Search Results (26)

This paper presents a checkerboard-patterned terahertz (THz) metamaterial absorber engineered for wide-band, dual-band absorption. The absorber consists of a gold metal layer patterned on a polyimide substrate, forming a unit cell structure with dimensions of 85 µm × 85 µm. At the core of the design is a square metal patch of 67 µm × 67 µm, which is divided into a 5 × 5 grid of 25 smaller cells. An integer-coded Particle Swarm Optimization (PSO) algorithm is employed to generate the pattern, where an input value of ‘1’ retains the metal in a cell, and a ‘0’ results in the removal of metal from that cell, resulting in a digitally optimized checkerboard pattern. The substrate height is also optimized and fixed at 7 µm to enhance resonance characteristics. The PSO algorithm is run for 50 iterations, with the fitness function defined as the number of frequency points at which the absorption exceeds 90%. The finalized design achieves two distinct absorption peaks with high efficiency: 99.53% at 3.434 THz, with a 90% absorption bandwidth of 212 GHz; and 99.35% at 3.823 THz, with a bandwidth of 177 GHz. While the absorption performance is already significant, it can be further improved by increasing the number of PSO iterations, albeit at the cost of higher computational complexity. The proposed absorber demonstrates strong potential for biomedical sensing, as validated through its ability to differentiate between cancerous and non-cancerous breast and blood cells. This work paves the way for fully automated, algorithm-driven metamaterial design strategies in the THz regime, particularly for applications in non-invasive biomedical diagnostics. Full article

The advancement of topology optimization (TO) and additive manufacturing (AM) has significantly enhanced structural design flexibility and the potential for lightweight structures. However, challenges such as intermediate density, mesh dependency, checkerboard patterns, and local extrema in TO can lead to suboptimal performance. Moreover, existing AM technologies confront geometric constraints that limit their application. This study investigates minimum compliance as the objective function and volume as the constraint, employing the solid isotropic material with penalization method, density filtering, and the method of moving asymptotes. It examines how factors like mesh type, mesh size, volume fraction, material properties, initial density, filter radius, and penalty factor influence the TO results for a metallic gooseneck chain. The findings suggest that material properties primarily affect numerical variations along the TO path, with minimal impact on structural configuration. For both hexahedral and tetrahedral mesh types, a recommended mesh size is identified where the results show less than a 1% difference across varying mesh sizes. An initial density of 0.5 is advised, with a filter radius of approximately 2.3 to 2.5 times the average unit edge length for hexahedral meshes and 1.3 to 1.5 times for tetrahedral meshes. The suggested penalty factor ranges of 3–4 for hexahedral meshes and 2.5–3.5 for tetrahedral meshes. The optimal geometric reconstruction model achieves weight reductions of 23.46% and 22.22% compared to the original model while satisfying static loading requirements. This work contributes significantly to the integration of TO and AM in engineering, laying a robust foundation for future design endeavors. Full article

Polyominoes are shapes formed by joining edge-connected unit squares in the square lattice. We review their symmetry classification using dihedral group actions and enumerate their distinct, coloured variants, called “chrominoes”, which arise when polyominoes are placed on a C-coloured checkerboard. This colouring method, defined via modular arithmetic, assigns colours cyclically in both directions. Our main theoretical result establishes that for $C=2$, a polyomino has either one or two chrominoes, depending on whether it has a colour-reversing symmetry. Additionally, we introduce a new classification of two-colour chrominoes into 15 symmetry-based classes. For $C\ge 3$, the number of chrominoes is a small integer multiple of C, determined by the polyomino’s symmetry class and the symmetries of the infinite C-coloured checkerboard plane. These findings have applications to integer linear programming methods for polyomino tiling problems. We validate our theoretical results through exhaustive search in MATLAB and illustrate them with examples. Full article

