Search Results (148)

Posttraumatic Stress Disorder (PTSD) is characterized by disruptions in central nervous system functioning and existential crises, yet the mechanistic links between neurobiological processes and dimensions of life meaning and identity remain underexplored. The aim of this study was to examine the relationships between stress biomarkers (serotonin, cortisol, noradrenaline, and interleukin-12 [IL-12]) and existential attitudes (measured using the Life Attitude Profile (Revised) [LAP-R]) in mining rescuers, considering PTSD duration and participant age. This cross-sectional study included 92 men aged 18–50 years, divided into three groups: no PTSD (n = 28), PTSD ≤ 5 years (n = 33), and PTSD > 5 years (n = 31). Serum levels of four biomarkers and LAP-R scores across eight domains were evaluated. Statistical analyses employed nonparametric tests, including the Kruskal–Wallis test for overall group differences (with Wilcoxon r effect sizes for pairwise comparisons, Mann–Whitney U tests for post hoc pairwise comparisons, and Spearman’s rank correlations for biomarker–LAP-R associations. Age effects were assessed in two strata: 18–35 years and 36–50 years. Kruskal–Wallis tests revealed significant group differences (p < 0.001) for all biomarkers and most LAP-R domains, with very large effect sizes (r > 0.7) in pairwise comparisons for serotonin (control median: 225.2 ng/mL vs. PTSD ≤ 5y: 109.9 ng/mL, r = 0.86; vs. PTSD > 5y: 148.0 ng/mL, r = 0.86), IL-12 (control: ~8.0 pg/mL vs. PTSD ≤ 5y: 62.4 pg/mL, r = 0.86; vs. PTSD > 5y: ~21.0 pg/mL, r = 0.69), and LAP-R scales such as Life Purpose (control: 54.0 vs. PTSD ≤ 5y: 39.0, r = 0.78; vs. PTSD > 5y: 20.0, r = 0.86) and Coherence (control: 53.0 vs. PTSD ≤ 5y: 34.0, r = 0.85; vs. PTSD > 5y: 23.0, r = 0.86). The PTSD ≤ 5y group exhibited decreased serotonin, cortisol (median: 9.8 µg/dL), and noradrenaline (271.7 pg/mL) with elevated IL-12 (all p < 0.001 vs. control), alongside reduced LAP-R scores. The PTSD > 5y group showed elevated cortisol (median: ~50.0 µg/dL, p < 0.001 vs. control, r = 0.86) and normalized IL-12 but persistent LAP-R deficits. Older participants (36–50 years) in the PTSD ≤ 5y group displayed improved existential attitudes (e.g., Life Purpose: 47.0 vs. 27.5 in 18–35 years, p < 0.001), whereas in PTSD > 5y, age exacerbated biological stress (cortisol: 57.6 µg/dL vs. 36.1 µg/dL, p = 0.003). Spearman correlations revealed stage-specific patterns, such as negative associations between cortisol and Death Acceptance in PTSD > 5y (ρ = −0.49, p = 0.005). PTSD alters biomarker levels and their associations with existential dimensions, with duration and age modulating patient profiles. These findings underscore the necessity for integrated therapies addressing both biological and existential facets of PTSD. Full article

The deployment of conditionally automated vehicles raises safety concerns, as drivers often engage in non-driving-related tasks (NDRTs), delaying takeover responses. This study investigates driver state monitoring (DSM) using multimodal physiological and ocular signals from the TD2D (Takeover during Distracted L2 Automated Driving) dataset, which includes synchronized electrocardiogram (ECG), photoplethysmography (PPG), electrodermal activity (EDA), and eye-tracking data from 50 participants across ten task conditions. Tasks were reassigned into three workload-based categories informed by NASA-TLX ratings. A unified preprocessing and feature extraction pipeline was applied, and 25 informative features were selected. Random Forest outperformed Support Vector Machine and Multilayer Perceptron models, achieving 0.96 accuracy in within-subject evaluation and 0.69 in cross-subject evaluation with subject-disjoint splits. Sensitivity analysis showed that temporal overlap had a stronger effect than window length, with moderately long windows (5–8 s) and partial overlap providing the most robust generalization. SHAP (Shapley Additive Explanations) analysis confirmed ocular features as the dominant discriminators, while EDA contributed complementary robustness. Additional validation across age strata confirmed stable performance beyond the training cohort. Overall, the results highlight the effectiveness of physiological and ocular measures for distraction detection in automated driving and the need for strategies to further improve cross-driver robustness. Full article

