Search Results (13,988)

Background and Objectives: De Quervain tenosynovitis (DQT) is a stenosing overuse condition of the synovial sheath of the first extensor compartment of the wrist. Open surgical release of the first dorsal compartment remains a standard intervention for DQT when conservative treatments fail. This systematic review evaluated the comparative efficacy of transverse versus longitudinal skin incisions for open release of the first dorsal compartment in DQT. Materials and Methods: Four studies with 259 patients were included in the review. Data from 17 patients were unavailable due to loss to follow-up; therefore, 243 wrists (242 patients) were included in the quantitative analysis. The transverse incision group consisted of 114 cases, and the longitudinal incision group of 129 cases. The primary outcome of the review was the incision-related incidence of injuries to adjacent anatomical structures, including injuries to the superficial branch of the radial nerve (SBRN), tendon injuries, and vein injuries. Secondary outcomes included hypertrophic scar formation, wound infection, and postoperative changes in pain severity measured using a visual analog scale (VAS). Results: Although there was a lower rate of SBRN injury in the longitudinal group (5.4% vs. 7% in the transverse group), the difference did not meet statistical significance (OR = 2.17; 95% CI, 0.39–11.99; p = 0.37; I² = 30%). Similarly, there was no significant difference in the risk of vein injury (RD = 0.06; 95% CI, −0.03 to 0.14; p = 0.21; I² = 61%), hypertrophic scar formation (OR = 1.39; 95% CI, 0.32 to 6.04; p = 0.66; I² = 35%), and wound infection (RD = 0.00; 95% CI, −0.03 to 0.03; p = 0.93; I² = 0%). Although both approaches resulted in significant pain improvement, no statistically significant difference in postoperative pain was observed between incision types, as assessed by the VAS for pain (mean difference = 0.30; 95% CI, −0.70 to 1.30; p = 0.56; I² = 43%). Conclusions: No significant differences were identified between incision techniques for DQT in terms of complication rates and postoperative pain outcomes. However, the available evidence is limited, and future high-quality trials are necessary to determine any clinically meaningful difference. Therefore, incision selection should be individualized based on surgeon preference, patient-specific anatomy, and procedural complexity. Despite the technique used, meticulous surgical technique is essential to prevent postoperative complications. Full article

As a typical C3-C4 intermediate plant, cassava (Manihot esculenta Crantz) exhibits high photosynthetic efficiency and low photorespiration. NADP-malic enzyme (NADP-ME) is a key enzyme in the C4 photosynthetic pathway that provides elevated CO${}_2$ concentrations for Rubisco. However, research on NADP-ME in C3-C4 intermediate species remains limited. In this study, we identified four NADP-ME genes in the cassava genome, with segmental duplication serving as the primary driving force for gene evolution. Cis-acting element analysis indicated potential roles of MeNADP-ME genes in environmental adaptation, stress responses, and growth regulation. Expression profiling using bulk RNA sequencing and single-cell RNA sequencing revealed distinct expression patterns in different tissues and cell subsets. Comparative analysis with Arabidopsis (Arabidopsis thaliana) and maize (Zea mays) NADP-ME families demonstrated that MeNADP-ME3 exhibits bundle sheath cell-specific expression analogous to ZmchlC4NADP-ME in maize. Notably, photosynthetic genes and plasmodesmata (PD)-related genes exhibited high co-expression within mesophyll subcluster 13 and bundle sheath cells, providing molecular evidence for a limited C4 photosynthetic pathway in cassava. Protein–protein interaction predictions implicated MeNADP-ME3 in photosynthetic carbon metabolism and photorespiration regulation. Furthermore, qRT-PCR revealed significant responsiveness of MeNADP-ME3 to various abiotic stresses, and confocal imaging confirmed its chloroplast localization. Functional validation demonstrated that Arabidopsis overexpressing MeNADP-ME3 exhibited 30–120% enhanced antioxidant enzyme activities (SOD, POD, CAT) and 20–32% reduced oxidative damage markers (MDA, H${}_2$O${}_2$) under drought and salt stresses. These findings reveal the evolutionary trajectory of NADP-ME genes in C3-C4 intermediate species and provide genetic resources for developing stress-tolerant cassava cultivars. Full article

