Search Results (2,008)

tRNA modifications are crucial for efficient protein synthesis, impacting codon recognition, tRNA stability, and translation rates. RNA viruses hijack the host’s translational machinery, including the pool of modified tRNA, to translate their own genomes. However, the mismatch between viral and host codon usage can lead to a limited availability of specific tRNA leading to ribosome stalling, posing a significant challenge for efficient protein translation. While some viruses address this challenge through codon optimization, we show here that SARS-CoV-2 (Coronavirus) and the Zika virus (ZIKV; Flavivirus) adopt a different approach, manipulating the host tRNA epitranscriptome. Analysis of codon bias indices confirmed a substantial divergence between viral and host codon usage, revealing a strong preference in viral genes for codons decoded by tRNAs requiring U34 wobble modification. Monitoring tRNA modification dynamics in infected cells showed that both SARS-CoV2 and ZIKV enhance U34 tRNA modifications during infection. Strikingly, impairing U34 tRNAs profoundly impacted viral replication, underscoring the strict reliance of SARS-CoV-2 and ZIKV on manipulating the host tRNA epitranscriptome to support the efficient translation of their genome. Full article

The rapid increase in the global population of older adults presents a significant challenge, but also a unique opportunity to leverage technological advancements for promoting independent living and well-being. This study introduces the CIREI framework, which is a comprehensive model designed to enhance the integration of smart home and assistive technologies specifically for pre-frail older adults. Developed through a systematic literature review and innovative and comprehensive co-design activities, the CIREI framework captures the nuanced needs, preferences, and challenges faced by older adults, caregivers, and experts. Key findings from the co-design workshop highlight critical factors such as usability, privacy, and personalised learning preferences, which directly influence technology adoption. These insights informed the creation of an intelligent middleware prototype named WISE-WARE, which seamlessly integrates commercial off-the-shelf (COTS) devices to support health management and improve the quality of life for older adults. The CIREI framework’s adaptability ensures it can be extended and refined to meet the ever-changing needs of the ageing population, providing a robust foundation for future research and development in user-centred technology design. All workshop materials, including tools and methodologies, are made available to encourage the further exploration and adaptation of the CIREI framework, ensuring its relevance and effectiveness in the dynamic landscape of ageing and technology. This research contributes significantly to the discourse on ageing in place, digital inclusion, and the role of technology in empowering older adults to maintain independence. Full article

Industrial robots are undergoing a transformative shift as Artificial Intelligence (AI)-driven and bio-inspired control strategies unlock new levels of precision, adaptability, and multi-dimensional sustainability aligned with Industry 5.0 (energy efficiency, material circularity, and life-cycle emissions). This systematic review analyzes 160 peer-reviewed industrial robotics control studies (2023–2025), including an expanded bio-inspired/human-centric subset, to evaluate: (1) the dominant and emerging control methodologies; (2) the transformative role of digital twins and 5G-enabled connectivity; and (3) the persistent technical, ethical, and environmental challenges. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, the study employs a rigorous methodology, focusing on adaptive control, deep reinforcement learning (DRL), human–robot collaboration (HRC), and quantum-inspired algorithms. The key findings highlight up to 30% latency reductions in real-time optimization, up to 22% efficiency gains through digital twins, and up to 25% energy savings from bio-inspired designs (all percentage ranges are reported relative to the comparator baselines specified in the cited sources). However, critical barriers remain, including scalability limitations (with up to 40% higher computational demands) and cybersecurity vulnerabilities (with up to 20% exposure rates). The convergence of AI, bio-inspired systems, and quantum computing is poised to enable sustainable, autonomous, and human-centric robotics, yet requires standardized safety frameworks and hybrid architectures to fully support the transition from Industry 4.0 to Industry 5.0. This review offers a strategic roadmap for future research and industrial adoption, emphasizing human-centric design, ethical frameworks, and circular-economy principles to address global manufacturing challenges. Full article

This study evaluates the feasibility and visibility of electric vehicles (EVs) in Egypt, addressing critical research gaps and proposing actionable strategies to drive adoption. Employing a systematic review of academic, governmental, and industry sources, the paper identifies underexplored areas such as rural–urban adoption disparities, lifecycle assessments of EV batteries, and sociocultural barriers, including gender dynamics and entrenched consumer preferences. Its primary contribution is an interdisciplinary framework that integrates technical aspects, such as grid resilience and climate-related battery degradation, with socioeconomic dimensions, providing a holistic overview of EV feasibility in Egypt tailored to Egypt’s context. Key findings reveal infrastructure limitations, inconsistent policy frameworks, and behavioral skepticism as major hurdles, and highlight the untapped potential of renewable energy integration, particularly through synergies between solar PV generation (e.g., Benban Solar Park) and EV charging infrastructure. Recommendations prioritize policy reforms (e.g., tax incentives, streamlined tariffs), solar-powered charging infrastructure expansion, public awareness campaigns, and local EV manufacturing to stimulate economic growth. The study underscores the urgency of stakeholder collaboration to transform EVs into a mainstream solution, positioning Egypt as a regional leader in sustainable mobility and equitable development. Full article