The replacement of greenhouse surfaces with photovoltaic cells currently presents issues with internal shading and uneven illumination, which adversely affect crop growth and yield. Therefore, in order to improve greenhouse lighting by altering the arrangement of photovoltaic cells for greater economic and environmental benefits, four cities (Harbin, Shenyang, Nanjing, and Guangzhou) were selected for this study. Greenhouse models were established using the DesignBuilder software tool, focusing on the summer and winter growth stages of cherry tomatoes and strawberries. Two arrangements were employed—compact (CR) and checkerboard (BR)—to evaluate 18 scenarios based on power generation, illuminance uniformity, and temperature. Analysis revealed that, among the four cities, the checkerboard arrangement improved average illumination uniformity by 37.34%, 37.9%, 38.2%, and 35.8%, respectively, compared with the compact arrangement. Except for nine rows of photovoltaic cells in Guangzhou, the unit of area power generation of the schemes exceeded 80 kWh/m² in summer, with excellent power generation efficiency. In winter, there was a relative decrease. Among the four cities, only Harbin reached seven rows of photovoltaic cells which produced more than 80 kWh/m² under the unit of area of photovoltaic cells, while the other three cities achieved five rows. Strawberries are not suitable for growing in Harbin and Shenyang in winter. In addition to this, cherry tomatoes and strawberries in different regions and at different stages have the best arrangements for growth and for maximizing cost efficiency. Full article

Existing camera calibration methods using a single image have exhibited some limitations. These limitations include relying on large datasets, using inconveniently prepared calibration objects instead of commonly used planar patterns such as checkerboards, and requiring further improvement in accuracy. To address these issues, a high-quality and convenient camera calibration method is proposed, which only requires a single image of the commonly used planar checkerboard pattern. In the proposed method, a nonlinear objective function is derived by leveraging the linear distribution characteristics exhibited among corners. An algorithm based on enumeration theory is designed to minimize this function. It calibrates the first two radial distortion coefficients and principal points. The focal length and extrinsic parameters are linearly calibrated from the constraints provided by the linear projection model and the unit orthogonality of the rotation matrix. Additionally, a guideline is explored through theoretical analysis and numerical simulation to ensure calibration quality. The quality of the proposed method is evaluated by both simulated and real experiments, demonstrating its comparability with the well-known multi-image-based method and its superiority over advanced single-image-based methods. Full article

Background/Objectives: Among various carbapenemases, New Delhi metallo-beta-lactamases (NDMs) are recognized as the most powerful type capable of hydrolyzing all beta-lactam antibiotics, often conferring multi-drug resistance to the microorganism. The objective of this review is to synthesize current scientific data on NDM inhibitors to facilitate the development of future therapeutics for challenging-to-treat pathogens. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews, we conducted a MEDLINE search for articles with relevant keywords from the beginning of 2009 to December 2022. We employed various generic terms to encompass all the literature ever published on potential NDM inhibitors. Results: Out of the 1760 articles identified through the database search, 91 met the eligibility criteria and were included in our analysis. The fractional inhibitory concentration index was assessed using the checkerboard assay for 47 compounds in 37 articles, which included 8 compounds already approved by the Food and Drug Administration (FDA) of the United States. Time-killing curve assays (14 studies, 25%), kinetic assays (15 studies, 40.5%), molecular investigations (25 studies, 67.6%), in vivo studies (14 studies, 37.8%), and toxicity assays (13 studies, 35.1%) were also conducted to strengthen the laboratory-level evidence of the potential inhibitors. None of them appeared to have been applied to human infections. Conclusions: Ongoing research efforts have identified several potential NDM inhibitors; however, there are currently no clinically applicable drugs. To address this, we must foster interdisciplinary and multifaceted collaborations by broadening our own horizons. Full article

