Search Results (19,002)

School-based mental health screening typically relies on single-time-point assessments, which assume that students’ emotional well-being is sufficiently stable for classification based on a single measurement. The present study examined this assumption by evaluating the stability of emotional well-being classifications under repeated mood monitoring. Students from two secondary schools (United Kingdom, n = 413; Australia, n = 354) completed the Brief Emotional Experience Scale weekly across six to seven weeks. Emotional well-being classifications were examined relative to a predefined low well-being threshold to assess stability across time, and a post-monitoring survey examined students’ self-reported perceptions of the monitoring experience. Most students (78%) showed consistently above-threshold classifications across monitoring occasions, while a small proportion (5%) showed persistently low classifications. However, 17% of students fluctuated above and below the low well-being threshold across weeks, indicating that classification status for this group was sensitive to assessment timing. When monitoring data were aggregated using different decision rules, the proportion of students flagged as low well-being varied substantially, ranging from approximately 5% under a conservative stability-based criterion to around 12% when classifications were based on averaged monitoring scores. Classifications derived from averaged monitoring scores showed high agreement with single-time-point classifications, while identifying a partially different subset of students as low well-being, underscoring the sensitivity of threshold-based decisions to classification approach. Student feedback provided preliminary contextual insight into the acceptability of repeated monitoring under routine school conditions, with over half of respondents reporting that the process supported their emotional understanding. A substantial minority also reported greater inclination to talk with others about their well-being. Overall, the findings indicate that single-time-point screening may provide an incomplete basis for emotional well-being classification for some students, and that repeated assessment offers additional temporal context for interpreting threshold-based screening decisions. Full article

(1) Background: Idiopathic scoliosis is a three-dimensional deformity, yet clinical and research decision-making still relies largely on radiographic Cobb angle measurements. As a radiation-free alternative, clinical assessment of transverse and sagittal plane deformities has gained importance. This study evaluated the concurrent validity and intra- and interrater reproducibility of continuous measurements of rib hump, thoracic kyphosis, and lumbar lordosis obtained using a smartphone application in adolescents with spinal deformities. (2) Methods: Adolescents aged 10–17 years with scoliosis (>10° Cobb) or hyperkyphosis (>50° Cobb) were recruited. Continuous measurements of angle of trunk rotation (ATR) during the Adams forward bend test and in standing position, as well as sagittal profile, were collected using the ISICO app mounted on a standardized plastic tool. Concurrent validity was assessed against a scoliometer using Spearman correlation, root mean square error, and Bland–Altman analysis, while reproducibility was evaluated using intraclass correlation coefficients, standard error of measurement, and minimal detectable change. (3) Results: Thirty-two adolescents were included for validation and intrarater analyses and 34 for interrater analyses. ATR measured during the Adams test showed very high correlation with the scoliometer and minimal bias, while standing ATR showed moderate correlation. Reliability was excellent for rib hump during forward bending and moderate for sagittal parameters, with the lowest values observed for lumbar lordosis. (4) Conclusions: These findings support the clinical use of continuous app-based ATR assessment and suggest that sagittal measurements may be useful with appropriate examiner training. Full article

This research examined the component structure of two child measures, the Trait Emotional Intelligence Questionnaire–Child Form (TEIQue-CF; 75 items) and its short form (TEIQue-CSF; 36 items), developed specifically for children aged 8 to 12 years. Study 1 analysed TEIQue-CF data using the nine facet scores from 720 UK primary school pupils in Years 3 through 6 using principal component analysis with parallel analysis for factor retention. Results supported a unifactorial solution in the total sample, with a single factor explaining 43.48% of the variance. Exploratory subgroup factor analyses (in boys and older children in Years 5 to 6) in Study 1 suggested a potentially interpretable bifactorial pattern, though parallel analysis did not support retaining the second factor. Study 2 examined the TEIQue-CSF in 1582 Year 6 pupils using parcel-level analysis. A clearer two-factor structure emerged, with Socioemotionality (Adaptability, Peer relations, Self-esteem, Emotion expression, Affective disposition, Emotion perception) and Emotion control (Impulse control, Emotion regulation, Self-motivation) explaining 53.7% of the variance. This structure replicated across gender subgroups. Taken together, the findings suggest a developmental trend in which trait EI shifts from a largely undifferentiated structure in middle childhood to a more differentiated two-factor organisation by the end of primary school. They support the use of global trait EI scores in younger children while indicating that differentiated assessment becomes appropriate as children approach adolescence. Full article