Background: The exocyst complex, a conserved hetero-octameric complex including the EXO70 subunit, is a pivotal regulator of various cellular and developmental processes in plants. Among the diverse EXO70 isoforms, the specific function of EXO70E2—a primary organizer of exocyst-positive organelles (EXPOs)—remains to be fully elucidated. Methods: Here, we investigated the functional impact of constitutive EXO70E2 overexpression in Arabidopsis thaliana. Results: We observe that EXO70E2 overexpression leads to severe etiolation and dwarfism, accompanied by dose-dependent inhibition of primary root elongation. The YFP-labeled EXO70E2 localizes to distinct punctate structures. Histochemical analysis shows EXO70E2 expression in root tips and leaf vasculature, and its promoter activity is strongly induced by the salicylic acid analog INA and pathogen infection. Further function dissection demonstrates that EXO70E2-overexpressing plants exhibit enhanced susceptibility to the necrotrophic fungus Botrytis cinerea, manifested as larger lesions, accelerated host cell death, and increased fungal biomass. Conclusions: Our findings position EXO70E2 as a key negative regulator of plant development and defense outcomes, which may play a role in the balance between growth and immunity. Full article

This paper presents a low-noise analog front-end (AFE) integrated circuit (IC) circuit for capacitive micro-electromechanical system (MEMS) accelerometers that can be used for optical image stabilization (OIS) in various optical imaging systems. The AFE circuit design features a fully differential chopper stabilization technique that efficiently minimizes low-frequency 1/f noise and parasitic coupling. The AFE circuit chip is fabricated in a 0.18 $\mathsf{\mu }$m complementary metal-oxide-semiconductor (CMOS) technology and co-packaged with an x-axis capacitive MEMS accelerometer based on a silicon-on-glass (SOG) process. The SOG accelerometer has a footprint of 1000 $\mathsf{\mu }\mathrm{m}$ $\times$ 950 $\mathsf{\mu }\mathrm{m}$. The packaged system demonstrates a sensitivity of 342 mV/g and a nonlinearity of 1.1% between −1 g and +1 g, a dynamic range of 88 dB, and an equivalent noise floor of 14 $\mathsf{\mu }\mathrm{g}/\sqrt{\mathrm{H}\mathrm{z}}$. Full article

This study examines the influence of SO₂ and its hydrate H₂SO₃ on the free energies of the core autocatalytic cycle of the formose reaction. We find that SO₂ and H₂SO₃ readily condense with aldehyde and alcohol functional groups to form bisulfite analogs of formose proto-metabolites under modeled conditions. The bisulfite functional group can provide intramolecular catalytic enhancement in specific isomers towards aldol additions and the retroaldol step that regenerates two equivalents of glycolaldehyde from tetrose. The bisulfite moiety reduces the favorability of the parasitic Cannizzaro side-reaction both thermodynamically and kinetically, thus potentially furnishing more throughput towards forming sugars. As a prebiotic analog to phosphate, we find that bisulfite slightly stabilizes ribose over its C₅ aldose diastereomers thermodynamically, although the effect is modest and may be influenced by solution dynamics. Full article

The clinical renaissance of psychedelic medicine has highlighted the therapeutic potential of rapid-acting neuroplastogens, or “psychoplastogens,” for psychiatric disorders. However, the widespread application of classical psychedelics—such as psilocybin and LSD—and the atypical dissociative ibogaine is severely limited by their hallucinogenic properties and, particularly in the case of ibogaine, life-threatening cardiotoxicity. Addressing these limitations, Tabernanthalog (TBG) has emerged as a frontrunner in the field. This non-hallucinogenic analog of ibogaine was rationally designed to eliminate interactions with the human ether-à-go-go-related gene (hERG, KCNH2) potassium channel, thereby mitigating cardiotoxic risks. While initially characterized for its anti-addictive and antidepressant-like properties, recent data from 2024–2025 have significantly expanded its therapeutic horizon. TBG demonstrates robust efficacy in preclinical models of neuropathic and visceral pain, as well as in the rescue of cognitive deficits associated with cancer-related cognitive impairment (CRCI). TBG has shown efficacy in reversing cognitive impairments induced directly by the presence of a tumor in preclinical models, rather than by chemotherapy-specific neurotoxicity. Crucially, emerging evidence suggests that TBG’s mechanism extends beyond simple 5-HT2A receptor agonism. New findings point to a multi-target profile involving the inhibition of nicotinic acetylcholine receptors (nAChRs), positive modulation of NMDA receptors, and functional crosstalk with mGlu2 receptors. Furthermore, TBG appears to induce structural neuroplasticity without the widespread induction of immediate early genes (IEGs) seen with classical hallucinogens, suggesting a decoupling of therapeutic rewiring from the subjective psychedelic experience. This review synthesizes current preclinical evidence to discuss TBG as a promising chemical scaffold for next-generation neurotherapeutics targeting the intersection of psychiatry and neurology. Full article

