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4,035 Results Found

  • Article
  • Open Access
13 Citations
7,045 Views
12 Pages

A Co-Culture-Based Multiparametric Imaging Technique to Dissect Local H2O2 Signals with Targeted HyPer7

  • Melike Secilmis,
  • Hamza Yusuf Altun,
  • Johannes Pilic,
  • Yusuf Ceyhun Erdogan,
  • Zeynep Cokluk,
  • Busra Nur Ata,
  • Gulsah Sevimli,
  • Asal Ghaffari Zaki,
  • Esra Nur Yigit and
  • Emrah Eroglu
  • + 2 authors

14 September 2021

Multispectral live-cell imaging is an informative approach that permits detecting biological processes simultaneously in the spatial and temporal domain by exploiting spectrally distinct biosensors. However, the combination of fluorescent biosensors...

  • Article
  • Open Access
3 Citations
4,579 Views
15 Pages

Co-Clinical Imaging Metadata Information (CIMI) for Cancer Research to Promote Open Science, Standardization, and Reproducibility in Preclinical Imaging

  • Stephen M. Moore,
  • James D. Quirk,
  • Andrew W. Lassiter,
  • Richard Laforest,
  • Gregory D. Ayers,
  • Cristian T. Badea,
  • Andriy Y. Fedorov,
  • Paul E. Kinahan,
  • Matthew Holbrook and
  • Kooresh I. Shoghi
  • + 17 authors

11 May 2023

Preclinical imaging is a critical component in translational research with significant complexities in workflow and site differences in deployment. Importantly, the National Cancer Institute’s (NCI) precision medicine initiative emphasizes the...

  • Review
  • Open Access
6 Citations
7,401 Views
24 Pages

Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials

  • Donna M. Peehl,
  • Cristian T. Badea,
  • Thomas L. Chenevert,
  • Heike E. Daldrup-Link,
  • Li Ding,
  • Lacey E. Dobrolecki,
  • A. McGarry Houghton,
  • Paul E. Kinahan,
  • John Kurhanewicz and
  • Rong Zhou
  • + 15 authors

16 March 2023

The availability of high-fidelity animal models for oncology research has grown enormously in recent years, enabling preclinical studies relevant to prevention, diagnosis, and treatment of cancer to be undertaken. This has led to increased opportunit...

  • Article
  • Open Access
10 Citations
6,431 Views
18 Pages

12 October 2020

In situ ATR-FTIR spectroscopy and imaging and image analysis were applied to the study of the multicomponent co-crystallization process involving S-valsartan and sacubitril in which LCZ696 crystals were formed. LCZ696 is a combination drug for use in...

  • Review
  • Open Access
2 Citations
4,013 Views
11 Pages

30 April 2023

Genetically engineered mouse models (GEMMs) and patient-derived xenograft mouse models (PDXs) can recapitulate important biological features of cancer. They are often part of precision medicine studies in a co-clinical setting, in which therapeutic i...

  • Perspective
  • Open Access
11 Citations
2,315 Views
15 Pages

Co-Clinical Imaging Resource Program (CIRP): Bridging the Translational Divide to Advance Precision Medicine

  • Kooresh I. Shoghi,
  • Cristian T. Badea,
  • Stephanie J. Blocker,
  • Thomas L. Chenevert,
  • Richard Laforest,
  • Michael T. Lewis,
  • Gary D. Luker,
  • H. Charles Manning,
  • Daniel S. Marcus and
  • Rong Zhou
  • + 6 authors

1 September 2020

The National Institutes of Health’s (National Cancer Institute) precision medicine initiative emphasizes the biological and molecular bases for cancer prevention and treatment. Importantly, it addresses the need for consistency in preclinical and cli...

