Search Results (197)

This study presents a finite element (FE) investigation of intervertebral disc (IVD) degeneration in the human lumbar spine (L1–L3 segment). The model, based on CT-derived geometry and isotropic hyperelastic representation of disc tissues, incorporates controlled simplifications, detailed in the limitations section. Degenerative changes were parametrically simulated across healthy, mild, moderate, and severe stages by reducing disc height (up to 60%), nucleus pulposus volume (up to 70%), and adjusting tissue stiffness to reflect dehydration and fibrosis. Displacement-controlled compressive loading was applied to assess von Mises stress distributions, reaction forces, and load transfer mechanisms. Results indicate significant load redistribution: annulus fibrosus stresses increased by up to 175% in severe degeneration, while nucleus pulposus stresses decreased by ~70%, indicating a diminished compressive load-bearing contribution of the nucleus. Model predictions were validated against cadaveric and in vivo data, confirming trends in intradiscal pressure (IDP) reductions (40–70%) and stress elevations. The parametric framework elucidates interactions between geometric and material changes, providing clinicians with insights into degeneration progression and guiding biomedical engineers in implant design and interventions. Full article

This paper presents an improved lattice Boltzmann method for simulating conjugate heat transfer. In conventional lattice Boltzmann methods, the coupling between thermal conductivity and relaxation time limits numerical stability for high-conductivity solids. To address this challenge, the proposed model introduces a correction source term to decouple the physical thermal conductivity from the relaxation parameter. The method is validated through representative test cases including heat conduction in a two-layered annulus, conjugate heat transfer in a layered channel, and natural convection in a square enclosure with discrete solid blocks. Numerical results demonstrate that the algorithm possesses second-order spatial accuracy. Moreover, the results show good agreement with the literature benchmarks at low thermal conductivity ratios and confirm the capability of the method to simulate conjugate heat transfer at high thermal conductivity ratios up to 1000. Full article

This paper investigates the complex flow characteristics and parameter prediction methods for axial-inlet cover-plate cavities in pre-swirl systems numerically. Using a full-annulus three-dimensional computational model, the flow mechanisms of cover-plate cavities are compared between axial and radial inlet configurations. The analysis reveals that the axial-inlet configuration exhibits intensified non-axisymmetric vortex pairs in the low-radius region due to axial inflow inertia. These vortex structures enhance radial angular momentum exchange, leading to a substantial inlet angular momentum deficit that consequently reduces swirl ratios and pressure coefficients relative to the radial-inlet configuration. Furthermore, parametric studies demonstrate that small gap ratio amplifies circumferential flow non-uniformity through strong impingement effects, while elevated inlet swirl ratio significantly extends the source region boundary by strengthening centrifugal forces. To address the prediction discrepancies in existing models, this work proposes a modified correlation for the effective inlet swirl ratio that account for the inlet momentum loss and develops a new predictive model for the edge of source region incorporating centrifugal effects. These physics-based corrections, validated against simulation data, significantly improve the prediction accuracy for axial-inlet cover-plate cavities compared to conventional models. Full article

The degradation of intervertebral disc proteoglycans, including the loss or shortening of their hydrophilic glycosaminoglycan chains, causes a loss of disc hydration, leading to an increase in solid matrix stresses. This illustrates one aspect of the complex multifactorial relationship between tissue degradation and the resulting mechanical dysfunction. Genipin matrix augmentation has previously been evaluated with regard to its ability to improve mechanical properties of the disc, increasing joint stability and permeability. The study aim was to evaluate the ability of genipin augmentation to increase retention of glycosaminoglycans in disc specimens subjected to free swelling. Three different models were utilized: whole bovine caudal discs, partial annulus specimens from bovine, and human thoracic discs. Total glycosaminoglycan release to a surrounding bath was quantified using a modified dimethyl-methylene blue assay. Genipin solution injections reduced glycosaminoglycan loss by 44.0% in intact bovine discs compared to buffer-only controls (p = 0.027), by 75.8% in partial bovine annulus specimens (p = 0.0004), and by 51.9% in human annulus specimens (p = 0.017). The combination of increased permeability and glycosaminoglycans retention may produce beneficial effects on nutritional flow, diurnal irrigation, and reduction of matrix solid phase stress. Combining these effects with the ability to improve joint stability and augment tissue mechanical properties suggests this nano-scale device may be capable of arresting ongoing degeneration. Full article

