Search Results (69,358)

Genetically modified foods represent an important application of modern biotechnology and remain a subject of public debate. Attitudes toward consumption are more likely to be influenced by varying levels of scientific knowledge. University students from the College of Science and the College of Agricultural and Food Sciences at King Faisal University, Saudi Arabia, are expected to possess the basic knowledge that may affect their attitudes toward consumption of genetically modified foods. This study aimed to assess undergraduate students’ knowledge as a predictor of future attitudes toward consumption of genetically modified foods. Using a descriptive method, an electronic questionnaire was administered to a random sample of 300 participants during the first semester of the academic year 2025/2026. Data were analyzed using confirmatory factor analysis and t-tests. The results indicate that students possess a moderate level of scientific knowledge. Their future attitudes toward consuming genetically modified foods were also moderate. Prior studying of genetics and biotechnology courses significantly affects students’ scientific knowledge and future attitudes toward consumption of genetically modified food. The students strongly supported strict regulations, but they expressed hesitation regarding consumption regardless of scientific assurances of safety. No statistically significant differences in knowledge or attitudes based on specialization or gender were found. The authors recommend integrating ethical and social considerations of this kind of food into educational curricula to support informed decision-making among future professionals. Full article

Mitigating heat stress in high-density historical districts remains a critical challenge in urban renewal due to complex morphological heterogeneity. Existing research often relies on isolated intervention measures, lacking systematic, multi-strategy assessments driven by high-precision spatial data. This study addresses this gap by establishing a quantitative framework that couples thermal infrared remote sensing with Computational Fluid Dynamics (CFD) to optimize microclimate responses in Beijing’s Liulichang Historic District. Remote sensing data were utilized to retrieve high-resolution Land Surface Temperature (LST), providing accurate thermal boundary conditions for micro-scale wind-thermal simulations. A baseline scenario (S0) and seven renewal strategies (S1–S7)—integrating varying configurations of greenery, water bodies, and permeable pavements—were evaluated using pedestrian-level comfort indices. Results reveal that single-factor interventions yield marginal improvements or thermodynamic trade-offs; specifically, adding greenery (S1) in narrow street canyons increased aerodynamic roughness, thereby obstructing ventilation and inducing localized warming. Conversely, composite strategies significantly enhanced microclimatic quality. The “greenery-water-permeable pavement” strategy (S4) achieved optimal synergistic effects, characterized by substantial cooling and spatial homogenization. Regression analysis identified water bodies as the dominant cooling driver, where a 10% increase in water coverage resulted in a temperature reduction of approximately 5.17 °C. Conversely, greenery alone showed no statistically significant cooling contribution (p > 0.05) without the synergistic presence of water or pavement modifications. This research suggests that urban renewal in high-temperature zones (>36 °C) should prioritize composite cooling networks. Furthermore, vegetation layouts near wind corridors must be precisely regulated to prevent ventilation degradation. These findings provide a scientific basis for the climate-adaptive sustainable regeneration of culturally significant, high-density urban blocks. Full article

The combination of Artificial Intelligence (AI) and Formative Assessment (FA) in Teacher Education explores how emerging technologies can enhance teaching practices and professional development. AI tools can provide personalized feedback, identify learning needs, and support reflective practice among educators. Integrating AI-driven formative assessment methods allows for continuous evaluation of teaching competencies, promoting adaptive learning, data-informed decision-making, and improved instructional quality in teacher education programs. The purpose of this study was to conduct a systematic review of the use of Formative Assessment (FA) and Artificial Intelligence (AI) in Teacher Education (TE) during the period 2020–2025 (inclusive). The review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology, which ensures a rigorous, transparent, and reproducible process in the selection and analysis of studies. To this end, scientific articles published in the Scopus, Web of Science and Dialnet databases were reviewed, considering publications in English and Spanish. The objective was to identify trends, methodological approaches, results, and research gaps that show how AI is being integrated, or not, into FA processes in TE. The review also sought to analyze the impact of AI on student participation in assessment, feedback, decision-making, and the learning and assessment process itself, synthesizing the current evidence on the relationship between AI and FA in TE. Full article

