Search Results (2,255)

Underwater Wireless Sensor Networks (UWSNs) play a vital role in ocean monitoring and exploration. However, harsh underwater conditions and frequent topology changes caused by node and sink mobility pose significant challenges for reliable routing. Conventional routing protocols that depend on global route reconstruction and static paths generate excessive control overhead and degrade performance in large-scale underwater environments. In this paper, we propose an energy-efficient virtual cell-based mobile-sink adaptive routing (VC-MAR) protocol for UWSNs. The sensing field is logically partitioned into a three-dimensional grid of virtual cells, where a cell-gateway is elected in each cell to construct a low-overhead routing backbone. To support sink mobility, VC-MAR introduces a localized route-adjustment mechanism that updates only the affected backbone segments rather than reconstructing the entire routing structure. By confining routing updates to neighboring cells influenced by sink movement, the proposed protocol significantly reduces control packet exchanges while ensuring stable and reliable data delivery. Simulation results show that the proposed VC-MAR improves the packet delivery ratio by up to 20% and reduces routing control overhead by about 34% compared with traditional grid-based routing methods. These results confirm the suitability of VC-MAR for dynamic and realistic underwater sensing scenarios. Full article

Small-cell lung cancer (SCLC) is an aggressive neuroendocrine carcinoma characterized by poor survival. Despite a high tumor mutation burden, biomarker discovery in SCLC remains challenging due to rapid tumor plasticity and limited tissue availability, highlighting the promise of liquid biopsy-based approaches. Epigenetic dysregulation of DNA 5-hydroxymethylcytosine (5hmC) has emerged as a cancer hallmark. However, its role in SCLC remains largely unexplored. Here, we characterized the cell-free DNA (cfDNA) 5hmC landscape in SCLC and evaluated its potential applications. We profiled the cell-free hydroxymethylomes of 107 pre-treatment SCLC patients and 53 matched controls using the 5hmC selective chemical labeling (5hmC-Seal) assay. SCLC displayed higher global 5hmC levels and distinct enrichment at neurodevelopmental and synaptic pathways, consistent with the neuroendocrine identity of SCLC. Concordance between plasma and matched circulating tumor cell patient-derived xenograft (CDX) demonstrated that cfDNA 5hmC reflects tumor epigenetic states and correlates with transcriptomic-derived molecular subtypes. Elevated SCLC-specific 5hmC levels and extensive stage (ES) disease were associated with inferior survival, with ES disease showing enrichment of pathways linked to cellular plasticity and neurodevelopment. Together, these findings indicate that cfDNA 5hmC profiling has potential as a biologically informative and clinically relevant biomarker in SCLC, with possible applications in tumor subtyping and risk stratification. Full article

Accelerating environmental degradation and the continued overshoot of planetary boundaries highlight the urgent need for scientifically grounded sustainability assessments that operate across scales. While the planetary boundaries framework provides a global reference for safe environmental limits, its translation to regional and local contexts remains a methodological and practical challenge. In response, this study presents a novel scalable framework for conducting regionally explicit assessments of absolute environmental sustainability, grounded in the planetary boundaries framework. The central objective is to enable scientifically robust and globally comparable evaluations that remain sensitive to local environmental and socioeconomic conditions. The method integrates historical environmental datasets, and satellite-based Earth observation, to assess environmental impacts at the regional scale. A structured three-step process is introduced: (1) regional thresholds are derived from historical reference conditions; (2) thresholds are validated using Earth observation; and (3) environmental impacts are quantified against the validated thresholds to detect transgressions. The framework was tested in the urban core of Kiruna, northern Sweden, across five planetary boundary indicators. The results reveal substantial boundary transgressions, most notably for genetic diversity, which reaches 269 extinctions per million species-years, and for land system change, where the regional threshold is fully exceeded. These findings illustrate both the analytical value and the methodological challenges of applying planetary boundaries at fine spatial scales. Kiruna, northern Sweden, was selected as a case study due to its role as a European mining center, its location within Sámi territories, and the overlap between resource extraction and settlement. The case study illustrates the difficulty of applying planetary boundaries at fine spatial scales. This highlights the need for careful interpretation and improved calibration when downscaling global thresholds to local conditions. Ultimately, the framework reveals the potential and limitations of regionalizing planetary boundaries, highlighting the importance of methodological transparency and contextual nuance in sustainability assessment. Full article

