Search Results (4,239)

Background: The year 2025 witnessed paradigm-shifting advances in gynecologic oncology, with pivotal clinical trial results redefining therapeutic standards across cervical, ovarian, endometrial, and vulvar cancers. Objectives: This systematic review aimed to comprehensively identify, synthesize, and critically evaluate pivotal phase II and III randomized controlled trials and major studies presented at the major annual meetings, alongside significant peer-reviewed publications from 2025 that introduce innovative therapeutic strategies across gynecologic malignancies. Methods: Conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, this review involved exhaustive searches of electronic databases (PubMed/MEDLINE, Embase), conference proceedings (ASCO 2025, ESMO 2025), and major oncology journals for records from January to December 2025. Inclusion criteria encompassed: (1) Phase II or III randomized controlled trials (RCTs) and (2) Non-randomized studies (including phase I and II trials), reporting on novel therapeutic approaches in gynecologic oncology. All studies were required to report primary survival endpoints (overall survival or progression-free survival) or key efficacy outcomes. Study selection, data extraction, and methodological quality assessment were performed independently by two reviewers, with disagreements resolved through consensus or third-party adjudication. Results: From 1842 records, 23 studies met inclusion criteria (17 phase-III RCTs and 6 non-phase III RCTs/early-phase studies), distributed as follows: cervical cancer (9 studies, 39%), ovarian cancer (9 studies, 39%), endometrial cancer (4 studies, 17.5%), and vulvar cancer (1 study, 4.5%). The major advances identified include: (1) In cervical cancer, the KEYNOTE-A18 trial established pembrolizumab combined with chemoradiotherapy as a new standard for high-risk locally advanced disease, while the PHENIX trial validated sentinel lymph node biopsy as a safe surgical de-escalation strategy. (2) In ovarian cancer, the ENGOT-ov65/KEYNOTE-B96 trial demonstrated the first statistically significant overall survival improvement with an immune checkpoint inhibitor in platinum-resistant recurrent disease, establishing pembrolizumab plus weekly paclitaxel as a new standard of care. Novel therapeutic mechanisms, including glucocorticoid receptor modulation (ROSELLA trial) and cadherin-6-targeted antibody-drug conjugates (REJOICE-Ovarian01), showed remarkable efficacy. (3) In endometrial cancer, updated analyses from NRG GY018 and RUBY trials solidified the role of first-line immuno-chemotherapy, with differential benefits according to mismatch repair status. (4) In vulvar cancer, a pivotal phase II study demonstrated meaningful clinical activity of anti-PD-1 therapy in advanced disease. (5) The extensive circulating tumor DNA analysis from the CALLA trial provided crucial insights into biomarker dynamics in cervical cancer. Conclusions: The convergence of high-impact data from 2025 established multiple new standards of care, emphasizing biomarker-driven approaches, immunotherapy integration across disease stages, and novel mechanisms to overcome resistance, while highlighting challenges in treatment sequencing and global access. Full article

This study presents the application of free, open-source artificial intelligence (AI) techniques to advance machine translation for low-resource Turkic languages such as Kazakh, Azerbaijani, Kyrgyz, Turkish, Turkmen, and Uzbek. This machine translation problem for Turkic languages is part of a project to generate meeting minutes from speech transcripts. Due to limited parallel corpora and underdeveloped linguistic tools for these languages, traditional machine translation approaches often underperform. The goal is to reduce digital inequality for these languages and to support scalability. We investigate the effectiveness of free open-source pre-trained specialized and general-purpose AI models for morphologically rich state Turkic languages. This research includes developing parallel corpora for six Turkic languages, fine-tuning, and performance evaluation using BLEU, WER, TER, and chrF metrics. The parallel corpora for five pair languages, each of 300,000 and 500,000 sentences, were generated and cleaned. The results for corpora 500,000 parallel sentences show significant improvements compared with baseline NLLB-200 1.3B on average: BLEU increased by 23.81 points, chrF increased by 26.05 points, and WER and TER decreased by 0.36 and 33.95, respectively, after cleaning and fine-tuning. Six Turkic-language multilingual parallel corpora of 3 885 542 sentences were developed and the fine-tuning of NLLB-200 1.3B shows the following, compared with the results for 500,000 cleaned corpus: BLEU increased by 4.3 points, chrF increased by 1.7 points, and WER and TER decreased by 0.1 and 4.75, respectively These results demonstrate the high efficiency of corpus cleaning and synthetic data generation to improve the quality of machine translation for low-resource Turkic languages using AI models. These results were confirmed by external evaluation on the FLORES 200 dataset and human evaluation. The scientific contribution of this article is the development of a methodology for generating parallel corpora using a specialized AI model of machine translation and fine-tuning the specialized AI model on the created corpora, creating new multilingual parallel corpora of Azerbaijan–Kazakh, Kyrgyz–Kazakh, Turkish–Kazakh, Turkmen–Kazakh, and Uzbek–Kazakh pairs using the proposed methodology, cleaning them, and conducting fine-tuning experiments. Full article