This study examined the perceived quality of life of Portuguese gifted students compared with their non-gifted peers using the KIDSCREEN-27, a widely used instrument for assessing health-related quality of life in children and adolescents. Quality of life is the subjective perception of overall well-being resulting from the interaction of physical, psychological, social, and environmental factors. Previous research suggests that high intellectual ability does not necessarily ensure greater well-being and may coexist with social–emotional challenges, including perfectionism, anxiety, and difficulties in social integration. The sample consisted of 102 Portuguese students aged between 10 and 15 years old. They were in two groups (gifted and non-gifted), matched by gender. Gifted participants had previously been identified through psychoeducational assessment and were enrolled in the PEDAIS enrichment program promoted by the National Association for the Study and Intervention in Giftedness (ANEIS). Five quality-of-life dimensions were analyzed: physical well-being, psychological well-being, autonomy and parent relationships, peer social support, and school environment. MANOVA results indicated statistically significant differences between the groups, with gifted students reporting lower scores in physical well-being, autonomy and parent relationships, peer social support, and school environment. There were no significant differences in psychological well-being, indicating similar levels of perceived emotional well-being in both groups. These findings highlight the importance of considering the social and contextual dimensions of well-being in gifted education and reinforce the need for educational strategies that combine cognitive development with social–emotional support. However, the results should be interpreted with caution, as the gifted participants were recruited from a structured enrichment program, which may limit the generalizability of the findings to the broader population of gifted students. Full article

Objectives: This study aims to examine Internet addiction profiles, their associations with comorbid anxiety and depression, and characterize network architectures of anxiety and depression across profiles. Methods: From November 2022 to November 2023, we conducted a short-term l cohort study including 2503 students. Latent profile analysis (LPA) and multinomial logistic regression analysis were employed to investigate the association between Internet addiction and comorbidity of anxiety and depression, and network analysis was used to characterize anxiety–depression network structure within each profile. Results: LPA identified three profiles of Internet addiction, which were labeled: “regular” (66.60%) profile, “risk” profile (23.09%), and “addiction” profile (10.31%). The incidence of comorbid anxiety and depression was 10.67%. Both the “risk” (adjusted OR = 1.76, 95% CI: 1.27–2.44) and “addiction” (adjusted OR = 2.12, 95% CI: 1.39–3.24) profiles were significantly associated with increased comorbidity risk. The “dass13” (“Downhearted and blue”) emerged as a core symptom, and “dass15” (“Close to panic”) was identified as a key bridge symptom across three network models. The edge weight for the dass05–dass21 (Lack of motivation–Meaninglessness of life) was higher in the “risk” profile than in the “addiction” profile. Conclusions: Children and adolescents in the “risk” and “addiction” profiles were significantly more likely to experience comorbid anxiety and depression. “dass13” (“Downhearted and blue”) and “dass15” (“Close to panic”) can be used as the key target during intervention. Targeted interventions can be implemented for children and adolescents in the “risk” and “addiction” profiles. Full article

Background: Adolescence is a sensitive developmental period marked by heightened emotional reactivity and increasing demands on emotion recognition and regulation. Although alexithymia has been associated with less adaptive and avoidant coping tendencies in adolescents, most prior research has relied on descriptive or bivariate approaches, leaving the underlying processes and model-based pathways insufficiently clarified. In particular, the explanatory role of difficulties in emotion regulation in the association between alexithymia and coping strategies remains underexplored. This study aimed to address this gap by examining whether difficulties in emotion regulation mediate the relationship between alexithymia and coping strategies in adolescents. Methods: In this cross-sectional study, 1415 adolescents (13–17 years) from public high schools in Central Anatolia, Türkiye, completed the Toronto Alexithymia Scale (TAS-20), the Difficulties in Emotion Regulation Scale (DERS-16), and the Coping Strategies Indicator (CSI). Pearson correlations were calculated. Mediation analyses were conducted using PROCESS Macro (Model 4) with 5000 bootstrap samples, adjusting for age, gender, academic achievement, and family type. Results: Alexithymia was moderately associated with emotion regulation difficulties (r = 0.49, p < 0.001). Mediation analyses revealed significant indirect effects for seeking social support (B = −0.068, 95% CI [−0.087, −0.051]) and problem solving (B = −0.067, 95% CI [−0.086, −0.049]), with direct effects remaining significant, indicating inconsistent (competitive) mediation patterns. For avoidance coping, the indirect effect was significant (B = −0.072, 95% CI [−0.090, −0.055]), whereas the direct effect became non-significant, consistent with an indirect-only mediation pattern. Correlations involving coping outcomes were small in magnitude. According to Cohen’s criteria, the association between alexithymia and emotion regulation difficulties was moderate in magnitude, whereas correlations involving coping outcomes were small. Conclusions: Difficulties in emotion regulation emerged as a statistical mediator within the proposed model, demonstrating systematic associations between alexithymia and distinct coping patterns in adolescents. These findings underscore the relevance of emotion regulation–focused prevention and intervention efforts in school settings. By examining multiple coping outcomes simultaneously within a covariate-adjusted mediation framework in a large community adolescent sample, this study offers an integrative, model-based perspective on how alexithymic traits are linked to coping through regulatory difficulties. Full article

