Search Results (127)

This study investigated the effects of Lactococcus lactis subsp. 1.2472 (L)-, Streptococcus thermophilus 1.2718 (S)-, and thermostable Lactobacillus rhamnosus HCUL 1.1901-1912 (T)-fermented rice flour with inoculum levels of 3–11% (w/w) on rice bread staling. Optimal staling resistance was achieved, as follows: 9% L-fermented rice bread (LRB), 7% T-fermented rice bread (TRB), and 5% S-fermented rice bread (SRB). Lactic acid bacteria-fermented rice flour significantly enhanced hydration properties. LF-NMR analysis revealed that T₂₁ (strongly bound water) and T₂₂ (weakly bound water) relaxation times decreased, while T₂₃ (free water) increased with prolonged storage. Fermented-rice-flour groups had significantly more strongly bound water than the control group on 7 d. The optimized formulations exhibited exceptional volumetric stability with specific volume change rates of 17.63% (LRB), 17.60% (TRB), and 19.58% (SRB), coupled with maximal porosities of 10.34%, 9.05%, and 9.41%, respectively. This study provides a theoretical foundation for improving rice bread’s anti-staling properties. Full article

The Tabu River Basin (TRB) is one of the most ecologically fragile areas in the arid regions of northern China; it is a key component of the desert steppe north of the Yinshan Mountains. The fractional vegetation coverage (FVC) represents a vital indicator of ecological health in the TRB. In this study, we explored the impacts of climate change and human activities on vegetation growth and utilized Landsat data (30 m) from the Google Earth Engine to generate a long-term FVC dataset (1986–2023) in the TRB. Furthermore, we established a framework for quantitatively identifying the effects of climate change and anthropogenic activities on the FVC in desert steppe regions. The results revealed that: (1) the FVC exhibits considerable spatial heterogeneity, with higher values observed in the southeastern and southwestern areas and lower values in the northern part; (2) over the past 38 years, the annual average FVC has shown fluctuations, with a slight declining trend, while the Hurst exponent indicates a reverse persistence pattern in the FVC across the TRB; and (3) the correlation between the FVC and the temperature is marginally stronger than that with precipitation, and the influence of climate change on promoting the FVC outweighs the role of human activities. These results offer valuable insights for ecological restoration and sustainable development efforts and provide scientific support for monitoring vegetation in the region. Full article

The paper shows the effect of using a lubricant in the form of an ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate (BMIM-PF₆), on the tribological properties of a hydrogenated diamond-like coating (DLC) doped with tungsten a-C:H:W. The coatings were deposited on 100Cr6 steel by plasma-enhanced chemical vapor deposition PECVD. Tribological tests were carried out on a TRB³ tribometer in a rotary motion in a ball–disc combination. 100Cr6 steel balls were used as a counter-sample. Friction and wear tests were carried out for discs made of 100Cr6 steel and 100Cr6 steel discs with a DLC coating. They were performed under friction conditions with and without lubrication under 10 N and 15 N loads. The ionic liquid BMIM-PF₆ was used as a lubricant. Coating thickness was observed on a scanning microscope, and the linear analysis of chemical composition on the cross-section was analyzed using the EDS analyzer. The confocal microscope with an interferometric mode was used for analysis of the geometric structure of the surface before and after the tribological tests. The contact angle of the samples for distilled water, diiodomethane and ionic liquid was tested on an optical tensiometer. The test results showed good cooperation of the DLC coating with the lubricant. It lowered the coefficient of friction in comparison to steel about 20%. This indicates the synergistic nature of the interaction: DLC coating–BMIM-PF₆ lubricant–100Cr6 steel. Full article

As network scale and demand rise, the Uncapacitated Facility Location Problem (UFLP), a classical NP-hard problem widely studied in operations research, becomes increasingly challenging for traditional methods confined to formulation, construction, and benchmarking. This work generalizes the UFLP to network setting in light of demand intensity and network topology. A new initialization technique called Network- and Demand-Weighted Roulette Wheel Initialization (NDWRWI) has been introduced and proved to be a competitive alternative to random (RI) and greedy initializations (GI). Experiments were carried out based on the TRB dataset and compared eight state-of-the-art methods. For instance, in the ultra-large-scale Gold Coast network, the NDWRWI-based Neighborhood Search (NS) achieved a competitive optimal total cost (9,372,502), closely comparable to the best-performing baseline (RI-based: 9,189,353), while delivering superior clustering quality (Silhouette: 0.3859 vs. 0.3833 and 0.3752 for RI- and GI-based NS, respectively) and reducing computational time by nearly an order of magnitude relative to the GI-based baseline. Similarly, NDWRWI-based Variable Neighborhood Search (VNS) improved upon RI-based baseline by reducing the overall cost by approximately 3.67%, increasing clustering quality and achieving a 27% faster runtime. It is found that NDWRWI prioritizes high-demand and centrally located nodes, fostering high-quality initial solutions and robust performance across large-scale and heterogeneous networks. Full article

