Search Results (93,410)

This paper analyzes the role of cereal products in the diet of individuals with disorders of carbohydrate metabolism, with particular emphasis on their impact on postprandial glycemia and the risk of developing type 2 diabetes (T2D). Cereal products, as the main source of dietary carbohydrates, also provide dietary fiber, minerals, B vitamins, and key bioactive compounds such as β-glucans, arabinoxylans, resistant starch (RS), and polyphenols. These components may reduce the rate of starch digestion and glucose absorption in the small intestine by increasing the viscosity of intestinal contents or by directly inhibiting digestive enzymes such as α-glucosidase. It has been shown that fermentation of these compounds by the gut microbiota leads to the production of short-chain fatty acids (SCFAs), which improve insulin sensitivity and stimulate the secretion of incretin hormones such as GLP-1. A literature review confirms that regular consumption of whole-grain products is associated with a reduced risk of T2D, whereas refining processes and excessive grain fragmentation lead to an increased glycemic index of products. Based on clinical guidelines and a narrative synthesis of the available literature, minimally processed whole-grain products were identified as a fundamental component of dietary therapy for diabetes, which is illustrated by the cereal product pyramid presented in the paper. This review involved a comprehensive literature search in PubMed, Scopus, and Web of Science using relevant keywords. Peer-reviewed articles, reviews, and meta-analyses (mainly 2000–2025) were included based on their relevance. Full article

Edible and medicinal mushrooms are widely studied for their bioactive compounds, yet their role as sources of essential vitamins remains inadequately defined and often overestimated. This review provides a critical assessment of vitamin composition in edible and medicinal mushrooms, with an emphasis on B-group vitamins and vitamin D₂, focusing on variability, bioavailability, and limitations for nutritional applications. Current evidence indicates that mushrooms can contribute to the intake of selected B vitamins, particularly riboflavin (B₂) and thiamine (B₁), at levels comparable to common plant foods. However, their relevance as a source of vitamin B₁₂ is highly uncertain due to pronounced compositional variability, the frequent occurrence of inactive corrinoid analogues, and limited evidence of physiological bioavailability. In contrast, vitamin D₂ represents a distinctive and technologically controllable feature of mushrooms, formed via the ultraviolet-induced conversion of ergosterol. Post-harvest UV exposure can substantially enhance vitamin D₂ content, enabling targeted biofortification strategies. Nevertheless, the nutritional significance of mushroom-derived vitamins is constrained by inconsistencies in reported concentrations, lack of standardized analytical methodologies, and insufficient clinical evidence. Overall, edible and medicinal mushrooms should not be regarded as universal natural sources of vitamins; rather, their nutritional relevance depends on species, cultivation conditions, post-harvest processing, analytical verification, and, particularly in the case of vitamin D₂, controlled UV-induced biofortification. Future research should prioritize standardized analytical approaches and well-designed human studies to support evidence-based nutritional applications. Full article

