Search Results (319)

Periprosthetic joint infections (PJIs) represent one of the most problematic complications following total joint replacement, with a significant impact on the patient’s quality of life and healthcare costs. The early and accurate diagnosis of a PJI remains the key factor in the management of such cases. However, with traditional diagnostic measures and risk assessment tools, the early identification of a PJI may not always be adequate. Artificial intelligence (AI) algorithms have been integrated in most technological domains, with recent integration into healthcare, providing promising applications due to their capability of analyzing vast and complex datasets. With the development and implementation of AI algorithms, the assessment of risk factors and the prediction of certain complications have become more efficient. This review aims to not only provide an overview of the current use of AI in predicting PJIs, the exploration of the types of algorithms used, and the performance metrics reported, but also the limitations and challenges that come with implementing such tools in clinical practice. Full article

Introduction: Total temporomandibular joint replacement (TMJR) is a well-established surgical solution for patients with severe TMJ disorders. It aims to relieve chronic pain, restore jaw mobility, and significantly enhance quality of life. This systematic review evaluates QoL outcomes following TMJR, analyzes complication profiles, compares custom versus stock prostheses, explores pediatric applications, and highlights technological innovations shaping the future of TMJ reconstruction. Methods: A systematic search of PubMed, Embase, and the Cochrane Library was conducted throughout April 2025 in accordance with PRISMA 2020 guidelines. Sixty-four studies were included, comprising 2387 patients. Results: Primary outcomes assessed were QoL improvement, pain reduction, and functional gains such as maximum interincisal opening (MIO). Secondary outcomes included complication rates and technological integration. TMJR consistently led to significant pain reduction (75–87%), average MIO increases of 26–36 mm, and measurable QoL improvements across physical, social, and psychological domains. Custom prostheses were particularly beneficial in anatomically complex or revision cases, while stock devices generally performed well for standard anatomical conditions. Pediatric TMJR demonstrated functional and airway benefits with no clear evidence of growth inhibition over short- to medium-term follow-up. Complications such as heterotopic ossification (~20%, reduced to <5% with fat grafting), infection (3–4.9%), and chronic postoperative pain (~20–30%) were reported but were largely preventable or manageable. Recent advancements, including CAD/CAM planning, 3D-printed prostheses, augmented-reality-assisted surgery, and biofilm-resistant materials, are enhancing personalization, precision, and implant longevity. Conclusions: TMJR is a safe and transformative treatment that consistently improves QoL in patients with end-stage TMJ disease. Future directions include long-term registry tracking, growth-accommodating prosthesis design, and biologically integrated smart implants. Full article

Background/Objectives: Temporomandibular joint (TMJ) ankylosis, characterized by osseous–fibrous fusion, severely impairs mandibular function. While alloplastic total joint replacement (TJR) is the gold standard, long-term outcomes remain understudied. The aim of this study is to evaluate the long-term esthetic and functional outcomes of prosthetic replacement and to retrospectively analyze our 20-year experience. Methods: A retrospective observational study (2003–2024) was conducted at a tertiary referral center in Turin and enrolled patients who underwent alloplastic total joint replacement for TMJ ankylosis. Data collected included demographic variables, etiology, characteristics of the ankylosis, prosthesis type (stock/custom), surgical details, and outcomes (maximal interincisal opening [MIO], pain, quality of life, diet consistency, Helkimo index, complications). Results: Among 28 patients (61% female, mean age 51.8 years), etiologies included post-traumatic (39%), osteoarthritis (32%), congenital (25%) and neoplastic (4%) causes. Custom prostheses were used in 57% of cases. Median follow-up was 11.5 years. Significant improvements were observed in MIO (p = 0.001), pain level (p = 0.001), quality of life (p = 0.001), diet score (p = 0.002), and Helkimo index (p = 0.001). Complications included facial nerve dysfunction (32.1%), salivary leakage (14.3%), and one recurrence (2.2%). Conclusions: Alloplstic TJR provides durable functional and esthetic restoration for TMJ ankylosis, with custom prostheses excelling in complex anatomies. Long-term stability (>10 years) supports its role as a definitive solution. Full article

