This article evaluates the institutional and constitutional requirements for governing transnational ecological risks and develops a testable design for a World Environmental Governance System (WEGS). Drawing on qualitative normative institutional an...
Although tremendous progress has been made over the past decades in elucidating the mechanisms of keloid formation and developing therapeutic interventions, keloid remains challenging to cure and prone to recurrence. Historically, keloid has been reg...
Agentic AI systems, possessing capabilities for autonomous planning and action, show great potential across diverse domains. However, their practical deployment is hindered by challenges in aligning their behavior with varied human values, complex sa...
Yeasts provide attractive host/vector systems for heterologous gene expression. The currently used yeast-based expression platforms include mesophilic and thermotolerant species. A eukaryotic expression system working at low temperatures could be par...
The accurate modeling of dynamic soil–structure interaction processes under impact loading is critical for advancing the design of soil-embedded barrier systems. Full-scale crash testing remains the benchmark for evaluating barrier performance;...
An overview comparing ordinary and partial differential equations of fractional order, which arose as a new result of the author’s research and mathematical description of the differential constitutive relations of known and new models of fract...
The mechanical response of geomembranes in hydraulic structures is strongly influenced by temperature variations, which alter both material stiffness and interface shear strength behavior. This study develops a non-linear, temperature-dependent tensi...
To probe into the time-dependent behaviour of the ballastless track–bridge structural system under train load, based on the import of the static and fatigue damage constitutive model of materials to simulate damage deterioration of the structur...
In this work, the balance equations of non-equilibrium thermodynamics are coupled to Galilean limit systems of the Maxwell equations, i.e., either to (i) the quasi-electrostatic limit or (ii) the quasi-magnetostatic limit. We explicitly consider a vo...
This paper deals with the issue of the independence of the Prosecutor’s Office of the Slovak Republic as an attribute that allows the Prosecutor’s Office to actually carry out its mission, regardless of the individual interests of the par...
Lactic acid bacteria (LAB) play a very vital role in food production, preservation, and as probiotic agents. Some of these species can colonize and survive longer in the gastrointestinal tract (GIT), where their presence is crucially helpful to promo...
In order to explore the problems of load transfer and anchorage mechanisms of tensile anchors under pull-out load for geotechnical anchoring systems, a step-wise mathematical model is established which considers the linear–nonlinear shear stres...
Reaction control systems (RCSs) provide rapid and effective attitude-control capabilities for high-speed vehicles operating in high-altitude, low-density environments, where conventional aerodynamic control surfaces become inefficient. However, inter...
Artificial intelligence (AI) systems are increasingly transforming criminal investigation by moving beyond the retrieval or matching of existing evidence toward the generation of inferences about identity, conduct, intention, knowledge, and other asp...
Uninfected alligators (Alligator mississippiensis) exhibited high constitutive levels of hepatic gene expression related to immune function, whereas the highest-expressed hepatic genes of uninfected mice were related to metabolism. Intraperitoneal ch...
Since its introduction in the late 1970s, the non-affine or slip parameter,
The deformation behavior and the constitutive description of materials are important in the design and numerical simulation of manufacturing processes. In this work, the rheological behavior of two quenchable boron steels was derived in the range of...
Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind v...
Motivated by the widespread occurrence of directional crystallization in nature, laboratory experiments and industrial facilities, we consider how a two-phase (mushy) region filled simultaneously with liquid and solid material influences the process...
Background: Article 32 of the Italian Constitution guarantees the right to health for all citizens, including detainees. Prison populations face unique health challenges due to high-risk lifestyles, psychosocial stressors, and limited access to care....
Objective: This study identifies specific patterns of exclusion in health insurance policies in India, based on age, gender and pre-existing ailments. Method: For its purposes, extensive primary research was conducted across different levels of the h...
Genetically modified T cells expressing chimeric antigen receptors (CARs) so far have mostly failed in the treatment of solid tumors owing to a number of limitations, including an immunosuppressive tumor microenvironment and insufficient CAR T cell a...
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the mol...
Among other calcium decoders, Ca2+-dependent protein kinases (CDPK) stands out for its ability, depending on calcium levels, to activate key components of the defence system. However, calcium dependence prevents the effective use of CDPKs in comprehe...
25 August 2020
In an effort to elucidate an aspirational vision for the food system and explore whether the characteristics of such a system inadvertently set unattainable standards for low-wealth rural communities, we applied discourse analysis to the following qu...