Global climate change leads to frequent extreme snowfall weather, which has a significant impact on the safety and operating efficiency of urban public transportation. In order to cope with the adverse effects of extreme weather, governments should vigorously develop sustainable transportation. Since urban public transportation is a critical component of building a sustainable city, traffic management departments should quantitatively analyze the performance changes of the urban public transportation network under extreme weather conditions. Therefore, fully considering the comprehensive effects of network performance and topology to improve the robustness of urban public transportation systems requires more attention. The urban public transport network with high robustness can achieve fewer recovery costs, lower additional bus scheduling costs, and achieve the sustainable development of the public transport network. Considering the impact of travelers’ travel time tolerance and in-vehicle space congestion tolerance under snowy conditions, this paper proposes a generalized-norm-based robustness evaluation model of the bus network. Example analyses are conducted using checkerboard and ring-radial topological network structures to verify the applicability of the proposed model. The results show the following: (1) In an extreme snowfall scenario, the robustness of checkerboard and ring-radiating bus networks is reduced by 38% and 39%, respectively. (2) In the checkerboard network, the central area units are always more important to the system robustness than the peripheral units, while, in the ring-radial network, the units with higher importance are all in the ring line. (3) The failure of Ring Line 5 has a great impact on both the checkerboard and ring-radial networks, causing the system robustness to decrease by 43% and 50%, respectively. Full article

Silver has been shown to improve the antibiotic effects of other drugs against both Gram- positive and -negative bacteria. In this study, we investigated the antibiotic potential of cannabidiol (CBD), cannabichromene (CBC) and cannabigerol (CBG) and their acidic counterparts (CBDA, CBCA, CBGA) against Gram-positive bacteria and further explored the additive or synergistic effects of silver nitrate or silver nanoparticles using 96-well plate growth assays and viability (CFUs- colony-forming units). All six cannabinoids had strong antibiotic effects against MRSA with minimal inhibitory concentrations (MICs) of 2 mg/L for CBG, CBD and CBCA; 4 mg/L for CBGA; and 8 mg/L for CBC and CBDA. Using 96-well checkerboard assays, CBC, CBG and CBGA showed full or partial synergy with silver nitrate; CBC, CBDA and CBGA were fully synergistic with silver nanoparticles against MRSA. Using CFU assays, combinations of CBC, CBGA and CBG with either silver nitrate or silver nanoparticles, all at half or quarter MICs, demonstrated strong, time-dependent inhibition of bacterial growth (silver nitrate) and bactericidal effects (silver nanoparticles). These data will lead to further investigation into possible biomedical applications of specific cannabinoids in combination with silver salts or nanoparticles against drug-resistant Gram-positive bacteria. Full article

Phosphorus (P) is an essential macronutrient crucial for both plant growth and crop production, playing a pivotal role in agriculture since the early 20th century. The symbiotic relationship between AMF and plants serves as a classic illustration. These fungi play a regulatory role in the growth and development of plants, especially in facilitating the absorption of P and carbon molecules by plants. While there has been a growing body of research on the community assembly of arbuscular mycorrhizal fungi (AMF) in recent decades, our knowledge of the processes governing the coexistence of these AMF communities influenced by P in agroecosystems remains limited. To investigate the impact of various P fertilizers on AMF communities in temperate agroecosystems, this study was conducted using soils sourced from wheat–maize rotation farmland at Henan Agricultural University Yuanyang Base. With the Illumina MiSeq high-throughput sequencing technique, we systematically examined the taxonomic composition of soil AMF at the Yuanyang Base of Henan Agricultural University in a wheat–maize rotation agricultural field. Our primary objective was to unravel the mechanisms behind AMF community assembly and stability under varying P gradient fertilization conditions. Nonmetric Multidimensional Scaling (NMDS) analysis revealed significant differences among AMF communities in field soil subjected to various treatments (p < 0.05). A torus translations test demonstrated positive associations with the three treatments in 36 out of the 51 examined AMF operational taxonomic units (OTUs), making up 70.59% (p < 0.05) of the results. Furthermore, 37.84% (14/37) of the OTUs displayed preferences for the low P concentration treatment, while 34.29% (12/35) and 32.26% (10/31) favored medium and high P concentrations, respectively. An analysis of the Normalized Stochasticity Ratio (NST) and Checkerboard Score (C-score) indicated that in temperate agroecosystems, deterministic processes predominantly governed AMF in all treatment groups, with high P conditions exerting a stronger influence than low or medium P conditions. This study underscores the profound impact of long-term P fertilizer application on AMF community structures within temperate agricultural systems employing wheat–maize rotation. Additionally, it highlights the dominant role played by deterministic processes in shaping the assembly of AMF communities in these temperate agricultural systems that use P fertilizers. These findings emphasize the need for balanced nutrient management, particularly concerning P, to ensure the stability of AMF communities. Full article

