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Search Results (330)

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Keywords = compact thermal model

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23 pages, 2788 KB  
Article
Green Cores as Architectural and Environmental Anchors: A Performance-Based Framework for Residential Refurbishment in Novi Sad, Serbia
by Marko Mihajlovic, Jelena Atanackovic Jelicic and Milan Rapaic
Sustainability 2025, 17(19), 8864; https://doi.org/10.3390/su17198864 - 3 Oct 2025
Abstract
This research investigates the integration of green cores as central biophilic elements in residential architecture, proposing a climate-responsive design methodology grounded in architectural optimization. The study begins with the full-scale refurbishment of a compact urban apartment, wherein interior partitions, fenestration and material systems [...] Read more.
This research investigates the integration of green cores as central biophilic elements in residential architecture, proposing a climate-responsive design methodology grounded in architectural optimization. The study begins with the full-scale refurbishment of a compact urban apartment, wherein interior partitions, fenestration and material systems were reconfigured to embed vegetated zones within the architectural core. Light exposure, ventilation potential and spatial coherence were maximized through data-driven design strategies and structural modifications. Integrated planting modules equipped with PAR-specific LED systems ensure sustained vegetation growth, while embedded environmental infrastructure supports automated irrigation and continuous microclimate monitoring. This plant-centered spatial model is evaluated using quantifiable performance metrics, establishing a replicable framework for optimized indoor ecosystems. Photosynthetically active radiation (PAR)-specific LED systems and embedded environmental infrastructure were incorporated to maintain vegetation viability and enable microclimate regulation. A programmable irrigation system linked to environmental sensors allows automated resource management, ensuring efficient plant sustenance. The configuration is assessed using measurable indicators such as daylight factor, solar exposure, passive thermal behavior and similar elements. Additionally, a post-occupancy expert assessment was conducted with several architects evaluating different aspects confirming the architectural and spatial improvements achieved through the refurbishment. This study not only demonstrates a viable architectural prototype but also opens future avenues for the development of metabolically active buildings, integration with decentralized energy and water systems, and the computational optimization of living infrastructure across varying climatic zones. Full article
(This article belongs to the Special Issue Advances in Ecosystem Services and Urban Sustainability, 2nd Edition)
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11 pages, 2360 KB  
Article
Temperature Hysteresis Calibration Method of MEMS Accelerometer
by Hak Ju Kim and Hyoung Kyoon Jung
Sensors 2025, 25(19), 6131; https://doi.org/10.3390/s25196131 - 3 Oct 2025
Abstract
Micro-electromechanical system (MEMS) sensors are widely used in various navigation applications because of their cost-effectiveness, low power consumption, and compact size. However, their performance is often degraded by temperature hysteresis, which arises from internal temperature gradients. This paper presents a calibration method that [...] Read more.
Micro-electromechanical system (MEMS) sensors are widely used in various navigation applications because of their cost-effectiveness, low power consumption, and compact size. However, their performance is often degraded by temperature hysteresis, which arises from internal temperature gradients. This paper presents a calibration method that corrects temperature hysteresis without requiring any additional hardware or modifications to the existing MEMS sensor design. By analyzing the correlation between the external temperature change rate and hysteresis errors, a mathematical calibration model is derived. The method is experimentally validated on MEMS accelerometers, with results showing an up to 63% reduction in hysteresis errors. We further evaluate bias repeatability, scale factor repeatability, nonlinearity, and Allan variance to assess the broader impacts of the calibration. Although minor trade-offs in noise characteristics are observed, the overall hysteresis performance is substantially improved. The proposed approach offers a practical and efficient solution for enhancing MEMS sensor accuracy in dynamic thermal environments. Full article
(This article belongs to the Section Navigation and Positioning)
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30 pages, 12156 KB  
Article
Spatial and Data-Driven Approaches for Mitigating Urban Heat in Coastal Cities
by Ke Li and Haitao Wang
Buildings 2025, 15(19), 3544; https://doi.org/10.3390/buildings15193544 - 2 Oct 2025
Abstract
With accelerating urbanization and global climate warming, Urban Heat Islands (UHIs) pose serious threats to urban development. Existing UHI research mainly focuses on inland regions, lacking systematic understanding of coastal city heat island mechanisms. We selected eight Chinese coastal cities with different backgrounds, [...] Read more.
