Search Results (43)

Antimicrobial resistance (AMR) poses a critical global health threat by rendering existing antibiotics ineffective against infections, leading to increased mortality, prolonged illnesses, and higher healthcare costs. Developing new antibiotics is essential to combat resistant pathogens, safeguard modern medical procedures, and prevent a return to a pre-antibiotic era where common infections become untreatable. We report a series of chiral tricarbonyl rhenium(I) complexes incorporating enantiopure pinene-substituted bipyridine ligands (L#) of the general formula fac-[Re(CO)₃L#X] and fac-[Re(CO)₃L#Py]⁺ (where X = Cl or Br and Py = pyridine). These complexes were isolated as mixtures of two diastereomers, characterized by standard techniques, and evaluated for cytotoxic activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus (MRSA and MSSA). The results revealed notable antibacterial efficacy (MIC = 1.6 μM), reflected in high therapeutic indices (Ti > 10). In contrast, analogous complexes bearing non-chiral 2,2′-bipyridine ligands exhibited no activity, underscoring the critical role of chirality in modulating biological interactions at the molecular level. These findings highlight the potential of chiral Re(I) complexes as promising scaffolds for the development of more potent and selective antibacterial agents. Full article

Background/Objectives: This article addresses an exploratory design study in the framework of the REMIND research study, which is focused on the importance of cultural and biographical components for the cognitive and sensory stimulation of persons with dementia. Through a case study conducted at a Day Centre from the Alzheimer Portugal association, it aims to demonstrate the relevance of including cultural elements in sensory stimulation artefacts for persons with dementia. It is hypothesised that the inclusion of cultural elements central to the biographical stories of these persons will have greater potential to stimulate their senses and reminiscences. In the context of this study, this hypothesis was explored through textile artefacts. Methods: Methods included participant observation, sensory and visual ethnography, interviews, focus groups, and a participatory design approach involving women with moderate and advanced Alzheimer’s disease and health professionals. Due to the severely compromised verbal communication abilities of some of the women, beyond-verbal communication strategies were adopted. Results: The results showed that textiles with a cultural presence tended to elicit greater reactions and reminiscences of events associated with the women’s life stories. Crochet artefacts were of particular relevance: women’s involvement in activities with crochet artefacts was substantially higher and, in certain cases of women with moderate dementia, these artefacts activated positive memories of the person, suggesting the potential of crochet for sensory stimulation. Conclusions: The results support the hypothesis; however, further research exploring other cultural elements and involving a broader demographic is needed. Based on the results obtained, a sensory blanket was developed, which is already in use at the Centre. Full article

Hyphantria cunea is a widespread pest that causes significant issues in forestry and agriculture, with a far-reaching global impact. However, ultramorphological studies of H. cunea, especially in terms of ultramorphological changes, are far from in-depth. Therefore, we investigated the ultrastructure of its eggs, larvae, and pupae using scanning electron microscopy, focusing on ultrastructural changes in larvae across different instars. The eggs have rough surfaces, and the micropylar region consists of rosette cells. The larval head chaetotaxy is symmetrically arranged, and there are three types of sensilla on the antennae and mouthparts. The abdominal and anal prolegs feature a uniordinal heteroideus midband of crochets. The pupal abdomen has ten segments; in females, the genital slit (Fgs) is located at the anterior edge of abdominal segment VIII, while in males, the genital slit (Mgs) is situated in the middle of abdominal segment IX. First-instar larvae exhibit only primary setae, and secondary setae emerge in the second instar. As the larvae mature, the head, thoracic legs, and abdominal and anal prolegs all become larger overall. The surface of the verrucae is initially smooth, with microtrichia appearing from the fourth instar onwards, and the setae on the verrucae gradually increase in size. These findings provide additional features for larval species identification and contribute to the morphological study of H. cunea. Full article

Environmental awareness has led industries and consumers to replace products derived from oil resources with products derived from natural sources. In the case of the composite materials industry, the replacement of synthetic fibres with natural fibres has increased in recent years. To study the influence that different types of natural fibres and different textile manufacturing techniques have on the mechanical properties of composites, bio-based epoxy matrix composites reinforced with different natural animal fibres were produced, some reinforced with sheep’s wool and others with dog wool, which were later subjected to bending and tensile tests. From the authors’ knowledge, there are few studies of composites produced with animal fibres, and even fewer with dog hair. The textile structures used as reinforcement were created using crochet, knitting, and weaving techniques. Prior to the composites production, the fibres were characterized by X-ray Diffraction (X-RD), and the yarns produced from these fibres were subjected to tensile tests. The results obtained suggest that the number of yarns and the diameter of the needles used during the production of the reinforcement have a significant impact on the mechanical properties of the composites. The green epoxy resin composites reinforced with sheep’s wool exhibit higher values of flexural strength, tensile strength, and Young’s modulus than those reinforced with dog wool, with average increases of 36.97%, 45.16%, and 72.99%, respectively. It was also possible to verify that the composites reinforced with woven fabrics and crocheted fabrics exhibit the highest values of tensile strength, flexural strength, and Young’s modulus. Additionally, the composites reinforced with woven fabrics exhibit the highest values of deformation at first failure/break and toughness. Full article

