Search Results (21)

Glyphosate is the most widely used herbicide in the world for weed control; however, due to lixiviation, wind and runoff effects, an important fraction can reach the soil, aquifers and surface waters, affecting environmental and human health. The behavior of glyphosate in two agricultural soils (C1: silty clay texture, and C2: silty loam texture) was analyzed in this study using a laboratory-scale model. Water transfer was modeled with the Richards equation, while glyphosate transport was modeled using the advection–dispersion equation, with both solved using finite difference methods. The glyphosate dispersion coefficient was obtained from laboratory concentration data derived from the soil profile via inverse modeling using a non-linear optimization algorithm. The goals of this study were to (i) quantify glyphosate retention in soils with different physical and chemical properties, (ii) calibrate a numerical model for the estimation of dispersivity and simulation of short- and long-term scenarios, and (iii) assess vulnerability to groundwater contamination. The results showed that C1 retained a greater amount of glyphosate in the soil profile, while C2 was considered more vulnerable as it liberated the contaminant more easily. The model accurately reproduced the measured concentrations, as evidenced by the RMSE and R² statistics, thus supporting further scenario simulations allowing for prediction of the fate of the herbicide in soils. The approach utilized in this study may be useful as a tool for authorities in environmental fields, enabling better control and monitoring of soil contamination. These findings highlight potential risks of contamination and reinforce the importance of agricultural management strategies. Full article

Despite advances in staged protocols and fixation techniques, treatment of pilon fractures remains a significant challenge in orthopedic trauma, with up to 21% of patients requiring revision surgery. Management of a pilon fracture that has failed initial treatment involves navigating a myriad of complicating variables, including infection, bone loss, malalignment, and nonunion. Although no single surgical approach can be aptly applied to the broad range of pathology and severity spanned by these patients, this narrative review provides a systematic framework for developing a revision pilon reconstruction plan. We present a protocol for pre-operative assessment and review current techniques for infection eradication, bone defect management, deformity correction, and joint-preserving versus joint-sparing surgery. These fundamental strategies form the foundation of a successful salvage plan and can be personalized to address specific fracture morphology, host factors, and goals of care. Full article

Irradiation with ultraviolet light-emitting diodes (UV-LEDs) represents a promising method for viral inactivation, but a detailed understanding of the wavelength-dependent action spectra remains limited, particularly across different viral components. In this study, we established standardized UV action spectra for infectivity reduction in pathogenic viruses using a system equipped with interchangeable LEDs at 13 different peak wavelengths (250–365 nm). The reduction in viral infectivity induced by UV-LED exposure was strongly related to viral genome damage, whereas no significant degradation of viral structural proteins was detected. Peak virucidal efficiency was observed at 267–270 nm across all tested viruses, representing a slight shift from the traditionally expected 260 nm nucleic acid absorption peak. Enveloped RNA viruses, including influenza A virus, respiratory syncytial virus, and coronavirus, exhibited greater UV sensitivity than nonenveloped viruses such as feline calicivirus and adenovirus. These observations indicate that structural characteristics, such as the presence of an envelope and genome organization, influence UV susceptibility. The wavelength-specific action spectra established in this study provide critical data for optimizing UV-LED disinfection systems to achieve efficient viral inactivation while minimizing energy consumption in healthcare, food safety, and environmental sanitation. Full article

This pragmatic analysis of Richard III examines how conversational strategies, speech acts, and Gricean maxims reveal the true intentions and nature of Richard and other characters. While Shakespeare’s history plays are often explored through social, cultural, historical, and political lenses, this approach focuses on understanding characterization through linguistic cues, especially Richard’s manipulative use of language. Pragmatics, a branch of linguistics, delves into the intended meanings behind interactions using linguistic signals, emphasizing the dynamics of conversation and context. In Richard III, speech acts—encompassing not just spoken words, but also the surrounding context—are crucial for understanding Richard’s ability to deceive, manipulate, and persuade. These speech acts not only convey what is said, but also the strategies employed to achieve specific goals, such as persuasion or domination. By applying pragmatic principles and speech act theory, this analysis enhances our understanding of Shakespeare’s characters and their interactions. Gricean maxims—quality, quantity, relevance, and manner—serve as a framework for exploring how Richard often flouts or manipulates these principles to control dialogue and perceptions. This combined approach reveals the layers of meaning and strategic language use that shape Richard’s character and the broader implications of his interactions within the play. This shows that Shakespeare’s theater continues to provide a compelling lens for exploring the relationship between language, politics, and identity, enhancing our comprehension of how literature both reflects and influences the socio-political context in which it was created. Full article