In this work, it is acknowledged that important attempts to devise an emergent quantum (gravity) theory require space-time to be discretized at the Planck scale. It is therefore conjectured that reality is identical to a sub-quantum dynamics of ontol...
Electroactive bacteria have a wide range of applications, including electricity production, bioremediation, and the sensing of toxic compounds. Bacterial biofilm formation is often mediated by the second messenger cyclic guanosine monophosphate (c-di...
China’s Recording and Review system has emerged as a central mechanism of constitutional supervision and has attracted increasing scholarly attention over the past decade. Although constitutional review has been extensively studied in comparati...
Chronic myeloid leukaemia (CML) is a haematological neoplasm driven by the BCR/ABL fusion oncogene. The monogenic aspect of the disease and the feasibility of ex vivo therapies in haematological disorders make CML an excellent candidate for gene ther...
Acute pancreatitis (AP) an inflammatory condition caused by the premature activation of pancreatic proteases, leads to organ damage, systemic inflammation, and multi-organ failure. Severe acute pancreatitis (SAP) has high morbidity and mortality, aff...
The carbon-fiber-reinforced polymer (CFRP) is a mainstream material for lightweight products from the end of the 20th century to the present day. Its compression molding process has obvious advantages in mass production. This paper attempts to establ...
In the Introduction to this Special Issue, an overview of the Dutch ‘pillarized’ education system is presented based on freedom of religion (Article 6 of the Dutch constitution) and freedom of education (Article 23 of the Dutch constituti...
To ensure ammunition safety, a protective structure and pressure detection system are essential; however, there is a lack of an accurate constitutive model to describe the mechanical response characteristics of protective structures composed of vario...
The mechanical properties of anisotropic materials are generally characterized based on the orthotropy or transverse isotropy. However, the two-dimensional plane stress problems cannot comprehensively characterize the anisotropy of materials. In this...
Silicone structural adhesives (SSAs) play a critical role in load transfer within glass curtain wall systems. With the increasing service life of existing glass curtain walls in recent years, their structural safety has become a significant concern a...
Constitutive relations are fundamental and essential to characterize physical systems. By utilizing the
Archive studies have traditionally conceptualized archives as documentary repositories and memory institutions, whereas territorial studies have examined territorialities as processes through which social groups produce, signify, and contest space. A...
Post-earthquake investigation shows that numerous reinforced concrete (RC) bridges were demolished because of large residual displacements. Improving the self-centering capability and hence resilience of these bridges located in earthquake-prone regi...
Alzheimer’s disease is a neurodegenerative disease characterized by the formation of amyloid plaques constituted prevalently by amyloid peptides. Due to the well-known challenges related to the study in solution of these peptides, several membr...
The cryosphere constitutes a vital component of the Earth’s system [...]
The oral cavity constitutes a unique and complex system and environment [...]
31 January 2023
In order to actively fulfill its international treaty obligations, China has established the goal of peaking CO2 emissions by 2030 and achieving carbon neutrality by 2060. Since 2018, when ecological civilization was written into the Constitution, th...
The CRISPR/Cas9 system has been widely used for targeted genome editing in numerous plant species. In Arabidopsis, constitutive promoters usually result in a low efficiency of heritable mutation in the T1 generation. In this work, CRISPR/Cas9 gene ed...
A model for blood flow is introduced in the context of the Rational Extended Thermodynamics (RET). The balance equations are applied to the two-hierarchy structure recently introduced by Ruggeri and Sugiyama. The constitutive relations are derived wi...
Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk betw...
Flooding constitutes one of the main natural hazards in Poland, which causes enormous social, economic and environmental losses. The main causes of the occurrence of floods include intensive rainfall, rapid melting of snow and ice cover, as well as s...
Over the past four decades, Latin American states have drafted relatively new constitutions in comparison with other regions of the world. These transformations, in some cases, have helped governments leave behind the former authoritarian regimes, or...
The complex mechanical properties of high-damping rubber (HDR), a commonly used seismic isolation material in buildings and bridges, present a significant challenge in civil engineering. In a previous study, the authors proposed an HDR constitutive m...
Sensors and actuators using polymeric systems, constitute one of the most promising fields of “smart polymers”, and it is becoming ever more important to associate artificial sensing and actuating systems with living organisms. [...]
Evolution by natural selection is believed to be the only possible source of spontaneous adaptive organisation in the natural world. This places strict limits on the kinds of systems that can exhibit adaptation spontaneously, i.e., without design. Ph...
of 156