Search Results (9,156)

In Seoul, neighborhood-scale commercial districts, known as Golmok commercial districts, are small-scale retail areas focused on local daily life but also play a significant role in the city’s economy. Existing classification strategies for supporting Seoul’s Golmok commercial districts primarily rely on static, administrative data, failing to sufficiently capture actual citizen usage patterns. This deficiency limits the effectiveness of revitalization efforts. This study employs a two-timescale analysis of de facto population data to build a more dynamic typology of Seoul’s Golmok commercial districts. An unsupervised machine learning approach, specifically time-series K-means clustering, was applied to both weekly (short-term) and multi-year (long-term) time series data. This enabled us to classify 1090 districts into 16 distinct types. This more granular typology reveals significant heterogeneity masked by the Seoul Metropolitan Government’s current system, which groups these districts into only four broad categories. Our results show that while a minority of districts maintain stable activity, many exhibit patterns of long-term decline or significant fluctuation, underscoring the diverse and dynamic nature of these areas. The short-term analysis also captures temporal variations in population activity. The proposed typology may offer a foundation for near real-time monitoring and more proactive policy interventions to support urban economic sustainability. Full article

Against the backdrop of deepening coordinated policy governance, the systemic synergy between digitalization and green transformation policies and their impact on corporate ESG performance has become a key issue requiring urgent exploration. Unlike existing studies that focus on the effects of individual policies, this paper adopts a policy system synergy framework to systematically investigate the impact of the coordinated implementation of big data administrative reform and low-carbon city pilot policies on corporate ESG performance. Using a sample of Chinese A-share listed companies from 2010 to 2022, this study applies a multi-period difference-in-differences (DID) method for empirical analysis. The findings show that the systemic synergy between digital and green policies significantly enhances corporate ESG performance, with this promoting effect substantially stronger than that of single pilot policies. Further causal re-identification using a double machine learning (DML) approach verifies the robustness of the baseline conclusion. Heterogeneity analysis indicates that the synergistic effect of digital and green policies is more pronounced in firms with higher levels of digital transformation, greater patient capital, and heavier tax burdens. Mechanism tests reveal that digital–green policy synergy improves ESG performance by enhancing external supervision from government, society, and the market, increasing green government subsidies, and incentivizing firms to engage in green innovation. At the same time, policy system synergy also reduces firms’ perceived uncertainty regarding economic policies and stabilizes their expectations, further enhancing ESG performance. This paper extends the research on the determinants of corporate ESG performance from the perspective of system synergy governance, providing new empirical evidence for understanding the interaction mechanisms between digital governance and green transformation policies. Full article

Muco-obstructive lung diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis, are characterized by the accumulation of highly viscoelastic mucus that compromises mucociliary clearance and fosters infection and inflammation. Mucoactive therapy, encompassing both true mucolytics and non-cleaving agents, seeks to restore airway patency by altering mucus structure, hydration, and transport properties, yet its clinical impact remains variable. This narrative review provides a critical reappraisal of the pharmacological actions and therapeutic outcomes of the main mucolytic agents: N-acetylcysteine (NAC), erdosteine, carbocisteine, bromhexine, ambroxol, and dornase alfa. Beyond their classical role in reducing mucus viscosity, these drugs exhibit pleiotropic effects, including antioxidant, anti-inflammatory, and immunomodulatory activities. Specifically, for thiol-based compounds, the action consists of breaking the disulfide bonds that stabilize the mucin network; for carbocisteine, it lies in modulating mucin glycosylation and chloride transport. Ambroxol and bromhexine act by stimulating surfactant secretion and enhancing mucociliary clearance. Finally, dornase alfa exerts an enzymatic effect on extracellular DNA, a key contributor to the tenacity of mucus in cystic fibrosis. Clinical evidence indicates that NAC and erdosteine can reduce exacerbation rates in COPD, carbocisteine shows benefit with prolonged administration, and dornase alfa remains a cornerstone in CF management. However, therapeutic efficacy is constrained by heterogeneous mucus composition, pharmacokinetic limitations, and disease-specific variability. A key interpretative message is that clinical benefit appears greatest when the dominant biophysical determinant of mucus pathology is specifically targeted, supporting a transition from broad disease-label prescribing to mechanism-informed, phenotype-aware mucolytic therapy. Emerging strategies, such as agents targeting mucin–DNA interactions and advanced inhalation delivery systems, promise improved specificity and durability. By integrating mechanistic insights with clinical data, this review underscores the need for personalized mucolytic therapy and innovative approaches to overcome current challenges in managing muco-obstructive lung diseases. Full article