Hops (Humulus lupulus L.) is a plant species with a multitude of uses in medicine, food science and agriculture. Xanthohumol, the major prenylflavonoid in hop cone extract, possesses anti-cancer activity. Xanthohumol also exhibits strong antimicrobial activity against Gram-positive bacteria (e.g., S. aureus), but not against Gram-negative bacteria. Xanthohumol can reduce blood glucose levels and body fat in obese male rats (not females), and mature hop bitter acids (MHBAs) have been found to decrease visceral and abdominal human fat. Xanthohumol can increase bone mineral density, decrease osteoclast numbers, and protect osteoblasts from oxidative stress in osteoporotic mice. Further clinical research, xanthohumol and bitter acids could be sourced from hop cone extracts to formulate novel drugs that can successfully treat a variety of diseases and potentially replace current therapies that have negative effects. In the food industry, hop cone extracts are mainly used in the brewing industry, with 98% of the world’s hop cones being used in brewing beer. Hop cone extracts are also used as food/drink preservatives due to their antimicrobial abilities, as previously mentioned, although there is less of a need for hops in extending food/drink shelf-life. Finally, hop cone extracts have several uses in agriculture, mainly as pesticides. For example, hop extracts can kill varroa mites, a parasite that impairs honeybee health. This benefits honeybee farmers as increased bee survival means more honey production, increasing profits. Overall, this review paper brings together recent studies that highlight hop extracts as valuable bioactive compound mixtures with many useful applications. Full article

Background: Jordan is increasingly recognized as a climate-vulnerable setting in the region, yet evidence on the psychosocial dimensions of climate change among young adults remains limited. Led by the Jordan Center for Disease Control, this study assessed climate change perceptual awareness and climate-related anxiety among university students and explored perceptions of climate impacts at global and national levels. Methods: In a cross-sectional survey conducted between April and May 2025, 1305 students were recruited from universities across Jordan using a questionnaire incorporating the 15-item Climate Change Perceptual Awareness Scale and the 13-item Climate Change Anxiety Scale. Results: Awareness of climate change and global warming was high (87% and 96%, respectively), yet only 23% were familiar with Jordan’s National Climate Change Policy 2022–2050. In regression analyses, higher climate anxiety was associated with female sex, married status, larger household size, diagnosed mental health conditions, and central-region university enrolment. Higher perceptual awareness was associated with female sex, older age, and the recognition of multidimensional climate impacts. Students identified heatwaves, drought, and forest fires as principal environmental threats, and respiratory and heat-related illnesses as foremost health concerns. Conclusions: Our findings position climate change as not only an environmental concern, but also as an educational, psychological, and public health priority. To support effective adaptation and resilience, climate awareness must be translated into informed engagement and action. Integrating climate and climate-health education into university curricula, improving youth-responsive communication of national climate strategies, and creating formal pathways for youth participation in climate governance are essential investments in Jordan’s climate resilience, health security, and long-term sustainable development. Full article

