Search Results (3,028)

The choice of a symmetric encryption algorithm in practice is rarely as straightforward as it may appear from theoretical comparisons alone. In addition to security considerations, real-world selection often depends on execution time, reliability, entropy-related behavior, resource efficiency, and suitability for different types of data. This paper presents an experimental software platform for benchmarking and multi-criteria recommendation of symmetric encryption algorithms. The platform combines automated encryption and decryption tests, metric collection, comparative analysis, and result visualization within a unified evaluation workflow. It also incorporates a multi-criteria model that transforms raw experimental measurements into an overall ranking and supports context-aware recommendation according to the requirements of a given usage scenario. The experimental study includes repeated tests on different input categories in order to examine algorithm behavior under varied operating conditions. The obtained results show that algorithm performance and overall suitability are strongly dependent on the evaluation perspective and the application context, which suggests that no single symmetric method should be regarded as universally optimal. The proposed platform offers a practical basis for comparative cryptographic analysis and may be useful both for research purposes and for informed decision-making in security-oriented software environments. Full article

The Internet of Medical Things (IoMT) enables real-time monitoring and decision support systems in healthcare. However, due to their heterogeneous structure, limited resources, and high criticality, IoMT networks are vulnerable to cyberattacks. This situation increases the need for low-latency, high-accuracy, and generalizable attack detection systems. In this experimental study, the Multi-Scale Depthwise Channel Attention Network (MSCA-Net) model is proposed for multi-class attack detection in IoMT environments. The model consists of three core components: multi-scale depthwise separable convolutions to capture traffic patterns across different time scales, a squeeze-and-excitation-based channel attention mechanism that adaptively weights discriminative features, and a lightweight unidirectional LSTM layer that models temporal dependencies. This architecture enables effective representation learning with low parameter costs. The proposed model was evaluated on the WUSTL-EHMS-2020 and CICIoMT2024 datasets. On the CICIoMT2024 dataset, it achieved 99.75% accuracy and a weighted F1 score of 99.77% in a 6-class scenario. It has also demonstrated competitive results in 19-class fine-grained classification. Experimental comparisons show that MSCA-Net offers a better performance-to-cost trade-off compared to nine different baseline models. Furthermore, it demonstrates a speed advantage of up to two times in inference time. The results obtained at the conclusion of the experimental study demonstrate that the proposed approach effectively addresses the challenges of multi-scale feature extraction, class imbalance, and computational efficiency. Furthermore, the model appears to offer a viable solution for real-time attack detection in IoMT environments. Full article

Social media studies often rely on one platform while drawing conclusions about online publics more generally. This study tests that inferential move through an event-centered comparison of El Niño discourse across X/Twitter, YouTube, Facebook, Reddit, TikTok, and LinkedIn. The observation window ran from 9 May through 17 May 2026, several days before and after the May 14 El Niño Watch issued by the National Oceanic and Atmospheric Administration (NOAA), which reported an 82 percent probability of El Niño emerging during May to July 2026 and a 96 percent probability of continuation through the 2026 to 2027 Northern Hemisphere winter. The corpus contains 8145 items classified as highly or moderately related to El Niño after platform-specific collection and common annotation. X/Twitter supplies 7075 items, YouTube 864, Facebook 66, Reddit 59, TikTok 50, and LinkedIn 31. Texts were annotated with a shared structured schema covering relevance, sentiment, emotion, topic, stance, likely misinformation, personal experience, humor, calls to action, language, engagement, and length. The results show that platform choice changes the empirical object. X/Twitter appears multilingual, fast-moving, and weather-heavy. YouTube is more negative, humorous, and personally experiential. Facebook is long-form and media/news oriented, with the highest model-flagged likely misinformation rate. Reddit is concentrated around weather concern. TikTok is short, playful, and personal. LinkedIn is small, professional, and mostly informational. These differences caution against generalizing from one platform to social media as a whole unless a study explicitly defines its scope, accounts for platform and genre differences, and recognizes that visible discourse may include organizational, algorithmically amplified, automated, or otherwise inauthentic activity alongside genuine human expression. Full article