With accelerating urbanization and global climate warming, Urban Heat Islands (UHIs) pose serious threats to urban development. Existing UHI research mainly focuses on inland regions, lacking systematic understanding of coastal city heat island mechanisms. We selected eight Chinese coastal cities with different backgrounds, quantitatively assessed urban heat island intensity based on summer 2023 Landsat 8 remote sensing data, established block-LCZ spatial analysis units, and employed a combination of machine learning models and causal inference methods to systematically analyze the regional differentiation characteristics of Urban Heat Island Intensity (UHII) and the influence mechanisms of multi-dimensional driving factors within land–sea interaction contexts. The results revealed the following: (1) UHII in the study area presents obvious spatial differentiation, with the highest value occurring in Hong Kong (2.63 °C). Northern cities generally had higher values than southern ones. (2) Different Local Climate Zone (LCZ) types show significant differences in thermal contributions, with LCZ2 (compact midrise) blocks presenting the highest UHII values in most cities, while LCZ G (water) and LCZ A (dense trees) blocks exhibit stable cooling effects. Nighttime light (NTL) and distance to sea (DS) are dominant factors affecting UHII, with NTL marginal effect curves generally presenting hump-shaped characteristics, while DS shows different response patterns across cities. (3) Causal inference reveals true causal driving mechanisms beyond correlations, finding that causal effects of key factors exhibit significant spatial heterogeneity. The research findings provide a new cognitive framework for understanding the formation mechanisms of thermal environments in Chinese coastal cities and offer a quantitative basis for formulating regionalized UHI mitigation strategies. Full article
(This article belongs to the Section Architectural Design, Urban Science, and Real Estate)
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30 pages, 10255 KB  
Article
Hybrid Design Optimization Methodology for Electromechanical Linear Actuators in Automotive LED Headlights
by Mario Đurić, Luka Selak and Drago Bračun
Actuators 2025, 14(10), 465; https://doi.org/10.3390/act14100465 - 24 Sep 2025
Viewed by 42
Abstract
The development of electromechanical linear actuators (EMLAs) aims at compactness, energy efficiency, and high reliability. Conventional design methods often rely on costly prototypes and individual considerations of mechanics, electromagnetics, and control dynamics. This leads to long development cycles, inadequate treatment of nonlinear effects, [...] Read more.
The development of electromechanical linear actuators (EMLAs) aims at compactness, energy efficiency, and high reliability. Conventional design methods often rely on costly prototypes and individual considerations of mechanics, electromagnetics, and control dynamics. This leads to long development cycles, inadequate treatment of nonlinear effects, and suboptimal performance. To address these challenges, our paper introduces a novel hybrid design methodology, integrating Analytical Modeling, Finite Element Analysis (FEA), Genetic Algorithms (GAs), and targeted experiments. Analytical Modeling provides rapid sizing, FEA combined with a GA refines geometry, and targeted experiments quantify nonlinear effects (friction, wear, thermal variability, and dynamic resonances). Unlike conventional methods, the integration is performed within iterative loops, using empirical data to refine simulation assumptions. As a result, development time is reduced by 30% and nonlinear effects are precisely addressed. The method is demonstrated on an automotive-grade EMLA. Its design is based on a claw-pole Permanent Magnet Stepper Motor, a trapezoidal lead screw, and an open-loop control with Hall effect end-position detection. After applying the method, the EMLA delivers more than 40 N of push force and achieves 600,000 actuations under the required conditions, making it suitable for various applications. Full article
(This article belongs to the Section High Torque/Power Density Actuators)
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29 pages, 7962 KB  
Article
Design and Validation of a Compact, Low-Cost Sensor System for Real-Time Indoor Environmental Monitoring
by Vincenzo Di Leo, Alberto Speroni, Giulio Ferla and Juan Diego Blanco Cadena
Buildings 2025, 15(19), 3440; https://doi.org/10.3390/buildings15193440 - 23 Sep 2025
Viewed by 211
Abstract
The growing interest in smart buildings and the integration of IoT-based technologies is driving the development of new tools for monitoring and optimizing indoor environmental quality (IEQ). However, many existing solutions remain expensive, invasive and inflexible. This paper presents the design and validation [...] Read more.