  • Article
  • Open Access
2 Citations
1,781 Views
16 Pages

Direct Jet Co-Electrospinning of Spinal Cord-Mimicking Phantom for Diffusion Magnetic Resonance Imaging

  • Qi Li,
  • Longji Xu,
  • Chunyan Hu,
  • Ziwei Zhang,
  • Daxiang Yang,
  • Weibo Chen,
  • Gareth Williams,
  • Geoff J. M. Parker,
  • Fei Gao and
  • Feng-Lei Zhou

24 April 2024

(1) Background: Spinal cord injuries and diseases necessitate sophisticated tools for accurate diagnosis and treatment planning. However, the lack of reliable phantoms mimicking the complex structure of the spinal cord hinders the development and val...

  • Article
  • Open Access
215 Views
20 Pages

16 January 2026

Optical and SAR image registration and fusion are pivotal in the remote sensing field, as they leverage the complementary advantages of both modalities. However, achieving this with high accuracy and efficiency remains challenging. This challenge ari...

  • Article
  • Open Access
1 Citations
1,145 Views
18 Pages

Bimodal Poly(lactic-co-glycolic acid) Nanocarrier with Zinc Oxide and Iron Oxide for Fluorescence and Magnetic Resonance Imaging

  • Thúlio Wliandon Lemos Barbosa,
  • Laurent Lemaire,
  • Isabelle Verdu,
  • Larissa Santos,
  • Natália Galvão de Freitas,
  • Mariana Picchi Salto and
  • Leila Aparecida Chiavacci

18 April 2025

Zinc oxide (ZnO) and iron oxide (IO) nanoparticles have been identified as promising candidates for biomedical applications, based on their unique physicochemical properties. The association of these nanoparticles in a single system creates a bimodal...

  • Article
  • Open Access
10 Citations
5,033 Views
13 Pages

Achieving a 99mTc labeled thymidine radiotracer for single photon emission tomography (SPECT) is considered to be of interest. In this study, four novel thymidine analogs, 6a, 6b, 6c and 6d, were successfully synthesized via “click reaction” route an...

  • Technical Note
  • Open Access
1 Citations
1,327 Views
14 Pages

2 February 2025

Due to its miniature size and single-pass nature, Unmanned Aerial Vehicle (UAV)-borne array synthetic aperture radar (SAR) is capable of obtaining three-dimensional (3D) electromagnetic scattering information with a low cost and high efficiency, maki...

  • Article
  • Open Access
3 Citations
2,567 Views
13 Pages

28 June 2022

A monolithic microfluidic free-flow electrophoresis device, fabricated using low-temperature co-fired ceramic technology, is presented. The device integrates gold electrodes and a 20 µm thick transparent ceramic optical window, suitable for flu...

  • Article
  • Open Access
16 Citations
3,805 Views
15 Pages

14 November 2024

The detection of heavy metal ions and organic pollutants from water sources remains critical challenges due to their detrimental effects on human health and the environment. Herein, a nitrogen and sulfur co-doped carbon quantum dot (NS-CQDs) fluoresc...

  • Article
  • Open Access
10 Citations
3,311 Views
18 Pages

8 April 2020

KOMPSAT-3, a Korean earth observing satellite, provides the panchromatic (PAN) band and four multispectral (MS) bands. They can be fused to obtain a pan-sharpened image of higher resolution in both the spectral and spatial domain, which is more infor...

  • Article
  • Open Access
5 Citations
1,940 Views
12 Pages

12 November 2022

For the co-saliency detection algorithm of an RGBD image that may have incomplete detection of common salient regions and unclear boundaries, we proposed an improved co-saliency detection method of RGBD images based on superpixels and hypergraphs. Fi...

  • Article
  • Open Access
7 Citations
3,895 Views
20 Pages

Semi-Supervised Medical Image Segmentation with Co-Distribution Alignment

  • Tao Wang,
  • Zhongzheng Huang,
  • Jiawei Wu,
  • Yuanzheng Cai and
  • Zuoyong Li

Medical image segmentation has made significant progress when a large amount of labeled data are available. However, annotating medical image segmentation datasets is expensive due to the requirement of professional skills. Additionally, classes are...

