Search Results (10,415)

Enhancing the real-world performance of sustainably designed and certified green buildings remains a significant challenge, particularly in hot climates where efforts to improve thermal comfort often conflict with energy efficiency goals. In the United Arab Emirates (UAE), even newly constructed facilities with green building certifications present opportunities for retrofitting and performance optimization. This study investigates the energy and thermal comfort performance of a LEED Gold-certified, mixed-use university campus in Dubai through a calibrated digital twin developed using IES thermal modelling software. The analysis evaluated existing sustainable design strategies alongside three retrofit energy conservation measures (ECMs): (1) improved building envelope U-values, (2) installation of additional daylight sensors, and (3) optimization of fan coil unit efficiency. Simulation results demonstrated that the three ECMs collectively achieved a total reduction of 15% in annual energy consumption. Thermal comfort was assessed using operative temperature distributions, Predicted Mean Vote (PMV), and Predicted Percentage of Dissatisfaction (PPD) metrics. While fan coil optimization yielded the highest energy savings, it led to less favorable comfort outcomes. In contrast, enhancing envelope U-values maintained indoor conditions consistently within ASHRAE-recommended comfort zones. To further support energy reduction and progress toward Net Zero targets, the study also evaluated the integration of a 228.87 kW rooftop solar photovoltaic (PV) system, which offset 8.09% of the campus’s annual energy demand. By applying data-driven thermal modelling to assess retrofit impacts on both energy performance and occupant comfort in a certified green building, this study addresses a critical gap in the literature and offers a replicable framework for advancing building performance in hot climate regions. Full article

Background: Breast cancer is the most prevalent malignancy among women globally. In Romania, it is the most frequent form of cancer affecting women, with approximately 12,000 new cases diagnosed annually, and the second most common cause of cancer-related mortality, second only to lung cancer. Methods: This study looked at 79 breast cancer patients from Oltenia, concentrating on epidemiology, histology, diagnostic features, and treatments. Patients were chosen based on inclusion criteria such as histopathologically verified diagnosis, availability of clinical and treatment data, and follow-up information. The analyzed biological material consisted of tissue samples taken from the breast parenchyma and axillary lymph nodes. Even though not the primary subject of this paper, all patients underwent immunohistochemical (IHC) evaluation both preoperatively and postoperatively. Results: We found invasive ductal carcinoma to be the predominant type, while ductal carcinoma in situ (DCIS) and mixed types were rare. We performed cross-tabulations of metastasis versus nodal status and age versus therapy type; none reached significance (all p > 0.05), suggesting observed differences were likely due to chance. A chi-square test comparing surgical interventions (breast-conserving vs. mastectomy) in patients who did or did not receive chemotherapy showed, χ² = 3.17, p = 0.367, indicating that chemotherapy did not significantly influence surgical choice. Importantly, adjuvant chemotherapy and radiotherapy were used at similar rates across age groups, whereas neoadjuvant hormonal (endocrine) therapy was more common in older patients (but without statistical significance). Conclusions: Finally, we discussed the consequences of individualized care and early detection. Romania’s shockingly low screening rate, which contributes to delayed diagnosis, emphasizes the importance of improved population medical examination and tailored treatment options. Also, the country has one of the lowest rates of mammography uptake in Europe and no systematic population screening program. Full article

The Tibetan-Himalayan region, recognized as a global biodiversity hotspot, is increasingly threatened by the dual pressures of climate change and human activities. Understanding the vulnerability of plant species to these forces is crucial for effective ecological conservation in this region. This study employed an improved Climate Niche Factor Analysis (CNFA) framework to assess the vulnerability of six representative alpine endemic herbaceous plants in this ecologically sensitive region under future climate changes. Our results show distinct spatial vulnerability patterns for the six species, with higher vulnerability in the western regions of the Tibetan-Himalayan region and lower vulnerability in the eastern areas. Particularly under high-emission scenarios (SSP5-8.5), climate change is projected to substantially intensify threats to these plant species, reinforcing the imperative for targeted conservation strategies. Additionally, we found that the current coverage of protected areas (PAs) within the species’ habitats was severely insufficient, with less than 25% coverage overall, and it was even lower (<7%) in highly vulnerable regions. Human activity hotspots, such as the regions around Lhasa and Chengdu, further exacerbate species vulnerability. Notably, some species currently classified as least concern (e.g., Stipa purpurea (S. purpurea)) according to the IUCN Red List exhibit higher vulnerability than species listed as near threatened (e.g., Cyananthus microphyllus (C. microphylla)) under future climate change. These findings suggest that existing biodiversity assessments, such as the IUCN Red List, may not adequately account for future climate risks, highlighting the importance of incorporating climate change projections into conservation planning. Our study calls for expanding and optimizing PAs, improving management, and enhancing climate resilience to mitigate biodiversity loss in the face of climate change and human pressures. Full article