Umbilical cord mesenchymal stromal cells (UC-MSCs) are a key element of regenerative medicine due to their ability to secrete growth factors that stimulate proliferation and angiogenesis, and modulate the inflammatory response. Despite their widespread use, the influence of the perinatal microenvironment on their biological properties remains poorly understood. The aim of this study was to assess the influence of pH and blood gas parameters in umbilical cord blood on the global transcriptomic profile of UC-MSCs and to analyze the correlation between the metabolic status of the newborn and the expression of key trophic factors: EGF, FGF2, FGFR1, FGFR3, GDNF, HGF, IGF1, NES, NGF, and PGF. Methods: The study was conducted in two stages. In the first phase, transcriptomic screening was performed using Affymetrix HuGene 2.0 ST microarray on cells isolated from three environmental groups defined by cord blood pH: acidic (pH < 7.35), physiological (7.35–7.39), and alkaline (pH ≥ 7.4). In the second phase, the results were validated using qPCR on an expanded study group (N = 50). Gene expression levels (RQ) were related to blood gas parameters (pH, pCO₂, pO₂, cHCO₃) and the presence of clinical features of threatened neonatal asphyxia. Results: Microarray analysis revealed that environmental pH acts as a molecular phenotypic switch. Under low pH conditions (<7.35), a shift in cell profile from proliferative to structural–migratory was observed. Significant overexpression of genes responsible for extracellular matrix (ECM) organization and adhesion (e.g., COMP, DCN, LUM, FMOD) was observed, while pathways related to cell cycle and cell division (↓CDK1, AURKA, TOP2A) were downregulated. qPCR validation confirmed these observations, demonstrating a strong positive correlation between blood pH and the expression of regenerative mediators: FGFR1 (r = 0.28), EGF (r = 0.30), NGF (r = 0.39), and IGF1 (r = 0.30). A negative correlation was also found between carbon dioxide pressure (pCO₂) and the expression of NGF, FGFR1, and EGF. A significant clinical finding was that in newborns diagnosed with threatened asphyxia, EGF, FGFR1, and NGF gene expression was significantly reduced, indicating impaired trophic potential of the cells in response to metabolic stress. Conclusions: These results indicate that cord blood gas parameters are critical regulators of the genetic activity of UC-MSCs. Metabolic and respiratory acidosis not only inhibit the cells’ proliferative potential but also force them into a matrix remodeling mode, permanently modifying their transcriptomic profile. This suggests that the neonatal acid–base status may serve as an objective indicator of the “biological quality” of isolated stromal cells, which has significant implications for their future applications in cell therapies. Full article

Background/Objectives: Advanced heart failure is associated with reduced functional capacity and impaired quality of life. Left ventricular assist devices (LVADs) are increasingly used as a long-term treatment option in patients with end-stage heart failure. Despite improvements in hemodynamic function after LVAD implantation, many patients continue to experience limitations in daily functioning. The aim of this study was to evaluate the relationship between physical activity and functional status in patients with LVAD support. Methods: This study included 262 adult participants divided into four groups according to LVAD support and declared physical activity. Functional status and quality of life were assessed using the Short Form-36 Health Survey (SF-36) and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). Results: Significant differences were observed between the analyzed groups in both SF-36 and MLHFQ scores. Physically active patients with LVAD achieved the most favorable results, indicating a better functional status and lower symptom burden, whereas inactive individuals demonstrated poorer outcomes. Significant correlations were found between physical activity and selected aspects of daily functioning, including walking, climbing stairs, performing household activities, and carrying groceries. Higher levels of physical activity were associated with better quality of life and fewer functional limitations. Conclusions: Physical activity may positively influence functional status and quality of life in patients with LVAD support. The findings suggest that regular physical activity should be considered an important component of rehabilitation and long-term management in patients with advanced heart failure treated with LVAD therapy. Full article

The digital preservation of built cultural heritage requires precise documentation techniques capable of capturing complex architectural geometries often affected by occlusions and data voids. This study presents a robust multi-sensor fusion workflow integrating Terrestrial Laser Scanning (TLS) and Unmanned Aerial Vehicle (UAV) photogrammetry for the 3D reconstruction of the Hasaköy (Sasima) Church in Niğde, Türkiye. To address the limitations of traditional registration methods, specifically the susceptibility of the Iterative Closest Point (ICP) algorithm to local minima in datasets with partial overlaps, this study proposes a fine-tuning approach based on the Multi-population Based Differential Evolution (MDE) algorithm. The methodology employs a coarse-to-fine strategy, initiating with Fast Point Feature Histogram (FPFH) extraction and RANSAC (Random Sample Consensus) for global alignment, followed by TR-ICP, MDE, PSO, and Aquila Optimizer (AO) evaluation, computational-time analysis, FPFH-radius sensitivity testing, and 6-DoF transformation decomposition to characterize both accuracy and operational cost. In the 30-run fine-tuning evaluation, MDE reduced the mean bidirectional trimmed RMSE from 0.4152 m for TR-ICP to 0.3726 m. With a population parameter of 10, MDE retained a low median RMSE of 0.3718 m, while PSO exhibited a wider stochastic tail under the same bounded 6-DoF search budget. AO produced a higher mean bidirectional trimmed RMSE of 0.5233 m. The decimeter-scale bidirectional RMSE should be interpreted as a cross-source, partial-overlap distance metric rather than sensor precision; the overlapping facade objective was approximately 2.4–2.8 cm, and the UAV block was independently controlled with a 1.34 cm GCP RMSE. This study establishes a transparent and reproducible framework for heritage documentation, supporting the faithful digital preservation of endangered monuments with complex typologies. Full article