Background: The purpose of this study was to clinically characterize neutrally satisfied patients and compare outcomes between satisfied, dissatisfied, and neutral patients. Methods: This was a secondary analysis from data collected in a multicenter longitudinal cohort study comprising total knee arthroplasty (TKA) patients using a digital care management platform. The Knee Society Score (KSS) satisfaction survey was administered at post-operative 90 days, and dissatisfaction was defined as a composite score of less than 20, satisfied as a score equal to or greater than 30, and neutral as a score of 20 up to 29. Patient-reported outcome measures (PROMs) were assessed pre-operatively and at post-operative one, three, six, and twelve months. Results: Approximately 58% of patients were satisfied (n = 1486), 29.4% neutral (n = 747), and 12.2% dissatisfied (n = 311). Neutral and dissatisfied patients were younger and more likely to be female and had lower pre-operative KSS scores compared to satisfied patients, though statistical differences were found between all groups. Pre-operative pain was significantly less in satisfied compared to neutral or dissatisfied patients. Changes in the pre-operative Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR) displayed significant differences between all groups at all time points, with greater improvements in satisfied versus neutral patients and neutral versus dissatisfied patients. Similarly, satisfied patients experienced significantly greater improvements in pain and KSS scores at post-operative three months, and neutral patients improved more than dissatisfied patients. Conclusions: Neutral patients present with distinctively different clinical outcomes compared to satisfied or dissatisfied patients and should be classified separately as neutral. Full article

The room for reducing carbon emissions and improving low-carbon practices in the building industry is significant. In this study, a bibliometric analysis shows that technology is the primary mechanism adopted for driving carbon reduction in the existing practices building industry, which is conducted by using the CiteSpace 6.2.R4 tool. It is considered that there is a limitation in promoting further low-carbon practices by technological dominance without a proper management paradigm. This paper, therefore, aims to search for a new management paradigm in order to help further reduce emissions in the building industry. This study adopts an innovative synergy theory to explain the mechanism by which the efforts of all management dimensions can be synergized to promote low-carbon practices in the building sector. Consequently, the outcome of this paper is the introduction of a total low-carbon management (TLCM) paradigm. Synergy theory supports our assertion that a joint force can be formed within the building industry system to drive TLCM practice, as all building-related elements (government departments, building organizations, building personnel, building activities, and building processes) in the system will have to follow the government’s actions towards low-carbon practices. The TLCM paradigm is integrated by five components: whole regulation, whole industry, whole enterprise, whole staff, and whole process. The new paradigm should be promoted to replace the existing technology-dominated paradigm in order to achieve low-carbon practices in the building industry. The TLCM paradigm will guide low-carbon management decisions and practices across all phases of the building project’s lifecycle, together with integrating quality and risk management. Full article

The current pre-clinical testing standards for total hip replacements (THRs), ISO standards, use simplified loading waveforms that do not fully replicate real-world biomechanics. These standards provide a benchmark of data that may not accurately predict in vivo wear, necessitating the evaluation of physiologically relevant loading conditions. Previous studies have incorporated activities of daily living (ADLs) such as walking, jogging and stair negotiation into wear simulations. However, these studies primarily used simplified adaptations that increased axial forces and applied accelerated sinusoidal waveforms, rather than fully replicating the complex kinematics experienced by THR patients. To address this gap, this study applied patient-derived ADL profiles—jogging and stair negotiation—using a three-station hip simulator, obtained through 3D motion analysis of total hip arthroplasty patients, processed via a musculoskeletal multibody modelling approach to derive realistic hip contact forces (HCFs). The results indicate that jogging significantly increased wear rates compared to the ISO walking gait waveform, with wear increasing from 15.24 ± 0.55 to 28.68 ± 0.87 mm³/Mc. Additionally, wear was highly sensitive to changes in lubricant protein concentration, with an increase from 17 g/L to 30 g/L reducing wear by over 60%. Contrary to predictive models, stair descent resulted in higher volumetric wear (8.62 ± 0.43 mm³/0.5 Mc) compared to stair ascent (4.15 ± 0.31 mm³/0.5 Mc), despite both profiles having similar peak torques. These findings underscore the limitations of current ISO standards in replicating physiologically relevant wear patterns. The application of patient-specific loading profiles highlights the need to integrate ADLs into pre-clinical testing protocols, ensuring a more accurate assessment of implant performance and longevity. Full article