Rainfall-induced landslides are widely distributed in many countries. Rainfall impacts the hydraulic dynamics of groundwater and, therefore, slope stability. We derive an analytical solution of slope stability considering effective rainfall based on the Richards equation. We define effective rainfall as the total volume of rainfall stored within a given range of the unsaturated zone during rainfall events. The slope stability at the depth of interest is provided as a function of effective rainfall. The validity of analytical solutions of system states related to effective rainfall, for infinite slopes of a granite residual soil, is verified by comparing them with the corresponding numerical solutions. Additionally, three approaches to global sensitivity analysis are used to compute the sensitivity of the slope stability to a variety of factors of interest. These factors are the reciprocal of the air-entry value of the soil α, the thickness of the unsaturated zone L, the cohesion of soil c, the internal friction angle ϕ related to the effective normal stress, the slope angle β, the unit weights of soil particles γ_s, and the saturated hydraulic conductivity K_s. The results show the following: (1) The analytical solutions are accurate in terms of the relative differences between the analytical and the numerical solutions, which are within 5.00% when considering the latter as references. (2) The temporal evolutions of the shear strength of soil can be sequentially characterized as four periods: (i) strength improvement due to the increasing weight of soil caused by rainfall infiltration, (ii) strength reduction controlled by the increasing pore water pressure, (iii) strength reduction due to the effect of hydrostatic pressure in the transient saturation zone, and (iv) stable strength when all the soil is saturated. (3) The large α corresponds to high effective rainfall. (4) The factors ranked in descending order of sensitivity are as follows: α > L > c > β > γ_s > K_s > ϕ. Full article

The Shakespearean actor is a readily recognisable figure within the transatlantic cultural landscape. They may move regularly between the theatrical environs, which garnered them the appellation and more mainstream fare in television or film, but they are always, somehow, Shakespearean. However, if easily identified, the Shakespearean actor is harder to define. For example, the multi-volume Great Shakespeareans shortlists individuals who, in editors Peter Holland’s and Adrian Poole’s words, have had ‘the greatest influence on both the interpretation, understanding and reception of Shakespeare, both nationally and internationally’). But such scholarly endeavours consistently stop short of describing any social or cultural function which the Shakespearean may fill or any implicit ideological work at hand in the naming of actors as Shakespeareans. These omissions are all the more curious because, while its attribution is inherently positive in the examples above, popular culture also abounds with rather less illustrious Shakespeareans. Consider, for instance, how Niles and Frasier Crane watched, appalled, while their childhood icon, Jackson Hedley (Derek Jacobi), gurned and groaned on stage. Playing a caricature of himself in Extras, meanwhile, Ian McKellen confides that he knew what to say in The Lord of the Rings because ‘the words were written down for me’. Welcome to bad Shakespeare: a trope that has existed for as long as there has been the potential for ‘good’ Shakespeareanism. For evidence, one needs only consider Hamlet’s stubborn insistence that actors deliver their lines ‘trippingly on the tongue’. Bad Shakespeare has no such luck, however. From Mr Wopsle in Great Expectations to Alan Rickman’s frustrated thespian-turned-science-fiction-star in Galaxy Quest (‘How did I come to this? I played Richard III. There were five curtain calls’), these Shakespeareans are hammy, self-congratulating and embarrassing; they exhibit what David McGowan calls ‘visible acting’. Reversing a more typical focus on prestige and skill, this article will reflect on what it says about our relationship to Shakespeare that we take such evident and knowing pleasure in watching highly respected performers apparently fail at their jobs. Building on film studies and scholarship on badfilms, I will consider whether these fictional performances of failure only reify existing norms of ‘good’ performance or if they offer more subversive possibilities. Full article