Food safety regulations and their implementations are becoming increasingly complex due to various reasons such as diverse food sources, supply chain, processing technologies, distribution systems and environmental concerns. Additionally, it is crucial to address diversified consumers and their preferences. To address these multifaceted challenges, adopting an integrated unified management system is essential. This review provides a comprehensive overview of the progressive food safety governance in the Sultanate of Oman. The country is transitioning from a multi-agency to an integrated food control management system. This integrated approach can enhance the coordination between different government agencies and other stakeholders, avoid duplication, identify required resources and ensure optimum use of the resources. The progress can enhance efficiency and effectiveness in managing food safety in Oman. It addresses the issues of the food safety management system, explores the legislative frameworks, risk-based assessment and their enforcement, and creates public awareness and required research for continuous improvement in food safety. This integration approach is expected to continue strengthening food safety governance in the country. Finally, future challenges in achieving food safety are envisioned, including new food sources and technologies, applications of artificial intelligence, and new sensors for quick identification of risks in foods. Full article

Deep margin elevation (DME) is a widely adopted technique for managing subgingival cervical proximal margins by repositioning them to a supragingival location. This approach enhances access, visibility, and control in these anatomically challenging areas. This narrative review aimed to evaluate current evidence on the indications, materials, clinical protocols, and outcomes of DME. A structured search was conducted in PubMed, the Cochrane Library and Scopus up to February 2025, using keywords such as “deep margin elevation”, “proximal box elevation” and “subgingival margin.” Clinical studies, in vitro investigations, relevant reviews and reports in English were included. A total of 59 articles were selected based on eligibility criteria. The hypothesis was that DME can serve as a reliable alternative to surgical crown lengthening in appropriate cases. A variety of materials have been investigated for use as the intermediate layer, with composite resins of varying viscosities and filler compositions being preferred due to their favorable long-term mechanical properties. DME may reduce the need for surgical intervention while maintaining periodontal health; however further randomized clinical trials are needed to clarify the material selection, establish long-term outcomes, and standardize clinical protocols. Understanding the indications, limitations, and protocol of DME is critical for achieving biologically sound and predictably functional restorations. Full article

This research analyzed university students’ perceptions of the use of generative artificial intelligence (hereafter Gen-AI) in a higher education context. Specifically, it addressed the potential benefits and challenges related to the application of these web-based resources. A mixed method was adopted and the sample consisted of 407 teacher training students enrolled in the Early Childhood and Primary Education Degrees in the Region of Murcia in Spain. The results indicated a clear recognition of the relevance of these technological tools for teaching and learning. Respondents highlighted the potential to engage them in academic tasks, increase their motivation, and personalize their learning pathways. However, participants identified some challenges related to technology dependency, ethical issues, and privacy concerns. By understanding learners’ beliefs and assumptions, educators and educational administrations can adapt Gen-AI according to learners’ needs and preferences to improve their academic performance. In learning practice, these adaptations could involve evidence-based interventions, such as AI literacy modules or hybrid assessment frameworks, to translate findings into practice. In addition, it is necessary to adjust materials, methodologies, and the assessment of the academic curriculum to facilitate student learning and ensure that all students have access to quality education and the adequate development of digital skills. Full article

