Search Results (9,493)

Despite increasing evidence that cigarette smoke is a significant source of indoor fine particulate matter (PM_2.5), quantitative emission factors (EFs) for PM_2.5 and its toxic chemical composition in mainstream (MS) and sidestream (SS) smoke are still not well defined. In this study, we employed a custom-designed chamber to separately collect MS (intermittent puff) and SS (continuous sampling) smoke from eleven cigarette models, representing six brands and two product types, under controlled conditions. PM_2.5 was collected on quartz-fiber filters and analyzed for carbon fractions (using the thermal–optical IMPROVE-A protocol), nine water-soluble inorganic ions (by ion chromatography), and twelve trace elements (via ICP-MS). SS smoke exhibited significantly higher mass fractions of total analyzed species (84.7% vs. 65.9%), carbon components (50.6% vs. 44.2%), water-soluble ions (17.1% vs. 13.7%), and elements (17.0% vs. 7.0%) compared to MS smoke. MS smoke is characterized by a high proportion of pyrolytic organic carbon fractions (OC₁–OC₃) and specific elements such as vanadium (V) and arsenic (As), while SS smoke shows elevated levels of elemental carbon (EC1), water-soluble ions (NH₄⁺, NO₃⁻), and certain elements like zinc (Zn) and cadmium (Cd). The toxicity-weighted distribution indicates that MS smoke primarily induces membrane disruption and pulmonary inflammation through semi-volatile organics and elements, whereas SS smoke enhances oxidative stress and cardiopulmonary impairment via EC-mediated reactions and secondary aerosol formation. The mean OC/EC ratio of 132.4 in SS smoke is an order of magnitude higher than values reported for biomass or fossil-fuel combustion, indicative of extensive incomplete combustion unique to cigarettes and suggesting a high potential for oxidative stress generation. Emission factors (µg/g cigarette) revealed marked differences: MS delivered higher absolute EFs for PM_2.5 (422.1), OC (8.8), EC (5.0), Na⁺ (32.6), and V (29.2), while SS emitted greater proportions of NH₄⁺, NO₃⁻, Cl⁻, and carcinogenic metals (As, Cd, Zn). These findings provide quantitative source profiles suitable for receptor-oriented indoor source-apportionment models and offer toxicological evidence to support the prioritization of comprehensive smoke-free regulations. Full article

Background: Enhancing bioavailability is the target of most pharmaceutical research; this can be achieved by modifying the physico-chemical characteristics of poorly water-soluble drugs intended for oral administration using different techniques. The preparation of liquitablets by blister molding technique provides an opportunity to increase the bioavailability of the drug using an optimal combination of release-facilitating additives. Lornoxicam is an effective non-steroidal anti-inflammatory drug with low water solubility. This study aimed to formulate a novel lornoxicam-containing liquitablets. The effect of different drying techniques on the physico-chemical properties and in vitro dissolution of lornoxicam was investigated. The physical parameters of the tablets were also studied. Methods: The additives applied in the formulation included Tween^® 80, Polyvinylpyrrolidone (PVP K90), Avicel^® PH-102, and sodium bicarbonate. Vacuum-drying and freeze-drying were employed to produce liquitablets. The influence of various drying methods on crystallinity and intra- and interparticle phenomena was investigated. In Vitro dissolution tests were performed at pH 1.2, and a comparison was made between our products and commercial tablets using the pairwise similarity factor model (f2). Results: The liquitablets demonstrated high hydrophilicity and a lower crystallinity of the drug. Freeze-dried liquitablet showed improved dissolution compared to that of the pure drug or the vacuum-dried product. A similarity was observed between our freeze-dried product and the marketed fast-release tablets. Conclusions: This research demonstrates that preparation of liquitablet in combination with freeze-drying has a significantly positive effect in improving the in vitro dissolution rate of lornoxicam. Full article

Phosphorus (P) stock scarcity is driving the need to develop alternatives to mineral fertilizers. The growing production of insects for high-protein feed results in significant amounts of residues (frass), which can be used as fertilizers. However, its efficiency as such a basic indicator for promoting the recycling of these residues has been rarely assessed. This work aimed to evaluate the efficiency of frass as a P fertilizer. To this end a study was conducted involving P fractionation of frass from two different species (TM: Tenebrio molitor and BSF: black soldier fly or Hermetia illucens) together with vermicompost and a 48-day pot experiment with lettuce (Lactuca sativa). In both frasses, water-soluble P and organic P accounted for more than 30% and 50% of total P, respectively. These P fractions explained the short- and long-term effects of frasses as P fertilizer, which showed a higher P use efficiency than mineral phosphate and vermicompost, with mineral fertilizer replacement values (MFRVs) of 150 and 180% for BSF and TM frass, respectively. Additionally, frass increased P bioavailability in soils more than superphosphate and boosted C and P cycling, thereby enhancing the soil P availability to plants. Therefore, frasses can be effective alternatives to mineral P fertilizers which also contribute to the enhancement of soil health indicators. Full article