Background: Breaststroke performance in young swimmers is influenced by a complex interaction of anthropometric, physiological, and technical factors. However, existing studies predominantly focus on pre-selected or elite youth swimmers, limiting insight into performance development in non-elite populations without early selection bias. Purpose: This study aimed to identify key predictors of 50-m breaststroke performance and to examine longitudinal changes in selected characteristics in pre-adolescent, non-elite female swimmers. Methods: Fourteen female swimmers (baseline biological age: 10.52 ± 0.37 years) who entered swimming training without prior anthropometric or physiological selection were followed over three consecutive years. Measurements were collected at six time points and included anthropometric dimensions, body composition, aerobic and anaerobic capacity, respiratory volumes, and 50-m breaststroke performance. This investigation was a prospective longitudinal cohort study. Data were analysed using generalised estimating equations. Results: The correlation-filtered model explained 76% of the variance in 50-m breaststroke time. Chest depth (B = −0.16, p = 0.03), foot length (B = −0.17, p = 0.04), foot width (B = 0.30, p < 0.001), and shoulder width (B = −0.07, p = 0.04) emerged as significant anthropometric predictors. Maximal oxygen uptake also showed a significant association with performance (B = −0.33, p = 0.02). Conclusions: In pre-adolescent, non-elite female swimmers, selected anthropometric characteristics—particularly trunk dimensions and foot morphology—are associated with short-distance breaststroke performance. Aerobic capacity appears to play an indirect, supportive role. These findings highlight the importance of longitudinal monitoring without early selection and support a development-oriented approach to youth swimming training. Full article

When using traditional approaches, such as pharmacokinetics and pharmacodynamics, the entire cellular or molecular response to drugs in the body cannot be fully ascertained or established. The oral medication process involves pharmacokinetics, followed by oral microbiomics and then gut microbiomics and pharmacodynamics. Recently, there has been increasing interest in the role of genetics (pharmacogenetics and pharmacogenomics) in both humans and microbiomes, as well as omics alterations (e.g., epigenetic, transcriptomic, proteomic, and metabolomic alterations as a consequence of drug exposure), which can help to ascertain the cellular responses to medications. Both the efficacy and toxicity of a drug are influenced by these factors. To assess these at an individual level, an integrative Personalized Medicine Model may be needed to help with medication management. Two example application cases for SSRIs and statins demonstrate the clinical usefulness of such a model, which can guide clinicians during drug selection and dosing to reduce reliance on trial-and-error, thus potentially improving patient outcomes and safety. Integrating this framework into practical clinical workflows requires the capture, analysis, and translation of multi-omics data in order to realize decision support protocols and actionable drug recommendations. This review also discusses IT requirements and different stakeholder roles. Although the proposed model can guide the treatment of diseases at the individual patient level, further research is still needed before it can be implemented as part of drug development research, clinical care, and healthcare delivery systems. Full article

Social identity approaches suggest that people favour ingroup members, yet ingroup favouritism does not necessarily translate into outgroup derogation. Using a sample of Croatian majority-group youth from a nationally and religiously homogeneous pre-COVID context, we examined whether personal values moderate the relationship between national identification and attitudes towards minorities. We conducted a latent profile analysis (LPA) on higher-order values among young Croatian Catholics who did not belong to minority groups (N = 994) and identified five value profiles that varied primarily in the prioritisation of openness to change versus conservation. Profiles differed in minority attitudes and national identification. Crucially, the association between national identification and minority attitudes varied across profiles: it was unrelated in the profile prioritising openness over conservation, whereas in the remaining profiles it tended to be negative and was most consistently negative in the profile prioritising conservation over openness. Taken together, the findings highlight the role of values in the relationship between group identification and attitudes towards outgroups, confirming their relevance for social cohesion and potential for the development of deradicalisation interventions. Full article