Africa is a continent experiencing the highest yearly rate of deforestation. As a result, there is debate about the causes and consequences of this phenomenon, as well as on the effectiveness of actions undertaken to address this problem. This study offers insights into economic aspects of deforestation in Africa with regard to the use of econometric and spatial data analysis and the inclusion of determinants not considered by previous research. Special attention is paid to the participation of African countries in UN-REDD (United Nations Collaborative Program on Reducing Emissions from Deforestation and Forest Degradation in Developing Countries) and grouping countries according to the level of their forest cover. We demonstrate a negative relationship between economic activity and forest cover using both econometric modeling and spatial data analysis, and present some moderate arguments in favor of the UN-REDD program and its effectiveness in mitigating deforestation in Africa. Importantly, there are no universal patterns across countries characterized by different levels of forest cover. Therefore, we conclude that advancement of this research area requires new methodological approaches based on big data, machine learning, and artificial intelligence to supplement existing approaches and enhance our understanding of the interplay between forest loss and economic growth. Full article

Forests play a critical role in Earth’s ecosystem, yet monitoring their long-term, large-scale spatiotemporal dynamics remains a significant challenge. This study addresses this gap by developing an integrated framework to map annual forest distribution in Hunan, China, from 1999 to 2023 at a high resolution of 30 m. Our methodology combines multi-temporal satellite imagery (Landsat 5/7/8/9) with key environmental variables, including digital elevation models, temperature, and precipitation data. To efficiently reconstruct historical maps, training samples were automatically derived from a reliable 2023 forest product using a transferable logic, drastically reducing manual annotation effort. Comprehensive evaluations demonstrate the robustness of our approach: (1) Qualitative analyses reveal superior spatial detail and temporal consistency compared to existing global forest maps. (2) Rigorous quantitative validation based on ∼9000 reference samples confirms high and stable accuracy (∼92.4%) and recall (∼91.9%) over the 24-year period. (3) Furthermore, comparisons with government forestry statistics show strong agreement, validating the practical utility of the data. This work provides a valuable, accurate long-term dataset that forms a scientific basis for critical downstream applications such as ecological conservation planning, carbon stock assessment, and climate change research, thereby highlighting the transformative potential of multi-source data fusion and automated methods in advancing geospatial monitoring. Full article

End-of-Line (EoL) quality control plays a crucial role in ensuring the reliability, safety, and performance of electric motors in modern industrial production. Increasing product complexity, tighter manufacturing tolerances, and rising production quantities have exposed the limitations of conventional EoL inspection systems, which rely primarily on manually crafted features, expert-defined thresholds, and rule-based decision logic. In recent years, artificial intelligence (AI) techniques, including machine learning (ML), deep learning (DL), and transfer learning (TL), have emerged as promising solutions to overcome these limitations by enabling data-driven, adaptive, and scalable quality inspection. This paper presents a comprehensive and structured review of the latest advances in intelligent EoL quality inspection for electric motor production. It systematically surveys the non-invasive measurement techniques that are commonly employed in industrial environments and examines the evolution from traditional signal processing-based inspection to AI-based approaches. ML methods for feature selection and classification, DL models for raw signal-based fault detection, and TL strategies for data-efficient model adaptation are critically analyzed in terms of their effectiveness, robustness, interpretability, and industrial applicability. Furthermore, this work identifies key challenges that prevent the widespread adoption of AI-based EoL inspection systems, including dependence on expert knowledge, limited availability of labeled fault data, generalization between motor variants and production condition, and the lack of standardized evaluation methodologies. Based on the identified research gaps, this review outlines research directions and emerging concepts for developing robust, interpretable, and data-efficient intelligent inspection systems suitable for real-world manufacturing environments. By synthesizing recent advances and highlighting open challenges, this review aims to support researchers and experts in designing next-generation intelligent EoL quality control systems that enhance production efficiency, reduce operational costs, and improve product reliability. Full article

