Search Results (58,801)

The increasing emphasis on responsible research assessment has renewed the need for conceptual tools that help communicate the complementary roles of quantitative and qualitative evaluation. This essay proposes an interpretative metaphor that frames bibliometric indicators as the “blood tests” of research systems—heuristic devices that reveal multidimensional aspects of system vitality, balance, and dysfunction. The metaphor, grounded in standard categories of clinical diagnostics (hematological, hepatic, renal, lipidic, and cardiovascular panels), provides an accessible language for scholars and policymakers in research. Each bibliometric technique—ranging from publication and citation counts to patent analysis, altmetrics, and topic modelling—is associated with a diagnostic function such as screening, monitoring, or early risk detection. By linking established principles of responsible metrics (DORA, Leiden Manifesto, Metric Tide, CoARA) with the professionalization of evaluators, the essay situates the metaphor within current debates on bibliometric literacy and the ethical interpretation of indicators. Rather than prescribing metrics or decision rules, the contribution invites reflection on how evaluators can interpret bibliometric signals diagnostically—as contextual evidence for institutional learning, strategic decision-making, and the cultivation of healthy, adaptive research systems. Consistent with the essay format, this contribution does not propose a new evaluative methodology nor empirical validation. Instead, it advances a heuristic and communicative framework intended to emphasize the holistic, contextual, and professionally informed interpretation of quantitative indicators in the evaluation of research activity. Full article

Background: Silybin, the primary active constituent of the milk thistle extract silymarin, has been historically recognized for its hepatoprotective properties. More recently, its potential effects on blood coagulation have garnered attention, suggesting a broader pharmacological profile. Methods: This study aimed to investigate silybin’s impact on hemostasis using rotational thromboelastometry (ROTEM) in normal human plasma. ROTEM enables the dynamic assessment of clot formation, providing a detailed analysis of coagulation processes in real-time. We specifically focused on the effects of silybin concentrations of 10 µM, 50 µM, and 100 µM on the ROTEM parameters compared to controls using normal human plasma with 0.1% dimethyl sulfoxide (DMSO). The parameters derived from the tests included clotting time (CT), α-angle (α), and amplitude at 10 and 20 min (A10 and A20) for each of the three channels: intrinsic pathway thromboelastometry (INTEM), extrinsic pathway thromboelastometry (EXTEM), and fibrinogen thromboelastometry (FIBTEM). Each measurement was performed four times. Results: Analysis of the INTEM assay results demonstrated that silybin at concentrations of 10 µM and 50 µM significantly reduced clotting time (CT) compared to the control. Additionally, all tested silybin concentrations significantly decreased the α-angle in the INTEM test. In the EXTEM assay, no significant effect on CT was observed at any silybin concentration. However, consistent with the INTEM findings, all silybin concentrations resulted in a significant reduction in the α-angle. In the FIBTEM assay, silybin at 10 µM and 50 µM significantly shortened CT. Furthermore, all tested concentrations led to a significant decrease in the α-angle and A20, while a reduction in A10 was observed only at the 50 µM concentration compared to the control. Conclusions: This study demonstrates that silybin modulates ROTEM parameters in a manner that tends to vary with concentration, with the strongest effects observed at lower concentrations (10–50 µM), notably reducing CT, α-angle, and clot firmness (A10, A20). These findings suggest a potential role of silybin in influencing coagulation dynamics. Full article

Postoperative facial scars frequently remain aesthetically problematic despite advances in laser-based treatments, as residual inflammation and disorganized dermal remodeling often limit clinical outcomes. Exosome-based formulations have gained attention as biologically active adjuncts capable of influencing key wound-healing pathways, including inflammatory regulation, neovascularization, and extracellular matrix modulation. This randomized, controlled clinical study aimed to evaluate the short-term clinical effect of laser-assisted delivery of exosome skin boosters for postoperative facial scars and facial rejuvenation. Seventy-five patients with postoperative facial scars were randomly allocated to receive fractional non-ablative Nd:YAG laser treatment alone or in combination with either human-derived or plant-derived exosome skin boosters. All participants completed five treatment sessions at two-week intervals. Clinical outcomes were evaluated using validated scar assessment tools, including the modified Vancouver Scar Scale and the Patient and Observer Scar Assessment Scale, along with objective imaging analyses using Mark-Vu and ImageJ software. Compared with laser monotherapy, adjunctive exosome treatment was associated with numerically greater short-term improvements in scar appearance and reductions in grayscale intensity. Improvements in additional skin quality parameters, such as pigmentation uniformity, erythema, pore size, and fine wrinkles, were also observed in the exosome-treated groups. Clinical responses were comparable between human- and plant-derived exosome formulations, and no serious adverse events were reported. These findings indicate that exosome-based skin boosters may serve as a safe and well-tolerated biological complement to laser therapy for short-term improvement of postoperative facial scars and skin quality. Larger studies with longer follow-up are warranted to determine long-term efficacy and clinical durability. Full article