Background: Anaemia remains a widespread global public health concern. According to previous research reports, the prevalence rate of anaemia among Chinese adults is lacking. Additionally, the association between anaemia and four common anthropometric indices remains unclear. This study aimed to estimate the prevalence of anaemia and its association with anthropometric indices. Methods: The data was from a large, cross-sectional, nationally representative survey which was conducted from August 2018 to June 2019. A total of 190,236 individuals aged 18 years or old were invited, and 159,468 participants with complete data were included in this study. Anaemia was defined as the decrease in adjusted haemoglobin concentrations, <120 g/L for non-pregnant females and <130 g/L for males. Crude and weighted prevalence of anaemia in the overall population and different strata of Chinese adults were calculated. Weighted logistic regression and restricted cubic spline (RCS) were used to evaluate the association between anaemia and four anthropometric indices, including body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and body roundness index (BRI). Results: In China, the weighted anaemia prevalence was 9% (95% CI: 8.5–9.6%), 4.9% (95% CI: 4.4–5.4%), and 13.2% (95% CI: 12.4–13.9%) for the overall population, males, and females, respectively. The weighted prevalence of anaemia was higher among females, rural residents, southwestern residents, and individuals with primary-school-level or lower education than others. The prevalence was highest among young females (14.4%, 95% CI, 13.3–15.5%) and older males (11.8%, 95% CI, 12.4–14.3%). In the fully adjusted logistic regression model, per SD increase in BMI (OR = 0.96, 95% CI: 0.95–0.97), WC (OR = 0.99, 95% CI: 0.98–0.99), WHtR (OR = 0.15, 95% CI: 0.07–0.32), and BRI (OR = 0.90, 95% CI: 0.87–0.94) were associated with a decreased risk of anaemia. Furthermore, the RCS curves depicted L-shaped relationships between the study variables and anaemia (all p for nonlinear <0.05). Conclusions: The prevalence of anaemia among Chinese adults, especially among young females and underweight older adults, remained unexpectedly high. More attention should be paid to these populations. Full article

Suicide in Japan remains elevated and uneven across regions. We hypothesized that (H1) unemployment and (H2) living alone each increase suicide mortality, and that (H3) their combination yields more-than-additive risk, especially among middle-aged men. Using specially tabulated mortality data (2018–2022) from the Japan Suicide Countermeasures Promotion Center, we cross-classified deaths and denominators into 24 strata by sex, age (20–39, 40–59, ≥60), employment (employed/unemployed), and cohabitation (with others/alone). Five-year average rates per 100,000 were computed; between-group differences were tested with chi-square (Holm-adjusted contrasts). Additive interaction between unemployment and living alone was quantified with the Interaction Contrast (ICR) and Synergy Index (SI), and Akita rates were benchmarked against national strata. Prefecture-level quantification and national benchmarking are rarely reported in Japan. Rates differed significantly across employment-by-cohabitation groups in every sex-by-age stratum (p < 0.001). Unemployment and living alone each elevated risk, with the highest rate reported among unemployed men aged 40–59 who were living alone (317.1; >14× employed, cohabiting peers at 22.1). Additive interaction was strongest in men aged 40–59 (ICR = 198.3; SI = 3.05) and present in men aged 20–39 and ≥60; among women, interaction was most evident at the ages of 40–59 and sub-additive at ≥60. Compounded effects among men were consistently larger in Akita than nationally, whereas the largest absolute burden fell on unemployed men aged ≥60 who were living with others (203 deaths). The novelty of this investigation lies in quantifying additive interaction with national benchmarking and contrasting per capita risk with absolute burden to guide dual-track prevention. The findings are ecological. Full article