Pseudomonas aeruginosa with difficult-to-treat resistance has been designated as an urgent or serious threat by the CDC in the United States; therefore, novel antibacterial drugs and combination strategies are urgently needed. The sensor kinase RoxS is necessary for the aerobic growth of Pseudomonas aeruginosa. This study aimed to screen candidate RoxS inhibitors and evaluate their efficacy in treating multi-drug-resistant and extensively drug-resistant Pseudomonas aeruginosa in combination with meropenem and amikacin to identify promising combination strategies. RoxS protein structures were constructed using homology modeling and potential RoxS inhibitors, including Ezetimibe, Deferasirox, and Posaconazole, were screened from the FDA-approved ZINC drug database using molecular docking and molecular dynamics simulations. MIC and checkerboard assays were used to determine the in vitro antimicrobial efficacy of the three drugs in combination with antibiotics. The results of in vitro experiments showed an additive effect of 100 μg/mL Deferasirox or 16 μg/mL Posaconazole in combination with meropenem and a synergistic effect of 1.5 μg/mL Deferasirox and amikacin. In summary, these three drugs are potential inhibitors of RoxS, and their combination with meropenem or amikacin is expected to reverse the resistance of P. aeruginosa, providing new combination strategies for the treatment of clinically difficult-to-treat Pseudomonas aeruginosa. Full article

Traditional stealth technologies all have their problems such as high cost and large thickness. To solve the problems, we used novelty checkerboard metasurface in stealth technology. Checkerboard metasurface does not have as high conversion efficiency as radiation converters, but it has many advantages such as small thickness and low cost. So it is expected to overcome the problems of traditional stealth technologies. Unlike other checkerboard metasurfaces, we improved it further by using two types of polarization converter units to be arranged in turn to form a hybrid checkerboard metasurface. Because the checkerboard metasurface composed of one type of polarization converter units can have a relatively wide radar cross-section (RCS) reduction in bandwidth when two types of polarization converter units are arranged in turn to form a hybrid checkerboard metasurface and mutual compensation of the two polarization converter units can broaden RCS reduction band further. Therefore, by designing the metasurface to be independent from the polarization, the effect of RCS reduction can be insensitive to the polarization of the incoming EM waves. The experiment and simulation results showed the value of this proposed hybrid checkerboard metasurface for RCS reduction. Mutual compensation of the units is a new attempt in the field of checkerboard metasurfaces for stealth technology and proved to be effective. Full article

Biofilm-mediated infections are critical to public health and a leading cause of resistance among pathogens, amounting to a prolonged hospital stay and increased mortality rate in the intensive care unit. In this study, the antibacterial and antibiofilm activities of rifampicin or carbapenem monotherapies were compared with rifampicin and carbapenem combination therapies against rifampicin-resistant and carbapenem-resistant Acinetobacter baumannii isolates. Among 29 CRAB isolates, 24/29 (83%) were resistant to rifampicin, with MIC values between 2–256 µg/mL. Checkerboard assays disclosed that combination therapies at FICIs between 1/8 and 1/4 improved the activity of carbapenems at subinhibitory concentrations. Time-kill kinetics indicated a 2- to 4-log reduction at 1/2 MIC rifampicin + 1/4 MIC carbapenem and 1/4 MIC rifampicin + 1/4 MIC carbapenem against the isolates, with the MIC values ranging from 2–8 µg/mL. The MTT assay revealed a dose-dependent decrease of the cell viability of established bacterial biofilm at 4 MIC rifampicin + 2 MIC carbapenems, with a percentage reduction of 44–75%, compared with monotherapies at 16 MIC. Scanning electron microscopy further confirmed bacterial cell membrane disruption, suggesting a synergism between carbapenem and rifampicin against a representative isolate. The findings demonstrated that the combination of rifampicin with carbapenems could improve antibacterial activities and eradicate established Acinetobacter baumannii biofilm. Full article