The effects of dietary tributyrin (TB) supplementation in juvenile Litopenaeus vannamei fed a high-soybean-meal diet were evaluated in an 8-week growth trial. The basal diet contained 24% fishmeal, while the experimental diet was supplemented with TB at 2.24 g kg⁻¹. Tanks were randomly assigned each dietary treatment in triplicate, with each tank consisting of 50 shrimp with 1.66 ± 0.24 g as an initial weight. Shrimp fed with the control diet exhibited the lowest growth, whereas supplementation with TB improved growth performance. For ADCs (apparent digestibility coefficients), non-significant variances were detected in dry matter, crude lipid, and crude protein; however, ash was highly significant in the control (0.00) group. Moreover, gross energy was highly significant in the TB-supplemented group. Whole-body and dorsal muscle proximate composition showed no substantial differences (p > 0.05), except that ash was highly significant in the whole body for the control diet, while lipids were highly significant in dorsal muscles for the TB diet. The biochemical, antioxidant and immune parameters of the hepatopancreas and hemolymph showed non-significant changes in both groups, except total protein (TP) and triglycerides (TGs) were highly significant in the TB-supplemented group in both the hemolymph and hepatopancreas. Conversely, malondialdehyde (MDA) was highly significant in the control group in the hemolymph. Non-significant changes were detected among treatment groups for most of the textural properties of the shrimp; however, hardness was highly significant in the control group. The TB group showed a highly significantly larger intestinal villus height (p < 0.05). Compared with shrimp fed a control diet, those receiving the tributyrin-supplemented diet showed improved gut morphology and structure, as well as enhanced histological characteristics of the hepatopancreas. Overall, TB supplementation significantly enhanced the specific growth rate, weight gain rate, final body weight, and intestinal morphology. Although some indicators were not affected, these results indicate that TB has potential as a valuable dietary supplement in aquaculture. Full article

Background: Cardiac channelopathies are rare but potentially life-threatening disorders that may present with syncope or seizure-like episodes in children, often leading to misdiagnosis and delayed recognition. Other arrhythmia-associated cardiac conditions may also present with similar clinical manifestations and require careful cardiac evaluation. Objective: To evaluate the prevalence of cardiac channelopathies and inherited arrhythmogenic cardiac disorders in pediatric patients presenting with syncope and seizure-like events and to identify associated clinical and electrocardiographic features. Methods: This retrospective cross-sectional study included pediatric patients presenting with syncope, presyncope, seizures, or seizure-like episodes who underwent cardiac evaluation at Ankara Dr. Sami Ulus Maternity and Children’s Health and Diseases Training and Research Hospital between January 2015 and April 2019. Cardiac evaluation was performed using a standard 12-lead electrocardiogram and was complemented by additional investigations, including 24 h Holter monitoring, exercise testing, pharmacological provocation, electrophysiological studies, and genetic analysis, when clinically indicated. Demographic, clinical, and diagnostic parameters were systematically evaluated. Results: A total of 363 patients were included in the final analysis. The mean age was 12.2 ± 4.7 years, and 58.7% were female. The most common diagnosis was vasovagal syncope (n = 160, 44.1%), followed by epilepsy (n = 53, 14.6%). Cardiac channelopathies, and arrhythmogenic right ventricular dysplasia (ARVD) were identified in 18 patients, corresponding to 4.9% of the pediatric cardiology-evaluated patients and 0.82% of the initial screened population. These diagnoses included long QT syndrome (n = 8), Brugada syndrome (n = 3), short QT syndrome (n = 3), catecholaminergic polymorphic ventricular tachycardia (n = 2), ARVD (n = 1), and malignant-type early repolarization (n = 1). Compared with other patients, those with cardiac channelopathies, malignant-type early repolarization, and ARVD more frequently had exercise-related triggers (p < 0.001), ventricular extrasystoles and ventricular tachycardia (p < 0.001), and abnormal exercise test findings (p < 0.001). Conclusions: Cardiac channelopathies are not uncommon in pediatric patients presenting with syncope and seizure-like events and should be considered in the differential diagnosis. Clinical triggers, family history, and electrocardiographic abnormalities may serve as important clues for early identification. A multidisciplinary approach, including detailed cardiac evaluation, is essential to prevent misdiagnosis and reduce the risk of sudden cardiac death. Full article