Background: Ferrous metals are used extensively in the manufacturing of plates, pins, Kirschner wires (K-wires), and screws, and in the performance of partial and total joint replacement surgeries for the shoulder, elbow, and wrist joints. The primary surgical procedures commonly performed are hip and knee replacement surgeries. Metals possess a combination of high modulus, yield point, and ductility, rendering them well suited for load-bearing applications, as they can withstand significant loads without experiencing substantial deformations or permanent alterations in their dimensions. Application of metals and alloys is of prime importance in orthopedics as they lead the way to overcoming many issues encountered in implant use. In some instances, pure metals are used, but alloys consisting of two or more elements typically exhibit greater material characteristics, including corrosion resistance as well as toughness. The first item to address when selecting a metallic implant material is its biocompatibility. In this regard, three classes of materials are also commonly known as biomedical metals—316L stainless steel, pure titanium, and titanium alloys. Objective: The aim of this work is to create a model describing the material behavior and then simulate the metals under a load of 2300 N, which is equivalent to plastic loading. Methods: Under ten different case studies, a sub-routine was developed to combine the material characteristics of titanium and 316L stainless steel with the software. Results: The outcomes of the research were then investigated. A femur model was created using ANSYS software, and two materials, stainless steel and titanium, were used. The model was then exposed to a force of 2300 N. Full article

Osteoarthritis (OA) is a leading cause of disability worldwide, with its prevalence rising due to aging populations. Management ranges from conservative treatments such as weight management and pharmacologic therapy to surgical interventions such as total joint replacement. However, treating moderate knee OA remains challenging for patients unresponsive to conservative care but not yet surgical candidates. Genicular artery embolization (GAE) has emerged as a minimally invasive procedure targeting abnormal angiogenesis and inflammation in OA. This article explores GAE’s mechanism, patient-selection criteria, and effectiveness in pain reduction and functional improvement. Studies suggest that GAE has the potential to significantly improve pain and function in mild to moderate OA, with sustained benefits. Patient selection is crucial for optimal outcomes, with imaging playing a key role. While conventional MRI assesses structural damage, Dynamic Contrast-Enhanced MRI (DCE-MRI) offers superior insights by evaluating synovitis, quantifying cartilage degradation, and monitoring treatment response. Due to its strong correlation with pain scores and status as the best surrogate marker for inflammation in synovitis, DCE-MRI holds significant potential to enhance patient selection and treatment monitoring for GAE. Full article

The process of formation of composite systems based on nanosilica A-300 and biologically active substances (BAS), namely gallic acid (GA), glycyrrhizic acid (GLA), and its salts, was studied using a set of physicochemical methods. It was shown that when BAS are immobilized on the silica surface by the method of joint grinding in a porcelain mortar, they pass into a nanosized X-ray amorphous state. Water adsorbed on the surface of such composite systems is also in a clustered state, and the radius of adsorbed water clusters is in the range of 0.4–50 nm. The chloroform environment has a complex effect on the size of water clusters. In general, there is a tendency for the radius of water clusters to increase when air is replaced by a chloroform environment. However, this does not always lead to a decrease in the interfacial energy. The possibility of the existence of metastable ice in the temperature range up to 287 K, stabilized by the surface of composite systems, was discovered. The amount of such ice can reach 20% of the total water content in the sample. The possibility of using complex viscosity measurements for hydrated silica powders and silica containing immobilized biologically active substances was shown. These measurements allow recording changes in the phase state of complex mixtures during the formation of compact composite forms under the influence of periodic mechanical loading. Full article