Background/Objectives: Acute respiratory infections (ARIs) remain a leading cause of morbidity and mortality in children under five in low- and middle-income countries. This study aimed to estimate the prevalence of caregiver-reported ARI symptoms and identify independent risk factors among Peruvian children under five using a nationally representative survey. Methods: We conducted an analytical cross-sectional study using the 2022 Demographic and Family Health Survey (ENDES) of Peru. Children under five with complete data were included. ARI symptoms were defined from the standardized DHS/ENDES question asking whether the child had a cough in the preceding two weeks. Analyses accounted for the complex survey design (weights, strata, primary sampling units). Associations were evaluated using modified Poisson regression with robust standard errors to estimate prevalence ratios (PRs) and 95% confidence intervals (CIs). Results: Among 6299 children under five, the prevalence of caregiver-reported ARI symptoms was 38.5%. After multivariable adjustment, male sex (adjusted PR: 1.07; 95% CI: 1.00–1.14; p = 0.04) and age 1 to <3 years (adjusted PR: 1.18; 95% CI: 1.09–1.27; p < 0.001) and 3 to <5 years (adjusted PR: 1.14; 95% CI: 1.05–1.24; p = 0.001) were associated with higher prevalence compared with infants <1 year. Wealth quintile, maternal education, and low birth weight were not independently associated with ARI symptoms. Conclusions: Caregiver-reported ARI symptoms remain highly prevalent among Peruvian children under five. Sex- and age-specific differences highlight the need for context-sensitive prevention, caregiver education, and efficient resource allocation within nationally representative, survey-informed child-health strategies. Full article

Artificial ground freezing (AGF), recognized for its environmental sustainability and safety, is commonly used in underground construction projects within water-saturated soils. This study presents the design scheme and monitoring results of an AGF reinforcement project for a cross passage located in strata with low seepage velocity on Hohhot Metro Line 2. A transient heat transfer model, based on the assumption of no seepage, was developed, incorporating phase transitions and nonlinear changes in thermal parameters. In the model, soil thermal parameters are treated as variables dependent on unfrozen water content, which is represented by the soil freezing characteristic curve (SFCC). To derive the SFCC expressions, a semi-empirical approach was employed. This approach avoids the complexity of obtaining SFCCs experimentally and mitigates the arbitrariness inherent in the commonly used traditional apparent heat capacity method. The model was subsequently validated using experimental data from the literature and field monitoring results. The development and key indicators, including the thickness and average temperature of the frozen curtain in a single stratum without seepage, were investigated. The results show that the central and slightly right areas of the cross-passage axis exhibit a thinner frozen curtain and higher average temperature, especially in the pump room area, where the effective thickness of the curtain is at its minimum. Therefore, it is recommended to closely monitor the development of the frozen curtain in these areas and optimize the layout of freezing pipes. This study may serve as a reference for similar projects. Full article

This study addresses gas drainage challenges in the Pingdingshan NO.10 mine JI_15-16 coal seam through coupled COMSOL-FLAC^3D numerical simulations. The research evaluates the effectiveness of a cross-measure borehole drainage system. It analyzes the failure mechanisms of the surrounding rock in both the machine roadway and floor roadway of the 24130 working face under the influence of boreholes. The results demonstrate that extended drainage duration progressively reduces both gas content and pressure within the borehole-affected zone of the coal seam while enhancing the effective permeability of the JI_15-16 coal stratum. The operational system extracted 1,527,357 m³ of methane, achieving a pre-drainage efficiency of 59.18% through cross-measure boreholes. The measured gas content aligns with simulated predictions, though field-recorded gas pressure registered slightly higher than modeled values. This validated drainage design complies with the Pingmei Group’s regulations for coal and gas outburst prevention. Critically, cross-measure boreholes alter stress distribution around both coal and floor roadways, promoting plastic zone expansion. Consequently, during the development of the 24130 working face’s machine roadway, intensified ground pressure monitoring is essential near borehole locations in the roof, floor, and rib strata. Supplementary support reinforcement should be implemented when required to prevent rib spalling and roof collapse incidents. Full article