Traditional costumes and crafts are a basic form and element of local culture and a vital pathway for perpetuating traditional art and design culture. They are an artistic form of historical and cultural significance. This paper focuses on three traditional costumes from Malta, Ireland, and Finland. The għonnella, worn by Maltese women of different social classes, consisted of a voluminous cape-like covering reinforced with whalebone and cardboard and was worn over the head and shoulders, reaching ankle length. Irish costumes were adorned with beautiful Irish lace, crochet, and embroidery. Celtic embroidery was added to clothing to develop a distinctive Irish dress style during the great cultural revival of the early 20th century. The Karelian costume from Finland was constructed using wool and linen. Ladies in Karelia wore handcrafted, highly embroidered gowns, and traditions were passed down from older ladies, including mothers and grandmothers. These costumes were collected in the late nineteenth and early twentieth centuries when Finnish Karelia was known as ‘The Old Finland’. This paper delves into the origins of these costumes and how social and cultural events, with their intriguing influence, shaped their styles, features, colors, and fabrics. Full article

Vaginal agenesis (VA) is frequently associated with mullerian agenesis. VA treatments include mechanical dilation and surgical vaginoplasty. We created a vaginal expansion sleeve (VES) as a novel device to progressively lengthen the vaginal canal. This study evaluated the histologic effects of the VES on rat vaginal tissue. The VES is a spring-like device made of proprietary woven cylindrical material and flat resin caps. The VESs were constructed as 25–30 mm, pre-contracted springs, which were secured into the vaginas of six Sprague Dawley rats and allowed to re-expand post-surgically. After one week, the VESs were removed, and the vaginas were harvested and measured in length. Test (n = 6) and control (n = 4) formalin-fixed paraffin-embedded tissues were stained with hematoxylin and eosin (H&E), Masson’s trichrome, and anti-Desmin antibodies. The VESs achieved significant vaginal lengthening. The mean vaginal canal length increased from 20.0 ± 2.4 mm to 23.8 ± 1.2 mm after removal of the VESs (n = 6, p < 0.001), a 19% increase. There was a positive correlation between the expander/tension generated in the vagina and the amount of acute and chronic inflammation. H&E staining revealed increased submucosal eosinophilia in five of the six test tissues. One VES sample that was lengthened to 30 mm long showed evidence of lymphocytic and neutrophilic inflammation. Desmin immunostaining and Masson’s trichrome stain revealed a thinner muscularis with more infiltrative fibrous tissue between muscle fibers in the test tissue compared to the control tissue. Although effective, the VES may provoke at least a transient increase in eosinophils consistent with a localized immune reaction during muscularis remodeling. Full article

Pyrene derivatives are regularly proposed for use in biochemistry as dyes due to their photochemical characteristics. Their antibacterial properties are, however, much less well understood. New complexes based on 4-[(E)-2-(1-pyrenyl)vinyl]pyridine (PyPe) have been synthesized with metal ions that are known to possess antimicrobial properties, such as zinc(II), cadmium(II), and mercury(II). The metal ion salts, free ligand, combinations thereof, and the coordination compounds themselves were tested for their antibacterial properties through microdilution assays. We found that the ligand is able to modulate the antibacterial properties of transition metal ions, depending on the complex stability, the distance between the ligand and the metal ions, and the metal ions themselves. The coordination by the ligand weakened the antibacterial properties of heavy metal ions (Cd(II), Hg(II), Bi(III)), allowing the bacteria to survive higher concentrations thereof. Mixing the ligand and the metal ion salts without forming the complex beforehand enhanced the antibacterial properties of the cations. Being non-cytotoxic itself, the ligand therefore balances the biological consequences of heavy metal ions between toxicity and therapeutic weapons, depending on its use as a coordinating ligand or simple adjuvant. Full article