Transposable elements (TEs) are key regulators of immunity in both health and disease. It has been proven that the activity and transcriptional expression levels of TEs increase during viral infections, correlating with the antiviral response. This study investigates non-LTR TE (LINE, SINE, and SVA) transcriptomic signatures in human PBMCs during infections caused by influenza A virus, HIV, and SARS-CoV-2 (Delta/Omicron variants) using single-cell RNA sequencing (scRNA-seq) data from 98 patients. In the HIV and SARS-CoV-2 patient cohorts, unique cell-specific TE expression patterns were identified that allow for the differentiation of disease severity, prediction of disease progression, and assessment of the therapy’s efficacy. The expression of LINE elements was found to be more dependent on the nature and course of the disease than that of SINE elements. The most variable TE expression profile was observed in precursor cytotoxic T-lymphocytes (T CD8+ Naive cells), which depended on the virus type and the severity of the viral disease. For this cell type, a bioinformatic analysis of the co-expression regulation of TE transcriptional networks and transcription factors during viral infections was performed. This analysis identified key players among those most involved in virus-specific responses, which could serve as diagnostic biomarkers or therapeutic targets for treating diseases caused by influenza A virus, HIV, and SARS-CoV-2. This work confirms the involvement of non-LTR TEs in mediating antiviral responses. Further research into the mechanisms of TE participation in antiviral defense is necessary to recommend them as potential biomarkers for the diagnosis, monitoring, and assessment of antiviral therapy, or as therapeutic targets for viral infections of various origins. Full article

The Meetings, Incentives, Conventions, and Exhibitions (MICE) sector has become a strategic driver of regional economic development, yet secondary cities often lack the structural, governance, and experiential capacities required for competitive MICE positioning. This study proposes and empirically validates a triangulated analytical framework that integrates structural readiness, stakeholder governance capacity, and tourist perceptions to capture systemic misalignments in emerging MICE destinations, going beyond conventional applied readiness assessments. This study evaluates the preparedness of Nakhon Si Thammarat, Thailand, to develop as a sustainable MICE destination using a triangulated mixed-methods design comprising (1) a city readiness assessment based on TCEB’s eight criteria, (2) a survey of 400 tourists and MICE visitors, and (3) in-depth interviews with 20 key stakeholders. The weighted assessment indicated a moderate overall readiness score (3.48/5), with strengths in environmental management, safety, supporting activities, and accommodation. However, MICE venue capacity and city image remained notably weak. Tourists consistently perceived high readiness across most areas, whereas stakeholders highlighted major systemic issues, including fragmented governance, inconsistent MICE service quality, limited capacity for large events, and inadequate transportation integration. Triangulating these viewpoints reveals three analytically distinct preparation gaps—structural, policy implementation, and experience expectations—demonstrating a fundamental misalignment between experiential appeal and institutional capabilities. This study conceptualizes preparedness as a relational outcome impacted by infrastructure, governance procedures, and market perceptions, adding to the MICE destination and governance literature. The methodology can be used to examine comparable misalignments in other emerging or secondary MICE destinations. The findings guide governance-driven MICE city development plans for sustainability and competitiveness. Full article