Background: Parental burnout results from chronic stress related to the parental role and reflects a persistent imbalance between parenting demands and available psychological resources, negatively affecting parental well-being and parent–child relationships. This study examined the associations between parental burnout, parenting attitudes, and psychological resilience within the parental adaptation of the job demands–resources model, with particular attention to the potential mediating role of parenting styles in the relationship between resilience and parental burnout, while controlling for sociodemographic factors. Methods: A cross-sectional design was applied with 447 Hungarian parents who completed an anonymous online questionnaire including the Parental Burnout Assessment, the Parenting Styles and Dimensions Questionnaire, and the 10-item Connor–Davidson Resilience Scale. Data were analyzed using nonparametric correlations, group comparisons, multiple linear regression models with bootstrap estimation, and mediation analyses. Results: Resilience showed negative associations with all dimensions of parental burnout. Authoritarian and permissive parenting styles were positively associated with burnout, whereas authoritative parenting style showed negative associations. In multivariate analyses, authoritative parenting attitudes and fulfillment of the ideal parental role emerged as protective factors, while authoritarian parenting style functioned as a significant risk factor. Mediation analyses further indicated that the association between resilience and parental burnout may partly operate through parenting styles, particularly across the dimensions of emotional exhaustion, contrast, and emotional distancing. Conclusions: Parental burnout appears to be a dynamic psychological process shaped by the interaction of internal resources and parenting functioning, underscoring the importance of resource-oriented approaches in prevention and intervention. Full article

This study examined acute pre- to post-match changes in perceived mental fatigue, subjective workload, and psychomotor performance in professional male soccer players, and whether cognitive changes were associated with GPS-derived external-load metrics, match outcome, and playing position. The dataset comprised 101 player–match measurements from 40 elite players, with paired pre–post psychomotor assessments yielding n = 202 total measurements. Pre–post comparisons were analysed using repeated-measures ANOVA, supplemented by linear mixed-effects models with a random intercept for player. Soccer matches produced large increases in perceived exertion, mental fatigue, mental demand, physical demand, and effort (all p < 0.001), and significant deteriorations in reaction time, accuracy, processing speed, and response variability (all p ≤ 0.005), confirmed in the mixed-effects analyses (all p ≤ 0.014). In the initial player–match-level analyses, high-intensity accelerations (>3 m·s⁻²) were weakly associated with greater Δreaction-time slowing (r = 0.203), increased response variability (r = 0.276), and reduced Rate Correct Score (r = −0.242), while high metabolic load distance was weakly associated with post-match perceived mental fatigue but not with psychomotor-performance changes. One-way ANOVAs indicated greater post-match psychomotor decrements following losses than draws. Once within-player dependence was modelled, the effects of match outcome, playing position, and most external-load metrics were attenuated, except for a residual match-outcome effect on accuracy and a high-intensity deceleration effect on accuracy. These findings indicate that competitive soccer match play is followed by acute psychomotor-performance decrements and increased perceived mental fatigue, whereas the contributions of mechanical load, match outcome, and playing position appear modest and partly reflect stable between-player differences. Full article