A novel design method of simultaneous beam forming and focusing using a checkerboard anisotropic surface is proposed and verified in this paper. The proposed multibeam control regardless of far and near regions can easily be achieved through a rearrangement of the checkerboard structure. The unit cell of the utilized anisotropic surface consists of two identical metallic structures divided by a dielectric material. When the EM wave with a circular polarization (CP) is incident on the unit cell, the maximum transmission phase variation of the unit cell is 360 degrees by half rotation of the unit cell. A microstrip patch antenna with trimmed corners is used to launch the CP wave and the distance between the microstrip patch antenna and anisotropic surface is about 2 wavelengths considering the optimized spillover and taper efficiencies. After designing each anisotropic surface for beam forming and focusing, the unit cells of the surface are rearranged in the form of a checkerboard. The feasibility of the proposed method is confirmed by full-wave simulation and measurement for anisotropic surface with a beam forming angle of 30 degrees and beam focusing point 60 mm away from center at 5.8 GHz. The forming angle and focal length are simulated and measured to be 28 degrees and about 65 mm, respectively. Full article

In this paper, a metamaterial absorber with a checkerboard patterned ITO (indium tin oxide) film as the surface is obtained by using flexible and optically transparent wave-absorbing material ITO–PET (polyethylene terephthalate), and a coding arrangement of two basic coding units based on the APS-PSO (Array Pattern Synthesis -Particle Swarm Optimization) algorithm. The surface structure of the absorber consists of ITO rectangular patch structures and ITO circular patch structures (110 Ω/sq). The ITO rectangular patch structures and ITO circular patch structures are symmetrical. The middle layer is made up of two layers of PET and one layer of PMMA, and the bottom surface is covered with a layer of low square resistance ITO film (8 Ω/sq). The experimental results, which are consistent with the simulation results, show that the absorber has superior performance: over 90% absorptance in the 5.06–9.01 GHz band, high transmittance, and a −10 dBsm RCS (radar cross-section) reduction in the 5.3–8.7 GHz band. This design also has polarization insensitivity and angular stability. Full article

Ionospheric disturbances caused by the 2016 West Sumatra earthquake have been studied using total electron content (TEC) measurements by Global Navigation Satellite System (GNSS) observation stations evenly distributed in Sumatra and Java, Indonesia. Previous observation focused on the coseismic ionospheric disturbances (CID) detected 11–16 min after the earthquake. The maximum TEC amplitude measured was 2.9 TECU (TEC Unit) with speed between 1 and 1.72 km/s. A comprehensive analysis needs to be done to see how the growth and direction of the movement of the CID due to the earthquake is using the 3D tomography method. The dimensions of 3D tomographic model are setup to 1° × 1.2° × 75 km. The continuity constraints were used to stabilize the solution, and multiple resolution tests with synthetic data were conducted to evaluate the precision of the results. This research focuses on the anomalous movement of the ionosphere observed in three dimensions. From the model, the positive anomaly initially appeared 11 min after the earthquake at the altitude of 300 km, which is the highest ionization layer and correspond to the electron density profile using IRI model. The anomalous movement appeared 12 min after the mainshock and moved 1° toward the geomagnetic field every minute. The density anomaly of the ionosphere began to weaken 8 min after the appearance of CID. To check the accuracy of the 3D tomography model, we carried out two types of tests, namely checkerboard resolution test and the second resolution test. Full article