This paper aims to explore the potentialities and systemic relationships between the ‘regenerative’ process and ‘circular economy’ concept within the conservation and reuse of a built cultural heritage framework through contextualizing the concept of ‘process programming’ of the Preventive and Planned Conservation methodology. As a case study, it depicts a decommissioned industrial agricultural silo in Corbetta—a small historic city with its hinterland located in the protected Southern Milan Regional Agricultural Park. The context includes the industrial agricultural lands of the 20th century, together with historical water infrastructure, farmhouses, and the typical flora of the Lombardy region, all evidences of Corbetta’s rural archaeological values and the sophisticated material culture of its past collective production/economy system—the locus in which the silo was once one of the main productive symbols of Corbetta’s agricultural identity. Within such a complex and challenging context, this paper argues in favor of the constructive role of such a methodology in upholding circular economy principles within the process of conservation and reuse of the silo, highlighting its broader application of the ‘coevolution’ concept from a multidisciplinary long-term perspective. Full article

Implementing nature-based solutions (NbSs) for wildfire risk management and other hazards has been challenging in emerging economies due to the high costs, the lack of immediate returns on investment, and stringent inclusion criteria set by organizations like the IUCN and domain experts. To address these challenges, this exploratory study proposes a new concept: green/blue initiatives. These initiatives represent intermediate steps, encompassing small-scale, community-driven activities that can evolve into recognized NbSs over time. To explore this concept, experiences related to wildfire prevention in the Biobío region of Chile were analyzed through primary and secondary source reviews. The analysis identified three initiatives qualifying as green/blue initiatives: (1) goat grazing in Santa Juana to reduce fuel loads, (2) a restoration prevention farm model in Florida called Faro de Restauración Mahuidanche and (3) the Conservation Landscape Strategy in Nonguén. They were examined in detail using data collected from site visits and interviews. In contrast to Chile’s prevailing wildfire policies, which focus on costly, large-scale fire suppression efforts, these initiatives emphasize the importance of reframing wildfire as a manageable ecological process. Lastly, the challenges and enabling factors for adopting green/blue initiatives are discussed, highlighting their potential to pave the way for future NbS implementation in central Chile. Full article

This study presents a comprehensive inventory of bryophytes in Serra dos Órgãos National Park (PARNASO), aiming to evaluate species richness, floristic composition and threatened taxa. Despite the state of Rio de Janeiro being one of the most extensively sampled regions for bryophytes in Brazil, detailed surveys of its conservation units remain scarce. Data were obtained through bibliographic review, herbarium specimen analysis, and new field collections. A total of 504 species were recorded, belonging to 202 genera and 76 families. The park harbors three locally endemic species, eight endemic to Rio de Janeiro, and sixty-nine species endemic to Brazil. Additionally, eleven species were identified as threatened, comprising seven Endangered (EN), two Critically Endangered (CR), and two Vulnerable (VU) according to the IUCN guidelines. PARNASO includes four distinct ecosystems along an altitudinal gradient: sub-montane forest (up to 500 m), montane forest (500–1500 m), upper-montane forest (1500–2000 m), and high-altitude fields (above 2000 m). Montane Forest showed the highest species richness, followed by high-altitude fields, upper-montane forest, and sub-montane forest. The findings highlight PARNASO’s importance in preserving bryophyte diversity in a highly diverse yet understudied region. This work contributes valuable baseline data to support conservation strategies and future ecological studies in Atlantic Forest remnants. Full article

The ten-year fishing ban on the Yangtze River aims to restore aquatic biodiversity and rebuild fishery resources. Megalobrama skolkovii, a key species in the basin, was investigated using 2024 data to provide a preliminary assessment of its population structure, stock dynamics, and early recovery. Age analysis (n = 243) showed that 1–6-year-olds were dominated by fish aged 3 (35%), with few older than 4, indicating moderate structural truncation. Growth parameters modeled by the von Bertalanffy Growth Function yielded L_∞ = 61.89 cm and k = 0.25 year⁻¹, with a weight–growth inflection age of 4.4 years. Natural mortality (M = 0.48 year⁻¹) was estimated using Pauly’s empirical formula, and total mortality (Z = 0.55 year⁻¹) was estimated from the catch curve analysis. While fishing mortality (F) was statistically indistinguishable from zero, a plausible low-intensity fishing scenario was explored to assess potential impacts of residual activities. Length-based indicators (LBIs) showed P_mat = 46.05%, P_opt = 9.51%, and P_mega = 6.88%, suggesting reproductive recovery but incomplete structural restoration. These preliminary findings reveal an asymmetrical recovery trajectory, whereby physiological improvements and enhanced recruitment have occurred, yet full structural restoration remains incomplete. This underscores the need for continued, long-term conservation and monitoring to support population resilience. Full article