Cervical cancer remains a significant global public health challenge, with human papillomavirus (HPV) as its primary cause. In response, the World Health Organization (WHO) launched a global strategy to eliminate cervical cancer by 2030 and, in its 2022 position paper, recommended a single-dose vaccination schedule. The objective of this review is to critically examine the current HPV vaccination landscape in China, including vaccination policies, immunization schedules, supply–demand dynamics, and the feasibility of transitioning to a single-dose regimen. By synthesizing recent developments in HPV virology, epidemiology, vaccine types, and immunization strategies, we identify both opportunities and barriers unique to the Chinese context. Results indicate that China primarily adheres to a three-dose vaccination schedule, with an optional two-dose schedule for girls aged 9–14, leaving a notable gap compared to the most recent WHO recommendation. The high prevalence of HPV types 52 and 58 contributes to a distinct regional infection pattern, underscoring the specific need for nine-valent vaccines tailored to China’s epidemiological profile. Despite the growing demand, vaccine supply remains inadequate, with an estimated annual shortfall of more than 15 million doses. This issue is further complicated by strong public preference for the nine-valent vaccine and the relatively high cost of vaccination. Emerging evidence supports the comparable efficacy and durable protection of a single-dose schedule, which could substantially reduce financial and logistical burdens while expanding coverage. This review advocates for the adoption of a simplified single-dose regimen, supported by catch-up strategies for older cohorts and the integration of HPV vaccination into China’s National Immunization Program (NIP). Sustained investment in domestic vaccine development and centralized procurement of imported vaccines may also possibly alleviate supply shortage. These coordinated efforts are critical for strengthening HPV-related disease prevention and accelerating China’s progress toward the WHO’s cervical cancer elimination targets. Full article

This paper explores the strategic implications of technological adoption within shipping logistics service supply chains, with a particular focus on blockchain technology (BCT). When integrating new technologies, supply chain stakeholders evaluate associated risks alongside complexity, profitability, and operational challenges, which influence their strategic behaviors. Anchored in the concept of technology trust, this study examines how different risk preferences affect BCT adoption decisions and freight rate strategies. A game-theoretic model is constructed using a mean-variance utility framework to analyze interactions between shipping companies and freight forwarders under three adoption scenarios: no adoption (NN), partial adoption (BN), and full adoption (BB). The results indicate that risk-seeking agents are more likely to adopt BCT early but face greater freight rate volatility in the initial stages. As the technology matures, strategic variability declines and the influence of adaptability on pricing becomes less pronounced. In contrast, risk-neutral and risk-averse participants tend to adopt more conservatively, resulting in slower but more stable pricing dynamics. These findings offer new insights into how technology trust and risk attitudes shape strategic decisions in digitally transforming supply chains. The study also provides practical implications for differentiated pricing strategies, BCT adoption incentives, and collaborative policy design among logistics stakeholders. Full article

In vitro meat presents a promising alternative to conventional meat production by addressing environmental and animal welfare concerns. However, broader market adoption depends on increasing consumer acceptance. Labels on product packaging have been shown to be effective in influencing consumer behavior in previous studies. This paper examines the impact of different front-of-package labels on German consumers’ choices regarding in vitro chicken meat, with the goal of identifying effective labeling strategies. To investigate this, an online choice experiment was conducted with 200 participants from Germany. In addition to the label, products varied in terms of price, origin, and calorie content. The data were analyzed using latent class analysis, which identified four distinct consumer segments characterized by their preferences, attitudes, and personal characteristics. The results were used to simulate market scenarios, evaluating the effectiveness of different labeling strategies for in vitro chicken meat. These insights provide a foundation for targeted marketing approaches that promote consumer acceptance and inform the introduction of in vitro meat products in Germany. Full article

Before the onset of global warming concerns, the idea of manufacturing electric vehicles on a large scale was not widely considered. However, electric vehicles offer several advantages that have garnered attention. They are environmentally friendly, with simpler drive systems compared to traditional fossil fuel vehicles. Additionally, electric vehicles are highly efficient, with an efficiency of around 90%, in contrast to fossil fuel vehicles, which have an efficiency of about 30% to 35%. The higher energy efficiency of electric vehicles contributes to lower operational costs, which, alongside regulatory incentives and shifting consumer preferences, has increased their strategic importance for many vehicle manufacturers. In this paper, we present a thematic literature review on electric vehicles charging station location planning and scheduling. A systematic literature review across various data sources in the area yielded ninety five research papers for the final review. The research results were analyzed thematically, and three key directions were identified, namely charging station deployment and placement, optimal allocation and scheduling of EV parking lots, and V2G and smart charging systems as the top three themes. Each theme was further investigated to identify key topics, ongoing works, and future trends. It has been found that optimization methods followed by simulation and multi-criteria decision-making are most commonly used for EV infrastructure planning. A multistakeholder perspective is often adopted in these decisions to minimize costs and address the range anxiety of users. The future trend is towards the integration of renewable energy in smart grids, uncertainty modeling of user demand, and use of artificial intelligence for service quality improvement. Full article

