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Analysis of the Setomimycin Biosynthetic Gene Cluster from Streptomyces nojiriensis JCM3382 and Evaluation of Its α-Glucosidase Inhibitory Activity Using Molecular Docking and Molecular Dynamics Simulations
- Kyung-A Hyun,
- Xuhui Liang,
- Yang Xu,
- Seung-Young Kim,
- Kyung-Hwan Boo,
- Jin-Soo Park,
- Won-Jae Chi and
- Chang-Gu Hyun
The formation of atroposelective biaryl compounds in plants and fungi is well understood; however, polyketide aglycone synthesis and dimerization in bacteria remain unclear. Thus, the biosynthetic gene cluster (BGC) responsible for antibacterial seto...