Background: Intervertebral disc degeneration is a prevalent condition and a major risk factor for disc herniation. Mechanical overload, aging, injury, and disease contribute to the annulus fibrosus’ structural failure, which allows nucleus pulposus material to escape and reduces the capacity to absorb shock. This study builds on previous investigations by evaluating additional thermoplastic polyurethane (TPU) filaments as potential materials for additively manufactured intervertebral disc replacements. Materials and Methods: Disc-shaped specimens (Ø50 × 10 mm) were fabricated using fused deposition modeling (FDM). A gyroid infill structure was employed with unit cell sizes ranging from 4 to 10 mm³ and wall thicknesses between 0.5 and 1.0 mm. The outer wall thickness varied from 0.4 to 0.8 mm. Four TPU filaments (Extrudr FlexSemiSoft, GEEE-TECH TPU, SUNLU TPU, and OVERTURE TPU) were tested, resulting in 36 parameter combinations per filament. Printed discs were examined via stereomicroscopy. Tensile testing was conducted according to DIN EN ISO 527-1 using Type 5A specimens. Mechanical performance under physiological loading was assessed through uniaxial compression tests, in which samples were compressed to 50% of their height while force–deformation curves were recorded. Target forces were defined as 4000–7500 N to maintain comparability with prior studies. Results: Across all filaments, a maximum of three parameter combinations per material achieved forces within the target range. Microscopy confirmed the dimensional accuracy of wall thicknesses with minimal deviation. Tensile strength values for GEEE-TECH, SUNLU, and FlexSemiSoft were comparable (10–11 MPa), while OVERTURE showed significantly lower strength (approximately 9 MPa). Tensile modulus values followed a similar trend: 25–30 MPa for three filaments and 17.5 MPa for OVERTURE. Conclusions: All four TPU filaments could be used to fabricate discs that met the mechanical requirements for compression. These results confirm that both the tested TPU materials and gyroid structures are suitable for potential intervertebral disc replacement applications. Full article

To improve the accuracy of gravimetric liquid hydrogen flow standard devices, the self-weight of the weighing tank must be minimized, because the total mass of the liquid hydrogen contained in the tank is far smaller than the structural mass of the tank itself, which severely compromises the sensitivity of gravimetric measurement. In this study, a three-dimensional finite element model of a vacuum-insulated liquid-hydrogen weighing tank was developed in ABAQUS. The inner and outer shells were modeled with 06Cr19Ni10 (304) and 06Cr17Ni12Mo2 (316) austenitic stainless steels, and Polyamide 6 (PA6) was used for the internal support. Three operating stages were considered: evacuation of the annulus (interlayer pressure reduced from 0.1 MPa to 0 MPa), pre-cooling to −253 °C, and pressurization of the inner tank (internal pressure increased from 0.1 MPa to 1 MPa). The equivalent stress and deformation were compared for different materials and wall thicknesses to evaluate structural safety and weight-reduction potential. The proposed configuration (inner shell 1.6 mm and outer shell 1.0 mm) achieves a mass reduction of more than 50% relative to the 3 mm minimum wall thickness commonly adopted for cryogenic vessels, while keeping stresses below the allowable limits. This reduction enables the use of higher-resolution load cells and thereby lowering the measurement uncertainty of the liquid hydrogen flow standard device and providing technical support for lightweight and cost-effective design, with potential applicability to other cryogenic tank systems. Full article