Background/Objectives: Osgood–Schlatter disease (OSD) is a common overuse condition in adolescents characterized by increased stiffness of the rectus femoris muscle, which contributes to pain and functional limitations around the knee. We investigated whether repeating 10 min passive joint movements of the hip and knee produces additional immediate reductions in elevated rectus femoris (RF) stiffness in adolescents with OSD. Methods: Fifteen patients (10–14 years of age) diagnosed with bilateral OSD were included. The legs of the participants were randomly assigned to either the intervention or the non-intervention side (control). The intervention side received two sets of 10 min of passive joint movement to the hip and knee, while the control side rested. RF stiffness was measured before the intervention and immediately after one and two sets of passive joint movements. Results: On the intervention side, RF stiffness decreased significantly from pre to post-1 and from pre to post-2; however, RF stiffness did not differ significantly between post-1 and post-2. None of the parameters changed significantly on the control side (rest condition). Conclusions: Passive joint exercise beyond one repetition (one set for 10 min) did not result in a further decrease in RF stiffness and is likely unnecessary for RF muscle stiffness due to OSD. Full article

Adolescent idiopathic scoliosis (AIS) is the most common three-dimensional spinal misalignment, with its impact often extending into adulthood and presenting a range of long-term health challenges. This review focuses on the long-term management strategies for adult patients with AIS and explores the unique physiological event of pregnancy and its influence on disease progression, clinical symptoms, and treatment decisions. We systematically analyze the natural history of adult AIS, the evolution of pain and functional impairment, and radiographic progression patterns. Special emphasis is placed on biomechanical changes of the spine and pelvis during pregnancy and postpartum, pain management approaches, delivery mode selection, and potential effects on offspring. By integrating current evidence and recent research findings, this review synthesizes key insights: the progression of AIS in adulthood is typically slow but can be exacerbated by factors such as significant curve magnitude at skeletal maturity; pregnancy does not consistently accelerate curve progression but may intensify pain and functional limitations, necessitating tailored multidisciplinary management; and evidence supports that most women with AIS can undergo vaginal delivery without increased obstetric risk, while anesthetic and analgesic planning requires careful consideration of spinal anatomy. This review aims to provide evidence-based guidance and clinical recommendations for comprehensive lifelong health management of this special patient population. Full article

Structural racism and discrimination (SRD) is a fundamental cause of health inequities that emerge during adolescence and persist throughout adulthood. This scoping review systematically synthesizes the evidence on policy and community-level interventions designed to disrupt SRD exposure among Black adolescents and mitigate its impact on their health behaviors and outcomes. Following PRISMA-ScR guidelines, we searched five databases for peer-reviewed intervention studies published through October 2025. Of 3417 abstracts screened, 9 studies met inclusion criteria. We examined the study characteristics, theoretical frameworks, implementation strategies, and effectiveness of interventions targeting three primary mechanisms of SRD exposure for adolescents. The majority focused on neighborhood and social integration interventions, with limited representation of resource-based and school-based approaches. Culturally grounded, community-engaged interventions buffered SRD’s negative effects on mental health, empowered youth as change agents, and removed structural barriers to health-promotive resources. The review identified several gaps in the research, including methodological and theoretical rigor, geographic contexts, and follow-up. Findings underscore the potential of culturally grounded, multilevel interventions to reduce inequities across mental health, physical health, and social outcomes for Black youth. This review highlights the need to expand systems-level interventions that address the root causes of the persistent racial health inequities experienced by Black youth. Full article