Honey maturity is increasingly discussed in relation to product integrity, fair trade, and the classification of immature honey production as a form of adulteration. This narrative critical review examines honey maturity using evidence from peer-reviewed microbiological, physicochemical, and metabolomic studies, combined with an analysis of international and European regulatory frameworks, including Codex Alimentarius CXS 12-1981, Council Directive 2001/110/EC, Regulation (EC) No 178/2002, and Regulation (EC) No 852/2004. Particular attention is given to the interpretation of osmophilic yeast counts, water activity ($a_w$), moisture content, comb cell capping, fermentation, and technological dehumidification. The reviewed evidence indicates that osmophilic yeasts are natural components of honey and that their presence, expressed as colony-forming units per gram (CFU/g), should not be treated as an independent non-compliance criterion in the absence of active fermentation. Existing honey standards define compositional and quality requirements, including moisture, hydroxymethylfurfural, enzymatic activity, and absence of fermentation or effervescence, but do not establish a honey-specific CFU/g limit for yeasts. On this basis, the review formulates a functional maturity assessment framework integrating $a_w$, moisture, enzymatic indicators, and metabolomic biomarkers. The proposed framework is presented as a conceptual model derived from the synthesis of the existing literature and requiring further multilaboratory validation prior to adoption in official control practice. This approach may improve proportionality in honey quality assessment and reduce the risk of misclassifying microbiologically stable honeys as immature or adulterated. Full article

Plants of the genus Astragalus are recognized as rich sources of bioactive compounds with antioxidant and therapeutic potential; however, European species remain less explored than the well-known Astragalus membranaceus (Fisch.) Bunge. The aim of this study was to compare the phytochemical composition and in vitro biological activity of selected Astragalus species occurring in Poland (A. cicer L., A. glycyphyllos L., A. membranaceus). Phenolic compounds in methanolic extracts obtained from the roots and aerial parts were analyzed using spectrophotometric methods and UHPLC–DAD–ESI/TOF–MS. Antioxidant activity was evaluated using DPPH, ABTS, FRAP, CUPRAC, metal chelation, superoxide radical scavenging, and lipid peroxidation (TBARS) assays. Additionally, enzyme inhibition toward α-amylase, lipase, hyaluronidase, tyrosinase, and butyrylcholinesterase was assessed. The root of A. membranaceus exhibited the highest total phenolic content (199.84 ± 3.64 mg GAE/g extract) and the strongest antioxidant activity (DPPH IC₅₀ = 36.53 ± 1.22 µg/mL; ABTS IC₅₀ = 26.31 ± 0.03 µg/mL), as well as the most pronounced α-amylase inhibition (IC₅₀ = 17.78 ± 1.16 µg/mL). It also demonstrated moderate protective effects against AAPH-induced lipid peroxidation. The herb of A. cicer showed moderate radical scavenging capacity and the most effective inhibition of lipid peroxidation at higher concentrations. Extracts of A. glycyphyllos displayed weaker radical scavenging but notable metal-chelating properties. Selected extracts also exhibited moderate inhibitory activity against tyrosinase and butyrylcholinesterase. A. membranaceus remains the most potent source of phenolic compounds and antioxidant activity; European species such as A. cicer and A. glycyphyllos represent promising, locally available alternatives and may be used in phytotherapy and functional products. Full article