  • Article
  • Open Access
2 Citations
3,028 Views
24 Pages

17 March 2023

Semi-supervised learning is a technique that utilizes a limited set of labeled data and a large amount of unlabeled data to overcome the challenges of obtaining a perfect dataset in deep learning, especially in medical image segmentation. The accurac...

  • Article
  • Open Access
1 Citations
2,583 Views
19 Pages

28 May 2020

Dimensionality reduction (DR) methods based on graph embedding are widely used for feature extraction. For these methods, the weighted graph plays a vital role in the process of DR because it can characterize the data’s structure information. M...

  • Review
  • Open Access
15 Citations
5,316 Views
22 Pages

Imaging Diagnostics and Pathology in SARS-CoV-2-Related Diseases

  • Manuel Scimeca,
  • Nicoletta Urbano,
  • Rita Bonfiglio,
  • Manuela Montanaro,
  • Elena Bonanno,
  • Orazio Schillaci and
  • Alessandro Mauriello

22 September 2020

In December 2019, physicians reported numerous patients showing pneumonia of unknown origin in the Chinese region of Wuhan. Following the spreading of the infection over the world, The World Health Organization (WHO) on 11 March 2020 declared the nov...

  • Article
  • Open Access
19 Citations
3,844 Views
17 Pages

20 June 2021

With the development of social networks and intelligent terminals, it is becoming more convenient to share and acquire images. The massive growth of the number of social images makes people have higher demands for automatic image processing, especial...

  • Feature Paper
  • Article
  • Open Access
39 Citations
8,869 Views
21 Pages

“Seeing Is Believing”—In-Depth Analysis by Co-Imaging of Periodically-Poled X-Cut Lithium Niobate Thin Films

  • Sven Reitzig,
  • Michael Rüsing,
  • Jie Zhao,
  • Benjamin Kirbus,
  • Shayan Mookherjea and
  • Lukas M. Eng

15 March 2021

Nonlinear and quantum optical devices based on periodically-poled thin film lithium niobate (PP-TFLN) have gained considerable interest lately, due to their significantly improved performance as compared to their bulk counterparts. Nevertheless, perf...

  • Article
  • Open Access
22 Citations
5,864 Views
18 Pages

SAR and Optical Image Registration Based on Deep Learning with Co-Attention Matching Module

  • Jiaxing Chen,
  • Hongtu Xie,
  • Lin Zhang,
  • Jun Hu,
  • Hejun Jiang and
  • Guoqian Wang

4 August 2023

Image registration is the basis for the joint interpretation of synthetic aperture radar (SAR) and optical images. However, the significant nonlinear radiation difference (NRD) and the geometric imaging model difference render the registration quite...

  • Article
  • Open Access
12 Citations
3,209 Views
16 Pages

SelfCoLearn: Self-Supervised Collaborative Learning for Accelerating Dynamic MR Imaging

  • Juan Zou,
  • Cheng Li,
  • Sen Jia,
  • Ruoyou Wu,
  • Tingrui Pei,
  • Hairong Zheng and
  • Shanshan Wang

Lately, deep learning technology has been extensively investigated for accelerating dynamic magnetic resonance (MR) imaging, with encouraging progresses achieved. However, without fully sampled reference data for training, the current approaches may...

  • Article
  • Open Access
9 Citations
3,328 Views
15 Pages

Photoacoustic-MR Image Registration Based on a Co-Sparse Analysis Model to Compensate for Brain Shift

  • Parastoo Farnia,
  • Bahador Makkiabadi,
  • Maysam Alimohamadi,
  • Ebrahim Najafzadeh,
  • Maryam Basij,
  • Yan Yan,
  • Mohammad Mehrmohammadi and
  • Alireza Ahmadian

21 March 2022

Brain shift is an important obstacle to the application of image guidance during neurosurgical interventions. There has been a growing interest in intra-operative imaging to update the image-guided surgery systems. However, due to the innate limitati...