The smart city represents a new stage in urban evolution, driven by technological progress, social transformations, and the increasing emphasis placed on sustainability. This metamorphosis generates hub-type architectural models, used not only for data collection and interconnection but also for the management and monitoring of people, resources, and urban services. This discussion addresses how digital urbanism has followed different paths globally by synthesising technological, economic, social, and governance perspectives. Compared with traditional models of urbanisation, new smart cities are built not only for digital interconnection but also to be citizen-centred, environmentally friendly, and resilient to global crises. This article analyses recent scientific literature on the theoretical and practical foundations of technologies that support data-driven decision-making, infrastructure efficiency, and the delivery of inclusive public services. At the same time, major challenges are highlighted, such as the lack of system interoperability, information fragmentation, and the risks associated with excessive surveillance, which can generate social exclusion, as well as financial and political constraints. International examples from Helsinki, Barcelona, Dubai, and Singapore offer both models that have achieved success and critical lessons about the limits of these approaches. This paper is not limited only to the problems faced by smart cities. It also highlights the opportunities they can bring. Finally, based on the conclusions of the analysis carried out and the identified trends, a strategic framework is proposed, oriented towards responsible innovation, collaboration, and sustainability. This approach contributes to informing researchers, decision-makers, urban planners, and the public interested in the transformation of the urban environment. Full article

Liver fibrosis is a regenerative mechanism, but it pathologically intensifies in the course of various diseases, leading to progressive impairment of organ function. This process involves parenchymal cells (hepatocytes) and non-parenchymal cells (Kupffer cells, stellate cells, and endothelial cells). Its classic mechanism is based on the activation of stellate cells, the main effector of fibrosis, by transforming growth factor β (TGF-β), which stimulates excessive collagen production. The role of interleukin 13 (IL-13), which enters the liver parenchyma from resident lymphoid cells, seems to be equally important. By binding to the IL-13Rα receptor on stellate cells, IL-13 initiates their activation and increases the production of type I collagen. This process is supported by the Erk1/2 pathway, which induces the expression of genes promoting extracellular matrix deposition. Due to its role as an initiator of the fibrotic cascade, IL-13 represents a promising therapeutic target for inhibiting progressive scarring. In this context, cell therapies are considered to be of great importance. Mesenchymal and epithelial stem cell secretions contain, among others, exosomes that carry paracrine mediators that can inhibit the profibrotic effects of IL-13 by modulating IL-13 signalling, limiting the development of organ scarring. However, the data on clinical applications of this molecular pathway is scarce, as there are no significant studies focusing on IL-13 influence in liver fibrosis. This review emphasizes the lack of clear clinical data linking the beneficial effects of cell therapy with modulation of the IL-13 pathway, which highlights the need for such studies. Full article

Background: Transport exclusion and difficult access to educational institutions pose a significant problem for maintaining daily routines, sleep patterns and eating habits and are a potential cause of gastroenterological disorders. This study aims to demonstrate the possible associations between transport difficulties and selected gastrointestinal symptoms. Methods: A cross-sectional anonymous online survey was conducted among 650 students aged 15–20 years from urban and rural areas. Data on place of residence, commuting time, wake-up time, breakfast habits, and gastrointestinal symptoms were analyzed by chi-square tests, nonparametric methods, and correlation analyses. Results: The survey demonstrated the association between commutes to school and the occurrence of morning nausea, abdominal pain, and irregular meal patterns. Early wake-up times are also associated with the risk of symptoms. Transport-related factors, particularly long commuting times and early wake-up schedules, are associated with more irregular eating patterns and a higher prevalence of morning gastrointestinal symptoms in adolescents. Conclusions: Transport exclusion may represent an important, yet understudied, factor influencing adolescent health. Full article