The growing interest in smart buildings and the integration of IoT-based technologies is driving the development of new tools for monitoring and optimizing indoor environmental quality (IEQ). However, many existing solutions remain expensive, invasive and inflexible. This paper presents the design and validation of a compact, low-cost, and real-time sensor system, conceived for seamless integration into indoor environments. The system measures key parameters—including air temperature, relative humidity, illuminance, air quality, and sound pressure level—and is embeddable in standard office equipment with minimal impact. Leveraging 3D printing and open-source hardware/software, the proposed solution offers high affordability (approx. EUR 33), scalability, and potential for workspace retrofits. To assess the system’s performance and relevance, dynamic simulations were conducted to evaluate metrics such as the Mean Radiant Temperature (MRT) and illuminance in an open office layout. In addition, field tests with a functional prototype enabled model validation through on-site measured data. The results highlighted significant local discrepancies—up to 6.9 °C in MRT and 28 klx in illuminance—compared to average conditions, with direct implications for thermal and visual comfort. These findings demonstrate the system’s capacity to support high-resolution environmental monitoring within IoT-enabled buildings, offering a practical path toward the data-driven optimization of occupant comfort and energy efficiency. Full article
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18 pages, 1926 KB  
Article
Predicting the Freezing Characteristics of Organic Soils Using Laboratory Experiments and Machine Learning Models
by Sewon Kim, Hyun-Jun Choi, Sangyeong Park and Youngseok Kim
Appl. Sci. 2025, 15(19), 10314; https://doi.org/10.3390/app151910314 - 23 Sep 2025
Viewed by 157
Abstract
Frozen ground regions have recently experienced increasing construction activity due to the vast undeveloped resources they contain. However, frozen soils exhibit thermal and mechanical properties that differ substantially from those of temperate soils, leading to a range of engineering challenges. This study investigates [...] Read more.
Frozen ground regions have recently experienced increasing construction activity due to the vast undeveloped resources they contain. However, frozen soils exhibit thermal and mechanical properties that differ substantially from those of temperate soils, leading to a range of engineering challenges. This study investigates the influence of organic matter content on the freezing behavior of soils through a series of laboratory experiments and machine learning (ML) modeling. Soil samples were collected from Alberta, Canada, and Gangwon Province, South Korea, and their organic matter contents were adjusted using the loss-on-ignition method combined with peat moss addition. Standard Proctor compaction tests and uniaxial compression tests under subzero conditions were performed to evaluate compaction characteristics and strength development. The unfrozen water content was measured at different subzero temperatures to assess thermal and hydraulic responses. The resulting experimental dataset was then used to develop ensemble ML models—random forest (RF) and extreme gradient boosting (XGB)—for predicting unfrozen water content. The results indicate that higher organic matter contents reduce compaction efficiency, increase residual unfrozen water content, and influence strength development under freezing conditions. Both RF and XGB achieved high predictive accuracy, demonstrating their potential as reliable tools for evaluating the freezing behavior of organic soils. Full article
(This article belongs to the Section Civil Engineering)
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20 pages, 2915 KB  
Article
From Lab to Launchpad: A Modular Transport Incubator for Controlled Thermal and Power Conditions of Spaceflight Payloads
by Sebastian Feles, Ilse Marie Holbeck and Jens Hauslage
Instruments 2025, 9(3), 21; https://doi.org/10.3390/instruments9030021 - 18 Sep 2025
Viewed by 295
Abstract
Maintaining physiologically controlled conditions during the transport of biological experiments remains a long-standing but under-addressed challenge in spaceflight operations. Pre-launch thermal or mechanical stress induce artefacts that compromise the interpretation of biological responses to space conditions. Existing transport systems are limited to basic [...] Read more.
