Drug Resistance and Novel Targets for Cancer Therapy—Third Edition
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 28 February 2026
Special Issue Editors
Interests: organic synthesis; medicinal chemistry; naphthoquinones; triazoles
Special Issues, Collections and Topics in MDPI journals
Interests: natural product; organic synthesis; cancer drugs; chemotherapeutic molecular targets
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug resistance is a complex phenomenon resulting from one or more mechanisms that render cells resistant to anticancer drugs. The molecular hallmarks of cancer and therapeutics against drug resistance mechanisms represent the leading targets in cancer treatment. Molecular-targeted therapy is attracting growing attraction due to it being specific to cancer and able to spare normal cells. Despite this, drug resistance still represents a major obstacle limiting sustained clinical benefits, not only in targeted cancer therapies but also in conventional chemotherapy. Notably, while some cancer patients do not respond to anticancer drugs due to primary resistance, even responders might eventually relapse following acquired resistance.
In this context, we are launching a new Special Issue encompassing the two major molecular pathways in cancer treatment: the determination of new cancer-related molecular targets and the development of drugs that block them and drugs designed to prevent resistance to treatment. We invite innovative research papers and review articles discussing new molecular targets or anticancer drugs. We encourage articles related to, but not restricted to, apoptosis induction, proliferative signaling, migration, angiogenesis, metastasis, immune checkpoints, tumor vaccine-related targets, chimeric antigen receptor T-cells, or possible drug resistance mechanisms. This Special Issue will address novel molecular targets, drugs designed to attack them, and possible resistance mechanisms that could be targeted to enable more durable and effective responses in cancer therapy.
Dr. Bruno Kaufmann Robbs
Dr. Fernando de Carvalho da Silva
Guest Editors
Dr. Fernando de Carvalho da Silva
Dr. Bruno Kaufmann K. Robbs
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer
- drug resistance
- targeted therapy
- conventional chemotherapy
- natural products
- molecular targets
- cancer hallmarks
- therapeutic agents
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