Background/Objectives: Dysphagia is common in tracheostomized patients with traumatic brain injury (TBI) and may be influenced by airway pathology and tracheostomy-related factors. This study investigated whether tracheostomy cannula type is independently associated with swallowing function and pharyngeal residue after accounting for airway stenosis and clinical variables. Methods: This retrospective observational study included 80 tracheostomized TBI patients using a speaking valve. Participants were grouped according to cannula type (non-fenestrated vs. fenestrated). Swallowing function was evaluated using Fiberoptic Endoscopic Evaluation of Swallowing (FEES), and pharyngeal residue severity was assessed using the Yale Pharyngeal Residue Severity Rating Scale (YPRSRS). Airway stenosis severity was graded using the Cotton–Meyer classification. Multivariable ordinal logistic regression analyses were performed to identify independent predictors of pharyngeal residue. Results: Higher pharyngeal residue scores were observed in the fenestrated cannula group under selected conditions, particularly for 5 mL liquid (p = 0.039) and 5 mL semi-solid boluses (p = 0.004) in the vallecular region, and for 5 mL semi-solid boluses in the pyriform sinuses (p < 0.001). Airway stenosis grade was strongly associated with increased pharyngeal residue and reduced SpO₂ levels (p < 0.001). In multivariable analyses, airway stenosis emerged as the factor most consistently associated with pharyngeal residue severity (e.g., OR = 4.909, 95% CI: 1.646–14.646, p = 0.004), whereas cannula type was not independently associated with most outcomes. Condition-specific associations were identified between fenestrated cannula use and pharyngeal residue in two models (vallecular residue for 5 mL semi-solid: OR = 0.354, 95% CI: 0.143–0.876, p = 0.025; pyriform sinus residue for 10 mL liquid: OR = 0.190, 95% CI: 0.073–0.495, p = 0.001); however, the direction of these associations differed from unadjusted comparisons, indicating prominent confounding by stenosis severity. Conclusions: FEES-estimated airway stenosis appeared to be the factor most consistently associated with pharyngeal residue severity in tracheostomized TBI patients, whereas the effect of cannula type appeared to be limited. Comprehensive airway assessment may therefore be important in dysphagia management. Full article

Background/Objectives: This study aimed to examine the associations between diet-related quality of life (DRQOL) and psychological distress, autonomic dysfunction, and migraine in patients with dizziness and balance disorders. Methods: In this retrospective cross-sectional study, 122 patients (56 men, 66 women; mean age 40.4 ± 12.8 years, minimum 14, maximum 65) from the vertigo outpatient clinic at JR Tokyo General Hospital completed self-reported questionnaires. These included the DRQOL scale, Dizziness Handicap Inventory (DHI), Hospital Anxiety and Depression Scale (HADS), Self-rating Depression Scale (SDS), Orthostatic Dysregulation (OD) checklist, and migraine assessments (POUNDing [Pulsating, duration of 4–72 h, Unilateral, Nausea, Disabling], MIDAS, migraine screener). Correlational analyses, group comparisons, and receiver operating characteristic (ROC) analyses were conducted. Results: Higher DRQOL scores indicate poorer DRQOL. DRQOL scores showed positive correlations with psychological distress (SDS: ρ = 0.57; HADS-A: ρ = 0.50; HADS-D: ρ = 0.53; all p < 0.001) and OD severity (ρ = 0.50, p < 0.001) but not with age, DHI, or individual migraine indices. Migraine screener-positive patients had significantly higher DRQOL scores (p < 0.01). DRQOL alone showed modest ability to discriminate migraine screener-positive from migraine screener-negative patients (AUC = 0.65); discrimination improved to an AUC of 0.77 in a multivariable model that also included age and sex. Conclusions: DRQOL appears to capture psychological and autonomic symptom burden rather than vestibular or headache severity, suggesting that it may serve as a complementary, patient-centered metric that adds a multidimensional perspective to conventional vestibular and headache assessments. Full article