Background: The limited aqueous solubility of BCS Class II drugs, exemplified by itraconazole (ITR), continues to hinder their bioavailability and therapeutic performance following oral administration. The present study investigated the development of amorphous solid dispersions (ASDs) of ITR via continuous manufacturing technologies, such as hot melt extrusion (HME) and spray drying (SD), to improve drug release. Methods: Polymer selection was guided by Hansen solubility parameter (HSP) analysis, film casting, and molecular modeling, leading to the identification of aminoalkyl methacrylate copolymer type A (Eudragit^® EPO), polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus^®), and hypromellose acetate succinate HG (AQOAT^® AS-HG) as suitable carriers. ASDs were prepared at drug-to-polymer ratios of 1:1, 1:2, and 2:1. Comprehensive characterization was performed using ATR-FTIR, NMR, DSC, PXRD, SEM, PLM, and contact angle analysis. Results: HME demonstrated higher process efficiency, solvent-free operation, and superior dissolution enhancement compared to SD. Optimized HME-based ASDs were formulated into tablets. The ITR–Eudragit^® EPO formulation achieved 95.88% drug release within 2 h (Weibull model, R² > 0.99), while Soluplus^® and AQOAT^® AS-HG systems achieved complete release, best described by the Peppas–Sahlin model. Molecular modeling confirmed favorable drug–polymer interactions, correlating with the formation of stable complex and enhanced release performance. Conclusions: HME-based continuous manufacturing provides a scalable and robust strategy for improving the oral delivery of poorly water-soluble drugs. Integrating predictive modeling with experimental screening enables the rational design of ASD formulations with optimized dissolution behavior, offering potential for improved therapeutic outcomes in BCS Class II drug delivery. Full article

To address the inherent challenge of poor interfacial compatibility in lignin/poly(butylene adipate-co-terephthalate) (PBAT) composites, lignin was extracted from Camellia oleifera shells and subjected to sequential solvent fractionation using ethanol, acetone, and tetrahydrofuran (THF). Two representative fractions—acetone-soluble (ACL) and THF-soluble (THFL)—were selected for composite preparation with PBAT via solvent casting. The influence of lignin fractionation on the structural and performance characteristics of the resulting composites was systematically evaluated through Fourier-transform infrared (FTIR) spectroscopy, the water contact angle (WCA), differential scanning calorimetry (DSC), tensile testing, and scanning electron microscopy (SEM). The results revealed that the abundant hydroxyl groups and benzene rings present in both ACL and THFL facilitated hydrogen bonding and conjugation interactions with the PBAT matrix, significantly improving interfacial adhesion. Notably, the ACL fraction effectively suppressed phase separation and increased the glass transition temperature (T_g) by 1.9 °C, leading to a 13.9% enhancement in tensile strength compared to neat PBAT. More strikingly, the incorporation of only 7 wt% THFL resulted in a remarkable 31% improvement in tensile strength. This substantial enhancement was primarily attributed to the favorable polarity match between THFL and PBAT, as well as the nucleating effect of THFL, which increased the crystallinity of PBAT by 25.3%. This study highlights the effectiveness of sequential lignin fractionation in tailoring the interfacial properties of biodegradable polymer composites. It also provides a promising strategy for the high-value utilization of lignin toward the development of high-performance, environmentally friendly materials. Full article

Background/Objectives: Herein, we investigated the effect of platelet-rich fibrin (PRF) treatment combined with no-ozone cold plasma (NCP) on growth factor levels, rat bone-marrow stem cell (rBMSC) proliferation, and alkaline phosphatase (ALP) activity in the early stage of differentiation into osteoblasts. Methods: The PRF used in the experiment was prepared by collecting blood from the jugular vein of rats, followed by centrifugation. The obtained PRF was treated with NCP, and the cell culture media were conditioned with the PRF extracts alone or with NCP-treated PRF extracts. Three different experimental groups were defined: no treatment (NT); cell culture media extracted from PRF (PRF); and cell culture media extracted from PRF treated with NCP (PRF + NCP). Enzyme-linked immunosorbent assays were performed to determine the levels of transforming growth factor (TGF)-β and platelet-derived growth factor (PDGF) AB. Water-soluble Tetrazolium-1 assay was performed to measure cell proliferation in rBMSCs. To analyze cell differentiation into osteoblasts, ALP staining and real-time PCR were performed. Results: Growth factor levels increased in response to treatment (TGF-β: p < 0.001, PDGF AB: p < 0.05), and the cell proliferation rate increased with treatment (145.29% and 150.05% for PRF and the PRF + NCP groups, respectively, relative to the NT group, p < 0.001). Evaluation of the ALP staining intensity and mRNA expression levels showed that the ALP activity was highest in the PRF + NCP group (p < 0.001). Conclusions: Our results confirmed that NCP treatment enhanced the release of several different growth factors contained in PRF to the culture media and that treatment with PRF and NCP increased the proliferation of rBMSCs and their differentiation into osteoblasts. Full article

