Search Results (215)

Rapid industrialization and urbanization have progressed in Korea, yet public attention to hazardous pollutants emitted from industrial complexes remains limited. With the increasing coexistence of industrial and residential areas, there is a growing need for real-time monitoring and management plans that account for the rapid dispersion of hazardous air pollutants (HAPs). In this study, we conducted spatiotemporal data collection and analysis for the first time in Korea using real-time measurements obtained through mobile extractive differential optical absorption spectroscopy (Me-DOAS) mounted on a solar occultation flux (SOF) vehicle. The measurements were conducted in the Saha Sinpyeong–Janglim Industrial Complex in Busan, which comprises the Sasang Industrial Complex and the Sinpyeong–Janglim Industrial Complex. BTEX compounds were selected as target volatile organic compounds (VOCs), and real-time measurements of both BTEX and fine particulate matter (PM) were conducted simultaneously. Correlation analysis revealed a strong relationship between PM₁₀ and PM_2.5 (r = 0.848–0.894), indicating shared sources. In Sasang, BTEX levels were associated with traffic and localized facilities, while in Saha Sinpyeong–Janglim, the concentrations were more influenced by industrial zoning and wind patterns. Notably, inter-compound correlations such as benzene–m-xylene and p-xylene–toluene suggested possible co-emission sources. This study proposes a GIS-based, three-dimensional air quality management approach that integrates variables such as traffic volume, wind direction, and speed through real-time measurements. The findings are expected to inform effective pollution control strategies and future environmental management plans for industrial complexes. Full article

Agriculture and its related industries produce annually a vast amount of byproducts and waste which comprise a large proportion of global waste. Only a small percentage is managed with environmentally acceptable procedures, while a large proportion is either incinerated or discarded into nearby open fields, causing serious environmental burdens. Since these byproducts exhibit a rich nutritional and phytochemical content, they may be considered as raw materials for various industrial applications, initiating the need for the development of sustainable and eco-friendly methods for their valorization. Among the various methods considered, Solid-State Fermentation (SSF) constitutes an intriguing eco-friendly bioprocess, being suitable for water-insoluble mixtures and providing products with improved stability and depleted catabolic suppression. Thus, there are several literature studies highlighting the aspects and efficacy of SSF for improving the nutritional and phytochemical contents of diverse agro-industrial waste. The review herein aspires to summarize these literature results with a special focus on the enhancement of their antioxidant potency. For this purpose, specific keywords were used for searching multiple scientific databases with an emphasis on the most recent studies and higher impact journals. The presented data establish the usefulness and efficacy of the SSF bioprocess to obtain fermentation products with enhanced antioxidant profiles. Full article

Polystyrene microplastics (PS-MPs) released in the environment reportedly affect the reproduction of various organisms, induced oxidative stress and apoptosis, resulting in altered sperm parameters. In this in vitro study, we tested the cytotoxicity and genotoxicity of PS-MPs by exposing human semen samples to PS-MPs levels (105 and 210 μg/mL) for 30–60–90 min. Semen parameters, genome stability, sperm DNA fragmentation (SDF) and reactive oxygen species (ROS) production were analyzed before and after exposure. Moreover, we also evaluated the expression level of spermatozoa-specific expressed genes essential for the fusion with oocyte (DCST1, DCST2, IZUMO1, SPACA6, SOF1, and TMEM95). After PS-MP exposure, semen concentration and morphology did not differ, while sperm vitality and motility decreased in a time-dependent manner. In addition, sperm agglutination was observed in the groups exposed to both PS-MPs concentrations tested. A time- and concentration-dependent reduction in genomic stability, as well as increased SDF and ROS production, was also observed. Moreover, all investigated transcripts were down-regulated after PS-MP exposure. Our results confirm the oxidative stress-mediated genotoxicity and cytotoxicity of PS-MPs on human spermatozoa. The sperm agglutination observed after treatment could be due to the aggregation of PS-MPs already adhered to the sperm membranes, hindering sperm movement and fertilizing capability. Interestingly, the downregulation of genes required for sperm–oocyte fusion, resulting from data on the in vitro experimental system, suggests that PS-MP exposure may have implications for sperm functionality. While these findings highlight potential mechanisms of sperm dysfunction, further investigations using in vivo models are needed to determine their broader biological implications. Possible environmental and working exposure to pollutants should be considered during the counselling for male infertility. Full article