LNG serves as a pivotal element within integrated energy systems, especially in coastal regions where the implementation of a stable and reliable LNG cold energy power generation system significantly elevates energy efficiency. This system can effectively meet concurrent demands for cold energy utilization and electricity supply while contributing to the mitigation of carbon emissions. However, the inherent complexity of the system coupled with the scarcity of historical operational data for the novel dual-Rankine cycle process renders conventional reliability assessment methodologies inadequate. This study proposes an integrated framework utilizing fuzzy Bayesian methods to address data scarcity during the early stages of equipment deployment. A hierarchical risk factor model, incorporating process decomposition, expert evaluations, and triangular fuzzy numbers, is developed to quantify uncertainties in failure probabilities. The Bayesian network models the causal relationships among equipment failure factors, allowing for the inference of overall system reliability from individual equipment performance. Through a case study of a LNG terminal in Zhoushan, this approach integrates sensitivity analysis with forward-backward reasoning methodologies to rigorously evaluate and quantify system reliability under operational conditions. The results show that under high load conditions within the 1000 h prior to overhaul, following long-term accumulated operation, the probability of complete system shutdown in the power generation system is 3.30%, while the probability of the LNG cold energy power generation system failing to operate fully due to aging-related faults is 8.24%, demonstrating the system’s strong reliability under extreme conditions. Critical risks identified through backward inference include the seawater pump SWP1, with a posterior failure probability of 59.92% during complete shutdown, and the propane-side pump SWP3, with a posterior failure probability of 32.29% when the cold energy power generation system can only operate in a single-cycle mode. This study provides an advanced methodological framework for risk management in newly constructed LNG cold energy power generation systems, playing a crucial role in promoting sustainable, low-carbon technologies in the energy sector. Full article

Itaúba (Mezilaurus itauba (Meisn.) Taub. ex Mez) is an Amazonian forest tree whose high-quality timber has driven sustained commercial exploitation, leading to its classification as threatened with extinction. This systematic scoping review synthesizes the current scientific knowledge on M. itauba. A systematic search of the Web of Science, Scopus, and SciELO databases retrieved studies published in English, Portuguese, and Spanish. Sixty-eight articles were analyzed using quantitative and qualitative approaches. Publications were concentrated between 2012 and 2025, largely derived from research conducted in Brazil and disseminated mainly through national journals. Overall, the literature is dominated by studies on wood technological properties, whereas research on the ecology and silviculture of M. itauba remains limited and often methodologically insufficient to support effective conservation actions. Based on the synthesis of identified knowledge gaps, we highlight as research priorities (i) the generation of empirical data on field performance across developmental stages, from nursery based seedling production to establishment and growth under open field and managed forest conditions; (ii) advancement of knowledge on genetic attributes, including structure and adaptive potential, to support conservation strategies and the selection of planting material; and (iii) integration of ecological interactions, ecophysiological responses, and regeneration processes into applied management frameworks capable of informing evidence based public policies. Addressing these priorities is essential to support conservation planning and the sustainable management of M. itauba. Full article

The identification and monitoring of pavement pathologies are critical for maintaining road infrastructure and ensuring transportation safety. As traditional inspection methods are often time-consuming, labor-intensive, and prone to human error, in recent years, Unmanned Aerial Vehicles (UAVs) have emerged as a promising tool for pavement condition assessment due to their mobility, efficiency, and ability to capture high-resolution imagery and multi-sensor data. This Systematic Literature Review aims to synthesize and evaluate existing research on the use of UAV for identifying pavement pathologies, such as cracks, potholes, rutting, and surface degradation. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) methodology, publications were screened and selected across major academic databases such as Scopus and Web of Science. A total of 361 relevant articles published from 2020 to July 2025 were identified and analyzed using bibliometric overview. And a full-text synthesis and qualitative analysis was performed on a subset of 108 studies, which met the quality assessment criteria. The review categorizes the UAV systems, computer vision approaches, pathology types, and pavement materials examined in the studies. The findings indicate a growing trend in the use of UAV and computer vision techniques for pavement pathology detection, along with evolving preferences for UAV platforms, analytical approaches, and targeted pathology categories over time. This review highlights current gaps and outlines future research directions to advance UAV-based pavement pathology identification as a viable and reliable alternative to conventional inspection methods. Full article