We construct three new families of asymmetric quantum MDS codes from nested Hermitian self-orthogonal generalized Reed–Solomon and extended generalized Reed–Solomon codes over ${\mathbb{F}}_{q^2}$. The construction is developed in three settings: affine partitions of ${\mathbb{F}}_{q^2}$, projective norm partitions of ${\mathbb{F}}_{q^2}^{*}$, and extended affine configurations obtained by adjoining the point at infinity. In each case, the Hermitian orthogonality conditions are reduced to explicit linear systems over ${\mathbb{F}}_q$, whose solvability follows from structured moment identities and Vandermonde-type arguments. This yields nested classical MDS codes satisfying the Hermitian dual-containment condition required in the Hermitian construction of asymmetric quantum codes. As a consequence, we obtain three explicit families of asymmetric quantum MDS codes with fully determined lengths, dimensions, and asymmetric distances $d_z$ and $d_x$. Our results show that affine and projective partition techniques provide a natural and effective framework for constructing optimal asymmetric quantum codes with flexible parameters. Full article

Background: Sarcopenia is highly prevalent in end-stage liver disease and is associated with adverse perioperative outcomes. However, its association with rocuronium pharmacodynamics during liver transplantation (LT) remains insufficiently defined. Aim: This study aimed to evaluate the association between sarcopenia, neuromuscular blockade kinetics, and clinical outcomes in LT recipients. Methods: In this prospective observational cohort study, 139 adult LT recipients were classified as sarcopenic (n = 70) or non-sarcopenic (n = 69) based on EWGSOP2 criteria, including SARC-F, handgrip strength, and psoas muscle index (PMI). Rocuronium (1 mg/kg, ideal body weight) was administered at induction, and quantitative neuromuscular monitoring was performed using train-of-four (TOF). The primary outcome was time to complete neuromuscular blockade (T0). Secondary outcomes included intraoperative neuromuscular recovery parameters, perioperative clinical variables, and postoperative outcomes. Multivariable GLM analyses were performed to evaluate factors associated with sarcopenia and T0, while logistic regression models were used to assess factors associated with mortality. Results: Sarcopenic patients exhibited significantly reduced PMI (p < 0.001) and lower handgrip strength (p = 0.001). In the baseline binomial-logit GLM, age was independently associated with sarcopenia (OR = 1.034, p = 0.025). The onset of neuromuscular blockade was significantly prolonged in the sarcopenic group (T0: 100 vs. 80 s; p < 0.001). In the adjusted Gamma regression model, sarcopenia remained significantly associated with longer T0 after adjustment for age, sex, MELD score, BMI, and hemoglobin level (adjusted ratio = 1.232, 95% CI: 1.105–1.372, p < 0.001). Postoperatively, they demonstrated prolonged extubation time (10 vs. 7 h; p < 0.001), extended ICU stay (9 vs. 6 days; p < 0.001), and higher mortality (27.1% vs. 8.7%; p = 0.009). In multivariable logistic regression, sarcopenia was independently associated with mortality (OR = 3.26; p = 0.023), while each additional ICU day was associated with an approximate 9% increase in mortality risk in the secondary model. Conclusions: Sarcopenia was associated with altered rocuronium pharmacodynamics in LT recipients, primarily characterized by delayed onset of complete neuromuscular blockade, and this association persisted after adjustment for age and other baseline clinical variables. Sarcopenic recipients also showed prolonged extubation time, longer ICU stay, and higher mortality. These findings support the integration of sarcopenia into perioperative risk stratification and individualized neuromuscular management strategies in this high-risk population. Full article