Background: Real-world data (RWD) related to the health status and care of cancer patients reflect the ongoing medical practice, and their analysis yields essential real-world evidence. Advanced information technologies are vital for their collection, qualification, and reuse in research projects. Methods: UNICANCER, the French federation of comprehensive cancer centres, has innovated a unique research network: Consore. This potent federated tool enables the analysis of data from millions of cancer patients across eleven French hospitals. Results: Currently operational within eleven French cancer centres, Consore employs natural language processing to structure the therapeutic management data of approximately 1.3 million cancer patients. These data originate from their electronic medical records, encompassing about 65 million medical records. Thanks to the structured data, which are harmonized within a common data model, and its federated search tool, Consore can create patient cohorts based on patient or tumor characteristics, and treatment modalities. This ability to derive larger cohorts is particularly attractive when studying rare cancers. Conclusions: Consore serves as a tremendous data mining instrument that propels French cancer centres into the big data era. With its federated technical architecture and unique shared data model, Consore facilitates compliance with regulations and acceleration of cancer research projects. Full article

In Denmark, heightened public interest surrounding migration politics has become embodied in the arts, leading to the development of migration-related arts projects. In this study we explore the experiences of women taking part in an arts-based integration project designed for migrant and Danish women to knit, sew, and crochet in female company, with a view to professionalise their handicrafts. Our findings, which are grounded in ethnographic fieldwork as well as interviews with members of the group, demonstrate how handicraft acts as a prism through which categories such as gender, class, and ethnicity are negotiated within the project. We found that group members’ national and cultural backgrounds shaped their different expectations and experiences in the project. The roles they occupied and their self-perception within the group were also shaped by other factors, such as their family status, their state of employment, and whether handicraft was more of a ‘hobby’ or a source of income. The study makes a case for appreciating the importance of social recognition. Understanding how these women perceived their own and each other’s work becomes a magnifier of the socio-political context in which the integration project is situated. Artistic practice both enabled members to respond to an integration and refugee discourse, while simultaneously positioning them within such frameworks. Full article

Sediments are dredged from waterways to maintain maritime activities and prevent floods. Exorbitant amounts of money are budgeted for the removal of dredged material (DM) and its disposal in landfills. We investigated the potential for reuse of DM as a road construction material using so-called bio-enzyme products as stabilizing agents. To improve the mechanical properties of DM, such as compressive strength, compressibility, Atterberg limits and the California bearing ratio (CBR), mixtures of DM were tested with two different amounts of a commercially available bio-enzyme product, which yielded enzymatically stabilized dredged material (ESDM). Unconfined compressive strength (UCS), compaction and Atterberg limits were measured in accordance with ASTM specifications on all samples. Data show that the addition of bio-enzymes resulted in increases in UCS but did not affect the optimum moisture content (OMC), maximum dry unit weight or Atterberg limits of the DM. A comparative field study was carried out to evaluate the CBR of the CH subgrade before and after treatments with the bio-enzyme product and with lime as a traditional stabilizing agent. The results of the field study supported the laboratory findings. Based on these data and results from the literature, models predicting the effect of bio-enzyme treatments on the value of CBR and of UCS were developed statistically. These models also underlined the importance of the clay fraction and PI values for the improvement of the engineering properties of soil using bio-enzyme additives. Full article

Hospitalization during pregnancy often produces psychosocial distress for pregnant women. In this study, 3D ultrasound and recreational therapy were compared to the standard treatment for their influence on depressive symptoms and anxiety. In this prospective one-year intervention study, women who were admitted to the hospital for any pregnancy complication, other than psychiatric, were included. A control group, with standard clinical treatment, and two intervention groups, both additionally receiving either 3D ultrasound or recreational therapy, were established. Psychological well-being was assessed at defined times by the PHQ-health-questionnaire. A total of 169/211 women were included: control group n = 79, 3D ultrasound group n = 43, and crochet group n = 83. A higher than estimated underlying depression was seen for all women on admission. The intervention groups showed less depression (p = 0.02762). No difference was seen between the intervention groups (p = 0.23029). Anxiety decreased throughout intervention, but not significantly. On admission, all women showed similar results of underlying depression, indicating that hospitalization itself already causes mild psychological stress. Both interventions decreased depressive symptoms. Intervention with either recreational therapy or 3D ultrasound can prevent the development of mild and major depression and decrease anxiety disorders, and therefore has a positive effect on well-being during hospitalization. These results emphasize the need to implement forms of interventions to improve the well-being of women, as this might improve pregnancy and neonatal outcome. Full article