Maintaining physiologically controlled conditions during the transport of biological experiments remains a long-standing but under-addressed challenge in spaceflight operations. Pre-launch thermal or mechanical stress induce artefacts that compromise the interpretation of biological responses to space conditions. Existing transport systems are limited to basic heating of small sample containers and lack the capability to power and protect full experimental hardware during mission-critical phases. A modular transport incubator was developed and validated that combines active thermal regulation, battery-buffered power management, and mechanical protection in a compact, field-deployable platform. It enables autonomous environmental conditioning of complex biological payloads and continuous operation of integrated scientific instruments during ground-based transport and recovery. Validation included controlled experiments under sub-zero ambient temperatures, demonstrating rapid warm-up, stable thermal regulation, and uninterrupted autonomous performance. A steady-state finite difference thermal model was experimentally validated across 21 boundary conditions, enabling predictive power requirement estimation for mission planning. Field deployments during multiple MAPHEUS® sounding rocket campaigns confirmed functional robustness under wind, snow, and airborne recovery scenarios. The system closes a critical infrastructure gap in spaceflight logistics. Its validated performance, modular architecture, and proven operational readiness establish it as an enabling platform for standardized, reproducible ground handling of biological payloads and experiment hardware. Full article
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20 pages, 2930 KB  
Article
Pain Level Classification from Speech Using GRU-Mixer Architecture with Log-Mel Spectrogram Features
by Adi Alhudhaif
Diagnostics 2025, 15(18), 2362; https://doi.org/10.3390/diagnostics15182362 - 17 Sep 2025
Viewed by 279
Abstract
Background/Objectives: Automatic pain detection from speech signals holds strong promise for non-invasive and real-time assessment in clinical and caregiving settings, particularly for populations with limited capacity for self-report. Methods: In this study, we introduce a lightweight recurrent deep learning approach, namely the [...] Read more.
Background/Objectives: Automatic pain detection from speech signals holds strong promise for non-invasive and real-time assessment in clinical and caregiving settings, particularly for populations with limited capacity for self-report. Methods: In this study, we introduce a lightweight recurrent deep learning approach, namely the Gated Recurrent Unit (GRU)-Mixer model for pain level classification based on speech signals. The proposed model maps raw audio inputs into Log-Mel spectrogram features, which are passed through a stacked bidirectional GRU for modeling the spectral and temporal dynamics of vocal expressions. To extract compact utterance-level embeddings, an adaptive average pooling-based temporal mixing mechanism is applied over the GRU outputs, followed by a fully connected classification head alongside dropout regularization. This architecture is used for several supervised classification tasks, including binary (pain/non-pain), graded intensity (mild, moderate, severe), and thermal-state (cold/warm) classification. End-to-end training is done using speaker-independent splits and class-balanced loss to promote generalization and discourage bias. The provided audio inputs are normalized to a consistent 3-s window and resampled at 8 kHz for consistency and computational efficiency. Results: Experiments on the TAME Pain dataset showcase strong classification performance, achieving 83.86% accuracy for binary pain detection and as high as 75.36% for multiclass pain intensity classification. Conclusions: As the first deep learning based classification work on the TAME Pain dataset, this work introduces the GRU-Mixer as an effective benchmark architecture for future studies on speech-based pain recognition and affective computing. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
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25 pages, 3452 KB  
Article
Characterizing the Thermal Effects of Urban Morphology Through Unsupervised Clustering and Explainable AI
by Feng Xu, Ye Shen, Minrui Zheng, Xiaoyuan Zhang, Yuqiang Zuo, Xiaoli Wang and Mengdi Zhang
Remote Sens. 2025, 17(18), 3211; https://doi.org/10.3390/rs17183211 - 17 Sep 2025
Viewed by 319
Abstract
The urban thermal environment poses a significant challenge to public health and sustainable urban development. Conventional pre-defined classification schemes, such as the Local Climate Zone (LCZ) system, often fail to capture the highly heterogeneous structure of complex urban areas, thus limiting their applicability. [...] Read more.