The rhizosphere, a confined area of soil plant roots, is an intersection of microbial activity and root exudates. Known as the rhizosphere effect, it enhances crop yield and sustainability by improving nutrient availability, beneficial compounds, and pathogen control. This study combines a field-based rhizosphere–bulk soil comparison for peanut with a geostatistical approach to quantify the spatial variability of rhizosphere-driven changes in soil quality indicators in the Ghardaïa region (southern Algeria), which is known for its sandy–clay and sandy–loam soils. Samples of rhizosphere and bulk soils were prospected using a systematic plan. Subsequently, the pH, electrical conductivity, calcium carbonate, organic matter, total nitrogen, available phosphorus, total potassium, and soluble sodium were determined for each soil (rhizosphere and bulk soil). To assess the spatial variability of rhizosphere soil parameters, semi-variograms of the fitted models were generated using auto-kriging. The results showed that both types of soils were moderately alkaline, with a reduction of 5.52% in the pH of the rhizosphere compared to the bulk soils. Soils were relatively low in organic matter, with only 3.3% of soils having organic matter levels above 20 g kg⁻¹. However, organic matter contents were consistently higher in the rhizosphere (8.51 ± 4.59 g kg⁻¹) than in the bulk soil (6.78 ± 3.52 g kg⁻¹). In the rhizosphere, an increase of 10% in labile phosphorus was noted. Total nitrogen was increased by 52.57%. T-tests suggested no significant difference in potassium and sodium levels, and they were moderately present in both soils. Significantly positive relationships were noted between available phosphorus and total nitrogen (R = 0.59, p < 0.001). However, negative correlations were revealed between pH and organic matter available phosphorus (R = −0.77, p < 0.001) and pH and total nitrogen (R = −0.56, p < 0.01). These results indicate the effects of rhizosphere interactions on soil property improvements and their implications for sustainable agricultural practices, including crop rotation, intercropping, and green manure applications. Full article

Aim: This study compared the effects of standard evening smartphone restriction with an adapted intervention combining progressive restriction, psychoeducational guidance, and pre-sleep relaxation on sleep, psychological state, cognitive performance, and physical performance in physically active physical education students with moderate-to-high nomophobia. Methods: Thirty participants (age 21.9 ± 1.2 years; intermediate chronotype) completed a randomized controlled trial consisting of a 7-day baseline period, a 14-day intervention phase, and post-intervention assessments. The standard group (n = 15) implemented a 2-h pre-bedtime smartphone restriction combined with general sleep hygiene guidance. The adapted group (n = 15) followed a progressive restriction protocol (30→60→120 min) supplemented with psychoeducational guidance targeting smartphone-related anxiety and a nightly slow-paced breathing routine. Objective sleep parameters were quantified using wrist-worn actigraphy. Subjective sleep quality, pre-sleep anxiety, and stress were assessed using visual analog scales. Cognitive performance (psychomotor vigilance task and choice reaction time) and physical performance (vertical jumps and agility) were evaluated at both morning and afternoon time points. Results: The adapted intervention produced significantly greater improvements in sleep efficiency (time × group: F(1,28) = 6.84, p = 0.014, ηp² = 0.20; d = 0.78) and sleep onset latency (F(1,28) = 5.97, p = 0.021, ηp² = 0.18; d = 0.72) compared with standard restriction. Significant reductions were also observed in pre-sleep anxiety (F(1,28) = 7.12, p = 0.012, ηp² = 0.20; d = 0.81) and stress (F(1,28) = 6.45, p = 0.017, ηp² = 0.19; d = 0.74). Cognitive performance showed significant time × group × time-of-day interactions, with improvements during afternoon assessments in psychomotor vigilance (F(1,28) = 7.48, p = 0.011; d = 0.83) and choice reaction time (F(1,28) = 6.89, p = 0.014; d = 0.79) exclusively in the adapted group. Physical performance outcomes remained stable across interventions. Conclusions: Progressive smartphone restriction combined with psychoeducational strategies and pre-sleep relaxation yields clinically meaningful improvements in sleep continuity, psychological arousal, and afternoon cognitive performance, exceeding the benefits achieved through behavioral restriction alone. Full article

Rural communities in developing countries face rising livelihood vulnerability due to climate change, agricultural price volatility, and dependence on linear production systems. This study examines whether circular utilization of cashew by-products can strengthen rural economies through a field-based case study in rural Cambodia. Primary data were collected through on-site observations, semi-structured interviews with farm owners and rural workers, and farm-level economic assessments. The results indicate that cashew apple juice processing is not financially viable as a standalone activity under prevailing wage and market conditions, producing negative net profits across all examined processing volumes. By contrast, integrating cashew apple utilization with other by-products shows more favorable outcomes. Cashew nut shells and pruning residues generate relatively stable supplementary income for farm operators, while cashew apple collection creates additional employment opportunities, particularly during off-harvest periods and low-yield years, helping to stabilize household labor income. Rather than relying on capital-intensive technologies, the observed practices represent low-cost and locally feasible circular economy approaches suitable for medium-sized commercial farm-based systems, with potential analytical transferability to smallholder contexts. Overall, these findings suggest that integrated by-product utilization may reduce income volatility and support sustainable rural community development in similar cashew-producing contexts. Full article