This article aims to discuss worldwide trends in the prevalence of narcissistic personality disorder (NPD) among prisoners compared to community samples. We also aim to show how this disorder is associated with criminal behavior and types of offenses. The results of the literature review document a relatively low and stable prevalence of narcissistic personality disorder compared to the frequency of other specified personality disorders in many countries worldwide. The results suggest that the rates of narcissistic personality disorder among prisoners in many countries are higher than those in communities. It has been found that this disorder is associated with domestic violence and other violent criminal behaviors, particularly with fraud and forgery violations. It has also been shown that offenders with narcissistic personality disorder are perceived as less guilty. Furthermore, research on the treatment of offenders with narcissistic personality disorder is sparse, which indicates that the treatment of NPD is limited, and it poses a challenge for mental health professionals as well as those who work in the penitentiary system. Full article

Hierarchical ZnO–SiO₂/carbon composites (C-Zn1, C-Zn2, C-Zn3) were synthesised via the carbonisation of resorcinol–formaldehyde gels in the presence of ZnO-modified fumed silica, and characterised by N₂ adsorption–desorption, FTIR, XRD, SEM, and zeta potential analysis. The composites exhibited hierarchical micro–mesoporous structures with BET surface areas of 467–499 m² g⁻¹; the non-microporous volume fraction increased from 0.09 (reference carbon RFC, 545 m² g⁻¹) to 0.54–0.63 upon ZnO–SiO₂ incorporation. Adsorption of methylene blue (MB), crystal violet (CV), and rhodamine 6G (R6G) followed the Marczewski–Jaroniec isotherm model. Maximum adsorption capacities for the best-performing composite (C-Zn1) reached 1.22 mmol g⁻¹ for MB, 1.04 mmol g⁻¹ for CV, and 0.63 mmol g⁻¹ for R6G, compared to 1.32, 1.17, and 0.67 mmol g⁻¹ for unmodified RFC. Kinetic analysis revealed up to 3.5-fold faster adsorption rates for C-Zn1 relative to RFC (for CV and R6G), attributed to enhanced diffusion through mesoporous channels while preserving the micropore-driven capacity. Agar well-diffusion assays against four bacterial strains showed no inhibition zones for any composite, indicating that no biologically active concentration of zinc species was released under the assay conditions. The proposed approach yields composites with enhanced adsorption kinetics, preserved capacity, and confirmed non-leaching character, positioning them as effective candidates for water purification. Full article

Ring-opening polymerization (ROP) of β-lactones yields biodegradable and bioresorbable polyesters exhibiting potential utility in medicine and environmental protection. β-butyrolactone (BL) is especially interesting, as it yields polymers analogous to natural poly(3-hydroxybutyrates) produced by bacteria, fungi, and enzymes in nature. The biopolymer produced by these microorganisms is isotactic. While it can be synthesized biotechnologically through the bacterial fermentation of substrates, such as sucrose, corn, and sugar, laboratory production typically involves the ring-opening polymerization of BL. However, the latter process is mainly atactic, syndiotactic, or partly isotactic, and other β-substituted β-lactones are less well-known. Ring-opening polymerization is an excellent pathway for the production of poly(β-lactones). This critical review presents the different conditions required to synthesize poly(β-lactones) and a broad overview of the different kinds of ROPs, i.e., anionic, cationic, coordinative, supramolecular-based, and enzymatic processes. A great variety of initiators/catalysts have been studied, covering both metal-based and metal-free systems (organo- and biocatalysts). In this review, several mechanisms of β-lactone polymerization are presented and discussed, especially with regard to the processes’ initiation steps. Full article

Background/Objectives: Patients with chronic kidney disease (CKD) have an increased risk of ischemic heart disease (IHD). Some discrepancies exist between cardiological and nephrological guidelines regarding the extent of diagnostic procedures in CKD patients who are candidates for kidney transplantation. The aim of this study was to assess the cardiac status of these patients after cardiological checkup. Methods: The present study included all kidney transplant candidates referred to the Regional Qualification Center between January 2021 and February 2024. We characterized the group of patients in whom IHD was diagnosed during the cardiological checkup. Results: Among 346 patients, IHD was newly identified in 44 (12.7%) subjects. These patients were significantly older [median 62.9 (51.9–65.4) vs. 47.2 (36.8–57.9) years; p < 0.001], had longer dialysis vintage [median 20 (12.5–42) vs. 14 (6–31) months; p < 0.05] and were more frequently diabetic (29.6 vs. 16.9%, p < 0.05) than the rest of the study cohort. Of note, they were also characterized by significantly more frequent manifestation of atherosclerosis lesions visualized using routine imaging methods (i.e., chest X-ray and abdominal aorta and iliac artery visualization). The stepwise logistic regression analysis revealed that age [OR 1.05 (1.02–1.09); p <0.01] and the ad hoc atherosclerotic score [OR 1.88 (1.27–2.77); p < 0.001] independently predicted the diagnosis of IHD during the cardiological qualification of potential kidney transplant candidates. Conclusions: During the cardiological examination, IHD was diagnosed in a substantial number of kidney transplant candidates. The presence of atherosclerotic lesions detected by routine noninvasive vascular system imaging methods may suggest the need for extending IHD diagnostics even in relatively young patients without clinical symptoms. Full article