This paper presents an original positional pneumatic actuator for long-stroke coordinate mechanisms. The design integrates a rodless pneumatic cylinder, a jet control system, and an external braking device. It achieves a positioning accuracy of 200 microns, a discrete step of 2 mm, and an average speed of 0.15 m/s over a maximum stroke of 6 m. This solution offers a two-fold improvement in technical, economic, and operational performance compared to electromechanical drives. A mathematical model of the drive was developed using SimInTech software and validated with a custom-built experimental stand. The discrepancy between calculated and experimental data does not exceed 18%. The study established the dependence of positioning accuracy on the load and kinematic characteristics of the drive, which helps reduce design time for coordinate mechanisms. As a result of the research, a new scheme of a positional pneumatic actuator has been developed and experimentally confirmed, which allows for a two-fold improvement in technical and economic indicators compared to electromechanical analogs due to the original combination of a rodless cylinder, a jet control system, and an external braking device. Full article

Noninvasive blood glucose monitoring has long been a critical research focus in diabetes management. Among emerging technologies, photoacoustic sensing, combining the molecular specificity with deep penetration, has garnered significant attention. It offers rapid response and pain-free operation, making it a strong candidate for next-generation portable blood glucose monitoring devices. This review systematically traces the development and current state of photoacoustic glucose sensing, with a particular focus on the selection and optimization of core system components. It also summarizes common interference in glucose detection and outlines strategies for their mitigation, along with signal processing and signal-to-noise ratio enhancement techniques suitable for real-world applications. Addressing the growing demand for wearable continuous glucose monitors, this work analyzes the key challenges in system integration and outlines recent advances in enabling technologies. It proposes multi-technology integration approaches to bridge the gap between photoacoustic sensing and microsystem design, offering theoretical foundations and practical guidance for future research on wearable photoacoustic systems. Full article

This study investigates how bio-inspired versus sustainability-focused framing influences lay evaluations of a specific bio-inspired building-technology scenario, testing the empirical validity of the so-called “biomimetic promise”. Employing a between-subjects experimental design ($N=582$), we examined assessments of a weather-responsive self-shading façade across bio-inspired, sustainable, and neutral framing conditions. We developed and validated the 12-item Perceived Bio-Inspiration Scale (PBS)—a novel standardized psychometric instrument designed to quantify lay recognition of biomimetic features across visual, intentional, and naturalistic dimensions. While results showed robust direct framing effects, we identified a significant negative spillover: emphasizing biological inspiration significantly reduced the technology’s perceived sustainability, while sustainability framing diminished its perceived bio-inspiration. These findings demonstrate, in this façade context, that laypersons evaluate bio-inspiration and sustainability as cognitively distinct and potentially competing constructs, indicating that “natural-is-better” bias is not universal across all technology domains. Consequently, merely invoking biological origins is insufficient to enhance a technology’s ecological appeal. To foster public trust, science communication should shift from abstract biological metaphors toward a performance-driven communication strategy that prioritizes the disclosure of verifiable life-cycle assessment and specific operational advantages over symbolic nature-based analogies. Full article