Background/Objectives: This cross-sectional study aimed to quantify hope levels in adolescents with chronic musculoskeletal pain (CMP) and examine patient-reported outcomes associated with hope. Methods: This was an exploratory, cross-sectional, secondary analysis of baseline data from a prospective, single-center longitudinal study of 60 youth presenting for an initial evaluation at a pediatric subspecialty pain clinic. Subjects were English-speaking 12–17-year-olds with a diagnosis of CMP, primarily female and non-Hispanic White, with diffuse pain, median pain duration of 2 years, and moderate to severe physical dysfunction. Subjects completed surveys measuring hope (Children’s Hope Scale [CHS]) and patient-reported mental, physical, and overall health. Associations between hope scores (total and each subscale) and patient-reported outcomes were evaluated using Spearman rank correlations. Results: The median CHS score was 20.0 (IQR: 16.5–25.0), indicating slight hope. Patient hope was negatively correlated with depression (r = −0.61), anxiety (r = −0.49), psychological distress (r = −0.52), functional disability (r = −0.43), and pain interference (r = −0.37), but not pain intensity. Adolescents’ hope was positively correlated with resilience (r = 0.74) and overall health (r = 0.55; all p < 0.01). Conclusions: Hope is correlated with various patient-reported health measures in youth with CMP. Although causal inferences are not possible due to the cross-sectional nature of this study, the results suggest that hope may be an important coping mechanism in pediatric chronic pain. Future efforts to incorporate existing resilience coaching programs into usual care may improve hope and health-related quality of life in youth with CMP. Full article

Background: Adolescence is a critical developmental period during which dietary habits are formed and may influence long-term health outcomes. Monitoring changes in adolescents’ eating behaviors and nutrition-related knowledge over time is important for developing effective health promotion strategies. The aim of this study was to compare adolescents’ (Lower Silesia, Poland) dietary habits and nutritional knowledge between two study periods (2011 and 2023) using comparable survey methods. Methods: A repeated cross-sectional comparison of two independent cohorts was conducted using an identical questionnaire in both study periods. The 2023 cohort included 14-year-old primary school students (n = 100; 48 girls and 52 boys), while the comparison group consisted of adolescents aged 13–15 years assessed in 2011 (n = 377; 202 girls and 175 boys). Anthropometric measurements and self-reported data on dietary habits and nutritional knowledge were analyzed using descriptive statistics and group comparison tests. Results: The findings indicate changes in selected dietary behaviors and levels of nutritional knowledge among adolescents over the studied period. A higher percentage of students in 2023 reported eating four meals per day and obtaining information about healthy eating from the Internet rather than from television. Students in 2023 were also more likely to recognize the relationship between diet and attention, identify the harmful effects of energy drinks and excessive fast-food consumption, and provide correct answers regarding proper nutrition. Nutritional knowledge improved over time, with a mean percentage of correct responses of 71.9% in 2023 compared with 63.7% in 2011. Although nutritional awareness improved in several areas, certain unhealthy eating habits remained prevalent, including irregular breakfast consumption and frequent intake of sweets. Changes in the distribution of body weight categories were also observed, with gender-specific differences between cohorts. Conclusions: The results suggest that improvements in nutritional knowledge alone may not be sufficient to ensure positive changes in dietary behavior among adolescents. Continued monitoring of adolescent nutrition and the development of comprehensive health promotion strategies addressing both knowledge and environmental influences remain necessary. Full article

Background: The contribution of intronic variants to the etiology of Mendelian diseases is still underrecognized, impacting the diagnostic yield. Whole genome sequencing (WGS) detects intronic variants, but besides canonical splice-sites, intronic variants are frequently excluded from the interpretation step or are classified as variants of uncertain significance (VUS). In fact, assessing their clinical significance often requires validation via RNA-sequencing (RNA-seq) or in vitro studies. Methods: We studied a 31-year-old patient with spinocerebellar ataxia who lacked a molecular diagnosis after WGS analysis. We applied the Detection of RNA Outliers Pipeline (DROP) to analyze RNA-seq data from patient fibroblasts. DROP integrates OUTRIDER and FRASER 2.0 algorithms designed to identify aberrant gene expression and splicing, respectively. Results: DROP identified differential expression and aberrant splicing of SNX14. Retrospective WGS data analysis revealed a homozygous NM_153816.6(SNX14): c.867+288A>G deep intronic variant, which caused pseudo-exon activation and reduced transcript levels. Biallelic loss-of-function variants in SNX14 cause autosomal recessive spinocerebellar ataxia type 20 (SCAR20; OMIM 616354), consistent with the clinical presentation of this case. Conclusions: We identify a deep intronic SNX14 variant as the genetic basis of SCAR20. We demonstrate the utility of RNA-seq to increase the diagnostic yield by identifying and resolving the pathogenicity of deep intronic variants. Defining aberrant splicing events is therapeutically relevant, as these mechanisms are targets for antisense oligonucleotide (ASO) based interventions. Full article