Background/Objectives: This study aimed to investigate school-based speech–language pathologists’ (SLPs) perceptions of their ability and needs to identify and remediate students with dyslexia. Methods: A qualitative approach was employed, utilizing semi-structured interviews with school-based SLPs. The findings were thematically analyzed by following six steps; (a) familiarization with the data; (b) initial code generation; (c) theme identification; (d) theme review; (e) defining and naming themes; and (f) report writing. Results: The findings revealed that participants had a very limited knowledge of dyslexia, and most did not consider reading difficulties within their scope of practice. Professional development opportunities, collaboration with teachers, and administrative support were identified as crucial factors to enhance SLPs’ practice supporting dyslexic cases in school settings. Conclusions: The study showed that school-based SLPs lack the necessary knowledge to work with students with dyslexia, which aligns with results observed in other countries. This finding highlights the importance of empowering their abilities to effectively support students with dyslexia. Full article

Digital technologies have fundamentally changed how public administration operates, moving it from traditional bureaucratic structures toward more efficient and responsive systems. This study analyzes the links between e-government usage (measured as the percentage of individuals who interact with public authorities via online platforms), governance quality, and fiscal performance across ten Central and Eastern European countries from 2010 to 2023. Using a fixed-effects panel data model, we investigate whether higher e-government usage is associated with stronger government effectiveness, improved budget balances, and more sustainable public debt levels, while controlling for key macroeconomic and structural factors. Employing a fixed-effects panel data model, we examine whether greater use of e-government services is associated with stronger government effectiveness, improved budget balances, and more sustainable public debt levels, while accounting for key macroeconomic and structural factors. The findings show a positive and statistically significant association between e-government usage and government effectiveness. The links to fiscal outcomes are more nuanced: e-government usage is associated with better budget balances, mainly through indirect channels such as higher tax compliance and tighter expenditure control. In contrast, its association with public debt levels is weaker and appears to depend more strongly on broader macroeconomic conditions. Overall, the findings suggest that greater e-government usage is associated with improvements in governance quality in the CEE region, although its contribution to long-term fiscal sustainability remains conditional on the quality of existing institutions. Full article

According to the most recent data published by the World Health Organization (WHO), it is estimated that approximately 332 million persons worldwide suffer from depression. The relationship between depression and alcohol consumption is complex and bidirectional. This study aimed to investigate the effects of cannabidiol (CBD) on behavior and malondialdehyde (MDA) imbalance in female Wistar rats exposed to chronic stress and alcohol. Sixteen intact cycle female 5-month-old Wistar rats were randomly assigned to two groups: the Control group (n = 8), and the CBD group (n = 8), which received CBD at a dose of 10 mg/kg. Following chronic stress induction, during the three-week treatment period, the animals were exposed to alcohol on three separate occasions. CBD-treated females showed increased freezing time in the Open Field test with no clear anxiolytic effect. In the Y maze and Morris Water Maze, they exhibited improved memory-related performance. Brain MDA levels were reduced, while plasma MDA was unchanged. Cortisol tended to be higher in the CBD group. CBD administration showed potential cognitive and central antioxidant effects, but no clear anxiolytic effect. Full article

Oncomodulin (OCM) is the most abundant Ca²⁺ buffering protein found in mature outer hair cells (OHCs). Cadherin 23 (CDH23) is a crucial component of the tip-links in hair cell stereocilia. The absence or dysfunction of these two proteins contributes to the early onset of age-related hearing loss (AHL). In this study, we investigated the effects of the Cdh23^753G→A mutation on OHC function using new Ocm-knockout (KO) mouse models (Ocm^tm1a/tm1a) with or without the Cdh23^753G→A mutation. Despite having the same genetic background, Ocm-KO mice carrying the Cdh23^753G→A mutation displayed a notable decline in OHC function across all measured frequencies as early as three months of age. In contrast, Ocm-KO mice without the Cdh23^753G→A mutation did not exhibit comparable hearing loss until they reached twelve months of age. Additionally, we examined the role of OCM in preserving OHC function under ototoxic stress induced by HPβCD (2-hydroxypropyl-β-cyclodextrin). The distortion product otoacoustic emission data show that the administration of HPβCD resulted in a more pronounced decline in OHC function in Ocm-KO mice compared to wild-type (WT) mice. Time-lapse recording also shows that HPβCD treatment led to greater structural deterioration and more rapid rupture events in OHCs from Ocm-KO mice than in those from WT mice. These findings suggest that the Cdh23^753G→A mutation, rather than other potential strain-specific genetic factors associated with AHL, significantly exacerbates the early onset of AHL phenotypes in Ocm-KO mice. Furthermore, our data indicates that the OCM protein in OHCs enhances their ability to withstand ototoxic stimuli. Full article