The increasing development and application of wireless devices and systems that radiate electromagnetic waves makes electromagnetic interference (EMI) shielding more and more important in everyday life. In practice, rigid EMI shields are the most commonly used ones. However, for humans or in automotive and aviation applications, flexible, drapable materials, such as textile fabrics, can be more effective and useful. Textile fabrics are usually nonconductive and not magnetic, i.e., they lack the requirements for EMI shielding. However, shielding properties of textile fabrics can be achieved by blending yarns with fine wires or coating fibers or by blending complete textile layers with conductive or magnetic materials. In this paper, shielding textile fabrics and 3D-printed materials, as references with different conductive (and partly also magnetic) properties, are examined. The measurements show a high shielding effectiveness of 80 dB given by densely woven fabrics with a thin metallic coating in the frequency range of 6.5–11 GHz, while large pores in crocheted fabrics significantly reduce the EMI shielding effectiveness, and other samples did not show shielding at all, suggesting that a combination of conductivity and the structure of the samples is responsible for the shielding potential. Full article

Textiles composed of fibers can have their mechanical properties adjusted by changing the arrangement of the fibers, such as strength and flexibility. Particularly, in the case of smart textiles incorporating active materials, various deformations could be created based on fiber patterns that determine the directivity of active materials. In this study, we design a smart fiber-based textile actuator with a chain structure and evaluate its actuation characteristics. Smart fiber composed of shape memory alloy (SMA) generates deformation when the electric current is applied, causing the phase transformation of SMA. We fabricated the smart chain column and evaluated its actuating mechanism based on the size of the chain and the number of rows. In addition, a crochet textile actuator was designed using interlooping smart chains and developed into a soft gripper that can grab objects. With experimental verifications, this study provides an investigation of the relationship between the chain actuator’s deformation, actuating force, actuator temperature, and strain. The results of this study are expected to be relevant to textile applications, wearable devices, and other technical fields that require coordination with the human body. Additionally, it is expected that it can be utilized to configure a system capable of flexible operation by combining rigid elements such as batteries and sensors with textiles. Full article

Cancer remains one of the leading causes of death worldwide. The interest in organometallic complexes as anticancer drug candidates continues to be pivotal for many researchers. Initially underestimated for their therapeutic potentials, rhenium complexes are now slowly gaining momentum. While tricarbonyl complexes of rhenium are widely investigated, dicarbonyl derivatives of the cis-[Re(CO)₂]⁺ core remain largely unexplored. In this study, we tested in vitro a variety of rhenium dicarbonyl complexes for their activity towards three cancer cell lines (A549, MCF-7 and HCT116) and one healthy cell line (HEK293). The most lipophilic compounds showed, like the tricarbonyl species, good activity against specific cancer lines (IC₅₀ = 1.5–2.5 µM); however, the same were also toxic towards healthy cells. In order to understand these differences, we performed a reactivity study of cis-[Re(CO)₂(NN)]⁺ species (where NN = diimine) with biologically relevant functional groups (-COOH, -NH₂, -SH and aromatic nitrogen-based ligands) and compared the chemistry to what is known for the fac-[Re(CO)₃]⁺ core. Overall, we found that the rhenium dicarbonyl complexes only show good reactivity with aromatic nitrogen-based ligands. The reaction of cis-[Re(CO)₂(NN)]⁺ species with common bio-functional groups leads, rather, to the formation of bis-diimine dicarbonyl complexes (cis-[Re(CO)₂(NN)₂]⁺) as the major by-product. Full article

In the context of the global health issue caused by the growing occurrence of antimicrobial resistance (AMR), the need for novel antimicrobial agents is becoming alarming. Inorganic and organometallic complexes represent a relatively untapped source of antibiotics. Here, we report a computer-aided drug design (CADD) based on a ‘scaffold-hopping’ approach for the synthesis and antibacterial evaluation of fac-Re(I) tricarbonyl complexes bearing clotrimazole (ctz) as a monodentate ligand. The prepared molecules were selected following a pre-screening in silico analysis according to modification of the 2,2′-bipyridine (bpy) ligand in the coordination sphere of the complexes. CADD pointed to chiral 4,5-pinene and 5,6-pinene bipyridine derivatives as the most promising candidates. The corresponding complexes were synthesized, tested toward methicillin-sensitive and -resistant S. aureus strains, and the obtained results evaluated with regard to their binding affinity with a homology model of the S. aureus MurG enzyme. Overall, the title species revealed very similar minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values as those of the reference compound used as the scaffold in our approach. The obtained docking scores advocate the viability of ‘scaffold-hopping’ for de novo design, a potential strategy for more cost- and time-efficient discovery of new antibiotics. Full article