This study aimed to investigate the effect of high-amylose corn starch (HACS) addition on the physicochemical properties and in vitro digestibility of an ultrasound-treated waxy rice flour (UWRF)–HACS blend system. As the proportion of HACS increased, the amylose content in the blends significantly increased (p < 0.05), while their water solubility index (WSI) and swelling power (SP) significantly decreased (p < 0.05). Additionally, the average particle size of the blends increased, and the surface of starch granules became smoother. Compared to UWRF, the blends did not generate new functional groups, but increased the starch’s relative crystallinity and short-range ordered structure. Rheological results indicated that the HACS-UWRF blends were mainly elastic and exhibited a typical weak gel system. In vitro digestibility results showed that the addition of HACS significantly increased the resistant starch (RS) content in the rice cakes (p < 0.05), while substantially reducing the hydrolysis index (HI) and estimated glycemic index (eGI) (p < 0.05). This study revealed the processing characteristics and gelatinization behavior changes in the HACS-UWRF blends. It provides a theoretical basis for the development of specialized flour for slow-glycemic rice cakes. Full article

The consistent quality control of ultrapure water (UPW) in semiconductor manufacturing depends on removing trace organonitrogen compounds such as urea. Due to its high solubility, chemical stability, and neutral polarity, urea is inadequately removed by conventional processes. Even at low concentrations, it elevates total organic carbon (TOC) and reduces electrical resistivity. The use of reclaimed water as a sustainable feed stream amplifies this challenge because its nitrogen content is variable and persistent. Conventional methods such as reverse osmosis, ultraviolet oxidation, and ion exchange remain limited in treating urea due to its uncharged, low-molecular-weight nature. This review examines the performance and limitations of these processes and explores electrochemical oxidation (EO) as an alternative. Advances in EO are analyzed with attention to degradation pathways, electrode design, reaction selectivity, and operational parameters. Integrated systems combining EO with membrane filtration, adsorption, or chemical oxidation are also reviewed. Although EO shows promise for selectively degrading urea, its application in UPW production is still in its early stages. Challenges such as low conductivity, byproduct formation, and energy efficiency must be addressed. The paper first discusses urea in reclaimed water and associated removal challenges, then examines both conventional and emerging treatment technologies. Subsequent sections delve into the mechanisms and optimization of EO, including electrode materials and operational parameters. The review concludes with a summary of main findings and a discussion of future research directions, aiming to provide a comprehensive foundation for validating EO as a viable technology for producing UPW from reclaimed water. Full article

Although the sediment–water interface of deep and large reservoirs is recognized as a dominant source of internal phosphorus (P) loading, the quantitative hierarchy of environmental drivers and their interaction thresholds remains poorly resolved. Here, we integrate 512 studies to provide the first process-based synthesis that partitions P release fluxes among temperature, pH, dissolved oxygen, salinity, sediment properties, and microbial activity across canyon, valley, and plain-type reservoirs. By deriving standardized effect sizes from 61 data-rich papers, we show that (i) a 1 °C rise in bottom-water temperature increases soluble reactive P (SRP) flux by 12.4% (95% CI: 10.8–14.0%), with sensitivity 28% lower in Alpine oligotrophic systems and 20% higher in warm monomictic basins; (ii) a single-unit pH shift—whether acid or alkaline—stimulates P release through distinct desorption pathways,; and (iii) each 1 mg L⁻¹ drop in dissolved oxygen amplifies release by 31% (25–37%). Critically, we demonstrate that these drivers rarely act independently: multi-factor laboratory and in situ analyses reveal that simultaneous hypoxia and warming can triple the release rate predicted from single-factor models. We further identify that >75% of measurements originate from dam-proximal zones, creating spatial blind spots that currently limit global P-load forecasts to ±50% uncertainty. To close this gap, we advocate coupled metagenomic–geochemical observatories that link gene expression (phoD, ppk, pqqC) to real-time SRP fluxes. The review advances beyond the existing literature by (1) establishing the first quantitative, globally transferable framework for temperature-, DO-, and pH-based management levers; (2) exposing the overlooked role of regional climate in modulating temperature sensitivity; and (3) providing a research agenda that reduces forecasting uncertainty to <20% within two years. Full article