Background: The advent of direct-acting antivirals (DAAs) has marked a significant milestone in the therapeutic landscape of hepatitis C, greatly improving treatment efficacy. A therapeutic regimen encompassing sofosbuvir (SOF), velpatasvir (VEL), and voxilaprevir (VOX) has demonstrated strong efficacy across all genotypes of the hepatitis C virus (HCV) and has recently been incorporated into the Korean healthcare system. This study aimed to evaluate the real-world efficacy and safety of these antivirals in the South Korean population. Methods: This prospective, multicenter, observational study enrolled patients with chronic HCV treated with SOF/VEL-based regimens at six hospitals between November 2022 and January 2024. DAA-naïve patients received SOF/VEL ± ribavirin for 12 weeks. Patients who had failed prior DAA therapy received SOF/VEL/VOX for 12 weeks. The primary endpoint was a sustained virological response at 12 weeks post-treatment (SVR12). Results: Among 101 patients treated with SOF/VEL, the mean age was 64.71 years, and 40.9% were male. Genotypes 1b and 2 were identified in 40.6% and 59.4% of patients, respectively. Two patients had a history of interferon-based treatment. The mean baseline HCV RNA level was 3,088,097 IU/mL. Cirrhosis was observed in 26.7% of patients (21.8% compensated; 5.0% decompensated). Of the 101 patients, 12 were lost to follow-up. Among the 89 patients who completed follow-up, SVR12 was achieved in 100.0% (89/89), including 5 patients with decompensated cirrhosis. In the SOF/VEL/VOX group, 17 patients were treated. The mean age was 61.84 years, 29.4% were male, and four had compensated cirrhosis. One patient was lost to follow-up. SVR12 was achieved in 100.0% (16/16) of the patients who completed follow-up. No serious adverse events (≥grade 3) were reported in either group during the DAA treatment period. Conclusions: In this first prospective real-world study in South Korea, SOF/VEL-based regimens demonstrated excellent efficacy and safety, achieving 100% SVR12 in the per-protocol population, including patients with cirrhosis and prior treatment failure. Full article

Monitoring SF₆ decomposition gases has emerged as a vital diagnostic technique for evaluating insulation conditions and identifying faults in SF₆-based electrical equipment. This study comprehensively explores the adsorption properties and sensing capabilities of a Pd-doped InSe (Pd-InSe) monolayer for SF₆ decomposition gases, including SO₂, SOF₂, and SO₂F₂, through density functional theory calculations. The Pd-InSe monolayer is constructed by substituting one Se atom with a Pd atom in the pristine InSe structure. Then, the Pd doping effect on the InSe monolayer and the adsorption behaviors of the Pd-InSe monolayer for three gases are thoroughly examined. The adsorption configurations, charge density differences, and electron localization functions are scrutinized to elucidate the gas adsorption mechanisms of the Pd-InSe monolayer; and the band structures, along with the density of states, are analyzed to gain insights into the resistive gas sensing mechanisms for detecting these three gases. Finally, the temperature-dependent recovery characteristics are evaluated to assess the reusability of the monolayer. These findings not only underscore the potential of the Pd-InSe monolayer for sensing SF₆ decomposition gases but also open new avenues for the development of next-generation 2D materials in gas sensing applications within the field of electrical engineering. Full article