Using the fly eye as a model system, we previously demonstrated that upregulation of the fly gene mask protects against FUS- and Tau-induced photoreceptor degeneration. Building upon this finding, we investigated whether the protective role of mask is conserved in mammals. To this end, we generated a transgenic mouse line carrying Cre-inducible ANKHD1, the human homolog of mask. Utilizing the TauP301S-PS19 mouse model for Tau-related dementia, we found that expressing ANKHD1 driven by CamK2a-Cre reduced hyperphosphorylated human Tau in 6-month-old mice. Additionally, ANKHD1 expression was associated with a trend toward reduced gliosis and preservation of the presynaptic marker Synaptophysin, suggesting a protective role of ANKHD1 against TauP301S-linked neuropathology. At 9 months of age, novel object recognition (NOR) testing revealed cognitive impairment in female, but not male, PS19 mice. Notably, co-expression of ANKHD1 restored cognitive performance in the affected female mice. Together, this study highlights the novel effect of ANKHD1 in counteracting the adverse effects induced by the mutant human Tau protein. This finding underscores ANKHD1’s potential as a unique therapeutic target for tauopathies. Full article

Deforestation and land-use changes lead to significant soil degradation and erosion, particularly in Amazonian ecosystems, due to the region’s climate and geology. This study characterizes soil quality using physical, chemical, and biological parameters across different land uses. It uses a soil quality index (SQI) based on a minimum data set (MDS), from 19 evaluated parameters. The land uses evaluated were cacao monoculture (CMC), agroforestry systems associated with fruit and timber species (FAFS and TAFS, respectively), and a secondary forest. The SQI was composed of six variables, bulk density (BD), soil organic matter (SOM), urease activity (UR), pH, dehydrogenase activity (DH), and leaf litter, which are considered relevant indicators that allow for an adequate evaluation of soil quality. According to the SQI assessment, FAFS has a moderate-quality rating (0.40), followed by secondary forest (0.35), TAFS (0.33), and CMC (0.30), the last three categorized as low-quality. The methods used are replicable and efficient for evaluating changes in soil properties based on different land uses and management systems in landscapes similar to those of the Ecuadorian Amazon. Also worth mentioning is the potential of agroforestry as a sustainable land-use strategy that can enhance above- and below-ground biodiversity and nutrient cycling. Therefore, implementing agroforestry practices can contribute to long-term soil conservation and the resilience of tropical ecosystems. Full article

Background/Objectives: Phase II oncology trials often rely on single-arm designs to test $H_0:\pi ={\pi }_0$ versus $H_a:\pi >{\pi }_0$, especially when randomized trials are infeasible due to cost or disease rarity. Traditional approaches, such as the exact binomial test and Simon’s two-stage design, tend to be conservative, with actual Type I error rates falling below the nominal $\alpha$ due to the discreteness of the underlying binomial distribution. This study aims to develop a more efficient and flexible method that maintains accurate Type I error control in such settings. Methods: We propose a convolution-based method that combines the binomial distribution with a simulated normal variable to construct an unbiased estimator of $\pi$. This method is designed to precisely control the Type I error rate while enabling more efficient trial designs. We derive its theoretical properties and assess its performance against traditional exact tests in both one-stage and two-stage trial designs. Results: The proposed method results in more efficient designs with reduced sample sizes compared to standard approaches, without compromising the control of Type I error rates. We introduce a new two-stage design incorporating interim futility analysis and compare it with Simon’s design. Simulations and real-world examples demonstrate that the proposed approach can significantly lower trial cost and duration. Conclusions: This convolution-based approach offers a flexible and efficient alternative to traditional methods for early-phase oncology trial design. It addresses the conservativeness of existing designs and provides practical benefits in terms of resource use and study timelines. Full article

During the transition of culture-featured district planning from static conservation to innovation-driven models, existing research remains constrained by mechanistic paradigms, reducing districts to functional containers and neglecting human perceptual interactions and meaning-production mechanisms. This study explores and quantifies the generative mechanisms of spatial communicability and cultural dissemination efficacy within human-centered frameworks. Grounded in humanistic urbanism, we analyze Harbin Central Street as a case study integrating historical heritage with contemporary vitality, developing a tripartite communicability assessment framework comprising perceptual experience, infrastructure utility, and behavioral dynamics. Machine learning-based threshold analysis reveals that spatial encoding elements govern communicability through significant nonlinear mechanisms. The conclusion shows synergies between street view-quantified greenery visibility and pedestrian accessibility establish critical human-centered design thresholds. Spatial data analysis integrating physiologically sensed emotional experiences and topologically analyzed spatial morphology resolves metric fragmentation while examining spatial encoding’s impact on interaction efficacy. This research provides data-driven decision support for sustainable urban renewal and enhanced cultural dissemination, advancing heritage sustainability. Full article