Currently, there is an increasing demand for plant-based and low-fat snacks. Non-conventional starch and grains are alternative ingredients. Environmentally friendly processing, such as liquid nitrogen and microwaves, can be used to obtain modified starch, as well as hot air frying to cook snacks. The aim of this work was to evaluate the impact of eco-friendly physical modification of starch from Oxalis tuberosa in a low-fat snack processed by hot air frying. First, native starch (NS) was treated with liquid nitrogen (LNS) and liquid nitrogen/microwaves (LNMS), and the amylose/amylopectin content and functional properties were determined. The snacks were formulated with NS or modified starches, amaranth flour, quinoa flour, corn, onion powder, salt, and water; the ingredients were mixed and placed in an electric pasta maker and cooked by hot air frying. The hardness, hedonic test, colorimetric parameters, acrylamide, proximal composition, and fatty acid profile were analyzed. All starches showed similar values of amylose and amylopectin content. LNMS starch had the lowest water solubility index as compared to NS and LNS. The snacks with the starch modified with liquid nitrogen showed the highest values of hardness as well as the highest score for the texture from a hedonic test. The snacks with modified starches showed a lower browning index than the snack formulated with NS. Acrylamide was not detected in any snacks. The lipid value of the snacks with modified starch was 1.9–2.70 g/100 g of sample, providing ω-9, ω-6, and ω-3 fatty acids. All snacks contained 7.7 g of protein/100 g of sample. These low-fat and plant-based snacks are a healthy option made by environmentally friendly technologies. Full article

In the present study, the effects of longan peel and seed on the quality of longan cake were determined, and the effects of longan peel extract (LPE) and longan seed extract (LSE) on the physicochemical properties of wheat starch were also measured. Furthermore, the phenolic profile and antioxidant activities of these extracts were observed. The results showed that both longan peel and seed could improve the color, texture, and volatile flavor compounds of longan cake. In addition, the properties of wheat starch, including gelatinization characteristics, thermogravimetric analysis, rheological properties, solubility, swelling power, water/oil-holding capacity and iodine binding ability, were all affected by LPE and LSE significantly. Both LPE and LSE had high contents of total phenols (LPE: 71.05 ± 2.57 mg/g, LSE: 78.49 ± 5.21 mg/g) and total flavonoids (LPE: 286.27 ± 6.04 mg/g, LSE: 423.21 ± 7.69 mg/g). Gallic acid, ellagic acid, and ellagic acid 4-O-α-l-arabinofuranoside were identified as the main phenolic compounds of LPE, while those of LSE were gallic acid, ellagic acid, ellagic acid 4-O-α-l-arabinofuranoside and (-)-epicatechin. Furthermore, LPE and LSE both exhibited good antioxidant activities to scavenge free radicals and showed high reducing power. All results suggest that longan peel and seed are rich in phenols and can improve the properties of starch so as to enhance the quality of starch product, which shows their potential application in food and chemical industries. Full article

Background: Alzheimer’s Disease (AD) is one of the most prevalent neurodegenerative disorders and the most common form of dementia. Although current treatments examine disease progression, many have side effects and primarily target symptomatic relief as opposed to halting further neurodegeneration. Objective: The current study aims to determine the neuroprotective effects of water-soluble coenzyme Q10 (Ubisol-Q10) and an ethanolic Ashwagandha extract (E-ASH) on a transgenic mouse model of AD. Methods: A variety of immunofluorescence staining of biomarkers was conducted to assess mechanisms commonly implicated in the disease. Additionally, spatial and non-spatial memory tests evaluated cognitive functions at two timepoints throughout the progression of the disease. Results: A substantial reduction in microglial activation and amyloid-β (Aβ) plaques when treated with a combination of natural health products (NHPs), Ubisol-Q10 and E-ASH. Moreover, activation of autophagy was upregulated in both the Ubisol-Q10 and combination (Ubisol-Q10+E-ASH given as a combined “Tonic” solution) groups. Oxidative stress was decreased across treated groups, while astrocyte activation was elevated in both the E-ASH and Tonic group. The Tonic group expressed an elevation in the fluorescent intensity of neuronal nuclei (NeuN) and brain-derived neurotrophic factor (BDNF) levels. Interestingly, treatment with E-ASH and Ubisol-Q10 enhanced synaptic vesicle formation compared to controls. Pre-mortem memory tests revealed the treatments to be effective at preserving cognitive abilities. Conclusions: Based on these findings, the combination of E-ASH and Ubisol-Q10 may effectively mitigate the various mechanisms implicated in AD and ultimately prevent further disease progression. Full article