Background: Anti-amyloid monoclonal antibodies represent the first disease-modifying therapeutic strategy targeting amyloid-β pathology in early Alzheimer’s disease (AD). Although several agents have demonstrated the ability to reduce cerebral amyloid burden, their clinical efficacy and safety remain subjects of substantial scientific and regulatory debate. This study aimed to synthesize randomized evidence evaluating the benefit–risk profile of anti-amyloid monoclonal antibodies in biomarker-confirmed early AD. Methods: A systematic review and classical pairwise meta-analysis of randomized controlled trials (RCTs) was conducted following the PRISMA 2020 guidelines. PubMed/MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched for phase III placebo-controlled trials evaluating lecanemab, donanemab, aducanumab, and gantenerumab in patients with mild cognitive impairment due to AD or mild AD dementia with biomarker confirmation of amyloid pathology. The primary outcome was change from baseline in the Clinical Dementia Rating–Sum of Boxes (CDR-SB) at the longest available follow-up. Safety outcomes included amyloid-related imaging abnormalities with edema or effusion (ARIA-E), amyloid-related imaging abnormalities with hemorrhage (ARIA-H), serious adverse events, and treatment discontinuation. Random-effects meta-analyses were performed. Results: Six randomized comparisons derived from four phase III trials involving 7695 participants met the eligibility criteria. Anti-amyloid monoclonal antibodies were associated with a statistically significant slowing of clinical progression compared with placebo (pooled mean difference in CDR-SB: −0.42 points; 95% CI −0.59 to −0.25; I² = 78%). The observed effect was primarily driven by trials of lecanemab and donanemab, whereas aducanumab demonstrated discordant results across trials and gantenerumab showed no clinically meaningful benefit. Despite statistical significance, the magnitude of the pooled effect approached the lower boundary of the minimal clinically important difference reported for CDR-SB in early AD. Treatment was associated with a markedly increased risk of ARIA-E (pooled risk ratio 10.1; 95% CI 7.8–13.0), with moderate heterogeneity across studies. Most ARIA-E events were asymptomatic and detected through protocol-mandated MRI monitoring. Conclusions: In biomarker-confirmed early Alzheimer’s disease, anti-amyloid monoclonal antibodies produce a statistically significant but modest slowing of clinical decline accompanied by a substantially increased risk of ARIA. The benefit–risk profile appears heterogeneous across individual antibodies and may reflect pharmacological differences in amyloid targeting and clearance mechanisms. These findings support cautious, individualized use of anti-amyloid therapies and highlight the need for longer-term studies to determine whether short-term slowing of decline translates into clinically meaningful disease modification. Full article

Background/Objectives: Early recurrence after curative-intent resection is a major determinant of poor prognosis in hepatocellular carcinoma (HCC). Artificial intelligence (AI)-driven predictive models have emerged to identify patients at high risk of recurrence but remain incompletely synthesized for early recurrence specifically. This review aimed to identify and appraise AI-driven models predicting early recurrence after surgical resection. Methods: PubMed/MEDLINE, Scopus and Web of Science were searched from inception to November 2025. Eligible studies developed and evaluated AI-driven models predicting early recurrence (≤24 months) after curative-intent hepatectomy as first-line treatment for HCC. Risk of bias and applicability were assessed using PROBAST+AI, and findings were synthesized narratively due to methodological heterogeneity. The review was registered in PROSPERO. Results: Thirty-six studies involving 14,716 patients were included. Most studies originated from China (33/36, 91.7%), were single-center (27/36, 75%), and retrospective (35/36, 97.2%). Magnetic resonance imaging (MRI) was the predominant imaging modality (15/36, 41.7%), followed by computed tomography (CT) (11/36, 30.6%) and ultrasound (US)/contrast-enhanced ultrasound (CEUS) (6/36, 16.7%). Three studies developed non-imaging models, and one combined CT and MRI. In within-study comparisons, multimodal models generally showed better discrimination than unimodal approaches. Peritumoral, habitat-based, and multiphasic strategies appeared promising. However, external validation was reported in only 6/36 studies (16.7%), calibration and decision-curve analysis were inconsistently reported, and most studies had high risk of bias. Conclusions: AI-driven models show potential to predict early recurrence of HCC after curative-intent resection. Nevertheless, evidence remains limited by methodological heterogeneity and restricted geographical diversity, while clinical utility remains inconsistently evaluated, and no model has yet been generalized in clinical practice. Prospective multicenter studies with standardized outcomes, transparent reporting, and external validation are needed for clinical implementation. Full article