Background: Skin cancer has become a global health issue because of increasing exposure to environmental contaminants and UV radiation. Terbinafine hydrochloride (TRB), a broad-spectrum antifungal medication, has demonstrated notable anti-tumor properties in previous studies; however, its repurposing for skin cancer therapy remains underexplored. Objective: This study reports for the first time, the development of a new delivery system: a nanoemulsion (NE)–foam hybrid system, i.e., “nanoemulfoam” (NEF), designed to enhance the topical TRB delivery to the skin. The study applied this new hybrid system on TRB for managing skin cancer. Method: The TRB-loaded NEF was produced by loading TRB into a liquid NE. then this was incorporated into a liquid foam base and actuated into foam using a non-propellant mechanism. The NE was developed utilizing peppermint oil as the oil phase and Tween-20/ethanol as the surfactant/co-surfactant combination (Smix). The formulation underwent optimization using the D-optimal design that enabled the simultaneous evaluation of the impact of oil concentration and Tween 20 concentration in the Smix on the particle size (PS), zeta potential (ZP), and dissolution efficiency percent (DE%). Results: The optimal NE formula displayed a small PS of 186.60 ± 2.84 nm, ZP of −13.90 ± 0.99 mV, and DE% of 68.50 ± 1.78% (mean ± SD, n = 3). After incorporation into the foam system, the produced TRB-loaded NEF demonstrated a 7.43-fold increase in the drug transdermal flux in comparison with plain drug foam (p < 0.05). The TRB-loaded NEF showed no signs of inflammation or irritation when applied to abdominal rabbit skin, indicating its safety. The optimum formula exhibited a statistically significant 10-fold increase in cytotoxicity against A-431 skin cancer cells compared to TRB alone, along with a 1.54-fold increase in apoptosis (p < 0.05). Molecular docking studies targeting CDK2, a key regulator of cell proliferation and a known TRB target, revealed that TRB displayed highly favorable binding scores compared to the reference drug. Conclusions: The TRB-loaded NEF represents a promising nanotechnology-based approach for the topical treatment of skin cancer, supporting further investigation toward clinical translation. Full article

Ecosystem services (ESs) are a life-support system for human development that are also a strategic root for realizing global ecological security and sustainable development. In this study, the spatial distribution pattern of land-use and ESs under three scenarios (an ecological protection scenario (EPS), a natural development scenario (NDS), and a cropland protection scenario (CPS)) in the Tarim River Basin (TRB), Northwest China, is predicted for 2035 using the Future Land-Use Simulation (FLUS)–Integrated Valuation of ESs and Trade-Offs (InVEST) model. Land-use data from 2000 to 2023 are utilized as the basic data, and the spatial and temporal characteristics of land-use and multiple ESs under different scenarios are explored. The results show that (1) the land-use structure of the TRB is dominated by barren land (55.12%) and grassland (30.28%), and the dynamic evolution of the land-use pattern from 2000 to 2023 is characterized by the continuous shrinkage of the area of barren land and the expansion of impervious surfaces, cropland, water bodies, and other productive and living land and water. (2) According to the prediction results of the FLUS model, the different scenarios of land-use for 2020–2035 show various change trends. In the EPS, the proportion of ecological land jumps to 35.23%, while production land and living land show a systematic contraction. Under the NDS, water bodies, grassland, and impervious surfaces experience a decreasing trend, whereas cropland, forest land, and barren land increase in area. Under the CPS, the trend of shrinkage for ecological land accelerates, especially the fragmentation of forest patches (shrinking by 24 km²) and the expansion of cropland and barren land. (3) A comparison and an analysis of the ESs in several scenarios for 2035 show an increase in ESs under the EPS compared with those in 2020, along with a marked improvement in the TRB’s future ecological environment under this scenario. By adhering to the guidance of ecological priority through optimization of the national spatial pattern and the integration of ecological elements, the dynamic balance between ecological protection and economic development can be effectively coordinated, providing core support for the sustainable development of the region. (4) Ecosystem services are significantly impacted by changes in grassland in a variety of settings, particularly in the NDS. Contradictory trade-offs between ecological functions are revealed in the CPS, where cropland expansion promotes soil conservation but worsens the degradation of grassland. In the EPS, the synergistic expansion of grassland and water favorably regulates ecosystem services. A major way to increase the capacity of regional ecosystem services and accomplish sustainable development is to optimize the land-use for ecological preservation, with an emphasis on increasing the acreage of grassland, forest, and water while decreasing the area of cropland and barren. Full article

