by the empirical literature, we argue that the interactive and embodied nature of AR/VR aligns with principles of cognitive load theory, dual coding theory, and affective neuroscience, supporting enhanced learning and memory consolidation. This paper aims to bridge the gap between technological innovation and cognitive understanding in cultural heritage dissemination, identifying concrete design principles for memory-driven digital heritage experiences. While promising, these approaches also raise important ethical considerations, including accessibility, cultural representation, and inclusivity—factors essential for equitable digital heritage dissemination. Full article
(This article belongs to the Special Issue Metaverse, Digital Twins and AI, 3rd Edition)
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17 pages, 11573 KiB  
Article
IFNγ Expression Correlates with Enhanced Cytotoxicity in CD8+ T Cells
by Varsha Pattu, Elmar Krause, Hsin-Fang Chang, Jens Rettig and Xuemei Li
Int. J. Mol. Sci. 2025, 26(14), 7024; https://doi.org/10.3390/ijms26147024 - 21 Jul 2025
Viewed by 388
Abstract
CD8+ T lymphocytes (CTLs) act as serial killers of infected or malignant cells by releasing large amounts of interferon-gamma (IFNγ) and granzymes. Although IFNγ is a pleiotropic cytokine with diverse immunomodulatory functions, its precise spatiotemporal regulation and role in CTL-mediated cytotoxicity remain incompletely [...] Read more.
CD8+ T lymphocytes (CTLs) act as serial killers of infected or malignant cells by releasing large amounts of interferon-gamma (IFNγ) and granzymes. Although IFNγ is a pleiotropic cytokine with diverse immunomodulatory functions, its precise spatiotemporal regulation and role in CTL-mediated cytotoxicity remain incompletely understood. Using wild-type and granzyme B-mTFP knock-in mice, we employed a combination of in vitro approaches, including T cell isolation and culture, plate-bound anti-CD3e stimulation, degranulation assays, flow cytometry, immunofluorescence, and structured illumination microscopy, to investigate IFNγ dynamics in CTLs. IFNγ expression in CTLs was rapid, transient, and strictly dependent on T cell receptor (TCR) activation. We identified two functionally distinct IFNγ-producing subsets: IFNγhigh (IFNγhi) and IFNγlow (IFNγlo) CTLs. IFNγhi CTLs exhibited an effector/effector memory phenotype, significantly elevated CD107a surface expression (a marker of lytic granule exocytosis), and higher colocalization with cis-Golgi and granzyme B compared to IFNγlo CTLs. Furthermore, CRTAM, an early activation marker, correlated with IFNγ expression in naive CTLs. Our findings establish a link between elevated IFNγ production and enhanced CTL cytotoxicity, implicating CRTAM as a potential regulator of early CTL activation and IFNγ induction. These insights provide a foundation for optimizing T cell-based immunotherapies against infections and cancers. Full article
(This article belongs to the Section Molecular Immunology)
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18 pages, 246 KiB  
Article
Defiance (2008) and the Cultural Memory of Resistance in the Holocaust
by William Stewart Skiles
Religions 2025, 16(7), 936; https://doi.org/10.3390/rel16070936 - 19 Jul 2025
Viewed by 311
Abstract
The film Defiance (2008) explores the true story of the Bielski Partisans in the Second World War, led by the brothers Tuvia and Zus Bielski. While the film is in many ways a conventional action-packed war story of resistance to Nazi domination during [...] Read more.
The film Defiance (2008) explores the true story of the Bielski Partisans in the Second World War, led by the brothers Tuvia and Zus Bielski. While the film is in many ways a conventional action-packed war story of resistance to Nazi domination during the war, the filmmakers conscientiously depicted the myriad and sundry ways Jews resisted Nazi racial hatred and the attempted extermination of European Jewry. The Bielski partisans are portrayed as violently opposing the Nazi domination and their Belorussian supporters in armed conflict; as engaging in acts of sabotage and destruction to hamper the Axis war effort; as preserving and engaging in Jewish culture and religion to ensure its propagation, even in the most extreme of circumstances; and as continually struggling for survival against Nazi efforts to murder them. Their struggle for freedom from oppression inspires these acts of resistance. Furthermore, the filmmakers explore the theological problem of understanding the Jews as God’s chosen people as they fight for their lives against Nazi policies of extermination. Full article
(This article belongs to the Special Issue Post-Holocaust Theologies of Jews and Judaism)
23 pages, 10100 KiB  
Article
Vestiges of the Sedimentary Archive of Late Paleolithic Inhumations from San Teodoro Cave: Insights into ST3 Burial and Site Stratigraphy
by Vittorio Garilli and Luca Galletti
Heritage 2025, 8(7), 285; https://doi.org/10.3390/heritage8070285 - 17 Jul 2025
Viewed by 285
Abstract
Studies of prehistoric burials are fundamental for understanding cultural human evolution. Those found in the San Teodoro cave (northeastern Sicily) are significant for the discovery at the turn of the 1930s and 1940s of at least four individuals (ST1–ST4). About 15–16 kyr ago, [...] Read more.
Studies of prehistoric burials are fundamental for understanding cultural human evolution. Those found in the San Teodoro cave (northeastern Sicily) are significant for the discovery at the turn of the 1930s and 1940s of at least four individuals (ST1–ST4). About 15–16 kyr ago, the bodies of ST1–ST4 were intentionally buried, apparently in a manner original to the context of prehistoric burials, namely by covering them with a continuous layer of red ochre found to connect the graves. Since the earliest excavations, plagued by clandestine digging, there is no material memory of the stratigraphic transition from the burial layer to the subsequent anthropogenic deposit through the red ochre, and nothing certain is known about the orientation of ST3, the presence of grave goods and the ochre cover related to this burial. Moreover, there is no exhaustive knowledge of how much is actually left of the anthropogenic layers described in the old literature. Based on field observations and 3D reconstruction of ST3’s skull position and deposits at the San Teodoro site, we provide insights into anthropological issues, such as the rediscovery of the red ochre vestiges that reasonably covered the ST3 burial, and the burial context of this individual, and shed light on what actually remains of the stratigraphic units described in the 1940s. Full article
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