Advances in surgical techniques, radiographic imaging capabilities, radiotherapy, and chemotherapy have led to improved outcomes for patients with rectal adenocarcinoma. Treatment strategies have correspondingly evolved, as seen with total neoadjuvant therapy (TNT) and organ preservation approaches. TNT is a treatment strategy for primary, non-metastatic, resectable mismatch repair proficient rectal cancer where the intent is to administer all appropriate adjuvant therapy in the preoperative phase, including both systemic therapy and chemoradiotherapy/radiotherapy. In this setting, TNT is increasingly administered for the purposes of maximizing tumour response to facilitate resection, improving treatment compliance, thus increasing the likelihood of a complete response to allow for organ preservation and for the possibility of improving survival. While several recent randomized controlled trials have described the role of TNT in the contemporary treatment of rectal cancer, there is significant heterogeneity in sequencing of treatments, dosing, allowance for non-operative management, and the potential for over-treatment. Our objective here was to incorporate current evidence to develop a consensus-based institutional treatment algorithm to be used in the ambulatory and multidisciplinary team setting for the treatment of stage I–III rectal cancer. Full article

Brucellosis is a common zoonotic infection in India, caused by a facultative intracellular bacterium, Gram-negative coccobacillus, and frequently presents with nonspecific symptoms. This study aimed to assess serum cytokine levels (IL-6, IL-10, IFN-γ, and IL-2) by ELISA and to correlate them with inflammatory markers (ESR and CRP) in patients with suspected brucellosis presenting with rheumatoid arthritis-like manifestations and polyarthralgia. This study included 111 patients, comprising 72 brucellosis-positive arthritis patients and 39 brucellosis-negative arthritis patients as controls. In this study, we investigated the variation in levels of four cytokines (IL-2, IL-6, IL-10 and IFN-γ) among brucellosis-positive and brucellosis-negative arthritis patients and their relationship with clinical parameters. The mean serum levels of IL-2 and IL-10 were numerically higher in brucellosis-positive arthritis patients compared to controls; however, these differences were not statistically significant (p > 0.05). Similarly, no statistically significant differences were observed for IL-6 and IFN-γ between the groups. Inflammatory markers such as ESR and CRP were elevated in brucellosis-positive patients, although these differences did not reach statistical significance. These findings indicate variability in cytokine and inflammatory marker levels between groups. The observed associations with raw dairy consumption, contact with unvaccinated livestock, and direct animal exposure highlight the need for early diagnosis, effective livestock immunisation programs, and strengthened One Health-based public health interventions to reduce disease burden. Full article

Background/Objective: This study examines how after-hours service demands (AHSD) are associated with dentists’ overall work experience (OWE) through the mediating role of compassion satisfaction (CS) and the moderating role of perceived organizational support (POS). Grounded in the Job Demands–Resources (JD-R) and Conservation of Resources (COR) theories, the study investigates how job demands, emotional resources, and organizational support jointly relate to dentists’ psychological well-being. Methods: Data were collected from 450 dentists across seven major Libyan cities—Tripoli, Benghazi, Misrata, Sabha, Al Bayda, Zawiya, and Derna—using a structured online questionnaire administered between May and August 2025. Results: Partial least squares structural equation modeling (PLS-SEM) results indicated that AHSD were positively associated with both CS and OWE, suggesting that demanding work conditions may, under certain conditions, coincide with more positive professional experiences when perceived as meaningful and supported. CS partially mediated the AHSD–OWE relationship, highlighting its role as a key emotional resource linked to more favorable work experiences. In addition, POS moderated the relationships between AHSD and CS, and between AHSD and OWE, although the effects were relatively modest, indicating that organizational support may provide incremental support in how dentists experience demanding work conditions rather than fundamentally altering these relationships. The moderated mediation analysis further suggested that the indirect association between AHSD and OWE via CS was stronger at higher levels of POS. Conclusions: Overall, the findings refine JD-R and COR perspectives by indicating that job demands, emotional resources, and organizational support are jointly associated with dentists’ work-related well-being in a high-demand healthcare context. Full article