Background: The rapid advancement in artificial intelligence (AI) has fundamentally reshaped gut microbiome research by enabling high-resolution analysis of complex, high-dimensional microbial communities and their functional interactions with the human host. Objective: This narrative review aims to synthesize recent methodological advances in AI-driven gut microbiome research and to evaluate their translational relevance for therapeutic optimization, personalized nutrition, and precision medicine. Methods: A narrative literature review was conducted using PubMed, Google Scholar, Web of Science, and IEEE Xplore, focusing on peer-reviewed studies published between approximately 2015 and early 2025. Representative articles were selected based on relevance to AI methodologies applied to gut microbiome analysis, including machine learning, deep learning, transformer-based models, graph neural networks, generative AI, and multi-omics integration frameworks. Additional seminal studies were identified through manual screening of reference lists. Results: The reviewed literature demonstrates that AI enables robust identification of diagnostic microbial signatures, prediction of individual responses to microbiome-targeted therapies, and design of personalized nutritional and pharmacological interventions using in silico simulations and digital twin models. AI-driven multi-omics integration—encompassing metagenomics, metatranscriptomics, metabolomics, proteomics, and clinical data—has improved functional interpretation of host–microbiome interactions and enhanced predictive performance across diverse disease contexts. For example, AI-guided personalized nutrition models have achieved AUC exceeding 0.8 for predicting postprandial glycemic responses, while community-scale metabolic modeling frameworks have accurately forecast individualized short-chain fatty acid production. Conclusions: Despite substantial progress, key challenges remain, including data heterogeneity, limited model interpretability, population bias, and barriers to clinical deployment. Future research should prioritize standardized data pipelines, explainable and privacy-preserving AI frameworks, and broader population representation. Collectively, these advances position AI as a cornerstone technology for translating gut microbiome data into actionable insights for diagnostics, therapeutics, and precision nutrition. Full article

Reconstructing original cusp dimensions in worn molars represents a fundamental challenge across dentistry, anthropology, and paleontology, as dental wear obscures critical morphological information. In this proof-of-concept study, we present a standardized machine learning pipeline for predicting original cusp height, specifically the horn tips of the enamel–dentine junction (EDJ), in worn lower molars using three-dimensional morphometric data from micro-computed tomography (micro-CT). We analyzed 40 permanent lower first (M1) and second (M2) molars from four hominin groups, systematically evaluated across three wear stages: original, moderately worn (worn1), and severely worn (worn2). Morphometric variables including height, area, and volume were quantified for each cusp, with Random Forest and multiple linear regression models developed individually and combined through ensemble methods. To mimic realistic reconstruction scenarios while preserving a known ground truth, models were trained on unworn specimens (original EDJ morphology) and tested on other teeth after digitally simulated wear (worn1 and worn2). Predictive performance was evaluated using root mean square error (RMSE) and coefficient of determination (R²). Our results demonstrate that under moderate wear (worn1), the ensemble models achieved normalized RMSE values between 11% and 17%. Absolute errors typically below 0.25 mm for most cusps, with R² values up to ~0.69. Performance deteriorated under severe wear (worn2), particularly for morphologically variable cusps such as the hypoconid and entoconid, but generally remained within sub-millimetric error ranges for several structures. Random Forests and linear models showed complementary strengths, and the ensemble generally offered the most stable performance across cusps and wear states. To enhance transparency and accessibility, we provide a comprehensive, user-friendly software pipeline including pre-trained models, automated prediction scripts, standardized data templates, and detailed documentation. This implementation allows researchers without advanced machine learning expertise to explore EDJ-based reconstruction from standard morphometric measurements in new datasets, while explicitly acknowledging the limitations imposed by our modest and taxonomically unbalanced sample. More broadly, the framework represents an initial step toward predicting complete crown morphology, including enamel thickness, in worn or damaged teeth. As such, it offers a validated methodological foundation for future developments in cusp and crown reconstruction in both clinical and evolutionary dental research. Full article

Prevention of cancer is an appealing strategy to reduce the burden of illness associated with cancer, but despite the rapidly advancing understanding of the early phases of carcinogenesis, translation of biologic insights into actionable public health strategies has been challenging. Phase III clinical trials have historically required large numbers of participants and lengthy durations to show effects in the minority of participants who develop cancer during the finite span of each trial. Early-phase trials help to refine intervention strategies and provide preliminary human safety and efficacy data to justify phase III trials. Recent advances in trial methodology and developments in immunopreventive strategies have energized the field of cancer prevention and provide potential paths for prevention of multiple cancer types. In this review we discuss the history and current state of cancer prevention trials, with a focus on overcoming inherent biologic and methodologic barriers to preventive agent development. Full article