Background: Academic performance is related to cognitive functions and satisfied physiological needs such as proper sleep, a factor frequently overlooked by university students. Our aim was to investigate sleep-related variables, cognitive performance and stress level measured by heart rate variability among university students. Methods: A novel psychophysiological measurement system was used for data collection in which a screen-adapted questionnaire was used to collect data on sleep; gamified versions of standard psychological tests were used to assess cognitive performance, and ECG data were recorded by a wearable ECG sensor, all synchronized by a software. University students volunteered for anonymous testing that lasted approximately one hour. Results: Of the 107 students (mean age: 22.2 years, SD ± 2.22; 52% female), those who reported being well-rested achieved significantly higher overall cognitive performance (p = 0.024). Sleep duration did not correlate with cognitive performance but longer sleep duration was associated with feeling rested (rho = 0.326; p < 0.001). Cognitive performance showed significant association with two HRV parameters such as the Baevsky Stress Index (r = 0.195), higher values of which reflect higher autonomic stress load. Significant negative relation was found between cognitive performance and RMSSD (r = −0.195), another HRV parameter, higher values of which allude to higher parasympathetic activity (p = 0.050 for both). These findings suggest a link between mild arousal and performance. Conclusions: Being rested and lower autonomic stress load are positively correlated with cognitive performance. The novel psychophysiological measurement system integrating subjective and objective measurements of cognitive and physiological functions is feasible for assessing cognitive functions and stress levels in students. Full article

Conservative management of rotator cuff disorders remains challenging, with no comprehensive, evidence-based framework integrating diagnosis, prognosis, rehabilitation, and biological therapies. Existing recommendations usually address isolated components of care, leading to inconsistent treatment strategies. This article proposes a global, pragmatic protocol for the non-surgical management of rotator cuff lesions, from initial assessment to long-term follow-up. Drawing on clinical expertise supported by recent literature, we outline a stepwise approach that begins with a comprehensive diagnostic process that combines history, clinical examination, and targeted imaging. Based on lesion type, associated shoulder or neurogenic conditions, and patient profile, rotator cuff disorders are stratified into three prognostic categories under conservative care: good, borderline, and poor prognosis, highlighting factors that require treatment adaptation or early surgical consideration. Rehabilitation objectives are structured around four domains: (1) inflammation and pain control, (2) mobility and scapular kinematics, (3) strengthening and motor control with tendon-sparing strategies, and (4) preservation or restoration of anatomy. For each prognostic category, we define a monitoring plan integrating clinical reassessment, ultrasound follow-up, and functional milestones, including return-to-play criteria for athletes. This comprehensive narrative review demonstrates that precise diagnosis and individualized rehabilitation can optimize medical follow-up, active strengthening, and complementary or regenerative therapies. Aligning therapeutic decisions with prognostic and functional goals allows clinicians to optimize patient satisfaction and recovery, providing a clear, evidence-informed roadmap for conservative management of rotator cuff disorders. Full article

Urban Heat Island effects and the general rise in outdoor temperatures are increasing the cooling demand in buildings. As a consequence, electrical cooling systems are becoming more common, increasing energy consumption and thus resulting in negative environmental impacts. Optimizing passive solutions that require no energy input can provide substantial benefits for building energy efficiency and urban sustainability. This study presents a research activity, financed by the EU-funded project LIFE SUPERHERO, that enhances existing roofing technologies based on passive cooling; defines an experimental method to assess their benefits in terms of energy savings; and finally evaluates their effectiveness in future climate scenarios based on greenhouse gas Representative Concentration Pathways across a set of mid-temperate/hot climate locations, also in comparison with traditional unventilated roofs. A new Climate Adaptation Efficiency Index (CAEI) was introduced to evaluate the energy efficiency potential of buildings equipped with highly ventilated and permeable clay tile roofs compared to a baseline scenario without the intervention. The results confirm the potential of ventilated and air-permeable roofs to reduce incoming heat flux and support cooling energy-efficiency planning. Indeed, CAEI values were above 20%, reaching 45–50% in hot Mediterranean and arid climates and 28–33% in cooler/temperate contexts. Under future climate scenarios, benefits further increase in the hottest Mediterranean locations, reaching up to 66%, while rising to about 44% in temperate climates, with an average increase of 10–15 percentage points, highlighting the strong potential of highly ventilated and air-permeable clay tile roofs as an effective, affordable, sustainable, and easy-to-install climate adaptation strategy. Full article