This study presents an eccentric pipe separator (EPS) designed according to the shallow pool principle and Stokes’ law as a compact alternative to conventional gravitational tank separators for offshore platforms. To investigate the internal oil-water flow characteristics and separation performance of the EPS, both field experiments with crude oil on an offshore platform and computational fluid dynamics (CFD) simulations were conducted, guided by dimensional analysis. Crude oil volume fractions were measured using a Coriolis mass flow meter and the fluorescence method. The CFD analysis employed an Eulerian multiphase model coupled with the renormalization group (RNG) k-ε turbulence model, validated against experimental data. Under the operating conditions examined, the separated water contained less than 50 mg/L of oil, while the separated crude oil achieved a purity of 98%, corresponding to a separation efficiency of 97%. The split ratios between the oil and upper outlets were found to strongly influence the phase distribution, velocity field, and pressure distribution within the EPS. Higher split ratios caused crude oil to accumulate in the upper core region and annulus. Maximum separation efficiency occurred when the combined split ratio of the upper and oil outlets matched the inlet oil volume fraction. Excessively high split ratios led to excessive water entrainment in the separated oil, whereas excessively low ratios resulted in excessive oil entrainment in the separated water. Crude oil density and inlet velocity exhibited an inverse relationship with separation efficiency; as these parameters increased, reduced droplet settling diminished optimal efficiency. In contrast, crude oil viscosity showed a positive correlation with the pressure drop between the inlet and oil outlet. Overall, the EPS demonstrates a viable, space-efficient alternative for oil-water separation in offshore oil production. Full article

Studies of swordfish growth provide essential biological parameters for stock assessment and fisheries management, informing both conventional population models and the evaluation of different management strategies. The present study aims to provide insight into the dynamics of the South Atlantic Ocean stock growth patterns. The sampling is the most complete to date in the literature, with a wide geographical distribution and in every month of the year. The analysis included 788 anal fins. Biometric relationships between different anal fin spine measurements and fish size were found. Some variation in the size of annulus one and vascularisation hiding some internal bands was found in larger specimens. Marginal increment ratio (MIR) and edge type analyses showed an annual band formation in the austral winter (July to September), thereby confirming the hypothesis of one annulus formation per year. Growth parameters were calculated using different growth models. The Gompertz model yielded the most reliable parameters (L_∞ = 341 cm LJFL, k = 0.13 yr⁻¹, T = 2.83 yr). The tagging and recapture data corroborated the selected model. Results were compared with other growth curves published. Full article

With growing global energy demand, deep and ultra-deep wells have become a focal point in oil and gas development. Wellbore temperature variations significantly impact drilling and completion operations in such wells. To analyze the temperature distribution in ultra-deep wellbores, a numerical model based on the Gauss–Seidel iterative algorithm was developed. This model explicitly accounts for the convective heat transfer coefficient and the distinct thermophysical properties of drilling fluids in both the drill string and the annulus. By employing adaptive meshing, it significantly enhances computational efficiency while ensuring accuracy. This study investigated the influence of key parameters—including drilling fluid density, specific heat capacity, drill pipe thermal conductivity, and formation properties—on bottom-hole temperature. The results show that the average deviation between the actual wellbore temperature and the model-predicted temperature is 0.5%. The heat transfer dynamics model for ultra-deep wells is validated by the close agreement between theoretical predictions and field data. This study offers a valuable theoretical basis for wellbore temperature management and the control of drilling fluid cooling systems, supporting safer and more efficient development of ultra-deep resources. Full article

This work assesses the aerodynamics of a short aero-engine intake for a new rig that is planned to be tested at the Large Low-Speed Facility of the German Dutch Wind Tunnels (LLF-DNW) in 2025. A range of computations were performed to assess whether the expected aerodynamics in this arrangement encompass the envisaged range of flow field characteristics of the equivalent isolated configuration. The effect of massflow capture ratio and angle of attack are investigated. In addition, an intake flow separation taxonomy is proposed to characterise the associated flows. The wind tunnel analysis is based on two different modelling approaches: an aspirated isolated intake and a coupled fan–intake configuration. The coupled configuration uses a full-annulus model with a harmonic mixing plane method. Across the range of operating conditions with changes in the massflow capture ratio and angle of attack, there are attached and separated flows. The main separation mechanisms are diffusion-driven and shock-induced, which shows the different aerodynamics that may be encountered in a short intake. Overall, this work provides an initial evaluation of the aerodynamics of the new fan/intake test rig configuration, provides guidance for wind tunnel testing, and lays a foundation for subsequent unsteady coupled fan–intake studies. Full article