Urban agglomerations have become the dominant spatial platform of urbanization, regional coordination, and economic transformation in China. Yet whether the expansion of agglomeration scale at the urban-agglomeration level alleviates or intensifies energy use remains insufficiently understood. Extending the scale of analysis from individual cities to integrated urban agglomerations, this study investigates 64 cities in four major Chinese urban agglomerations, including Beijing–Tianjin–Hebei, the Yangtze River Delta, the Pearl River Delta, and Chengdu–Chongqing, over the period 2006–2023. Using panel data models, this study examines the impact of the scale agglomeration within urban agglomeration on urban energy intensity. The results show that the overall agglomeration scale generated by urban agglomeration formation significantly suppresses energy intensity while indicating a robust energy-saving effect: every 10% increase in agglomeration scale is associated with a decline of approximately 0.0893 million tons of standard coal per CNY 100 million of GDP. This finding remains stable after addressing endogeneity concerns and performing a series of robustness checks. Mechanism analyses further suggest that this effect operates primarily through talent agglomeration, technological progress, and public transportation expansion. In addition, the energy-saving effect is more pronounced in smaller cities, cities with lower administrative rank, cities with weaker factor mobility, and cities characterized by poorer air quality but stronger public environmental attention. These findings contribute to the literature on urban agglomeration and green development by showing that the agglomeration scale within urban agglomerations can generate inclusive energy-efficiency gains, especially for relatively disadvantaged cities, thereby offering important implications for spatial governance and low-carbon transition in rapidly urbanizing economies. Full article

Background: H1-antihistamines are widely used for allergic and upper respiratory conditions; however, several agents included in this class have been associated with cardiac electrophysiological adverse effects, including QT interval prolongation and torsades de pointes (TdP). These effects are largely exposure-dependent and mechanistically linked to inhibition of cardiac ion channels. Chlorpheniramine maleate (CPM), a first-generation H1-antihistamine, has been implicated in arrhythmic events primarily under conditions of increased systemic exposure, prompting interest in whether alternative routes of administration may lower cardiac risk. Methods: This narrative review integrates mechanistic, preclinical, clinical, pharmacokinetic, and regulatory evidence. Information was extracted from PubMed, Google Scholar, and Scielo using search terms such as cardiotoxicity, chlorpheniramine, QT prolongation, intranasal administration, and cardiac arrhythmias, with no language restriction. Results: Comparative pharmacokinetic evidence shows that, on a dose-normalized basis, intranasal and oral chlorpheniramine exhibit comparable bioavailability; however, in a clinical context, intranasal doses (1.12–2.24 mg) are lower than oral daily doses (4–12 mg/day), resulting in a lower systemic exposure (Cmax and AUC) with intranasal administration. Available pharmacovigilance or epidemiological data have not specifically evaluated intranasal chlorpheniramine, and the number of dedicated safety trials remains limited. Conclusions: Preclinical, in vitro, mechanistic studies suggest that intranasal administration of chlorpheniramine should confer superior cardiac safety compared to the oral route. However, clinical data from human studies directly comparing the cardiac safety of intranasal chlorpheniramine versus systemic chlorpheniramine is extremely limited. More data from clinical trials, case–control studies, and regulatory databases are needed to validate these theoretical claims. Full article