Additive manufacturing technologies are being increasingly adopted in the manufacturing industries due to their capabilities in producing complex geometries without the need for special tools. Material extrusion (MEX-TRB/P) is a popular additive manufacturing technology due to its simple operation. However, optimization of various process parameters remains a challenge, as incorrect combinations can lead to reduced dimensional accuracy and incapacitated mechanical properties of the fabricated parts. Given that the MEX-TRB/P process relies on the heating and cooling of thermoplastic materials, understanding the role of temperature is critical to optimizing the MEX-TRB/P printed parts. This article reviews existing research on the effects of process parameters, specifically those that are temperature sensitive, on the mechanical properties of the printed parts. The review first classified the process parameters into temperature sensitive and non-temperature sensitive process parameters. Then, the influence of temperature on the bonding quality and material properties is investigated, and a relationship between the thermal conditions and mechanical properties of 3D printed parts is established. This review also summarizes experimental and numerical methods for investigating temperature evolution during printing. This study aims to provide a deep understanding of the optimization of temperature-sensitive process parameters and their role in enhancing the mechanical properties of MEX-TRB/P-printed parts. Full article

Climate change has intensified the melting of glaciers and permafrost in high-altitude cold regions, leading to more frequent extreme hydrological events. This has caused significant variations in the spatiotemporal distribution of meltwater runoff from the headwater cryosphere, posing a major challenge to regional water security. In this study, the HBV hydrological model was set up and driven by CMIP6 global climate model outputs to investigate the multi-scale temporal variations of runoff under different climate change scenarios in the Tuotuo River Basin (TRB) within the source region of the Yangtze River (SRYR). The results suggest that the TRB will undergo significant warming and wetting in the future, with increasing precipitation primarily occurring from May to October and a notable rise in annual temperature. Both temperature and precipitation trends intensify under more extreme climate scenarios. Under all climate scenarios, annual runoff generally exhibits an upward trend, except under the SSP1-2.6 scenario, where a slight decline in total runoff is projected for the late 21st century (2061–2090). The increase in total runoff is primarily concentrated between May and October, driven by enhanced rainfall and meltwater contributions, while snowmelt runoff also shows an increase, but accounts for a smaller percentage of the total runoff and has a smaller impact on the total runoff. Precipitation is the primary driver of annual runoff depth changes, with temperature effects varying by scenario and period. Under high emissions, intensified warming and glacier melt amplify runoff, while low emissions show stable warming with precipitation dominating runoff changes. Full article

The Tumen River Basin (TRB), a critical China border region, has experienced a complex evolution of runoff due to climate change and human activities. This study aims to quantify the main drivers of runoff variations in the TRB based on the Budyko framework to assess the relative contributions of climate change and human activities to runoff fluctuations. Results indicate pronounced warming and increased precipitation in the TRB, while runoff exhibits a declining trend with temporal variability. Runoff decreased during 1956–1980 but increased post 1980. Overall, climate change is the dominant factor driving runoff fluctuations in the TRB. A comparison across different sub-basins shows that the contribution of climate change to runoff variations is higher in the middle and upper reaches of the Tumen River, reaching up to 93.8%. In the lower basin, human activities contribute significantly to runoff variations. Higher forest cover and reservoir construction help maintain the long-term stability of watershed runoff. This study provides a scientific basis and data support for water resources development and ecological protection in the basin. Full article