Liquid-fueled molten salt reactors (MSRs) are characterized by the use of liquid nuclear fuel, which leads to a unique thermal-hydraulic phenomenon in the core involving the simultaneous occurrence of nuclear fission heat generation and convective heat transfer. This distinctive behavior creates a critical need for high-fidelity experimental data on internally heated flows, yet such studies are severely constrained by the lack of methods to generate controllable, high-power-density volumetric heat sources in fluids. To address this methodological gap, this study proposes and numerically investigates a novel experimental concept based on microwave heating. The design features an innovative multi-tier hexagonal resonant cavity with fifteen strategically staggered magnetrons. A comprehensive multi-physics model was developed using COMSOL Multiphysics to simulate the coupled electromagnetic, thermal, and fluid flow processes. Simulation results confirm the feasibility of generating a volumetric heat source, achieving an average power density of 6.9 MW/m³. However, the inherent non-uniformity in microwave power deposition was quantitatively characterized, revealing a high coefficient of variation (COV) for power density. Crucially, parametric studies demonstrate that this non-uniformity can be effectively mitigated by optimizing the flow channel geometry. Specifically, using a smaller diameter tube or an annulus pipe significantly improved temperature field uniformity, reducing the temperature COV by over an order of magnitude, albeit at the cost of reduced absorption efficiency. Preliminary discussion also addresses the extension of this approach towards molten salt experiments. The findings establish a practical design framework and provide quantitative guidance for subsequent experimental investigations into the thermal-hydraulic behavior of internally heated fluids, offering a promising pathway to support the design and safety analysis of liquid-fueled MSRs. Full article

Mercury hosts widespread smooth plains that are concentrated in the Caloris impact basin, in an annulus surrounding the Caloris basin, and in the adjacent northern smooth plains. The origins of these smooth plains are uncertain, although prior work suggests these plains in the northwestern Caloris annulus might reflect volcanic activity, impact ejecta, or a combination of the two. Deciphering the timing and mode of emplacement of these plains would provide a critical constraint on regional late-stage volcanism or impact effects. In this work, the region northwest of Caloris was investigated using geomorphological and color-based mapping, crater counting techniques, and spectral analyses with the goal of placing constraints on the source of the observed units and identifying the primary emplacement mechanism. Mapping and spectral analyses confirm previous findings of two distinct, yet intermingled, units within these plains, each with similar crater count model ages that postdate the formation of the Caloris impact basin. Mapping, spectra analysis, ages, and the identification of potential flow pathways are more consistent with a predominantly volcanic origin for the smooth plains materials, although these data do not rule out contributions from impact ejecta or impact melt. We propose several hypothetical scenarios, including post-emplacement modification by near-surface volatiles, to explain these observations and clarify the emplacement mechanism for these specific smooth plains regions. Further observations from the BepiColombo mission should provide data to potentially address the outstanding questions from this work. Full article

Designed to mitigate the significant low-frequency vibration and noise inherent in conventional marine centrifugal pump systems, the magnetic levitation pump constitutes a novel form of centrifugal pump employing active magnetic bearing technology. While this fully levitated design effectively enhances vibration and noise performance, it results in the complete immersion of the rotor within a confined fluid domain, which contains narrow fluid clearances. This poses significant challenges for the accurate computation of rotor wet modes, which is crucial for the structural design of the rotor system to avoid the resonance induced by flow. Despite exerting a substantially greater influence on rotor wet modal characteristics than unconfined domains, the analysis of rotors under confined fluid conditions has received comparatively little research attention. This study focuses on two types of magnetic levitation pump rotors. From the perspective of analytical modeling, an improved analytical method for wet modal computation based on added mass correction is proposed. The validation of this method included examining two distinct computational approaches for the added mass, the thickening treatment for axially elongated disk components, and the methodology for implementing disk equivalent density. Based on this foundation, wet modal analysis was performed on both rotors utilizing the proposed analytical method, alongside acoustic fluid–structure interaction simulations. The results indicate that for the first bending mode, the errors between the analytical and experimental values are 1.2% and 4.1%, respectively, while the discrepancies between the simulated and experimental values are 0.1% and 3.2%. Finally, regularity analysis was conducted on the wet modal characteristics of the rotor under confined water, considering various fluid clearances. The results reveal that the first three bending modes generally exhibit an increasing trend with the enlargement of the fluid clearance, with a triple-size annulus serving as a transition point. However, increasing the annulus size does not always elevate the modal frequencies above their initial values. This study contributes to understanding the influence mechanisms of confined water on the wet modal properties of magnetic levitation pump rotors. Furthermore, the proposed analytical method improved computational efficiency for the early design stages of water-immersed rotors, alongside a model of greater accuracy essential for magnetic bearing control. Full article