Background and Objectives: Although survival after congenital cardiac malformations (CCM) has improved, little is known about Romanian children’s own perceptions of health-related quality of life (HRQoL) or their emotional burden. We compared HRQoL, depressive symptoms, and anxiety across lesion severity strata and explored clinical predictors of impaired HRQoL. Methods: In this cross-sectional study (1 May 2023–30 April 2025), 72 children (mean age 7.9 ± 3.0 years, 52.8% male) attending a tertiary cardiology clinic completed the Romanian-validated Pediatric Quality of Life Inventory (PedsQL), Children’s Depression Inventory (CDI) and the Screen for Child Anxiety-Related Emotional Disorders questionnaire (SCARED-C, child version). Lesions were classified as mild (n = 22), moderate (n = 34), or severe (n = 16). Left-ventricular ejection fraction (LVEF) and unplanned cardiac hospitalisations over the preceding 12 months were extracted from electronic records. Results: Mean PedsQL total scores declined stepwise by severity (mild 80.9 ± 7.3; moderate 71.2 ± 8.4; severe 63.1 ± 5.4; p < 0.001). CDI and SCARED-C scores rose correspondingly (CDI: 9.5 ± 3.0, 13.6 ± 4.0, 18.0 ± 2.7; anxiety: 15.2 ± 3.3, 17.2 ± 3.8, 24.0 ± 3.4; both p < 0.001). PedsQL correlated positively with LVEF (r = 0.51, p < 0.001) and negatively with hospitalisations (r = −0.39, p = 0.001), depression (r = −0.44, p < 0.001), and anxiety (r = −0.47, p < 0.001). In multivariable analysis, anatomical severity remained the sole independent predictor of lower HRQoL (β = −8.4 points per severity tier, p < 0.001; model R² = 0.45). Children with ≥ 1 hospitalisation (n = 42) reported poorer HRQoL (69.6 ± 8.0 vs. 76.1 ± 11.1; p = 0.005) and higher depressive scores (p < 0.001). Conclusions: HRQoL and internalising symptoms in Romanian children with CCM worsen with increasing anatomical complexity and recent hospital utilisation. The severity tier outweighed functional markers as the main determinant of HRQoL, suggesting that psychosocial screening and support should be scaled to lesion complexity. Integrating the routine use of the Romanian-validated PedsQL, CDI, and SCARED-C questionnaire into cardiology follow-up may help identify vulnerable patients early and guide targeted interventions. Full article

Introduction: The sodium-to-potassium (Na:K) ratio in the diet is a critical biomarker for cardiovascular and metabolic health, yet global adherence to recommended levels remains poor. Objectives: The objective of this study was to identify dietary determinants of the dietary Na:K ratio and its associations with micronutrient intake and diet quality. Methods: An observational cross-sectional survey was conducted in a representative sample of manufacturing workers through a combined stratified proportional and two-stage probability sampling plan, with strata defined by company size and industrial sector from the state of Rio Grande do Norte, Brazil. Dietary intake was assessed using 24 h recalls via the Multiple Pass Method, with Na:K ratios calculated from quantified food composition data. Diet quality was assessed with the Diet Quality Index-International (DQI-I). Multiple linear regression was used to analyze associations of Na:K ratio with the study variables. Results: The survey was conducted in the state of Rio Grande do Norte, Brazil, in 921 randomly selected manufacturing workers. The sample mean age was 38.2 ± 10.7 years, 55.9% males, mean BMI 27.2 ± 4.80 kg/m². The mean Na:K ratio was 1.97 ± 0.86, with only 0.54% of participants meeting the WHO recommended target (<0.57). Fast food (+3.29 mg/mg per serving, p < 0.001), rice, bread, and red meat significantly increased the ratio, while fruits (−0.16 mg/mg), dairy, white meat, and coffee were protective. Higher Na:K ratios were associated with lower intake of calcium, magnesium, phosphorus, and vitamins C, D, and E, as well as poorer diet quality (DQI-I score: −0.026 per 1 mg/mg increase, p < 0.001). Conclusions: These findings highlight the critical role of processed foods in elevating Na:K ratios and the potential for dietary modifications to improve both electrolyte balance and micronutrient adequacy in industrial workers. The study underscores the need for workplace interventions that simultaneously address sodium reduction, potassium enhancement, and overall diet quality improvement tailored to socioeconomic and cultural contexts, a triple approach not previously tested in intervention studies. Future studies should further investigate nutritional consequences of imbalanced Na:K intake. Full article