The transition toward a circular water economy addresses accelerating water scarcity and pollution. A PRISMA-2020 systematic review of 50 peer-reviewed articles (January 2018–April 2024) mapped current technologies and management strategies, seeking patterns, barriers, and critical bottlenecks. Bibliometric analysis revealed the following three dominant patterns: (i) rapid diffusion of membrane bioreactors, constructed wetlands, and advanced oxidation processes; (ii) research geographically concentrated in Asia and the European Union; (iii) industry’s marked preference for by-product valorization. Key barriers—high energy costs, fragmented regulatory frameworks, and low social acceptance—converge as critical constraints during scale-up. The following three practical action lines emerge: (1) adopt progressive tariffs and targeted tax credits that internalize environmental externalities; (2) harmonize water-reuse regulations with comparable circularity metrics; (3) create multi-actor platforms that co-design projects, boosting local legitimacy. These findings provide policymakers and water-sector practitioners with a clear roadmap for accelerating Sustainable Development Goals 6, 9, and 12 through circular, inclusive, low-carbon water systems. Full article

The present study adopts the social constructivism theory and consumer decision-making process model with the aim of examining the social identity that consumers build through the purchase of electric vehicles (EVs) in line with their income, age, gender, and education. The study’s findings indicate that this social identity, shaped by income, age, gender and education, exerts a significant influence on consumer decision-making behavior. This identity is shaped not only by the make and model of EVs chosen, but also by their preferences for vehicle performance and technical features. The adoption of EVs by consumers is driven by dual objectives: the fulfilment of practical needs and the shaping of social identities in social interactions that correspond to their income, age, gender, and education. The study’s findings are of significant value in understanding the social identity aspirations of consumers in the electric vehicle consumer market, and provide a theoretical foundation for future electric vehicle companies to create products and corporate cultures that meet their target customers, thereby effectively promoting the popularization of electric vehicles. Full article

Mass spectrometric (MS) fingerprinting coupled with chemometrics for the detection of plants in plant mixtures is sparsely researched. This paper aims to check its value for herbal adulteration concerning plants with slimming as an indication. Moreover, it is among the first to exploit the full three-dimensional dataset (i.e., time × intensity × mass) obtained with liquid chromatography hyphenated with MS for herbal fingerprinting purposes. The MS parameters were optimized to achieve highly specific fingerprints. Trituration’s (total 55), blanks (total 11) and reference plants were injected in the MS system to generate the dataset. The dataset was complex and humongous, necessitating the application of compression techniques. After compression, Partial Least Squares-Discriminant Analysis (PLS-DA) was performed to generate models validated for accuracy using cross-validation and an external test set. Confusion matrices were constructed to provide insight into the modeling predictions. A complimentary evaluation between data obtained using a previously developed Diode Array Detection (DAD) method and the MS data was performed by data fusion techniques and newly generated models. The fused dataset models were comparable to MS models. For ease of application, MS modeling was deemed to be superior. The future market studies would adopt MS modeling as the preferred choice. A proof of concept was carried out on 10 real-life samples obtained from illegal sources. The results indicated the need for stronger monitoring of (illegal) plant food supplements entering the market, especially via the internet. Full article

Background/Objectives: Proton therapy delivers highly conformal doses to the target area without producing an exit dose, minimizing cumulative doses to healthy liver tissue. This study aims to evaluate current practices, challenges, and variations in the implementation of proton stereotactic body radiation therapy (SBRT) and hypofractionated therapy for liver malignancies, with the goal of providing a technical assessment to promote broader adoption and support future clinical trials. Methods and Materials: An extensive survey was conducted by NRG Oncology across North American proton treatment centers to assess the current practices of proton liver SBRT and hypofractionated therapy. The survey focused on key aspects, including patient selection, prescription and normal tissue constraints, simulation and motion management, treatment planning, quality assurance (QA), treatment delivery, and the use of image-guided radiation therapy (IGRT). Results: This survey captures the current practice patterns and status of proton SBRT and hypofractionated therapy in liver cancer treatment.  Proton therapy is increasingly preferred for treating inoperable liver malignancies due to its ability to minimize healthy tissue exposure. However, the precision required for proton therapy presents challenges, particularly in managing uncertainties and target motion during high-dose fractions and short treatment courses. Survey findings revealed significant variability in clinical practices across centers, highlighting differences in motion management, dose fractionation schedules, and QA protocols. Conclusion: Proton SBRT and hypofractionated therapy offer significant potential for treating liver malignancies. A comprehensive approach involving precise patient selection, treatment planning, and QA is essential for ensuring safety and effectiveness. This survey provides valuable insights into current practices and challenges, offering a foundation for technical recommendations to optimize the use of proton therapy and guide future clinical trials. Full article