  • Article
  • Open Access

3 February 2026

Fine-grained food image segmentation is essential for accurate dietary assessment and nutritional analysis, yet remains highly challenging due to ambiguous boundaries, inter-class similarity, and dense layouts of meals containing many different ingre...

  • Article
  • Open Access
4 Citations
2,452 Views
18 Pages

Development of a Mouse-Adapted Reporter SARS-CoV-2 as a Tool for Two-Photon In Vivo Imaging

  • Hiroshi Ueki,
  • Maki Kiso,
  • Yuri Furusawa,
  • Shun Iida,
  • Seiya Yamayoshi,
  • Noriko Nakajima,
  • Masaki Imai,
  • Tadaki Suzuki and
  • Yoshihiro Kawaoka

29 March 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) often causes severe viral pneumonia. Although many studies using mouse models have examined the pathogenicity of SARS-CoV-2, COVID-19 pathogenesis remains poorly understood. In vivo imaging...

  • Article
  • Open Access
5 Citations
6,171 Views
20 Pages

As contemporary role models in the digital space, influencers are seen as one of the actors able to engage users with their posts, which also affects the image of a destination, and thus contributes to the co-creation process. At the same time, less...

  • Article
  • Open Access
12 Citations
3,121 Views
21 Pages

Infrared and Visible Image Fusion Based on Co-Occurrence Analysis Shearlet Transform

  • Biao Qi,
  • Longxu Jin,
  • Guoning Li,
  • Yu Zhang,
  • Qiang Li,
  • Guoling Bi and
  • Wenhua Wang

8 January 2022

This study based on co-occurrence analysis shearlet transform (CAST) effectively combines the latent low rank representation (LatLRR) and the regularization of zero-crossing counting in differences to fuse the heterogeneous images. First, the source...

  • Article
  • Open Access
13 Citations
3,747 Views
24 Pages

28 January 2022

The co-registration between SAR and optical images is a challenging task because of the speckle noise of SAR and the nonlinear radiation distortions (NRD), particularly in the one-look situation. In this paper, we propose a novel density descriptor b...

  • Article
  • Open Access
4 Citations
2,386 Views
22 Pages

Object-Oriented Remote Sensing Image Change Detection Based on Color Co-Occurrence Matrix

  • Zhu Zhu,
  • Tinggang Zhou,
  • Jinsong Chen,
  • Xiaoli Li,
  • Shanxin Guo,
  • Longlong Zhao and
  • Luyi Sun

1 June 2023

Aiming at the problem of misdetection caused by the traditional texture characteristic extraction model, which does not describe the correlation among multiple bands, an object-oriented remote sensing image change detection method based on a color co...

  • Article
  • Open Access
14 Citations
3,839 Views
24 Pages

23 July 2020

The Inverse Gas Chromatography (IGC) technique has been employed for the surface thermo-dynamic characterization of the polymer Poly(vinylidene chloride-co-acrylonitrile) (P(VDC-co-AN)) in its pure form. IGC attributes, such as London dispersive surf...

  • Article
  • Open Access
8 Citations
3,727 Views
20 Pages

1 June 2023

Universities play a significant role in the economic development of society as they provide knowledge and skills that are essential for social sustainability. In recent years, universities shifted their focus towards student-centered education and ne...

  • Article
  • Open Access
202 Citations
25,355 Views
21 Pages

AROSICS: An Automated and Robust Open-Source Image Co-Registration Software for Multi-Sensor Satellite Data

  • Daniel Scheffler,
  • André Hollstein,
  • Hannes Diedrich,
  • Karl Segl and
  • Patrick Hostert

1 July 2017

Geospatial co-registration is a mandatory prerequisite when dealing with remote sensing data. Inter- or intra-sensoral misregistration will negatively affect any subsequent image analysis, specifically when processing multi-sensoral or multi-temporal...