Large-scale cultural events generate substantial greenhouse gas emissions, raising increasing concerns regarding carbon neutrality. In Taiwan, long-standing forest conservation policies have largely restricted commercial logging since the early 1990s, resulting in extensive secondary forests where active management options are limited. Within this policy context, improved forest management (IFM) provides a potential pathway to enhance carbon sequestration while maintaining conservation objectives. This study evaluates the feasibility of using afforestation combined with IFM to offset the carbon emissions of the Taipei Biennial 2020, estimated at approximately 390 t CO₂-e. Carbon sequestration was assessed using the Verified Carbon Standard (VCS) methodology (VM0005 v1.2) under the principles of Measurement, Reporting, and Verification (MRV). A total area of 52.70 ha was assessed, with 10.11 ha designated as the project activity area. Over a 25-year period, projected CO₂ sequestration across four baseline scenarios ranged from 3816 to 4523 tons, indicating that event-related emissions could be offset within 8–9 years. Uncertainty remains due to hypothetical management assumptions, highlighting the need for continuous monitoring and adaptive management. Full article

Offshore wind-farm performance remains constrained by persistent wake deficits and turbulence that compound across intra-farm, intra-cluster, and inter-cluster scales, particularly under atmospheric neutral–stable stratification. A concept is advanced whereby offshore wind-farm yield may be augmented by pairing conventional horizontal-axis wind turbines (HAWTs) with lighter-than-air parafoil systems that entrain higher-momentum air and re-energise wakes, complementing yaw/induction-based wake control and enabling higher array energy density. A concise synthesis of wake physics and associated challenges motivates opportunities for active momentum re-injection, while a review of kite technologies frames design choices for lift generation and spatial keeping. Stability and control, spanning static and dynamic behaviours, tether dynamics, and response to extreme meteorological conditions, are identified as key challenges. System-integration pathways are outlined, including alignment and mounting options relative to turbine rows and prevailing shear. A staged validation programme is proposed, combining high-fidelity numerical simulation with wave-tank testing of coupled mooring–tether dynamics and wind-tunnel experiments on scaled arrays. Evaluation metrics emphasise net energy gain, fatigue loading, availability, and Levelized Cost of Energy (LCOE). The paper concludes with research directions and recommendations to guide standards and investment, and with a quantitative assessment of the techno-economic significance of kite–HAWT integration at scale. Full article

Rootstocks play a central role in modulating grapevine responses to water scarcity, yet their morpho-functional strategies remain highly genotype-dependent. This study compared three functionally contrasting rootstocks, 1103 Paulsen, 420 A, and M2, grafted with Vitis vinifera cv. Merlot, which differ in root system architecture, hydraulic efficiency, canopy development, and stomatal regulation, with the aim of elucidating their hydraulic, morphological, and physiological responses under controlled conditions. Plants were grown in containers and assessed for root system architecture, hydraulic conductance, gas exchange including transpiration rate, chlorophyll fluorescence, and biomass allocation. The results revealed three distinct adaptive strategies: 1103 P exhibited the highest structural root biomass and rootstock hydraulic conductivity, supporting elevated axial water transport, higher transpiration rates, and a larger canopy, consistent with an “active tolerance” strategy; 420 A showed balanced structural and absorptive root development, moderate hydraulic performance, and the highest transpiration rates, reflecting a flexible, opportunistic response to water availability. In contrast, M2 displayed markedly reduced structural root biomass but a high proportion of absorptive roots and the greatest scion hydraulic conductance combined with low stomatal conductance, reduced transpiration, and high intrinsic water use efficiency, which is indicative of a conservative, resource-efficient strategy. These findings demonstrate that the three rootstocks express fundamentally different drought response syndromes driven by coordinated variation in root morphology, hydraulic traits, canopy development, and stomatal behavior. The integration of hydraulic and morphological traits provides a robust framework for selecting rootstocks tailored to specific pedoclimatic and management contexts in water-limited environments. Full article