The combination of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) is recommended as a salvage therapy for treatment-experienced chronic hepatitis C (CHC) patients. However, it is used in our country for treatment-naïve and treatment-experienced patients. This study aims to present real-world data from Türkiye on CHC patients treated with SOF/VEL/VOX. The present study was conducted by the Viral Hepatitis Study Group of the Turkish Society of Clinical Microbiology and Infectious Diseases (KLİMİK). It was a multicenter, retrospective, observational study. The data were collected from patients receiving SOF/VEL/VOX therapy at 12 medical centers in Türkiye between 1 June 2022 and 31 December 2024. The patients had received the treatment for 8 to 12 weeks. Of the 139 patients enrolled, 63.3% (n = 88) were male, with a mean age of 54.4 years. Most patients were non-cirrhotic (94.2%, n = 131) and treatment-naïve (92%, n = 128); 49.6% (n = 69) were infected with genotype 1b. Early virologic response (EVR) could be assessed in 126 patients, with an EVR rate of 82.5% (n = 104). End-of-treatment data were available for 113 patients, all achieving an end-of-treatment response. Among the 80 patients for whom week-12 post-treatment data were available, 97.5% sustained virologic response at week 12 (SVR12). Significant improvements were observed in AST, ALT, and platelet levels, along with reductions in APRI and FIB-4 scores (p = 0.001).” No serious adverse events leading to treatment discontinuation were reported. Mild adverse events included pruritus (2.1%, n = 3), fatigue (2.1%, n = 3), and nausea (1.4%, n = 2). The SOF/VEL/VOX combination is a highly effective and well-tolerated treatment option in treatment-naïve CHC patients, achieving an SVR12 rate of 97.5%. Full article

Hepatitis C virus (HCV) remains a global health challenge, contributing to chronic liver disease and hepatocellular carcinoma. In Thailand, HCV prevalence has declined from ~2% in the 1990s due to universal blood screening, harm reduction, and expanded treatment. This narrative review draws on diverse sources—including PubMed and Scopus databases, international and national health websites, government reports, and local communications—to compile epidemiological data, genotype distribution, and elimination strategies, with a focus on Phetchabun province, Thailand, as a model for achieving the World Health Organization’s (WHO) hepatitis C elimination targets. National surveys in 2004, 2014, and 2024 show a prevalence drop from 2.15% to 0.56%. However, HCV persists among high-risk groups, including people who inject drugs, people living with HIV, patients undergoing maintenance hemodialysis, and prisoners. Thailand’s National Health Security Office has expanded treatment access, including universal screening for those born before 1992. The Phetchabun Model, launched in 2017, employs a decentralized test-to-treat strategy. By April 2024, 88.64% (288,203/324,916) of the target population was screened, and 4.88% were anti-HCV positive. Among those tested, 72.61% were HCV-RNA positive, and 88.17% received direct-acting antivirals (i.e., SOF/VEL), achieving >96% sustained virological response. The Phetchabun Model demonstrates a scalable approach for HCV elimination. Addressing testing costs, improving access, and integrating microelimination strategies into national policy are essential to achieving the WHO’s 2030 goals. Full article

The author reviewed and classified maintenance reports that cited smoke, odor, or fumes (SOFs) that US airlines sent to the FAA over four years between 2018 and 2023. The US fleet composition was also calculated to put the number of SOF reports on each aircraft type in perspective. “Fume events” (engine oil or hydraulic fluid) were the most common type of onboard SOFs reported by US airlines (43%), followed by electrical (20%), and fans (6.1%). During these years, A320fam aircraft made up 20% of the US fleet but 80% of the reported fume events. Conversely, B737fam aircraft made up 27% of the US fleet but only 3.0% of the reported fume events. Aircraft design features, airline reporting practices, and maintenance procedures that may contribute to these differences were reviewed. Pilots were most likely to document a fume event during descent (47%) and takeoff/climb (19%). The A320fam, MD80fam, A330, and ERJ140-145 aircraft were over-represented in other types of SOFs reports. Airline narratives show that the APU can be the primary source of oil/hydraulic fumes, even when it is not operating. Additionally, failure to find the source of fumes, rectify it, and clean any secondary sources of fumes can cause repeat events. Full article