The lumbar degenerative cascade is a pathological process that affects most of the aging adult population and has significant negative economic consequences. Lumbar fusion surgery remains a mainstay of treatment for refractory degenerative disease but carries significant long-term consequences. More recently, lumbar arthroplasty and motion-sparing technology has become an increasingly popular alternative surgical option in carefully indicated patients. Arthroplasty technology carries the theoretical benefits of spinal segment motion preservation and decreased degeneration of adjacent segments as compared to traditional fusion procedures. This article will review the lumbar degenerative cascade and its related anatomic considerations, current management strategies and the challenges surrounding lumbar spinal fusion, including adjacent segment disease. This article will also review the theoretical benefits of lumbar arthroplasty and motion preservation. Furthermore, this paper will highlight the current state of lumbar arthroplasty, including current concepts of implant design, limitations, outcomes and ongoing development. It will review the development and current state of artificial disk arthroplasty, total joint arthroplasty and posterior column motion-preserving implants, including flexible rods and facet joint replacement. Full article

Background: Over the past few decades, shoulder arthroplasty has evolved rapidly, driven by a growing demand for surgical solutions to degenerative, traumatic, and irreparable rotator cuff-related pathologies, particularly in an aging but increasingly active population. Objective: This narrative review aims to examine the main clinical indications and the most commonly used implant designs, highlighting differences in functional outcomes, complication rates, and revision rates between anatomic total shoulder arthroplasty (ATSA) and reverse total shoulder arthroplasty (RTSA). Methods: Articles published between 2011 and 2025 were selected through PubMed and the Australian Joint Replacement Registry reports from 2023 and 2024. The included studies comprised randomized controlled trials, systematic reviews, and meta-analyses involving adult patients treated for primary osteoarthritis, proximal humerus fractures, and massive irreparable rotator cuff tears. Results: ATSA remains the preferred option in younger patients with an intact rotator cuff, due to superior outcomes in mobility and prosthesis longevity. However, glenoid component loosening remains a significant limitation. Initially reserved for irreparable cuff tears and complex fractures, RTSA has seen a progressive expansion of its indications, offering lower revision rates and satisfactory functional results, particularly in elderly patients. Recent prosthetic innovations include stemless implants, augmented glenoid components, and convertible platforms. Conclusions: The choice between ATSA and RTSA should be individualized, based on patient-specific factors such as age, rotator cuff integrity, functional demands, and bone quality. Advances in implant materials and design, together with improved patient selection, have significantly enhanced clinical outcomes. Full article

Gorlin-Goltz syndrome (GGS) is also known as Nevoid basal cell carcinoma syndrome (NBCCS). In the most common manifestation, GGS is diagnosed based on multiple cysts in the jaw bones, namely OKCs (odontogenic keratocysts). Other features might include major and minor clinical and radiological criteria to confirm this syndrome. Quite commonly, BCCs (basal cell carcinomas), bifid ribs, palmar and plantar pits, and ectopic calcification of the falx cerebri can be found in the majority of patients. Currently, the mutation of the PTCH1 gene seems to be responsible for GGS occurrence, while the male-to-female ratio is 1:1. The following radiological study based on OPGs and CBCT confirmed multiple cystic lesions in jaw bones, confirmed to be OKCs in the histopathological evaluation with an occurrence of numerous skin BCC lesions. In cases of most oral OKC cystic lesions, either surgical removal, curettage, or enucleation with or without any bone grafting can be used with a good amount of success. Rarely, some stable bone osteosynthesis procedures have to be carried out to avoid pathological bone fractures after cyst removal. A special consideration should include the temporomandibular joint. TMJ surgery and the replacement of the joint with an alloplastic material can be performed to improve biting, chewing, proper mouth opening, and maintain good patient occlusion. The authors want to present how effective and simple a standard dental panoramic radiograph combined with CBCT is and how it is suitable for GGS detection. They also want to underline how a standard TMJ prosthesis can be used as an alternative to a custom-made prosthesis. Full article