A tapered roller bearing (TRB) is a specialized type of bearing with a high load-to-volume ratio, designed to support both radial and axial loads. Lubrication plays a crucial role in TRB operation by reducing friction and dissipating heat generated during rotation. However, it can also negatively impact TRB performance due to the viscous and inertial effects of the lubricant. Extensive research has been conducted to examine the role of lubrication in TRB performance. Lubrication primarily influences the frictional characteristics, thermal behavior, hydraulic losses, dynamic stability, and contact mechanics of TRBs. This paper aims to collect and classify the scientific literature on TRB lubrication based on these key aspects. Specifically, it explores the scope of research on the use of Newtonian and non-Newtonian lubricants in TRBs. Furthermore, this study analyzes research based on TRB size and type, considering both oil and grease as lubricants. The findings indicate that both numerical and experimental studies have been conducted to investigate Newtonian and non-Newtonian lubricants across various TRB sizes and types. However, the results highlight that limited research has focused on non-Newtonian lubricants in TRBs with an Outer Diameter (OD) exceeding 300 mm, i.e., those typically used in wind turbines, industrial gearboxes, and railways. Full article

Background & Objectives: Targeted-release budesonide (TRB) is the first approved agent aimed at targeting the early pathogenetic cascade in IgA nephropathy (IgAN). Materials and Methods: This prospective study included Caucasian IgAN patients diagnosed within the last 5 years, who had started a 10-month TRB treatment and were followed in the outpatient clinic. All participants had been on the maximal supportive care dose for at least the previous 6 months. Kidney function and proteinuria levels were recorded at the start of TRB treatment (T0) and at 3, 6, and 10 months (T3, T6, and T10, respectively), while urinary monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9) and clusterin (CLU) levels were measured at T0 and T3. Results: In the cohort of all patients (mean age 53.24 ± 12.76 years, estimated glomerular filtration rate (eGFR 52.84 ± 25.93 mL/min/1.73 m², proteinuria 2.84 ± 1.26 g/24 h), significant correlations were observed at T0 between MMP-9 and MCP-1 (r = 0.74, p = 0.004), MMP-9 and uCLU (r = 0.77, p = 0.002), and MCP-1 and uCLU (r = 0.65, p = 0.01). At T3, a significant correlation between MMP-9 and urinary CLU (uCLU) persisted (r = 0.71, p = 0.03). Higher MCP-1 (r = −0.560, p = 0.046) and MMP-9 (r = −0.330, p = 0.012) levels at T0 were associated with reduced proteinuria. Conversely, increased clusterin at T3 (r = 0.599, p = 0.031) was associated with worsening proteinuria. Conclusions: The treatment response to TRB was heterogeneous, with recent diagnosis (RD) patients showing improved kidney function and proteinuria, while older diagnosis (OD) patients exhibited worsening biomarkers and declining kidney function. Therefore, early interventions are crucial in IgAN patients. Finally, the biomarkers studied can be used prognostically to monitor disease progression. Full article

It is of great significance to optimize water resource management and promote sustainable development in the Tarim River Basin (TRB) by using the water footprint (WF) evaluation method to evaluate the water shortage of fruit trees in the TRB and analyse its water-saving potential. This study aimed to elucidate the WF spatial–temporal distribution characteristics of fruit trees in the water-limited TRB from 2000 to 2020 and evaluate their water-saving potential capability. The WF was calculated using a combination of irrigation technology simulation and water usage assessments for four different fruit trees (apple, pear, date, and walnut). The results indicate that the green WF (WF_green) initially increased and then decreased, reaching its lowest value of only 175.09 m³/t in 2020, and decreased by 22.71% from 2000 to 2020. WF_blue decreased by 47.13% over the same period. In 2020, the WF_blue of date and walnut accounted for a higher percentage of WF_blue. WF_blue significantly exceeded WF_green, indicating their high water consumption and the limited adoption of water-saving technologies in the study area. Due to the increase in fruit tree planting area and fertilization, WF_grey exhibited an overall upward trend. Meanwhile, the total WF (WF_total) indicated a general downward trend, though the walnut tree had the highest WF_total at 2.21 × 10⁵ m³/t, indicating the popularization of water-saving technology. The results show that, taking 2020 as the baseline, the WF_blue of the four fruit trees in the TRB was 2.64 × 10⁵ m³/t (accounting for 89.1%), total WF_blue decreased by 0.73 × 10⁵ m³/t (a decrease of 48.38%) after drip irrigation, and the water-saving potential in the five prefectures of the TRB was in the range of 38.55–56.18%. Therefore, the promotion of drip irrigation technology plays a key role in alleviating the water pressure of fruit trees and promoting the sustainable utilization of water resources in the TRB. Full article