Growing water scarcity across the European Union (EU) increases the need for improved water-use efficiency in water-intensive sectors such as recreational facilities. This study evaluates the feasibility of integrating alternative water sources—including rainwater, graywater, and filter backwash water—into swimming pool operations through a comparative analysis of EU legislation and selected national regulatory frameworks. The study is based on a structured desk review of scientific literature, legal documents, and technical standards published between 2010 and 2025, complemented by a qualitative SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis. Previous studies indicate that public swimming pool facilities may consume approximately 20–50 m³ of water per day, highlighting the potential benefits of alternative water supply strategies. However, regulatory fragmentation and the absence of harmonized EU-level quality standards for recreational water reuse remain the main barriers to wider implementation. While Regulation (EU) 2020/741 establishes minimum requirements for reclaimed water reuse in agricultural irrigation, no dedicated framework exists for swimming pool facilities. Among the analyzed options, rainwater harvesting and graywater reuse appear to be the most feasible solutions. Clearer regulatory guidance and risk-management procedures could support the safe adoption of alternative water sources and contribute to improving water-use efficiency in the recreational sector. Full article

The environmental crisis and the growing need to reduce solid waste make it imperative to adopt integrated, scientifically sound, and environmentally friendly solid waste management practices in order to ensure a sustainable future. This study presents an alternative waste management proposal in accordance with the standards set out in the European Waste Directive (Directive 2018/850/EC) in order to lessen greenhouse gas emissions. The primary objective is to develop a circular waste management system that uses waste as feedstock for the production of biofuel in order to meet Catalonia’s energy needs and, at the same time, reduce its environmental footprint. Waste that is highly biodegradable and rich in organic matter cannot be disposed of in landfills, according to order TED/834/2023, and is therefore used to produce biogas through anaerobic digestion (AD) or to produce compost. In addition, gas emissions from landfills, which are rich in methane, are also collected and used for biogas production. Plans for biogas production at landfills and at an anaerobic digestion biogas plant, and for compost production from organic waste, were implemented using SuperPro Designer simulation software. The research has shown that this approach to solid waste management offers positive results in terms of energy due to biogas production, in terms of the environment due to waste reduction and compost production, and in terms of the economy due to a 25% increase in the efficiency of the biogas plant. Full article

The effect of alcohol on health is a controversial topic when it comes to the moderate or conscious consumption of fermented beverages. The recent claim by the World Health Organisation (WHO) and the European Heart Network (EHN) that the safe level of alcohol consumption is zero has compromised the efforts of the fermentation scientific community in developing healthier and more sustainable beverages. Therefore, the objective of this review was to assess the scientific background for such a claim that appears to be the result of recent scientific evidence. Using the meta-analytic data supporting WHO and EHN guidelines, it was possible to demonstrate that fermented beverages (e.g., wine and beer) have lower effects compared to spirits, that some population ethnicities have higher sensitivity to alcohol, and that drinking patterns influence the outcomes. Moreover, higher relative risks associated with younger individuals are mostly related to injuries (e.g., car accidents, self-inflicted injuries) and not with diseases. Sequential WHO studies produced significantly higher limits and emphasized that preventive policies should be tailored to populations at higher risk. In conclusion, the statement that “all alcohol is hazardous” has no scientific background and should be understood under the perspective that “one drink is too many and one thousand is never enough” used in alcoholism prevention. Fermentation researchers should continue their efforts on the promotion of healthier lifestyles, sustainable development and on the preservation of cultural heritage under the responsible drinking perspective. Full article

During elections, information manipulation on social media has accelerated the use of artificial intelligence, yet the evidence is difficult to interpret without an integrated view of methods, data, and evaluation. We mapped 557 English-language journal articles from Scopus and Web of Science, combining performance indicators, science mapping, and a focused full-text synthesis of highly cited papers. The literature grows sharply after 2019, peaks in 2025, and shows geographically uneven production, with collaboration structured around a small set of hubs. The thematic structure suggests that, during the pandemic era, infodemic-related research served as a catalyst, intensifying scientific attention to fake news and disinformation and expanding the associated detection and monitoring agendas. In addition, socio-political harm constructs such as hate speech, extremism, and polarization appear as recurrent and structurally central targets, highlighting that election-relevant work often extends beyond veracity assessment toward monitoring discourse risks. Blockchain also emerges as a novel and adjacent integrity theme, aligned with authenticity and provenance-oriented mitigation rather than mainstream detection pipelines. AI for electoral disinformation is not reducible to veracity classification, as influential studies also target automation and coordinated behavior, verification support, diffusion analysis, and estimation frameworks that focus on exposure and impact. Evaluation remains heterogeneous and is often shaped by benchmark settings, making high accuracy values hard to compare and potentially misleading when labeling quality, topic leakage, or context shift are not characterized. Overall, the findings motivate evaluation protocols that align operational objectives with modeling roles and explicitly address robustness to temporal and platform changes, asymmetric error costs during election windows, and representativeness across electoral contexts and languages, while also guiding future work on emerging integrity challenges and governance-relevant deployment settings. Full article