Fluctuations in ovarian hormones across the menstrual cycle (MC) have been suggested to influence neuromuscular performance in female athletes. However, phase-specific variations in lower-limb muscle strength remain underexplored, particularly within the soccer population. This study investigated phase-related differences in lower-limb muscle strength across MC phases in female soccer players. A repeated-measures design was employed involving 50 competitive female soccer players. Bilateral lower-limb muscle strength was assessed using a handheld dynamometer (VALD DynaMo Plus) during the three MC phases: menstruation, late follicular, and luteal phase. Estimated menstrual cycle phases were identified using calendar-estimated tracking or an MC monitoring application (FitrWoman). Phase-related differences were analysed using repeated-measures analysis of variance with Bonferroni-adjusted post hoc comparisons, and effect sizes were reported as partial eta squared (ηp²). Significant differences in lower-limb muscle strength were observed across estimated MC phases (p < 0.05, ηp² = 0.12–0.31). Both the non-dominant and dominant limbs demonstrated higher strength values during the late follicular phase, with hip abductors emerging as the strongest muscle group bilaterally (≈149 ± 37 kg). Most muscle groups exhibited lower strength values during the menstruation phase. Lower-limb muscle strength appears to vary across calendar-estimated MC phases in female soccer players, with higher strength values observed during the late follicular phase and lower values during menstruation. These findings should be interpreted with caution due to the method of phase identification but may have implications for the scheduling of strength assessments and training load management in female athletes. Full article

Background: Dental ankylosis (DA) in growing patients leads to progressive infraocclusion and alveolar ridge deformities, compromising future implant rehabilitation. Decoronation has been proposed as a biologically driven alternative to extraction for preserving alveolar bone during growth. Objective: We aimed to evaluate the clinical outcomes of decoronation—alveolar ridge preservation, infraocclusion progression, implant site development, and the influence of treatment timing—in growing patients with ankylosed permanent anterior teeth. Methods: This systematic review was conducted in accordance with PRISMA 2020 guidelines. A comprehensive search of MEDLINE (EBSCO), EMBASE, Scopus, and Web of Science was performed (January 2006–May 2026), supplemented by grey literature screening. Eligible studies included clinical investigations reporting outcomes of decoronation in patients ≤18 years. Risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) and Joanna Briggs Institute (JBI) checklist. Certainty of evidence was evaluated using the GRADE framework. Lastly, an inter-rater agreement was quantified using Cohen’s kappa coefficient. Results: Five studies (two retrospective cohorts and three case series) comprising 140 decoronated teeth with follow-up periods ranging from 1 to 30 years were included. A total of 78 records were identified across four databases; five studies met the eligibility criteria after duplicate removal and screening. Inter-rater agreement at the full-text eligibility stage was good (κ = 0.70). The overall risk of bias was low to moderate, and the certainty of evidence was rated as low using the GRADE framework. Vertical alveolar bone preservation or gain was consistently observed, particularly when decoronation was performed during the prepubertal or pubertal growth phases. The largest cohort (n = 103) reported substantial vertical bone gain when intervention occurred at a mean age of 13.0 years in girls and 14.6 years in boys. Infraocclusion stabilisation or improvement was reported across all studies. In contrast, horizontal ridge reduction persisted, with the only quantitative study reporting a mean bucco-palatal loss of 1.67 ± 1.12 mm (p = 0.004). No included study directly assessed implant placement outcomes. Overall, the certainty of evidence was low due to observational study designs, heterogeneity in outcome assessment, and absence of controlled comparators. Conclusions: Decoronation appears to be a promising strategy for preserving vertical alveolar bone and stabilising infraocclusion in growing patients with ankylosed teeth, particularly when performed before or during the pubertal growth phase. Evidence showed considerable bone height preservation, though horizontal ridge reduction persisted across cases. However, the certainty of evidence remains low because available studies are observational, heterogeneous, and lack direct extraction comparators. Therefore, high-quality prospective studies with standardised outcome measures and controlled comparisons are required to establish definitive clinical protocols. Participants underwent decoronation during childhood or adolescence (≤18 years); reported follow-up periods of up to 30 years reflect monitoring that extended into adulthood. Clinical significance: For clinical decision-making, decoronation should be considered once ankylosis with progressive infraocclusion is confirmed during active growth, ideally before the pubertal spurt; the decision should be guided by growth stage rather than chronological age, and clinicians should anticipate likely horizontal ridge reduction by planning for possible augmentation at implant placement and coordinating multidisciplinary follow-up until skeletal maturity. Full article