Anthocyanins, the most ubiquitous water-soluble phytopigments in terrestrial flora, have garnered substantial attention in sustainable food packaging research owing to their exceptional chromatic properties, pH-responsive characteristics, and putative health-promoting effects. Nevertheless, their inherent chemical lability manifests as rapid chromatic fading, structural degradation, and compromised bioactivity/bioavailability, ultimately restricting industrial implementation and incurring significant economic penalties. Recent advances in stabilization technologies through molecular encapsulation within polymeric matrices or nanoscale encapsulation systems have demonstrated remarkable potential for preserving anthocyanin integrity while augmenting multifunctionality. The integration of anthocyanins into advanced functional materials has emerged as a promising strategy for enhancing food safety and extending shelf life through smart packaging solutions. Despite their exceptional chromatic and bioactive properties, anthocyanins face challenges such as chemical instability under environmental stressors, limiting their industrial application. Recent advancements in stabilization technologies, including molecular encapsulation within polymeric matrices and nanoscale systems, have demonstrated significant potential in preserving anthocyanin integrity while enhancing multifunctionality. This review systematically explores the integration of anthocyanins with natural polymers, nanomaterials, and hybrid architectures, focusing on their roles as smart optical sensors, bioactive regulators, and functional components in active and smart packaging systems. Furthermore, the molecular interactions and interfacial phenomena governing anthocyanin stabilization are elucidated. The review also addresses current technological constraints and proposes future directions for scalable, sustainable, and optimized implementations in food preservation. Full article

Hybrid systems combining animal and plant proteins are promising for developing sustainable, high-protein foods. However, structural incompatibility between proteins like casein and pea protein hinders the formation of stable systems such as gels. This study explores pH-shifting (alkalization at pH 12 followed by neutralization) as an innovative strategy to improve pea protein functionality and compatibility in hybrid gels. Modified pea protein showed increased solubility, reduced particle size, higher zeta potential, and decreased intrinsic fluorescence intensity, indicating conformational changes and exposure of buried tryptophan residues. These structural changes influenced gel behavior depending on the protein ratio (casein/pea—80:20, 50:50, 20:80). Gels with higher pea content showed increased hardness and water-holding capacity, while in casein-rich gels, hardness decreased, likely due to altered protein–protein interactions. This is the first study to systematically apply pH-shifting to enhance the compatibility between pea protein and casein in high-protein gels, integrating structural and functional analyses. The results demonstrate the potential of pH-shifting as a sustainable and effective approach for improving plant protein performance in hybrid formulations. Full article

The growing population and increasing concerns about food security and sustainability demand innovative solutions to minimize food waste and transform by-products into functional ingredients valuable to the food sector. Brewery by-products, including brewer’s spent grain (BSG) and brewer’s spent yeast (BSY), are underutilized resources despite their high protein contents and potential as sustainable food ingredients. This study aimed to transform BSG and BSY into protein hydrolysates (BSGH and BSYH, respectively) through enzymatic hydrolysis and thus add value to these brewery industry by-products to be used in the food industry. These protein hydrolysates were incorporated into non-alcoholic malt beverages at three different concentrations, and their effects on the physicochemical properties, including color, kinematic viscosity, turbidity, foaming capacity and foam stability, of the non-alcoholic malt beverages were evaluated. Both BSGH and BSYH exhibited higher water solubility (WS) and lower water binding capacity (WBC) values when compared to their native non-hydrolyzed forms, enhancing their suitability as ideal ingredients for protein supplementation of a wide range of food and beverage products. The production of peptides of varying sizes underscored the effectiveness of enzymatic hydrolysis which resulted in an increase in cysteine and methionine levels in BSYH but a decrease in BSGH. The addition of BSGH and BSYH increased the kinematic viscosity and turbidity but reduced the lightness values in color of the non-alcoholic malt beverages. When the properties of the protein hydrolysates were compared, BSYH was more effective than BSGH in forming foams and maintaining their stability for longer periods. These findings highlight the potential of brewery by-products, after enzymatic hydrolysis, as protein-rich ingredients that can support more sustainable food systems and contribute to the nutritional enhancement of various low-protein food and beverage products. Full article