Ion-adsorption rare earth element (REE) deposits represent strategic critical resources in China, which were traditionally considered to be predominantly hosted in granite weathering crusts. However, the recent discovery of new deposit types within the weathering crusts of shallow metamorphic rocks in South China has opened up novel exploration frontiers, while research on their metallogenic mechanisms remains insufficient. To elucidate the REE enrichment mechanisms in shallow metamorphic rock weathering crusts, this study focuses on the Getengzui ion-adsorption REE deposit in southern Jiangxi Province. Twenty-four samples were collected from the weathering crust profiles of the Qingbaikouan Shenshan and Kuli Formations. Multiple analytical approaches were employed, including major and trace element analysis, Chemical Index of Alteration (CIA), Base Leaching Index (BA), and quantitative evaluation of element mass transfer coefficients (τ). Trace element spider diagrams, REE distribution patterns, and A-CN-K diagram analysis were also utilized. The results reveal that the weathering crusts have progressed to the middle–late stage of chemical weathering. The average CIA value is 83 for the middle-upper part of the completely weathered horizon in the Kuli Formation. In contrast, for the completely weathered horizon in the Shenshan Formation, the value is 86. Intense chemical weathering has resulted in the near-complete decomposition of primary silicate minerals and extensive leaching of base cations. This progress has created an acidic pore water environment, which is critical for REE mobilization. REEs exhibit characteristics of in situ secondary enrichment, with significant enrichment of ΣREE in the middle-upper part of the completely weathered horizon. The peak τ(ΣREE) values reach 0.78 and 2.43 for the Kuli and Shenshan Formations, respectively. Apatite dissolution is identified as the primary source of REE ions. Differences exist in the geochemical mobility sequences of elements between the two formations. REE enrichment is controlled by multi-stage geochemical barriers, including an oxidation barrier and a clay adsorption barrier. The oxidation barrier preferentially fixes Ce⁴⁺, whereas the clay adsorption barrier serves as the dominant mechanism for large-scale REE enrichment. Parent rock lithology is the primary factor governing the efficiency, scale, and fractionation characteristics of REE enrichment. The Kuli Formation is favorable for forming the thick, large-scale orebodies enriched in light rare earth elements (LREEs). In the contrast, the Shenshan Formation tends to host higher-grade orebodies, characterized by a relatively balanced ratio of LREEs and heavy rare earth elements (HREEs). This study clarifies the main controlling factors for ion-adsorption REE mineralization in two shallow metamorphic rocks. It thereby provides a theoretical basis for future exploration. This framework is applicable to analogous REE resources within shallow metamorphic rock distributions across South China and nationwide. Full article

The construction of partial minimum spanning trees is an NP-hard problem, leading to the development of various heuristic algorithms. Existing heuristics, including Kruskal’s algorithm, frequently employ shortest paths to connect tree components. This study introduces an approximate algorithm for constructing the minimum Steiner tree, which serves as the optimal structure for diffusion multicast. The proposed approach utilizes graph-based structures that provide advantages over conventional shortest-path methods. The algorithm incorporates connections analogous to those in simple Steiner trees when required. These simple trees are represented by hyperedges, and a Hyper Metric Closure can also be applied. Experimental results indicate that this hypergraph-based method enables constructions that more closely approximate the optimal Steiner tree cost compared to traditional pairwise techniques, offering a scalable balance between computational complexity and routing efficiency. Full article

Via constructing an explicit Lagrangian for which the perturbation equations are analogs of a scalar field propagating in a planar black-hole space–time, it is found that all planar black holes conformal to a Painlevé–Gullstrand-type line element can be realized as analog metrics. We also introduce the concept of holographic entanglement entropy for planar black-hole space–times. This is valid for an arbitrary choice of conformal and blackening factor, thereby vastly extending the number of known examples of explicitly known analog metrics. Full article

Background and Objectives: Complicated osteoporotic thoracolumbar fractures represent a major surgical challenge because compromised bone quality predisposes to progressive deformity, neurological deterioration, and fixation failure. This study aimed to evaluate the clinical and radiological outcomes of hybrid stabilization in patients with severe osteoporotic fractures classified as AO Spine-DGOU OF4–OF5. Materials and Methods: This single-center retrospective observational cohort study included 87 consecutively treated patients with complicated osteoporotic thoracolumbar fractures who underwent surgical treatment between 2012 and 2022. Clinical outcomes were assessed using the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI). Radiological outcomes included the regional kyphotic angle (RKA) and interbody fusion graded according to the Bridwell classification. Imaging was reviewed preoperatively, immediately postoperatively, and at follow-up, with 12-month outcomes used for the principal analysis. Additionally, a retrospective comparative analysis was undertaken between the two largest fixation subgroups within the cohort to explore outcome differences across the most representative construct patterns. Results: At 12 months, complete interbody fusion (Bridwell grade I) was achieved in 75.9% of patients. Mean RKA improved from 29.4° ± 14.1° preoperatively to 7.9° ± 8.0° immediately after surgery, with only minimal loss of correction during follow-up. Mean VAS improved from 7.0 ± 1.8 to 2.1 ± 1.2, while mean ODI decreased from 61.3% ± 6.8% to 9.8% ± 1.2% (both p < 0.001). Reoperation for implant-related mechanical failure was required in three patients (3.4%). Conclusions: Hybrid stabilization with cement augmentation was associated with marked improvement in pain, functional disability, and sagittal alignment, as well as a high rate of interbody fusion at 12 months, in patients with complicated osteoporotic thoracolumbar fractures. Given the retrospective observational design, these findings should be interpreted as associations within the treated cohort. Prospective comparative studies are warranted to further validate these results. Full article