Red sandstones of the Cambrian age are globally distributed and represent an important sedimentation phase during this critical time interval. Their sedimentology and geochemistry can provide key information about the sedimentation style, paleoclimatic conditions, and weathering trends during the Cambrian. In the Salt Range of Pakistan, the Khewra Sandstone constitutes the Lower Cambrian strata and consists of red–maroon sandstones with minor siltstone and shale in the basal part. Cross-bedding, graded bedding, ripple marks, parallel laminations, load casts, ball and pillows, desiccation cracks, and bioturbation are the common sedimentary features of the formation. The sandstones are fine to medium to coarse-grained with subangular to subrounded morphology and display an overall coarsening upward trend. Petrographic analysis indicates that the sandstones are sub-arkose and sub-lithic arenites, and dolomite and calcite are common cementing materials. X-ray Diffraction (XRD) analysis indicates that the main minerals in the formation are quartz, feldspars, kaolinite, illite, mica, hematite, dolomite, and calcite. Geochemical analysis indicates that SiO₂ is the major component at a range of 53.3 to 88% (averaging 70.4%), Al₂O₃ ranges from 3.1 to 19.2% (averaging 9.2%), CaO ranges from 0.4 to 25.3% (averaging 7.4%), K₂O ranges from 1.2 to 7.4% (averaging 4.8%), MgO ranges from 0.2 to 7.4% (averaging 3.5%), and Na₂O ranges from 0.1 to 0.9% (averaging 0.4%), respectively. The results of the combined proxies indicate that the sedimentation occurred in fluvial–deltaic settings under overall arid to semi-arid paleoclimatic conditions with poor to moderate chemical weathering. The Khewra Sandstone represents the red Cambrian sandstones on the NW Indian Plate margin of Gondwana and can be correlated with contemporaneous red sandstones in the USA, Europe, Africa, Iran, and Turkey (Türkiye). Full article

The formation of acidic goaf water in abandoned coal mines poses significant environmental threats, especially in karst regions where the risk of groundwater contamination is heightened. This study investigates the geochemical processes responsible for the generation of acidic water through batch and column leaching experiments using coal mine surrounding rocks (CMSR) from Yangquan, China. The coal-bearing strata, primarily composed of sandstone, mudstone, shale, and limestone, contain high concentrations of pyrite (up to 12.26 wt%), which oxidizes to produce sulfuric acid, leading to a drastic reduction in pH (approximately 2.5) and the mobilization of toxic elements. The CMSR samples exhibit elevated levels of arsenic (11.0 mg/kg to 18.1 mg/kg), lead (69.5 mg/kg to 113.5 mg/kg), and cadmium (0.6 mg/kg to 2.6 mg/kg), all of which exceed natural crustal averages and present significant contamination risks. The fluorine content varies widely (106.1 mg/kg to 1885 mg/kg), with the highest concentrations found in sandstone. Sequential extraction analyses indicate that over 80% of fluorine is bound in residual phases, which limits its immediate release but poses long-term leaching hazards. The leaching experiments reveal a three-stage release mechanism: first, the initial oxidation of sulfides rapidly lowers the pH (to between 2.35 and 2.80), dissolving heavy metals and fluorides; second, slower weathering of aluminosilicates and adsorption by iron and aluminum hydroxides reduce the concentrations of dissolved elements; and third, concentrations stabilize as adsorption and slow silicate weathering regulate the long-term release of contaminants. The resulting acidic goaf water contains extremely high levels of metals (with aluminum at 191.4 mg/L and iron at 412.0 mg/L), which severely threaten groundwater, particularly in karst areas where rapid cross-layer contamination can occur. These findings provide crucial insights into the processes that drive the acidity of goaf water and the release of contaminants, which can aid in the development of effective mitigation strategies for abandoned mines. Targeted management is essential to safeguard water resources and ecological health in regions affected by mining activities. Full article

Taking the shield construction of Xiamen Metro Line 2 tunnel side-crossing the Tianzhushan overpass and under-crossing the Shen-Hai Expressway as the engineering background, FLAC3D 6.0 software was used to examine the deformation of adjacent structures based on shield construction parameters in upper-soft and lower-hard strata. The reliability of the numerical simulation results was verified by comparing measured and predicted deformations. The study results indicate that deformation of the pile will occur during the construction of the tunnel shield next to the pile foundation. The shape of the pile deformation curve in the horizontal direction is significantly influenced by the distance from the pile foundation to the adjacent tunnel’s centerline, as well as by soil bin pressure, grouting layer thickness, and stress release coefficient. During the tunnel shield construction beneath the expressway, increasing the soil bin pressure, the grouting layer thickness, and reducing the stress release coefficient can effectively minimize surface deformation and differential settlement on both sides of the deformation joints between the bridge and the roadbed. The practice shows that, by optimizing shield construction parameters in upper-soft and lower-hard strata, the deformation of nearby bridges and pavements can be kept within allowable limits. This is significant for reducing construction time and costs. The findings offer useful references for similar projects. Full article