Spent mushroom substrate (SMS), spent coffee grounds from espresso production (SCG), faba bean harvest residues (FBR), pistachio shells (PS) wheat straw (WS) (control) agro-industrial waste were combined in different ratios, with or without supplements (wheat bran, soybean flour), to create novel substrates for Pleurotus columbinus growth. The impact of the substrates on the mycelial growth rate (Kr), biomass production, laccase, total cellulases and carbohydrate synthesis, along with the C and N consumption by P. columbinus, were examined in fully colonized substrates. The incubation period, earliness and biological efficiency (B.E.) (%) were also determined. Then, the intracellular polysaccharide (ICP) contents of the P. columbinus produced mushrooms were evaluated in the most promising substrates. P. columbinus was grown successfully in a wide range of C/N ratios of substrates and the fastest Kr (7.6 mm/d) was detected on the 70 SMS-30 FBR, without supplements, whereas substrates consisting of SCG enhanced biomass production (700.0–803.7 mg/g d.w.). SMS and PS or SCG led to the shortest incubation and earliness period of P. columbinus. The C content was reduced and the N content was substantially increased in all the colonized substrates. The 70 SMS-30 FBR and 80 SMS considerably enhanced the laccase production (up to 59,933.4 U/g d.w.) and substrates consisting of PS promoted total cellulases activities. Greater amounts of carbohydrates (3.8–17.4 mg/g d.w.) than that in the control were recorded for all the substrates. The combination of SMS and SCG or WS led to the highest B.E. values (59.3–87.1%) and ICP amounts (34.7–45.9%, w/w), regardless of the supplement addition. These findings support the effective utilization of agro-industrial waste in P. columbinus cultivation, producing high-value-added compounds and supporting mushroom growth. Full article

This paper presents a method to design a parameter adaptive suspension controller to boost ride comfort and to reduce motion sickness. According to recently published papers, combined motions of a sprung mass (SPMS) along heave and pitch directions tend to make motion sickness severe. To reduce motion sickness, it is necessary to design a controller which can reduce the heave and pitch vibrations of a SPMS. To avoid full-state feedback which is very difficult to implement in a real vehicle, a static output feedback (SOF) control is chosen as a feedback structure. With the SOF structure, linear quadratic SOF and parameter adaptive controllers are designed. When designing parameter adaptive controllers, an extended Kalman filter (EKF), equivalent to recursive least square (RLS), is selected for parameter adaptation. To verify performance of the controllers, simulation is performed on vehicle simulation tool. From simulation responses, it is checked whether the proposed parameter adaptive controllers are effective or not and which is the best controller, with respect to ride comfort and motion sickness. Full article

This paper presents a method for designing a static output feedback integrated path tracking controller for autonomous vehicles. For path tracking, state–space model-based control methods, such as linear quadratic regulator, H_∞ control, sliding mode control, and model predictive control, have been selected as controller design methodologies. However, these methods adopt full-state feedback. Among the state variables, the lateral velocity, or the side-slip angle, is hard to measure in real vehicles. To cope with this problem, it is desirable to use a state estimator or static output feedback (SOF) control. In this paper, an SOF control is selected as the controller structure. To design the SOF controller, a linear quadratic optimal control and sliding mode control are adopted as controller design methodologies. Front wheel steering (FWS), rear wheel steering (RWS), four-wheel steering (4WS), four-wheel independent braking (4WIB), and driving (4WID) are adopted as actuators for path tracking and integrated as several actuator configurations. For better performance, a lookahead or preview function is introduced into the state–space model built for path tracking. To verify the performance of the SOF path tracking controller, simulations are conducted on vehicle simulation software. From the simulation results, it is shown that the SOF path tracking controller presented in this paper is effective for path tracking with limited sensor outputs. Full article

Background/Objectives: To evaluate the efficacy and visual quality provided by the extended depth-of-focus AcrySof IQ Vivity lens (Alcon Laboratories, Inc., Fort Worth, TX, USA) in patients undergoing refractive lens exchange (RLE) surgery for presbyopia correction. Methods: This descriptive prospective single-arm clinical study included 30 patients (60 eyes) aged 49–69 years (mean 60.2) who underwent clear lens surgery for presbyopia correction. Postoperative 3-month assessments included uncorrected distance visual acuity (UDVA), uncorrected intermediate visual acuity (UIVA), uncorrected near visual acuity (UNVA), distance-corrected intermediate visual acuity (DCIVA), and distance-corrected near visual acuity (DCNVA) measurements. Patient satisfaction and visual disturbances were evaluated using a standardized questionnaire. Results: Postoperative binocular visual acuity results were as follows: UDVA, 0.00 ± 0.06 logMAR; UIVA 0.08 ± 0.07 logMAR; and UNVA, 0.18 ± 0.10 logMAR. Refractive outcomes showed mean spherical equivalent values of −0.15 D ± 0.28 diopters (D) for the right eye and −0.18 D ± 0.30 D for the left eye postoperatively. Most patients (93.2%) were satisfied or very satisfied with the surgery, and 63.3% never needed glasses at any distance postoperatively. Mild and non-disabling photic phenomena were reported by 23% of patients for halos and 30% for glares. Conclusions: The study IOL provides excellent visual acuity for far and intermediate distances, as well as functional near vision under photopic conditions, with high levels of patient satisfaction and minimal visual disturbances. This lens is a promising option for non-cataract patients undergoing RLE for presbyopia correction. Full article