This study examines administrative staff perceptions of selected AI-related dimensions and their association with sustainable administrative performance at the University of Hail. Specifically, it focuses on expert systems, automated machine learning, and ease of use as perceived dimensions of AI-related administrative support. Methodology: A quantitative cross-sectional survey design was employed. Data were collected using a structured Likert-scale questionnaire administered to a purposive sample of 230 administrative staff members. Descriptive statistics and regression analysis were used to assess the perceived level of AI-related support and its association with sustainable administrative performance. Results: The overall perceived level of AI-related support was moderate, indicating partial integration of AI-related practices in administrative work. Expert systems, automated machine learning, and ease of use each showed a positive and statistically significant association with sustainable administrative performance. Expert systems showed the strongest standardized association. Collectively, the three dimensions explained a substantial proportion of the variance in sustainable administrative performance. Limitations: The study is limited by its cross-sectional design, reliance on self-reported questionnaire data, and focus on a single university using purposive sampling, which restricts causal interpretation and generalizability. The findings also reflect perceptions rather than objectively verified implementation data. Full article

Background: Effective sick-day management, including ketosis home management aimed at preventing diabetic ketoacidosis (DKA), is essential for families living with a child/adolescent with type 1 diabetes (T1D). Methods: Adolescents living with T1D and caregivers of younger children living with T1D were invited to participate in an interview consisting of five parts: (I) demographic data, (II) subjective self-ratings on competence in ketosis home management, (III) objective assessment of competence in ketosis home management using a standardized clinical case scenario consisting of 10 management steps, in which participants were asked to describe the actions they would take to prevent DKA, and (IV) practical demonstrations to objectively assess skills in (IVa) urine dipstick self-testing and (IVb) insulin administration, (V) household availability of (Va) urine dipsticks and (Vb) insulin cartridges. Results: (I) We enrolled 61 adolescents and 79 caregivers. (II) Competence in ketosis home management was subjectively self-rated as good to very good. (III) Adolescents reported 4 (median; Q25/Q75 3/5) and caregivers 5 (4/5) of 10 management steps. Never self-testing ketone levels was reported by 33% of adolescents and 11% of caregivers. (IVa) At least one handling error occurred in 100% of adolescents’ and in 98% of caregivers’ practical demonstrations of urine dipstick self-testing and in (IVb) 98% of adolescents’ and 98% of caregivers’ insulin administrations. (Va) Altogether urine dipsticks were available in 43% of households, whereas (Vb) insulin cartridges were available in 78% of households. Conclusions: Our results demonstrate a mismatch between challenges in ketosis home management and high subjective self-ratings. Full article

Hydrogen refueling stations (HRSs) are a critical enabling infrastructure for fuel cell electric vehicles (FCEVs), yet their deployment in dense metropolitan areas often faces a dual challenge: limited travel-time accessibility for users and low public acceptance driven by perceived safety risks. This study develops an integrated, city-scale framework to quantify HRS accessibility and resident acceptance and to identify expansion priorities for Seoul, South Korea. We combine (i) an online perception survey of 1000 adult residents (October 2024) capturing environmental awareness, perceived safety, siting preferences, and willingness-to-travel distance; (ii) spatial demand data on FCEV registrations by administrative dong (n = 2443 vehicles, 2022); and (iii) network-based travel-time analysis using the Seoul road network and the current HRS supply (n = 10, 2024). Accessibility is evaluated under three travel-time thresholds (10, 15, and 20 min), with service-area delineation and demand-weighted underserved-area diagnosis. Candidate expansion sites are generated and screened using operational and regulatory constraints (e.g., site area and proximity to protected facilities), followed by a p-median location-allocation optimization to select five additional sites that minimize demand-weighted travel impedance. Results indicate that, under the 20 min threshold (7.7 km at an average operating speed of 23.1 km/h), 50 of 425 dongs (11.8%) and 244 of 2443 FCEVs (10.0%) are outside the baseline service coverage. After adding five sites (total n = 15), underserved dongs decrease to 5 (1.2%) and underserved FCEVs to 26 (1.1%) for the 20 min threshold, with consistent improvements across shorter thresholds. Survey responses further reveal that only 12.5% of respondents perceive HRSs as safe, while 46.5% report a maximum willingness-to-travel distance of up to 5 km, underscoring the need for both accessibility enhancement and risk-aware communication. The proposed workflow offers a transparent, reproducible approach to support equitable and risk-informed HRS planning by jointly considering network accessibility, demand distribution, and social acceptance, thereby contributing to sustainable urban mobility, low-carbon transport transition, and socially acceptable hydrogen infrastructure deployment. Beyond local accessibility improvement, the study is framed in the broader context of sustainability, as equitable and socially acceptable hydrogen refueling infrastructure can support low-carbon urban transport transitions and more resilient metropolitan energy-mobility systems. Full article