Global challenges such as climate change, ecological imbalance, and resource scarcity are closely related with land-use change. Arid land, which is 41% of the global land area, has fragile ecology and limited water resources. To ensure food security, ecological resilience, and sustainable use of land resources, there is a need for multi-scenario analysis of land-use change in arid regions. To carry this out, multiple spatial analysis techniques and land change indicators were used to analyze spatial land-use change in a typical inland river basin in arid Northwest China—the Tailan River Basin (TRB). Then, the PLUS model was used to analyze, in a certain time period (1980–2060), land-use change in the same basin. The scenarios used included the Natural Increase Scenario (NIS), Food Security Scenario (FSS), Economic Development Scenario (EDS), Water Protection Scenario (WPS), Ecological Protection Scenario (EPS), and Balanced Eco-economy Scenario (BES). The results show that for the period of 1980–2020, land-use change in the TRB was mainly driven by changes in cultivated land, grassland, forest land, and built-up land. For this period, there was a substantial increase in cultivated land (865.56 km²) and a significant decrease in forest land (197.44 km²) and grassland (773.55 km²) in the study area. There was a notable spatial shift in land use in the period of 1990–2010. The overall accuracy (OA) of the PLUS model was more than 90%, with a Kappa value of 85% and a Figure of Merit (FOM) of 0.18. The most pronounced expansion in cultivated land area in the 2020–2060 period was for the FSS (661.49 km²). This led to an increase in grain production and agricultural productivity in the region. The most significant increase in built-up area was under the EDS (61.7 km²), contributing to economic development and population growth. While the conversion of grassland area into other forms of land use was the smallest under the BES (606.08 km²), built-up area increased by 55.82 km². This presented an ideal scenario under which ecological conservation was in balance with economic development. This was the most sustainable land management strategy with a harmonized balance across humans and the ecology in the TRB study area. This strategy may provide policymakers with a realistic land-use option with the potential to offer an acceptable policy solution to land use. Full article

To enhance the operational stability and service life of tapered roller bearings (TRBs), this study investigates the application of surface texturing technology using laser marking to fabricate micro-dimples with controlled diameters and distributions on the TRB outer ring. An orthogonal experimental design was implemented to systematically evaluate the effects of three key dimple parameters—diameter, depth, and angular distribution—on the tribological performance under starved lubrication. The results demonstrate that the textured surfaces significantly improve friction-reducing performance and wear resistance. Optimal dimple parameters (diameter: 200 μm, depth: 10 μm, angular interval: 0.9°) were identified, achieving a 43.6% reduction in the average coefficient of friction (COF) and a 75.7% decrease in wear loss compared to smooth bearings. These findings would offer a practical approach to enhancing the durability and operational reliability of TRBs in industrial applications. Full article

Metabolically unhealthy obesity (MUO) is associated with increased inflammation and a higher risk of metabolic disorders compared to metabolically healthy obesity (MHO). T cell dysregulation in blood and adipose tissue may contribute to obesity-induced metabolic dysfunction, yet the characteristics of T cell subset profiles and T-cell receptor (TCR) repertoires in MHO and MUO remain unclear. We analyzed T cell subsets and TCR repertoires in peripheral blood and omental adipose tissue (oAT) from age- and BMI-matched MHO and MUO individuals using flow cytometry and high-throughput TCR sequencing. MUO individuals exhibited a higher proportion of memory CD4⁺ T cells in both compartments, with an increased frequency of central memory T cells. Circulating CD8⁺ T cells were increased in MUO, whereas CD8⁺ T cell subset composition remained unchanged in both blood and oAT. The TCR repertoire in oAT was significantly more restricted than in blood and showed greater skewing in MUO, with selective amplification of specific TRB V genes (TRBV12-4, TRBV18, TRBV7-9) and altered CDR3 length distributions. These findings suggest that distinct CD4⁺ T cell populations and specific TCR signatures may serve as potential biomarkers for metabolic dysfunction in obesity, providing insights into immune mechanisms underlying the transition from MHO to MUO. Full article