This paper presents two innovative wireless network designs for the automation system of the Sof-Algeen water station in Zintan, addressing the challenge of connecting field instruments—such as pressure switches, solenoid valves, and differential pressure sensors—over distances of up to 4 km. Due to high costs, limited flexibility, and scalability concerns, traditional hardwired solutions are impractical for such distances. A comprehensive analysis of various Industrial Internet of Things (IIoT) network designs determined that the IEEE 802.11 standard and Phoenix Contact’s Trusted Wireless technology best meet the project’s requirements for long-distance connectivity, real-time data acquisition, system compatibility, and compliance with national telecommunications regulations. This study proposes optimal network designs using the IEEE 802.11 standard and a hybrid mesh and star network for Trusted Wireless, and evaluates these technologies based on performance, reliability, and infrastructure compatibility using simulation. The network designs were validated using the Radio Mobile tool, considering the water station’s specific terrain and wireless module parameters. The findings indicate distinct differences in structure, operation, and cost-effectiveness between the two proposed solutions, highlighting the benefits of each in achieving optimal link feasibility for robust water station automation. Full article

With growing importance in sustainable agriculture and environmental protection, the use of liquid organic fertilizers (LOFs) as a replacement for or supplement to chemical fertilizers has grown in popularity. The effectiveness of LOFs depends on the content of elemental nutrients as well as plant growth regulators. Three types of materials, i.e., brassica vegetables, mushrooms, and soybeans, were fermented for 60 days to produce LOFs. The soybean-based fertilizer (SOF) contained the highest concentrations of mineral nutrients (0.99% N, 0.11% P), organic carbon (6.75%), and IAA (24 µg/mL), followed by the mushroom-based fertilizer (MOF) and brassica-based fertilizer (BOF). During fermentation, polyamines (PAs) in LOFs dramatically increased with time, with MOF and SOF containing higher concentrations of PAs than BOF. Greenhouse-grown rice (Oryza sativa L.) plants at 21 d old were sprayed with diluted (1:75) solutions of LOFs or chemical fertilizers (CF) before being treated for 7 and 14 days with 100 mM NaCl. For both non-stress and salt-stress groups, the root and shoot dry weights, chlorophyll contents, net photosynthesis rates, and endogenous PAs of the LOF- and CF-treated plants were significantly higher than those of the plants receiving no fertilizers. The SOF was the most effective and enhanced growth and photosynthesis at a similar level as the chemical fertilizer and had good potential to be employed as an eco-friendly substitute for chemical fertilizer. Full article

This paper presents a comparative study on active suspension controllers for ride comfort. Two types of active suspension controllers are designed and compared in terms of ride comfort: static output feedback (SOF) and parameter adaptive ones, which have identical controller structure. A quarter-car model is selected as a vehicle model. To date, LQR has been used as an active suspension controller. LQR is hard to implement in real vehicles due to the full-state measurement requirement. To avoid the full-state measurement of LQR, SOF control is selected as a controller structure in this paper. Suspension stroke and its rate are selected as sensor outputs for SOF and parameter active controllers. Two types of SOF controllers are designed. The first is the LQ SOF controller, designed with the state-space model and LQ cost function. The second is SOF controllers, designed by simulation-based optimization (SBOM) for the quarter-car model with nonlinear spring and damper. A parameter adaptive controller is designed with the recursive lease square (RLS) algorithm and its equivalent extended Kalman filter (EKF). For comparison, LQR is designed and used as a baseline. From simulation results, it is shown that the static output feedback and parameter adaptive controllers are equivalent to each other in terms of controller structure and ride comfort and which conditions are needed for better control performance on those controllers. Full article