Natural Killer (NK) cells have the potential to eliminate HIV-1-infected cells by antibody-dependent cellular cytotoxicity (ADCC). NK cell activation is tightly regulated by the engagement of its inhibitory and activating receptors. The activating receptor CD16 drives ADCC upon binding to the Fc portion of antibodies; NK cell activation is further sustained by the co-engagement of activating receptors NTB-A and 2B4. During HIV-1 infection, Nef and Vpu accessory proteins contribute to ADCC escape by downregulating the ligands of NTB-A and 2B4. HIV-1 also evades ADCC by keeping its envelope glycoproteins (Env) in a “closed” conformation which effectively masks epitopes recognized by non-neutralizing antibodies (nnAbs) which are abundant in the plasma of people living with HIV. To achieve this, the virus uses its accessory proteins Nef and Vpu to downregulate the CD4 receptor, which otherwise interacts with Env and exposes the epitopes recognized by nnAbs. Small CD4-mimetic compounds (CD4mc) have the capacity to expose these epitopes, thus sensitizing infected cells to ADCC. Given the central role of NK cell co-activating receptors NTB-A and 2B4 in Fc-effector functions, we studied their contribution to CD4mc-mediated ADCC. Despite the fact that their ligands are partially downregulated by HIV-1, we found that both co-activating receptors significantly contribute to CD4mc sensitization of HIV-1-infected cells to ADCC. Full article

Few plays make such varied or such bravura use of soliloquies as Shakespeare’s Richard III. The opening forty-one-line monologue by Richard himself allows an actor to show what he can do and to capture his audience and offers a view on processes of historical causation: having started with six uses of the word ‘our’, Richard not only moves on to say ‘I’ nine times (supplemented by ‘my’ and ‘me’), but also explains that his plans are going to affect the future of others, too. His plot to set his brothers against each other is going to change the course of history; moreover, it will do so by using the stalking-horse of a prophecy, a form of speech which presumes that the future is already unalterably fixed. Other soliloquies in the play also offer insights into historical process. This paper examines the differing tonality of the play’s soliloquies and the kind of information offered in them to argue that while Richard III officially subscribes to Tudor myths of the past, it not only implicitly urges the audience to a more sceptical take, but in fact raises questions about whether we can ever be sure about how history was made. Full article

Shakespeare’s treatment of Richard III has long been the cause of debates about Tudor defamations of the last Yorkist king. Within this context, some attention has been paid to the play’s extreme compression of events that in fact took place over a period of seven years, from the death of George, Duke of Clarence in 1478 to the Battle of Bosworth Field in 1485. This study investigates the momentum of events to gauge the extent to which the representation of Richard does paint him in an entirely negative light. Detailed analysis of the timeline demonstrates that the way the play re-structures historical moments is designed to foreground not only the figure of Richard himself, with all its attendant associations, but also the very methods used to concentrate attention upon him. The self-referential nature of the play’s relationship to history points to its own constructions, foregrounding the techniques used to show not only the legend of Richard, but how it is elaborated. The play therefore draws attention to its own manipulation of events, which in turn makes any assumptions about its representation of Richard as villain open to question. Full article

Tree growth models describe the growth and development of forest ecosystems by considering how the dimensions of each simulated tree change within a certain time. These models have commonly used three growth parameters that describe various biological processes and behaviours, considering a sigmoid growth function: (i) the upper asymptote (θ₁), which is the maximal yield indicated by a final dimension (such as the maximal stem diameter); (ii) the maximum specific growth rate (θ₂), defined as the slope of the tangent at the inflexion point; and (iii) the time elapsed (θ₃), defined by the intercept of this tangent with the abscissas. To the best of our knowledge, however, associations between the three parameters have not been documented for tree species. Using diameter growth data from pine trees located in typical mixed and uneven-aged pine-oak forests in the Sierra Madre Occidental, Mexico, our study aims were: (i) to quantify the putative associations between the three growth parameters and (ii) to test the accuracy of a proposed Hybrid Chapman-Richards growth model based on associations between the three growth parameters, but including only one single parameter, relative to the widely used Generalized Algebraic Difference Approach (GADA) based on the Chapman-Richards, Lundqvist and Hossfeld models and the Hybrid Weibull Model. For statistical comparison of the quality of the models, we used the mean relative percentage error, root mean square error, coefficient of determination and Akaike information criterion to assess the quality of the fit. Although the quality of the five growth models studied was similar, from a practical point of view, the proposed Hybrid Chapman-Richards Model (CR-H) is easier to apply than the other models and has a lower data collection and computational cost. The parameter of CR-H can be easily obtained, by measuring just the dominant trees, especially in coniferous forests with irregular ages. Moreover, in contrast to the Chapman-Richards-GADA factor χ₀, when θ₂ is assumed to be site-specific, the CR-H has always a closed-form solution. Full article