  • Article
  • Open Access
10 Citations
3,573 Views
25 Pages

This research aims to examine the use of image processing and texture analysis to find a more reliable and efficient solution for identifying and classifying types of meat, based on their texture. The method used involves the use of feature extractio...

  • Article
  • Open Access
1 Citations
2,407 Views
13 Pages

Acute Macular Neuroretinopathy after SARS-CoV-2 Infection: An Analysis of Clinical and Multimodal Imaging Characteristics

  • Jiyang Tang,
  • Siying Li,
  • Zongyi Wang,
  • Ye Tao,
  • Linqi Zhang,
  • Hong Yin,
  • Heng Miao,
  • Yaoyao Sun and
  • Jinfeng Qu

5 December 2023

Background: This study aimed to analyze clinical and multimodal imaging characteristics of acute macular neuroretinopathy (AMN) post-recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: Retrospective observational s...

  • Article
  • Open Access
35 Citations
6,336 Views
15 Pages

Clinical and Imaging Characteristics in Patients with SARS-CoV-2 Infection and Acute Intracranial Hemorrhage

  • Jawed Nawabi,
  • Andrea Morotti,
  • Moritz Wildgruber,
  • Gregoire Boulouis,
  • Hermann Kraehling,
  • Frieder Schlunk,
  • Elif Can,
  • Helge Kniep,
  • Götz Thomalla and
  • Peter Sporns
  • + 4 authors

6 August 2020

Background and Purpose: Intracranial hemorrhage has been observed in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19), but the clinical, imaging, and pathophysiological features of intracranial bleeding...

  • Concept Paper
  • Open Access
3 Citations
3,412 Views
19 Pages

Toward Practical Integration of Omic and Imaging Data in Co-Clinical Trials

  • Emel Alkim,
  • Heidi Dowst,
  • Julie DiCarlo,
  • Lacey E. Dobrolecki,
  • Anadulce Hernández-Herrera,
  • David A. Hormuth,
  • Yuxing Liao,
  • Apollo McOwiti,
  • Robia Pautler and
  • Michael T. Lewis
  • + 8 authors

10 April 2023

Co-clinical trials are the concurrent or sequential evaluation of therapeutics in both patients clinically and patient-derived xenografts (PDX) pre-clinically, in a manner designed to match the pharmacokinetics and pharmacodynamics of the agent(s) us...

  • Article
  • Open Access
197 Citations
11,724 Views
15 Pages

22 June 2017

To address the problem of image texture feature extraction, a direction measure statistic that is based on the directionality of image texture is constructed, and a new method of texture feature extraction, which is based on the direction measure and...

  • Article
  • Open Access
1 Citations
2,031 Views
11 Pages

High uniformity of positron emission tomography (PET) images in the field of nuclear medicine is necessary to obtain excellent and stable data from the system. In this study, we aimed to apply and optimize a PET/magnetic resonance (MR) imaging system...

  • Article
  • Open Access
1,063 Views
20 Pages

6 June 2025

Multimodal image fusion and semantic segmentation play pivotal roles in autonomous driving and robotic systems, yet their inherent interdependence remains underexplored. To address this gap and overcome performance bottlenecks, we propose SC-CoSF, a...

  • Article
  • Open Access
13 Citations
3,357 Views
11 Pages

Development of a Cell-Based SARS-CoV-2 Pseudovirus Neutralization Assay Using Imaging and Flow Cytometry Analysis

  • Jerilyn R. Izac,
  • Edward J. Kwee,
  • Linhua Tian,
  • Elzafir Elsheikh,
  • Adolfas K. Gaigalas,
  • John T. Elliott and
  • Lili Wang

2 August 2023

COVID-19 is an ongoing, global pandemic caused by the novel, highly infectious SARS-CoV-2 virus. Efforts to mitigate the effects of SARS-CoV-2, such as mass vaccination and development of monoclonal therapeutics, require precise measurements of corre...