Wetlands play a vital role in the global carbon cycle and serve as critical carbon sink systems. However, increasing human disturbances and land-use changes have led to widespread wetland degradation, severely weakening their carbon sequestration capacity. This study investigated the Huixian Wetland in the Li River Basin of Southwest China to examine the impacts of wetland degradation on soil physicochemical properties, organic carbon fractions, and carbon fluxes. Based on vegetation and environmental conditions, the wetland was classified into four degradation gradients: non-degraded (ND), slightly degraded (SD), moderately degraded (MD), and heavily degraded (HD), and their spatial differences were systematically analyzed. The results showed that with increasing degradation, soil moisture, total nitrogen, and total phosphorus significantly decreased, whereas soil bulk density and electrical conductivity exhibited an increasing trend. Total organic carbon and active organic carbon fractions, including readily oxidizable organic carbon, light fraction organic carbon, microbial biomass carbon, and dissolved organic carbon, exhibited a pronounced decreasing trend along the degradation gradient, with the decline being most evident in the HD area. Among the labile carbon fractions, microbial biomass carbon (MBC) and light fraction organic carbon (LFOC) exhibited the most drastic declines in heavily degraded areas, indicating their high sensitivity as early warning indicators of wetland degradation. Observations of CO₂ fluxes revealed that from April to September, the net ecosystem exchange (NEE) was negative across all areas, indicating that the wetland functioned as a carbon sink overall. However, NEE values increased with higher degradation levels, suggesting a progressive decline in the carbon sequestration capacity of the wetland; ecosystem respiration (ER) peaked in July and increased with the degree of degradation. The findings indicate that wetland degradation leads to soil environment deterioration, reduction in organic carbon storage, and enhanced CO₂ emissions, ultimately weakening its carbon sink function. To enhance carbon sequestration capacity and maintain ecological functions, sustainable management strategies such as hydrological restoration and vegetation reconstruction are recommended. This study provides a scientific basis for wetland ecological conservation and carbon management in the context of climate change. Full article

Green finance has emerged as a crucial instrument for driving the macroeconomic transition toward a low-carbon economy, yet its specific transmission mechanisms warrant deeper empirical scrutiny. Leveraging China’s Green Finance Reform and Innovation Pilot Zones as a quasi-natural experiment, this scientific study employs a staggered difference-in-differences (DID) framework using provincial panel data from 2009 to 2023. To overcome the limitations of unidimensional metrics, we developed a comprehensive Industrial Structure Upgrading Index (ISUI) that integrates structural rationalization, advancement, and greening. The empirical findings reveal that the green finance pilot policy exerts a significant and positive impact on the ISUI. This core result remains robust under a series of rigorous checks, including the Callaway and Sant’Anna (CS-DID) estimator. Mechanism analyses demonstrate a dual “push–pull” dynamic: Green Credit Intensity (GCI) acts as the primary mediating channel by directing targeted financial resources (financial pull), while stringent environmental regulation positively moderates this effect (administrative push). Furthermore, the moderating role of digital finance is statistically non-significant, underscoring the policy’s broad inclusiveness and its independence from regional digital infrastructure. Heterogeneity estimations identify a clear structural catch-up effect, with more pronounced benefits observed in resource-dependent regions and areas with historically lower innovation capacities. Ultimately, these findings indicate that coordinating targeted financial incentives with environmental oversight can effectively drive multidimensional industrial upgrading, providing valuable evidence for sustainable transition strategies. Full article