This narrative review examines the clinical application of tiletamine–zolazepam (TZ) in exotic pet and wildlife anesthesia, addressing the complexities inherent in managing a broad taxonomic spectrum with diverse physiological profiles and temperaments. As a fixed-dose combination, TZ is a cornerstone of multimodal protocols designed to achieve balanced anesthesia. Its lyophilized formulation permits reconstitution with various sedative solutions, facilitating low-volume administration, a critical requirement for the immobilization of wildlife and small exotic patients. Given the significant variability in species-specific responses and environmental influences, selecting and adapting appropriate TZ-based protocols remain a challenge for practitioners. By synthesizing heterogeneous data into expert-validated guidance, this review provides specialized and general veterinarians with practical considerations for the judicious use of TZ. Emphasis is placed on integrating TZ within multimodal protocols to mitigate arousal risks, ensure consistent immobilization, and facilitate rapid recovery. This approach seeks to optimize anesthetic outcomes and promote animal welfare across these physiologically diverse populations. Full article

The COVID-19 pandemic intensified communication challenges for community college leaders navigating prolonged uncertainty and organizational disruption. This qualitative study examines how community college administrators described and interpreted their communication practices during the pandemic. Guided by the Elaboration Likelihood Model (ELM), this study explores how leaders made sense of message design, audience responsiveness, and trust under conditions of information overload and emotional strain. Semi-structured interviews were conducted with twelve administrators from community colleges across the United States, including presidents, vice presidents, and senior-level directors. Data were analyzed using reflexive thematic analysis. Five themes emerged: communication breakdowns between employee groups; tailored messaging for specific constituencies; preferences for in-person and interactive communication; trust-building through transparency; and reliance on collaborative communication structures. Participants described communication as an ongoing relational and organizational practice rather than a one-time transmission of information. Administrators reported adapting strategies by combining repetition, audience-specific framing, interactive formats, and structural supports to manage uncertainty and sustain institutional trust. Findings are not intended to be generalizable but provide contextually grounded insight into leadership communication during an extended crisis. This study contributes to scholarship on higher education leadership and crisis communication by illustrating how persuasion, sensemaking, and relational cues intersected in administrators’ communication practices. Full article

Background/Objectives: Dietary antioxidants are frequently utilized by breast cancer (BC) patients to mitigate treatment-related toxicities and enhance quality of life. However, their clinical efficacy remains highly controversial due to conflicting epidemiological and clinical data. This review aims to critically evaluate the molecular mechanisms, clinical outcomes, and translational challenges of antioxidant supplementation in BC management. Methods: A comprehensive evaluation of current literature—encompassing observational cohorts, randomized controlled trials, and mechanistic in vitro/in vivo models—was conducted. The analysis focused on the pharmacological interactions of diverse bioactive compounds (polyphenols, vitamins, carotenoids) with BC progression and standard antineoplastic regimens. Results: Current evidence demonstrates a paradoxical, double-edged role of antioxidants in oncology. While specific interventions (e.g., Coenzyme Q10, melatonin) effectively ameliorate treatment-induced toxicities without compromising therapeutic efficacy, the concurrent administration of antioxidants during cytotoxic chemotherapy can inadvertently neutralize essential reactive oxygen species (ROS), correlating with increased disease recurrence and mortality. Furthermore, clinical translation is severely hindered by the intrinsic hydrophobicity of natural compounds, the lack of whole-food matrix standardization, and dose-dependent hepatotoxicity. Emerging targeted delivery systems, such as lipid nanoformulations, show significant potential in overcoming these pharmacokinetic barriers. Conclusions: The therapeutic viability of antioxidant supplementation in BC is not universal; it is heavily dictated by intrinsic tumor biology, specific treatment modalities, and chronopharmacology. These findings underscore a critical biological imperative to transition from generalized dietary guidelines toward a rigorous paradigm of precision nutritional oncology, strictly avoiding concurrent antioxidant supplementation during active oxidative therapies. Full article