The ability to generate and sustain high punch intensity is a key determinant of boxing performance. However, the relationship between mechanical output and physiological responses during intermittent high-intensity efforts remains insufficiently understood. This pilot study explored associations between mechanical punch intensity and physiological responses in elite and amateur boxers, considering sex and competitive level. Twenty boxers (10 elite and 10 amateurs; 5 males and 5 females per group) were assessed using the inertial sensor-derived Intensity Score to quantify mechanical punch intensity, alongside physiological measurements of heart rate (HR) and oxygen uptake (VO₂) during a Repeated Punch Ability Test (RPAT). Data were analyzed using repeated-measures ANOVA and Spearman correlations (p < 0.05). A significant main effect of round was observed for all variables (p < 0.001), with a progressive decline in mechanical punch intensity and stabilization of physiological responses after the first round. Elite boxers showed descriptively higher mechanical punch intensity values than amateurs, particularly in later rounds, but subgroup comparisons should be considered preliminary. Correlation analyses indicated a positive association between mechanical punch intensity and VO₂ that appeared to increase from the first to the third round (ρ = 0.398–0.563; p < 0.05), whereas the relationship with HR was weak or negative. No significant correlations were found between HR and VO₂. Overall, the findings suggest preliminary patterns in which fatigue and competitive level may be associated with mechanical punch intensity, while VO₂ may become more closely related to mechanical output under fatigue. These results should be interpreted as exploratory and non-causal. Full article

Introduction: Compassion is defined as the emotional response that arises when an individual perceives another’s suffering and is motivated to alleviate it. Purpose: To explore levels of self-compassion among nurses working in pediatric hospitals and examine their associations with nurses’ characteristics. Materials and Methods: This cross-sectional study included a convenience sample of 208 nurses from a public pediatric hospital. Data were collected through interviews using the Neff Self-Compassion Scale (SCS) which includes the following subscales: Self-Kindness, Common Humanity, Mindfulness, Self-Judgment, Isolation, and Over-Identification. The Greek-validated version of the instrument was used with acceptable internal consistency in the present sample (Cronbach’s alpha = 0.849). Data analysis included descriptive statistics and inferential tests (non-parametric comparisons and multiple linear regression), with statistical significance defined as p < 0.05. Results: The mean total Self-Compassion score was 83.24 ± 12.6 (range: 26–130). Regarding family-related factors, total Self-Compassion (p = 0.029), Common Humanity (p = 0.033), and Over-Identification (p = 0.041) were associated with the number of children. In relation to age, Self-Kindness (p = 0.033), Isolation (p = 0.005), and Over-Identification (p = 0.005) showed significant associations. Professional factors were also relevant, as Isolation was associated with total years of nursing experience (p = 0.032) and choice of nursing as a profession (p = 0.004), while Over-Identification was associated with years of experience in pediatric settings (p = 0.004) and choice of nursing as a profession (p = 0.049). Additionally, marital status was associated with Over-Identification (p = 0.045). Conclusions: Demographic and professional characteristics appear to influence the expression of Self-compassion. Healthcare organizations should implement targeted training programs to individualize professional development. Future research should explore work-related and personal factors influencing self-compassion to improve care quality and outcomes. Full article