Background/Objectives: Mesh repair reduces hernia recurrence compared with suture repair, but permanent synthetic meshes are associated with chronic foreign-body complications. Biosynthetic poly-4-hydroxybutyrate mesh (Phasix™) provides temporary reinforcement with gradual resorption; however, short-term real-world outcomes across different hernia types remain limited. This study evaluated short-term outcomes after Phasix™ hernia repair and identified factors associated with baseline recurrent hernia at presentation. Methods: This retrospective cohort included patients ≥ 16 years who underwent open or laparoscopic hernia repair with Phasix™ at King Abdulaziz Medical City (2020–2023). Patients receiving other mesh types were excluded. Demographic, operative, and postoperative data were analyzed. Multivariable logistic regression identified factors associated with baseline recurrent hernia. Results: Among the 228 patients (51.8% female; mean age 55 years), hernia types were incisional (36.0%), paraumbilical (26.3%), and inguinal (24.6%). Early complications were uncommon: seroma in 2.2% and surgical site infection in 1.8% at 1 month. One-year recurrence occurred in 1.3% (3/228). Female sex, prior incisional hernia repair, previous mesh removal, and open repair independently predicted baseline recurrent hernia, while laparoscopic repair was protective. Conclusions: Phasix™ repair demonstrated low short-term complication rates and rare 1-year recurrence across ventral and inguinal hernias. Short-term outcomes were driven mainly by patient and procedural factors rather than mesh-specific effects. Full article

Polluted mangroves are ecologically sensitive habitats that provide ecosystem services. In a selected polluted forest of Simaisma, viable aerobic, halophilic, and heterotrophic hydrocarbon-degrading bacterial strains were isolated from both rhizosphere and non-rhizosphere regions. The chemical composition of sediment showed a clear distinction between the rhizosphere and non-rhizosphere sites, as well as coastal and non-coastal sediments, as per Principal Component Analysis (PCA) clustering. Anthracene, an indicator of oil pollution, was present along with vanadium, another marker of oil pollution. Through selective enrichment cultures, a total of 25 hydrocarbon-degrading bacterial strains were isolated, including Lysinibacillus xylanilyticus, Bacillus cereus, Lysinibacillus sphaericus, Pseudomonas stutzeri, Acinetobacter calcoaceticus, and Staphylococcus warneri. To link the adaptation of bacteria to sediment chemistry, nine B. cereus strains were investigated using their MALDI-TOF MS protein profiles combined with their dendrogram. The relationship between protein profiles of B. cereus strains with their biosurfactant production capabilities was explained by a tanglogram. The tanglegram suggests that biosurfactant production is an important functional trait in B. cereus, but it is not consistently reflected in the overall protein profile. This suggests that bacterial adaptation in the polluted mangrove sediments may involve changes at multiple cellular levels, including metabolic activity and variation in protein expression profiles. These findings confirm the involvement of mangrove-associated bacteria in the sustainability of mangrove forests by promoting bioremediation of oil pollution, thereby protecting coastal ecosystems and their environmental and socio-economic aspects. Full article

Most established street-vitality assessment tools were developed in temperate, predominantly Western urban settings and therefore do not adequately capture the climatic and socio-spatial conditions of hot–arid cities. This study develops and validates the Resident-Centered Street Vitality Framework (RCSVF) using Riyadh as a case study representative of the Arabian Desert urban context. Drawing on a cross-sectional quantitative design, the research integrates a resident survey across nineteen neighborhoods (N = 1102), physical observations of 133 street segments, a visual preference survey (N = 418), and GIS-based spatial analysis. The results reveal marked intra-urban inequality in perceived environmental quality and demonstrate that service proximity is a substantially stronger predictor of residential satisfaction than street physical quality alone. Residents consistently rated shading, green space, and pedestrian infrastructure as the weakest dimensions of their neighborhoods. These findings indicate that street vitality in hot–arid settings cannot be validly assessed through imported observer-based metrics. A resident-centered, climate-responsive framework is required to capture how thermal exposure, functional accessibility, and everyday social use interact in shaping street experience. Full article