The mountainous rivers of Central Asia host diverse ichthyofauna threatened by increasing anthropogenic pressures, particularly water pollution, abstraction, and hydropower development. This study provides valuable morphometric and ecological data for Schizothorax eurycephalus (snow trout) and Triplophysa ferganaensis (stone loach) in the Shakhimardan River basin, Uzbekistan. S. eurycephalus exhibited positive allometric growth, while T. ferganaensis showed negative near-isometric growth. The mean Fulton’s Condition Factor was 1.0 for S. eurycephalus and 0.7 for T. ferganaensis, with site-specific variations. Strong correlations among morphometric parameters, particularly length–height relationships, support non-invasive monitoring techniques. Dietary analysis revealed S. eurycephalus was predominantly herbivorous, with around 70% algae consumption. Early sexual maturity was observed in S. eurycephalus males, whereas T. ferganaensis showed no clear maturity signs, but swollen bellies suggested ongoing or recent reproductive activity. These baseline morphometric and ecological data establish a solid foundation for future ecological assessments, conservation strategies, and the design and monitoring of mitigation measures to address anthropogenic impacts in this vulnerable region. Full article

Diabetes mellitus poses a significant global health challenge, primarily due to its chronic metabolic dysregulation, leading to widespread tissue and organ damage. This systemic impact results in a range of complications that markedly reduce patients’ quality of life. Therefore it is critical to understand the mechanisms underlying these complications. DJ-1 (also known as PARK7) is a highly conserved multifunctional protein involved in antioxidative defense, metabolic equilibrium, and cellular survival. Recent studies have highlighted that DJ-1 is critically involved in the pathogenesis and progression of diabetic complications, including macrovascular issues like cardiovascular disease and microvascular conditions such as diabetic nephropathy, retinopathy, and neuropathy, suggesting that it may serve as a promising therapeutic target. Importantly, drugs targeting DJ-1 have shown therapeutic effects. This review provides a comprehensive overview of the current under-standing of DJ-1’s role in diabetes-related complications, emphasizing recent research advances. Full article

Urban wildlife conservation is emerging as a critical component of sustainable city ecosystems. Rather than simply increasing tree abundance or species richness, conservation management should focus on key species. In this research, Xishan Forest Park in Beijing was chosen as a case study. Our aim was to identify keystone taxa critical for avian foraging and nesting during the breeding season. We performed a network analysis linking bird species, their diets, and nest plants. Dietary components were detected using DNA metabarcoding conducted with avian fecal samples. Nest plants were identified via transect surveys. Two indices of the network, degree and weighted mean degree, were calculated to evaluate the importance of the dietary and nest plant species. We identified 13 bird host species from 107 fecal samples and 14 bird species from 107 nest observations. Based on the degree indices, fruit trees Morus and Prunus were detected as key food sources, exhibiting both the highest degree (degree = 9, 9) and weighted mean degree (lnwMD = 5.21, 4.63). Robinia pseudoacacia provided predominant nesting sites, with a predominant degree of 7. A few taxa, such as Styphnolobium japonicum and Rhamnus parvifolia, served dual ecological significance as both essential food sources and nesting substrates. Scrublands, as a unique habitat type, provided nesting sites and food for small-bodied birds. Therefore, targeted management interventions are recommended to sustain or enhance these keystone resource species and to maintain the multi-layered vertical vegetation structure to preserve the diverse habitats of birds. Full article

This paper investigates how governance frameworks shape sustainable tourism outcomes in protected areas by comparing Tara National Park (Serbia) and Triglav National Park (Slovenia). Both parks, established in 1981 and classified under IUCN Category II, exhibit rich biodiversity and mountainous terrain but differ markedly in governance structures, institutional integration, and local community engagement. Using a qualitative, indicator-based methodology, this research evaluates ecological, economic, and social dimensions of sustainability. The findings reveal that Triglav NP demonstrates higher levels of participatory governance, tourism integration, and educational outreach, while Tara NP maintains stricter ecological protection with less inclusive management. Triglav’s zoning model, community council, and economic alignment with regional development policies contribute to stronger sustainability outcomes. Conversely, Tara NP’s centralized governance and infrastructural gaps constrain its potential despite its significant conservation value. This study highlights the importance of adaptive, inclusive governance in achieving the Sustainable Development Goals (SDGs) within protected areas. It concludes that hybrid approaches, combining legal rigor with participatory flexibility, can foster resilience and sustainability in ecologically sensitive regions. Full article