Fall armyworm (FAW) Spodoptera frugiperda (J.E. Smith, 1797) (Lepidoptera: Noctuidae) was recorded for the first time in 2016 attacking maize fields in central and west Africa. Soon after, several other regions and countries have reported the pest in almost the entire sub-Saharan Africa. In the present study, we assumed that (i) a variety of alternative plant species host FAW, especially during maize off-season, (ii) a wide range of local parasitoids have adapted to FAW and (iii) parasitoid species composition and abundance vary across seasons. During a two-year survey (from June 2018 to January 2020), parasitoids and alternative host plants were identified from maize and vegetable production sites, along streams and lowlands, on garbage dumps and old maize fields in southern and partly in the central part of Benin during both maize growing- and off-season. A total of eleven new host plant species were reported for the first time, including Cymbopogon citratus (de Candolle) Stapf (cultivated lemon grass), Bulbostylis coleotricha (A. Richard) Clarke and Pennisetum macrourum von Trinius (wild). The survey revealed seven parasitoid species belonging to four families, namely Platygastridae, Braconidae, Ichneumonidae, and Tachinidae associated with FAW on maize and alternative host plants. The most abundant parasitoid species across seasons was the egg parasitoid Telenomus remus (Nixon) (Hymenoptera: Platygastridae). These findings demonstrate FAW capability to be active during the maize off-season in the selected agro-ecologies and provide baseline information for classical and augmentative biocontrol efforts. Full article

A new high-performance numerical model (Frehg) is developed to simulate water flow in shallow coastal wetlands. Frehg solves the 2D depth-integrated, hydrostatic, Navier–Stokes equations (i.e., shallow-water equations) in the surface domain and the 3D variably-saturated Richards equation in the subsurface domain. The two domains are asynchronously coupled to model surface-subsurface exchange. The Frehg model is applied to evaluate model sensitivity to a variety of simplifications that are commonly adopted for shallow wetland models, especially the use of the diffusive wave approximation in place of the traditional Saint-Venant equations for surface flow. The results suggest that a dynamic model for momentum is preferred over diffusive wave model for shallow coastal wetlands and marshes because the latter fails to capture flow unsteadiness. Under the combined effects of evaporation and wetting/drying, using diffusive wave model leads to discrepancies in modeled surface-subsurface exchange flux in the intertidal zone where strong exchange processes occur. It indicates shallow wetland models should be built with (i) dynamic surface flow equations that capture the timing of inundation, (ii) complex topographic features that render accurate spatial extent of inundation, and (iii) variably-saturated subsurface flow solver that is capable of modeling moisture change in the subsurface due to evaporation and infiltration. Full article

Richardsitas Betsch is a small genus of Sminthurinae with only two species described so far, both from Madagascar. It resembles other Sminthurinae with long antennae, especially Temeritas Richards. Here we provide the first record of Richardsitas from Australia, Richardsitas subferoleum sp. nov., which is similar to R. najtae Betsch and R. griveaudi Betsch in males’ large abdomen chaetotaxy and presence of tenent-hairs on tibiotarsi II–III, but lacks mucronal chaeta and has 28 segments on the fourth antennal segment plus a unique pair of sensilla on the second. We also provide an updated genus diagnosis to Richardsitas, a key to its species, a discussion of the affinities of Temeritas and Richardsitas to other Sminthurinae, and an updated key to this subfamily. Full article

The multiple uses of religion in Shakespeare’s plays seem to counter each other at every turn. In one respect, though, I have found a surprising consistency. Moments when Shakespeare’s drama imagines the afterlife are moments that lend significant insights into the play’s action or characterization, even though the image of one undiscovered country may differ drastically from another. Across the canon, the afterlife may appear as a place of religious judgment, as in Othello, Hamlet, Merchant of Venice; as a classical Elysium or Hades where the spirit or shadow removes elsewhere (Antony and Cleopatra, Titus Andronicus); as Abraham’s Bosom—a place of rest between death and the Last Judgment (Henry V, Richard III, Hamlet); or an unidentifiable life to come (Measure for Measure, Macbeth, King Lear). Full article