This study examines the flow behavior of water-lubricated heavy oil transport utilizing the core annular flow (CAF) technique. The goal is to enhance efficiency and minimize risks in pipeline operations. The flow was numerically simulated in a horizontal pipe using a Large Eddy Simulation (LES) model within a commercial Computational Fluid Dynamics (CFD) framework. The Geo Reconstruct scheme is employed to accurately capture the oil–water interface, and both oil and water initialization methods were assessed against experimental data. Results show that the LES model accurately reproduces the main flow features observed experimentally, particularly for low-viscosity oil–water systems. This suggests that the model can be a reliable tool for predicting flow behaviour in similar fluid systems. Further validation with varying parameters could enhance its applicability across a broader range of conditions. In cases of heavy oil, the velocity profile remains nearly constant within the oil core, indicating rigid body-like motion surrounded by a turbulent water annulus. Turbulence intensity and oil volume fraction distributions were closely related, with higher turbulence in water and lower in oil. Although wall adhesion modelling limited fouling prediction, simulations confirmed that fouling can significantly increase pressure losses. This illustrates the value of considering both fluid dynamics and material interactions in such systems. Future studies could explore the impact of varying temperature and pressure conditions on fouling behaviour to further refine predictive models. Overall, the LES approach proved suitable for analysing turbulent CAF, offering insights for optimizing viscosity ratios, flow rates, and design parameters for safer and more efficient heavy oil transport. Full article

Current therapeutic strategies for intervertebral disc degeneration (IDD)-related low back pain are limited to symptomatic alleviation. Notochordal cells (NCs), as progenitor cells of the nucleus pulposus (NP), lead us to develop innovative NC-based new therapies for IDD. A total of 40 NP specimens, obtained according to IDD criteria with defined Pfirrmann grades and histological degeneration score, were categorized as either normal (Grade II) or degenerated (Grade IV). An IDD model was established in SD rats by needle puncture of the annulus fibrosus. Degenerated NP tissue was identified using MRI, H&E, Safranin O, and Masson staining. NCs and NP cells (NPCs) were isolated and identified based on specific cellular markers. Furthermore, mRNA-seq was performed to profile gene expression in these cells. GO annotation and KEGG pathway analysis were employed to perform functional enrichment analysis of the differentially expressed genes (DEGs). Cell viability was assessed using the CCK-8 assay. An in vitro cell degeneration model was established by treating NPCs with TBHP. Analysis of specific marker expression was performed using Western blotting, immunohistochemistry, and immunofluorescence. We found that the number of NCs in degenerated NP tissues was significantly reduced compared to those in normal NP tissues, but a small amount of notochordal cell markers could still be detected. Analysis of sequencing data identified 2391 upregulated and 3813 downregulated DEGs. GO enrichment analysis indicated that these DEGs were significantly associated with regulatory signals including cellular senescence and oxidative stress. KEGG pathway analysis further revealed that the DEGs were primarily enriched in the TNF and HIF-1 signaling pathways. Subsequent screening identified the top 10 key genes potentially related to IDD: Sod2, Cxcl12, Spp1, Fn1, Cat, Il6, Ccl2, Igf1, Fgf2, and Acta2. Collectively, our findings establish a clear link between SOD2/CAT and the pathogenesis of IDD. SOD2 and CAT may serve as promising new potential therapeutic targets for IDD by inhibiting oxidative stress and cellular senescence in NPCs. Full article