The urban thermal environment poses a significant challenge to public health and sustainable urban development. Conventional pre-defined classification schemes, such as the Local Climate Zone (LCZ) system, often fail to capture the highly heterogeneous structure of complex urban areas, thus limiting their applicability. This study introduces a novel framework for urban thermal environment analysis, leveraging multi-source data and eXplainable Artificial Intelligence to investigate the driving mechanisms of Land Surface Temperature (LST) across various urban form types. Focusing on the area within Beijing’s 5th Ring Road, this study employs a K-Means clustering algorithm to classify urban blocks into nine distinct types based on their building morphology. Subsequently, an eXtreme Gradient Boosting (XGBoost) model, coupled with the SHapley Additive exPlanations (SHAP) method, is utilized to analyze the non-linear impacts of ten selected driving factors on LST. The findings reveal that: (1) The Compact Mid-rise type exhibits the highest annual average LST at 296.59 K, with a substantial difference of 11.29 K observed between the hottest and coldest block types. (2) SHAP analysis identifies the Normalized Difference Built-up Index (NDBI) as the most significant warming factor across all types, while the Sky View Factor (SVF) plays a crucial cooling role in high-rise areas. Conversely, road density (RD) shows a negative correlation with LST in Open Low-rise areas. (3) The influence of urban form is twofold: increased building height (BH) can induce warming by trapping heat while simultaneously providing a cooling effect through shading. (4) The impact of land use functional zones on LST is significantly modulated by urban form, with temperature differences of up to 2 K observed between different functional zones within compact block types. The analytical framework proposed herein holds significant theoretical and practical implications for achieving fine-grained thermal environment governance and fostering sustainable development in the context of global urbanization. Full article
(This article belongs to the Special Issue Remote Sensing for Landscape Dynamics)
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24 pages, 4376 KB  
Article
Experimental and ANN-Based Evaluation of Water-Based Al2O3, TiO2, and CuO Nanofluids for Enhanced Engine Cooling Performance
by Gadisa Sufe, Zbigniew J. Sroka and Monika Magdziak-Tokłowicz
Energies 2025, 18(18), 4828; https://doi.org/10.3390/en18184828 - 11 Sep 2025
Viewed by 325
Abstract
This study presents an integrated experimental and computational investigation into the thermal and hydraulic performance of three oxide-based nanofluids: aluminum oxide (Al2O3), titanium dioxide (TiO2), and copper oxide (CuO) for advanced engine cooling applications. A custom-built test [...] Read more.
This study presents an integrated experimental and computational investigation into the thermal and hydraulic performance of three oxide-based nanofluids: aluminum oxide (Al2O3), titanium dioxide (TiO2), and copper oxide (CuO) for advanced engine cooling applications. A custom-built test rig was used to assess nanofluid behavior under varying flow rates, nanoparticle volume fractions, and temperature gradients, replicating realistic engine conditions. According to the results, at ideal concentrations, CuO nanofluids continuously demonstrate better heat transfer properties, outperforming TiO2 by up to 15% and AlO3 by 7%. However, performance plateaus beyond 1.5% volume fraction due to increased viscosity and pressure drop. A multilayer feedforward artificial neural network (ANN) model was developed to predict convective heat transfer coefficients and friction factors based on experimental inputs, achieving a mean absolute percentage error below 5% and a coefficient of determination (R2) exceeding 0.98. The ANN demonstrated robust generalization across varying operating conditions and nanoparticle types, confirming its utility for surrogate modeling and optimization. This work is distinguished by its dual focus on thermal efficiency and hydraulic stability, as well as its use of data-driven modeling validated by empirical results. The findings provide actionable insights for thermal management system design in internal combustion, hybrid, and electric vehicles, where efficient, compact, and reliable cooling solutions are increasingly vital. The study advances the practical application of nanofluids by offering a comparative, ANN-validated framework that bridges the gap between lab-scale performance and real-world automotive cooling demands. Full article
(This article belongs to the Section I2: Energy and Combustion Science)
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16 pages, 3050 KB  
Article
Hot-Point Ice Thermal Drills: Design Parameters, Recommendations, and Examples
by Mikhail A. Sysoev, Pavel G. Talalay, Xiaopeng Fan, Nan Zhang, Da Gong, Jialin Hong, Yang Yang and Ting Wang
Water 2025, 17(17), 2650; https://doi.org/10.3390/w17172650 - 8 Sep 2025
Viewed by 655
Abstract
Hot-point thermal drills are among the simplest and most compact tools for drilling boreholes in ice by melting. They are widely used in glaciological and geophysical research, including subsurface access on Earth and planetary missions. This study focuses on electrically heated hot-point drills. [...] Read more.