Total hip replacement (THR) is a common procedure used in veterinary medicine to treat hip joint diseases, particularly in medium- and large-sized dogs. Although cementless techniques have become the standard owing to concerns regarding the aseptic loosening of cemented implants, complications such as stem fractures can still occur. This study reports a case of a 1-year-old, 2.8 kg Toy Poodle that underwent cementless THR using the Zurich mini-cementless hip system to treat Legg–Calvé–Perthes disease. Six months post-surgery, the dog developed a fractured stem, and a second surgery was performed using the “window technique” to replace the broken stem. The procedure involved creating a small window in the femoral cortex to remove the damaged stem and insert a new one. The dog recovered successfully with no further lameness. This case highlights the effectiveness of the window technique for stem replacement in small dogs and emphasizes the importance of optimal stem selection and positioning during the initial THR. Full article

Background: Tibiotalocalcaneal (TTC) arthrodesis using talar allografts has emerged as a viable surgical option for managing complex hindfoot pathologies, including post-traumatic avascular necrosis (AVN), infection-related complications, and failed total ankle replacement (TAR). These conditions present significant therapeutic challenges due to extensive bone loss and joint instability. Previous reports have focused on TTC arthrodesis using talar allografts, highlighting its potential to provide enhanced structural support. This study aims to further evaluate the efficacy and safety of this surgical approach by assessing union, clinical outcomes, and complications in a diverse patient population. Methods: This retrospective study reviewed 11 patients who underwent TTC arthrodesis with talar allograft between January 2020 and November 2022. The study cohort included patients with post-traumatic AVN, infection-related complications, and failed TAR. Preoperative and postoperative evaluations included X-rays, computed tomography scans, and functional outcome scores such as the Visual Analog Scale (VAS) and the Foot and Ankle Outcome Score (FAOS). Results: This study included 11 patients who underwent surgical treatment between January 2020 and November 2022, with a minimum follow-up of 24 months and a mean follow-up of 33.45 months (range, 24–50 months). Successful arthrodesis was observed in nine patients, yielding a success rate of 82%. Significant improvements in functional outcomes were noted, including marked reductions in pain and enhanced activity levels, as evaluated by VAS and FAOS scores. Two patients demonstrated radiographic nonunion (one tibiotalar, one subtalar), but both remained asymptomatic and did not require revision surgery. No other complications such as infection, wound issues, or thromboembolism were observed. Immediate postoperative radiographs confirmed appropriate allograft alignment and placement. Conclusions: TTC arthrodesis using structural talar allografts may be a viable and safe option for managing severe hindfoot pathology, potentially resulting in satisfactory fusion rates and clinical outcomes. Full article

Total hip arthroplasty (THA) is a widely performed procedure to restore hip function in patients with degenerative joint diseases. Traditional “press-fit” fixation methods rely on sufficient bone quality for stability, but additional screw fixation is often necessary for patients with suboptimal bone conditions. However, comprehensive studies utilizing predictive modeling to optimize screw placement strategies in THA remain limited. This study integrates finite element analysis (FEA) with deep learning (DL) to optimize screw fixation strategies, enhancing implant stability and reducing revision rates. The design optimization process was conducted to refine key implant parameters before training the deep learning surrogate model. By utilizing advanced simulation techniques—including Goodness of Fit analysis, Response Graphs, Local Sensitivity Analysis, and Spider Charts—critical factors influencing stress distribution and fixation stability were identified. The optimization process ensured that the dataset used for deep learning training consisted of well-validated simulations, thereby improving the predictive accuracy of stress–strain responses. The findings indicate that optimized screw placement significantly improves load distribution, reducing stress concentrations and enhancing long-term implant stability. The comparative analysis of FEA and DL results showed that the DL-FEA surrogate model successfully replicated deformation patterns, though with a mean squared error (MSE) of 24.06%. While this suggests room for improvement, the model demonstrates potential for streamlining surgical planning. A comparative assessment with traditional methods highlights the advantages of DL-FEA in reducing computational time while maintaining precision. Future improvements will focus on refining the DL model, increasing the dataset size, and incorporating clinical validation. These findings contribute to developing a computational protocol for personalized acetabular cup fixation, with implications for reducing revision rates and improving surgical outcomes. Full article