Rock slopes exhibiting anti-inclined interbedded strata have widespread distribution and complex deformation mechanisms. In this study, we used a physical model test with basal friction to replicate the evolution process of the slope deformation. Digital Image Correlation (DIC) and Particle Image Velocimetry (PIV) methods were used to capture the variation in slope velocity and displacement fields. The results show that the slope deformation is conducted by bending of soft rock layers and accumulated overturning of hard blocks along numerous cross joints. As the faces of the rock columns come back into contact, the motion of the slope can progressively stabilize. Destruction of the toe blocks triggers the formation of the landslides within the toppling zone. The toppling fracture zones form by tracing tensile fractures within soft rocks and cross joints within hard rocks, ultimately transforming into a failure surface which is located above the hinge surface of the toppling motion. The evolution of the slope deformation mainly undergoes four stages: the initial shearing, the free rotation, the creep, and the progressive failure stages. Full article

Settlement analyses of foundation soils are very important for the investigation, design, and construction of buildings. However, due to complex natural sedimentary processes, soil-forming environments, and geological tectonic stress histories, settlement properties show obvious spatial variability and autocorrelation. Moreover, measurement data on the physical and mechanical parameters of building foundation soils are limited. This limits the accuracy of formation stability analyses and safety evaluations. In this study, a series of field tests of building foundation soils were carried out, and the statistical physical and mechanical properties of the clay strata were obtained. A random field method and copula functions of uncertain geotechnical properties with limited survey data are proposed. A dual-yield surface constitutive model of the soil properties and a stability analysis method for uncertain deformation were developed. The detailed analytical procedures for soil deformation and stratum settlement are presented. The reliability functions and failure probabilities of variable settlement processes are calculated and analyzed. The impact of the spatial variation and cross-correlation of geotechnical properties on the probabilistic stability of variable land subsidence is discussed. This work presents an innovative analysis approach for evaluating the variable settlement properties of building foundation soils. The results show that the four different mechanical parameters can be regressed to linear equations. The horizontal fluctuation scale is significantly larger than the vertical scale. Copula theory provides a powerful framework for modeling limited geotechnical parameters. The bootstrap approach avoids parametric assumptions, leveraging empirical data to enhance the reliability analysis of variable settlement. The variability parameter exerts a greater influence on land subsidence processes than the correlation structure. The failure probabilities of variable stratum settlement for different cross-correlations of building foundation soils are different. These results provide an important reference for the safety of building engineering. Full article

This study examines the determinant factors of women’s empowerment in Chepén, Peru, during 2024, analyzing how socioeconomic status potentially moderates this relationship. Using a quantitative approach with a non-experimental, cross-sectional design, the research surveyed 367 women aged 22–52 years through digital questionnaires employing validated scales. The results revealed that both internal factors (individual and collective psychological competencies) and external factors (economic and cultural conditions) significantly influence female empowerment (β = 0.57, p = 0.049 and β = 0.87, p = 0.039, respectively). Contrary to our hypothesis, socioeconomic status did not significantly moderate these relationships (internal factors × socioeconomic level: β = 0.02, p = 0.323; external factors × socioeconomic level: β = −0.02, p = 0.584). The models demonstrated strong explanatory power, with internal factors explaining 84.3% and external factors explaining 58.5% of the variance in women’s empowerment. The study found moderate levels of autonomy and decision-making (44.8%) and cultural dimensions (43.3%). While 76.1% of participants had higher education, 41.8% earned below PEN 1500, highlighting a significant education–income gap. These findings suggest that psychological competencies and sociocultural environment enhancement are more critical than initial economic conditions for promoting women’s empowerment across all socioeconomic strata. The study recommends implementing targeted public policies to improve cultural and economic conditions, establish flexible educational programs, and promote dignified employment opportunities that recognize women’s capabilities regardless of socioeconomic background. Full article