Plant immunity research is being reshaped by integrative multi-omics approaches that connect transcriptomic, proteomic, and interactomic data to build systems-level views of plant–pathogen interactions. This review outlines the scope and methodological landscape of these approaches, with particular emphasis on how transcriptomic and proteomic insights converge through network-based analyses to elucidate defense regulation. Transcriptomics captures infection-induced transcriptional reprogramming, while proteomics reveals protein abundance changes, post-translational modifications, and signaling dynamics essential for immune activation. Network-driven computational frameworks including iOmicsPASS, WGCNA, and DIABLO enable the identification of regulatory modules, hub genes, and concordant or discordant molecular patterns that structure plant defense responses. Interactomic techniques such as yeast two-hybrid screening and affinity purification–mass spectrometry further map host–pathogen protein–protein interactions, highlighting key immune nodes such as receptor-like kinases, R proteins, and effector-targeted complexes. Recent advances in machine learning and gene regulatory network modeling enhance the predictive interpretation of transcription–translation relationships, especially under combined or fluctuating stress conditions. By synthesizing these developments, this review clarifies how integrative multi-omics and network-based frameworks deepen understanding of the architecture and coordination of plant immune networks and support the identification of molecular targets for engineering durable pathogen resistance. Full article

Deep learning has emerged as a transformative methodology in modern cosmology, providing powerful tools to extract meaningful physical information from complex astronomical data. This paper implements a novel Bayesian graph deep learning framework for estimating key cosmological parameters in a primordial magnetic field (PMF) cosmology from simulated Cosmic Microwave Background (CMB) maps. Our methodology utilizes DeepSphere, a spherical convolutional neural network architecture specifically designed to respect the spherical geometry of CMB data through HEALPix pixelization. To advance beyond deterministic point estimates and enable robust uncertainty quantification, we integrate Bayesian Neural Networks (BNNs) into the framework, capturing aleatoric and epistemic uncertainties that reflect the model confidence in its predictions. The proposed approach demonstrates exceptional performance, achieving $R^2$ scores exceeding 89% for the magnetic parameter estimation. We further obtain well-calibrated uncertainty estimates through post hoc training techniques including Variance Scaling and GPNormal. This integrated DeepSphere-BNNs framework delivers accurate parameter estimation from CMB maps with PMF contributions while providing reliable uncertainty quantification, enabling robust cosmological inference in the era of precision cosmology. Full article

This work addresses the challenges of inadequate data acquisition and the limited availability of labeled samples for shearer rocker arm bearing faults by developing a data augmentation methodology that synergistically incorporates the Genetic Algorithm-optimized Wavelet Transform Symmetrical Dot Pattern (GA-WT-SDP) with a Wasserstein Conditional Generative Adversarial Network (WCGAN). In the initial step, the Genetic Algorithm (GA) is employed to refine the mapping parameters of the Wavelet Transform Symmetrical Dot Pattern (WT-SDP), facilitating the transformation of raw vibration signals into advanced and discriminative graphical representations. Thereafter, the Wasserstein distance in conjunction with a gradient penalty mechanism is introduced through the WCGAN, thereby ensuring higher-quality generated samples and improved stability during model training. Experimental results validate that the proposed approach yields accelerated convergence and superior performance in sample generation. The augmented data significantly bolsters the generalization ability and predictive accuracy of fault diagnosis models trained on small datasets, with notable gains achieved in deep architectures (CNNs, LSTMs). The research substantiates that this technique helps overcome overfitting, enhances feature representation capacity, and ensures consistently high identification accuracy even in complex working environments. Full article

This study introduces a framework for estimating the optical scattering properties of thin-film phantoms using a custom-built Spectral-Domain Dental Optical Coherence Tomography (DEN-OCT) system operating within the 780–900 nm spectral range. The purpose of this work was to assess the performance of this system. The system exhibited high depth-resolved imaging performance with an axial resolution of approximately 16.30 µm, a signal-to-noise ratio of about 32.4 dB, and a 6 dB sensitivity roll-off depth near 2 mm, yielding an effective imaging range of 2.5 mm. Thin-film phantoms with controlled optical characteristics were fabricated and analyzed using Beer–Lambert and diffusion approximation models to evaluate attenuation behavior. Samples representing different tissue analogs demonstrated distinct scattering responses: one sample showed strong scattering similar to hard tissues, while the others exhibited lower scattering and higher transmission, resembling soft-tissue properties. Spectrophotometric measurements at 840 nm supported these trends through characteristic transmittance and reflectance profiles. While homogeneous samples conformed to analytical models, the highly scattering sample deviated due to structural non-uniformity, requiring Monte Carlo simulation to accurately describe photon transport. OCT A-scan analyses fitted with exponential decay models produced attenuation coefficients consistent with spectrophotometric data, confirming the dominance of scattering over absorption. The integration of OCT imaging, optical modeling, and Monte Carlo simulation establishes a reliable methodology for quantitative scattering estimation and demonstrates the potential of the developed DEN-OCT system for advanced dental and biomedical imaging applications. The innovation of this work lies in the integration of phantom-based optical calibration, multi-model scattering analysis, and depth-resolved OCT signal modeling, providing a validated pathway for quantitative parameter extraction in dental OCT applications. Full article