Hot-point thermal drills are among the simplest and most compact tools for drilling boreholes in ice by melting. They are widely used in glaciological and geophysical research, including subsurface access on Earth and planetary missions. This study focuses on electrically heated hot-point drills. It presents a comparative review of four analytical models commonly used to describe thermal penetration into ice. Our theoretical processing and computation allow for the analysis and optimization of the drilling performance of thermal drill heads. The predictive accuracy of the adapted model was evaluated through comparison with experimental data obtained using the RECAS-200 thermal sonde. Based on the analysis of various sources and calculations using the modified model, a set of recommendations is proposed for early-stage estimation of drilling parameters and assessment of thermal drilling efficiency in the design of hot-point drills for autonomous and resource-constrained missions. Full article
(This article belongs to the Section Oceans and Coastal Zones)
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25 pages, 7608 KB  
Article
Characteristic Model-Based Discrete Adaptive Integral SMC for Robotic Joint Drive on Dual-Core ARM
by Wei Chen
Symmetry 2025, 17(9), 1436; https://doi.org/10.3390/sym17091436 - 3 Sep 2025
Viewed by 447
Abstract
Addressing escalating demands for high-precision compact robotic actuators, this study overcomes persistent challenges from nonlinear transmission dynamics and computational constraints through a co-designed framework integrating three innovations. A real-time second-order characteristic modeling approach enables 10 kHz online parameter identification, reducing computational load by [...] Read more.
Addressing escalating demands for high-precision compact robotic actuators, this study overcomes persistent challenges from nonlinear transmission dynamics and computational constraints through a co-designed framework integrating three innovations. A real-time second-order characteristic modeling approach enables 10 kHz online parameter identification, reducing computational load by 13.1% versus MPC. Building on this foundation, a hybrid integral sliding-mode controller eliminating modeling errors while maintaining ≤0.25 rad/s tracking error (SRMSE) under variable loads was created. These algorithmic advances are embedded within a miniaturized dual-ARM platform (47 × 47 × 12 mm3) achieving <30-ns overcurrent protection and 36% cost reduction versus DSP/FPGA solutions. Validated via Lyapunov stability proofs and experiments, this framework is particularly effective for high-performance robotic joint control in spatially- and thermally-constrained environments while dynamically compensating for unmodeled nonlinearities. Full article
(This article belongs to the Section Engineering and Materials)
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24 pages, 4241 KB  
Article
Numerical Study of Self-Heating Maintenance Performance of an Integrated Regenerative Catalytic Reactor
by Fangdong Zhu, Mingming Mao, Youtang Wang and Qiang Chen
Energies 2025, 18(17), 4654; https://doi.org/10.3390/en18174654 - 2 Sep 2025
Viewed by 527
Abstract
Efficient utilization of low-calorific-value gases reduces emissions but remains challenging. Self-heat-maintained combustion uses fuel’s exothermic heat to sustain stability without external heat, yet the feed gas typically requires preheating (typically 573–673 K). This study innovatively proposes a compact regenerative catalytic reactor featuring an [...] Read more.
Efficient utilization of low-calorific-value gases reduces emissions but remains challenging. Self-heat-maintained combustion uses fuel’s exothermic heat to sustain stability without external heat, yet the feed gas typically requires preheating (typically 573–673 K). This study innovatively proposes a compact regenerative catalytic reactor featuring an integrated helical heat-recovery structure and replaces empirical preheating with a user-defined function (UDF) programmed heat transfer efficiency model. This dual innovation enables self-sustained combustion at 0.16 vol.% methane, the lowest reported concentration for autonomous operation. Numerical results confirm stable operation under ultra-lean conditions, with significantly reduced preheating energy demand and accelerated thermal response. Transient analysis shows lower space velocities enable self-maintained combustion across a broader range of methane concentrations. However, higher methane concentrations require higher inlet temperatures for self-heat maintenance. This study provides significant insights for recovering energy from low-calorific-value gases and alleviating global energy pressures. Full article
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25 pages, 7796 KB  
Article
Time-Dependent Optothermal Performance Analysis of a Flexible RGB-W LED Light Engine
by Md Shafiqul Islam and Mehmet Arik
Micromachines 2025, 16(9), 1007; https://doi.org/10.3390/mi16091007 - 31 Aug 2025
Viewed by 628
Abstract
The wide application of light emitting diodes (LEDs) in lighting systems has necessitated the inclusion of spectral tunability by using multi-color LED chips. Since the lighting requirement depends on the specific application, it is very important to have flexibility in terms of the [...] Read more.