Background: Endothelial dysfunction and renal injury are emerging as a common feature of long COVID, especially in those with hypertension. It is not yet well characterised whether SARS-CoV-2 infection exacerbates podocyte dysfunction, fibrotic signalling and renal hemodynamic remodelling, over and above the effects of hypertension alone and there are no reliable early biomarkers in this population. Methods: We conducted a comparative cross-sectional study with prospective 6-month treatment response follow-up in 120 adult patients (aged 30–60 years) with essential hypertension (Stage I, II or III; n = 40 per stage), at Bukhara Regional Multidisciplinary Hospital. Each stage subgroup was further divided into post-COVID (3–6 months after recovery; n = 20) and non-COVID (n = 20) strata. Patients with diabetes, known chronic kidney disease, previous myocardial infarction or stroke and other major comorbidities were excluded. Serum cystatin-C, creatinine, aldosterone, TGF-β1 and VEGF-A; urinary nephrin and microalbumin; cystatin-C-derived eGFR (CKD-EPI) and oral protein-loaded renal functional reserve (RFR); and renal Doppler indices (Vps, Ved, RI, PI) of the main, segmental and interlobar arteries were assessed before and after 6 months of guideline-based renin–angiotensin–aldosterone system (RAAS) blockade (enalapril 5–10 mg or azilsartan 40–80 mg, ±eplerenone). Comparisons were made by Student’s t-test—associations by Pearson correlation. Results: At baseline, post-COVID hypertensive patients exhibited consistently higher endothelial–podocyte injury markers than non-COVID counterparts. Urinary nephrin was elevated across all stages (Stage I: 126.5 ± 9.1 vs. 91.9 ± 8.3 pg/mL, p < 0.01; Stage III: 203.3 ± 11.2 vs. 164.5 ± 9.7 pg/mL, p < 0.05), as were VEGF-A (Stage III: 286.1 ± 16.4 vs. 223.2 ± 12.6 pg/mL, p < 0.01) and TGF-β1 (Stage III: 186.4 ± 10.1 pg/mL, 1.3-fold higher; p < 0.01). The detection of microalbuminuria was 100% in Stage III post-COVID patients and 85% in non-COVID controls. The post-COVID groups had selective loss of renal functional reserve (7.8 ± 1.1% in Stage III compared to 12.5 ± 1.6% in non-COVID controls, p < 0.001). Nephrinuria correlated strongly with RFR (r = −0.824, p < 0.001), eGFR (r = −0.797, p < 0.001) and aldosterone (r = 0.613, p < 0.001). Six months of RAAS blockade reduced nephrinuria, microalbuminuria and TGF-β1 in both arms but the magnitude of biomarker reduction appeared smaller in the post-COVID group, particularly in Stage III. Conclusions: Long COVID appears to be associated with persistent endothelial dysfunction and podocyte injury in hypertensive patients. These results indicate that nephrinuria, VEGF-A, TGF-β1 and renal functional reserve are potential exploratory markers of endothelial and renal abnormalities in hypertensive patients following COVID-19. Before clinical utility can be determined, larger studies with multivariable modelling, diagnostic-performance analyses and correction for multiple testing are needed. The differences in biomarker response between groups observed in this study need to be confirmed in larger prospective studies with multivariable modelling and formal interaction analyses. Full article

Musculoskeletal pain is a major cause of disability and long-term analgesic use, increasing interest in safe non-pharmacological interventions. This focused narrative review examines light-emitting diode (LED)-based photobiomodulation (PBM) for musculoskeletal pain, integrating molecular, mechanistic, clinical, and translational evidence. Red and near-infrared LED-PBM may act through mitochondrial and non-mitochondrial photoacceptors, modulation of ATP production, reactive oxygen species, nitric oxide, calcium signaling, inflammatory pathways, oxidative stress responses, and extracellular matrix repair. Clinical evidence suggests a potential benefit in selected conditions, particularly temporomandibular disorders, fibromyalgia, cervical and myofascial pain, tendon and plantar fascia disorders, knee osteoarthritis, and mild-to-moderate peripheral nerve compression, while findings for non-specific low back pain remain inconsistent. The reviewed literature indicates that therapeutic response depends less on emitter identity alone than on wavelength, irradiance, radiant exposure, treatment geometry, target depth, timing, disease phenotype, and protocol quality. LED-based PBM appears generally well tolerated and clinically promising as an adjunct to rehabilitation, but current evidence is limited by heterogeneous devices, incomplete dosimetry, variable comparators, and short follow-up. Future studies should prioritize standardized reporting, depth-aware dosing, phenotype-based recruitment, biomarker-linked outcomes, and direct laser–LED comparisons under dosimetrically matched conditions. Full article