Background: Cardiorenal syndrome (CRS) represents a complex clinical entity characterized by the bidirectional dysfunction of the heart and kidneys. Despite advances in pharmacological therapy, CRS remains associated with high morbidity and mortality. Pathophysiological drivers, including oxidative stress, chronic inflammation, and mitochondrial derangements, create a self-perpetuating cycle of organ damage that necessitates multitarget therapeutic approaches. Objective: This review synthesizes current preclinical evidence regarding the protective roles of plant-derived polyphenols—specifically bergamot, curcumin, quercetin, catechins, and resveratrol—in mitigating the cardiorenal continuum. Methods: An analysis of recent literature was conducted, focusing on the molecular mechanisms by which these bioactives modulate redox balance, inflammatory signaling, and mitochondrial homeostasis in experimental models of CRS. Results: Polyphenols act at the crossroads of several stress-response pathways. Key mechanisms include the activation of the Nrf2/HO-1 axis to enhance endogenous antioxidant defenses, the suppression of the NLRP3 inflammasome to attenuate systemic “inflammaging”, and the preservation of mitochondrial quality through SIRT1/PINK1/Parkin-mediated mitophagy. Furthermore, emerging evidence highlights the role of polyphenols in modulating the gut-kidney-heart axis by reducing microbiota-derived uremic toxins. Conclusions: Preclinical data suggest that polyphenols are potent multifunctional agents capable of breaking the feedback loops of cardiorenal injury. While bioavailability remains a significant translational challenge, novel nano-delivery systems and synthetic analogs offer promising strategies for clinical application. Integrating these bioactives into CRS management could provide a decisive adjunctive strategy to improve metabolic homeostasis and prevent end-stage organ failure. Full article

Background/Objectives: Peripheral vestibular hypofunction (PVH) commonly causes dizziness, imbalance, gait disturbances, and reduced quality of life. Task-oriented circuit training (TOCT) is a rehabilitation approach in which patients perform structured, task-specific functional movements repetitively to improve real-life motor performance. TOCT integrates functional, multisensory, and repetitive exercises based on motor learning and neuroplasticity principles, potentially enhancing rehabilitation outcomes. This study aimed to investigate the effects of TOCT on dizziness, vertigo, balance, gait, disability, and quality of life in patients with PVH. Methods: In this single-blind, randomized controlled trial, 28 patients with PVH were randomly allocated to either a task-oriented circuit training (TOCT) group (n = 16) or a control group (n = 12). The control group performed a conventional home-based vestibular exercise program consisting of gaze stabilization and walking exercises. The TOCT group completed 25 task-specific stations, targeting gaze stabilization, balance, and gait, three times per week for four weeks. Outcomes were assessed at baseline and post-intervention using the Visual Analog Scale for dizziness and vertigo, the Sensory Organization Test for balance, spatiotemporal gait analysis, and the Dizziness Handicap Inventory (DHI) for disability and quality of life. Data were analyzed using two-way repeated-measures ANOVA, with the group × time interaction used to determine whether changes over time differed between the TOCT and control groups. Results: Significant time × group interactions favored TOCT for dizziness severity, vertigo severity, vestibular-related balance parameters, cadence during eyes-closed walking, and DHI total scores (p < 0.05). Within-group analyses demonstrated moderate-to-large improvements in all measured outcomes for the TOCT group, whereas the control group showed limited improvements in dizziness measures and minimal changes in balance, gait, and DHI scores. Conclusions: Task-oriented circuit training significantly improves dizziness, vertigo, balance, gait, disability, and overall quality of life in patients with PVH compared with conventional home-based vestibular exercises. Incorporating functional, multisensory, and task-specific activities within structured circuits may optimize vestibular rehabilitation outcomes. Full article