The wide application of light emitting diodes (LEDs) in lighting systems has necessitated the inclusion of spectral tunability by using multi-color LED chips. Since the lighting requirement depends on the specific application, it is very important to have flexibility in terms of the driving conditions. While many applications use single or rather white color, some recent applications require multi-spectral lighting systems especially for agricultural or human-medical treatment applications. These systems are underexplored and pose specific challenges. In this paper, a mixture of red, green, blue, white (RGB-W) LED chips was used to develop a compact light engine specifically for agricultural applications. A computational study was performed to understand the optical distribution. Later, attention was turned into development of prototype light engines followed by experimental validation for both the thermal and optical characteristics. Each LED string was driven separately at different current levels enabling an option for obtaining an infinite number of colors for numerous applications. Each LED string on the developed light engine was driven at 300 mA, 500 mA, 700 mA, and 900 mA current levels, and the optical and thermal parameters were recorded simultaneously. A set of computational models and an experimental study were performed to understand the optical and thermal characteristics simultaneously. Full article
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28 pages, 6373 KB  
Article
Preformulation Study of Controlled-Release Galantamine Matrix Tablets Containing Polyethylene Oxide, Hydroxypropyl Methylcellulose, and Ethylcellulose
by Andres C. Arana-Linares, Paola A. Caicedo, María Francisca Villegas-Torres, Andrés F. González-Barrios, Natalie Cortes, Edison H. Osorio, Constain H. Salamanca and Alvaro Barrera-Ocampo
Pharmaceutics 2025, 17(9), 1139; https://doi.org/10.3390/pharmaceutics17091139 - 30 Aug 2025
Viewed by 883
Abstract
Background/Objectives: The rational design of modified-release matrix tablets requires a thorough understanding of granulometric analysis, compaction behavior, and drug release profile. In this study, we evaluated the physicochemical, granulometric, and mechanical properties of hydroxypropyl methylcellulose, polyethylene oxide, and ethylcellulose in galantamine matrix [...] Read more.
Background/Objectives: The rational design of modified-release matrix tablets requires a thorough understanding of granulometric analysis, compaction behavior, and drug release profile. In this study, we evaluated the physicochemical, granulometric, and mechanical properties of hydroxypropyl methylcellulose, polyethylene oxide, and ethylcellulose in galantamine matrix formulations. Methods: Spectroscopic (FTIR) and thermal (DSC) analyses demonstrated drug–polymer compatibility. We assessed flowability, cohesion, and aeration behavior through granulometric analysis and applied compressibility models (Kawakita, Heckel, Leuenberger) to characterize deformation mechanisms. Results: Hydroxypropyl methylcellulose showed superior compactability (Tmax = 4.61 MPa) and sustained drug release (85.4% at 12 h, DE% = 62.2%), while polyethylene oxide enabled gradual erosion and consistent delivery (88.7% at 12 h, DE% = 57.5%). In contrast, ethylcellulose exhibited high cohesiveness but poor matrix integrity, leading to premature drug release (76.6% at 1 h, DE% = 73.7%). Only hydroxypropyl methylcellulose and polyethylene oxide formulations met USP criteria. Conclusions: These results demonstrate that polymer selection critically influences powder behavior and matrix performance, underscoring the need for integrated granulometric and mechanical evaluation in the development of robust controlled-release systems. Full article
(This article belongs to the Section Drug Delivery and Controlled Release)
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