To map and describe the scientific evidence on germicidal ultraviolet C (UV-C) light for hospital surface disinfection, this scoping review examined device types, reported operational parameters, microbiological and clinical outcomes, and implementation aspects. Primary studies conducted in hospital settings and evaluating UV-C or ultraviolet germicidal irradiation on environmental surfaces were searched in four databases without date restrictions. Data were synthesized descriptively in tables and narrative form following JBI and PRISMA-ScR guidance. Eleven studies (2007–2025) met the inclusion criteria. Reported microbial reductions ranged from 1 to ≥5 log₁₀. Higher and more consistent reductions were predominantly observed under laboratory or controlled experimental conditions, whereas reductions in real-world hospital surface sampling were more variable and influenced by pathogen type, surface material, room geometry, and shadowing. Integration of UV-C with manual cleaning and multi-position irradiation cycles was associated with greater effectiveness. Reporting of key radiometric parameters (dose, exposure time, and distance) was frequently incomplete, limiting reproducibility and cross-study comparability. Clinical findings were heterogeneous: some interrupted time-series analyses suggested reductions in healthcare-associated infections, although effects were not uniform across microorganisms. Implementation reports described room-level cycle times compatible with turnover, variable staffing requirements, and limited economic evaluation. Overall, UV-C appears to be a promising adjunct to standard cleaning practices in hospital environments. However, standardized radiometric reporting, multicenter studies, and robust clinical and economic evaluations are necessary to support safe, reproducible, and sustainable large-scale implementation. Full article

Background/Objectives: Oral mucositis (OM) is a common complication in onco-hematological patients undergoing chemotherapy and hematopoietic stem cell transplantation, negatively affecting comfort, nutrition, and quality of life. Despite existing assessment tools and recommendations, OM management—particularly non-pharmacological approaches—remains inconsistent, and evidence on nurses’ perspectives and contextual factors is limited. This study explored nurses’ perceptions and experiences regarding non-pharmacological treatments for OM, including educational needs and barriers and facilitators to implementation in clinical practice. Methods: A qualitative descriptive study using inductive content analysis was conducted. Semi-structured interviews were carried out with nurses working in onco-hematological settings in Italy. Data were analysed according to the Elo and Kyngäs framework. Results: Twelve nurses with extensive experience in onco-hematology and transplant care participated in the study. Five main themes emerged: (1) education and training pathways; (2) approaches to mucositis management; (3) nursing competence in OM care; (4) interprofessional collaboration; and (5) governance of practice, including protocols and guidelines. Findings highlighted strong experiential competence, high levels of nursing autonomy in assessment and patient education, and effective interprofessional collaboration, particularly in specialised settings. However, training pathways were predominantly informal, and the availability and use of protocols varied widely across clinical contexts. Conclusions: Non-pharmacological management of OM appears to be sustained primarily by advanced nursing competence and a specialised clinical culture rather than by structured education and standardised governance. Addressing educational gaps and promoting shared protocols may enhance the consistency, quality, and equity of supportive care while ensuring that the findings are clearly reflective of nurses’ experiences. Full article

The essential reaction of CO₂ hydration, fundamental to all living organisms, is facilitated by the enzyme carbonic anhydrase (CA, EC 4.2.1.1). This enzyme plays a crucial role in regulating various physiological and pathological processes. A series of heterocyclic benzenesulfonamide derivatives (19 compounds) were evaluated as possible inhibitors of human CAs. Their inhibitory properties were tested against several isoforms such as the cytosolic hCA I and hCA II, as well as the transmembrane isoforms hCA IV, hCA IX and hCA XII. The tested molecules demonstrated notable inhibitory potential, particularly toward hCA II and hCA IV, where five and four compounds, respectively, exhibited greater potency than the reference inhibitor, acetazolamide. Molecular docking simulations were further performed to elucidate the binding interactions of the most active compounds with the human CA II, IV IX and XII isoforms Full article