  • Article
  • Open Access
9 Citations
3,997 Views
23 Pages

CCT: Conditional Co-Training for Truly Unsupervised Remote Sensing Image Segmentation in Coastal Areas

  • Bo Fang,
  • Gang Chen,
  • Jifa Chen,
  • Guichong Ouyang,
  • Rong Kou and
  • Lizhe Wang

5 September 2021

As the fastest growing trend in big data analysis, deep learning technology has proven to be both an unprecedented breakthrough and a powerful tool in many fields, particularly for image segmentation tasks. Nevertheless, most achievements depend on h...

  • Article
  • Open Access
3 Citations
2,374 Views
26 Pages

30 June 2025

Multi-modal remote sensing images often exhibit complex and nonlinear radiation differences which significantly hinder the performance of traditional feature-based image registration methods such as Scale-Invariant Feature Transform (SIFT). In contra...

  • Article
  • Open Access
13 Citations
3,891 Views
13 Pages

Multispectral Imaging and OCT-Guided Precision Treatment of Rhinophyma with CO2 and Dye Lasers: A Comprehensive Diagnostic and Therapeutic Approach

  • Simone Amato,
  • Steven Paul Nisticò,
  • Alessandro Clementi,
  • Giorgio Stabile,
  • Fortunato Cassalia,
  • Annunziata Dattola,
  • Giuseppe Rizzuto and
  • Giovanni Cannarozzo

13 December 2024

Background/Objectives: Rhinophyma, an advanced form of rosacea, is characterized by significant nasal tissue enlargement and deformation, leading to aesthetic and psychosocial challenges. Traditional treatments are often invasive with variable outcom...

  • Article
  • Open Access
1 Citations
2,047 Views
13 Pages

14 February 2025

Neutralization assays have become an important tool since the beginning of the COVID-19 pandemic for testing vaccine responses and therapeutic antibodies as well as for monitoring humoral immunity to SARS-CoV-2 in epidemiological studies. The spike g...

  • Essay
  • Open Access
11 Citations
2,282 Views
15 Pages

In order to recognize breast cancer histopathological images, this article proposed a combined model consisting of a pyramid gray level co-occurrence matrix (PGLCM) feature extraction model and an incremental broad learning (IBL) classification model...

  • Article
  • Open Access
21 Citations
5,346 Views
24 Pages

26 March 2019

Thanks to the recent development of laser scanner hardware and the technology of dense image matching (DIM), the acquisition of three-dimensional (3D) point cloud data has become increasingly convenient. However, how to effectively combine 3D point c...

  • Article
  • Open Access
4 Citations
2,304 Views
17 Pages

28 October 2022

The application of ultra-high spatial resolution imagery from small unpiloted aerial systems (sUAS) can provide valuable information about the status of built infrastructure following natural disasters. This study employs three methods for improving...

  • Article
  • Open Access
8 Citations
2,526 Views
14 Pages

Outcome Prediction for SARS-CoV-2 Patients Using Machine Learning Modeling of Clinical, Radiological, and Radiomic Features Derived from Chest CT Images

  • Lorenzo Spagnoli,
  • Maria Francesca Morrone,
  • Enrico Giampieri,
  • Giulia Paolani,
  • Miriam Santoro,
  • Nico Curti,
  • Francesca Coppola,
  • Federica Ciccarese,
  • Giulio Vara and
  • Lidia Strigari
  • + 4 authors

28 April 2022

(1) Background: Chest Computed Tomography (CT) has been proposed as a non-invasive method for confirming the diagnosis of SARS-CoV-2 patients using radiomic features (RFs) and baseline clinical data. The performance of Machine Learning (ML) methods u...

  • Article
  • Open Access
1 Citations
3,355 Views
12 Pages

26 March 2025

Background/Objectives: Accurate diagnosis during ultrasound examinations of patients with kidney and gallbladder stones is crucial. Although stone areas typically show posterior acoustic shadowing on ultrasound images, their accurate diagnosis can be...

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