The aim of this study was to evaluate the effect of matrix type and dose of polyphenolic core from rose petals on the physicochemical and functional properties of microcapsules. Microcapsules were obtained by ionotropic gelation using four carrier systems: sodium alginate (SA), sodium alginate with added starch (SA + S), protein isolate (SA + P), and vegetable gum (SA + G). Polyphenolic compounds isolated from rose petals (E) were used as the core at six concentrations (0.25, 0.5, 1.0, 1.5, 2.0, and 2.5%). Differences between microcapsules were assessed based on physicochemical properties, polyphenol and anthocyanin content, antioxidant activity, swelling index, and biocompatibility. The results showed that both the extract dose and the matrix system significantly affected the analyzed parameters. The highest encapsulation efficiency was demonstrated for the lowest dose (0.25%), regardless of the matrix used. Total polyphenol and anthocyanin content significantly increased for all microcapsule versions with increasing extract dose, with the highest concentrations obtained for the SA + G system. These results strongly correlated with antioxidant activity and biocompatibility with human colonocyte membranes. In turn, the swelling index decreased with extract dose, showing the highest values in small intestinal fluid and the lowest in gastric fluid. These findings may have significant implications for the design of functional carriers for use in food and dietary supplement production. Full article

Geometric monitoring of slender support structures, particularly steel lattice transmission towers, is a critical component of power infrastructure diagnostics. Such structures are susceptible to environmental influences and long-term deformation processes, which necessitates precise assessment of their geometric axis. The aim of this study was to evaluate the influence of the terrestrial laser scanning (TLS) scanner class and point cloud registration strategy on the determination of the geometric axis of a steel high-voltage lattice transmission tower (hereafter LTT). Unlike previous studies focused primarily on TLS-based axis reconstruction, this work introduces a comparative assessment of registration strategies, an error propagation model, and the proposed Axis Drift Index (ADI) as quantitative indicators of axis stability. The analysis was based on data obtained using a tachymetric method (reference), a compact scanner (Leica BLK360), and a survey-grade scanner (Riegl VZ-400i). The comparison included planimetric axis deviation, consistency of deformation direction, variation in results with height, and the influence of registration quality. The results show that TLS measurements performed using a survey-grade scanner and target-based registration exhibit high agreement with tachymetric results. In contrast, cloud-to-cloud registration without a stable reference framework leads to cumulative errors and instability of the reconstructed axis, particularly in the upper parts of the structure. The observed deviations in the BLK360 dataset were dominated by registration-related geometric instability rather than unequivocal structural deformation signals. The findings indicate that the accuracy of geometric axis determination in slender structures is governed more by the adopted point cloud registration strategy than by the scanner class itself. The proposed ADI parameter and linear error propagation model additionally enabled a quantitative assessment of geometric consistency with height. From an engineering perspective, this highlights the importance of stable reference systems and appropriate survey design in high-precision TLS applications. Although the study was conducted on a single lattice tower, the results provide practical insight into the reliability of TLS workflows for slender structures characterized by discontinuous geometry and high sensitivity to registration errors. Full article

Background: Acute kidney injury (AKI) is a frequent and prognostically important complication of cardiac surgery, yet early risk stratification remains challenging. The purpose of this prospective exploratory study was to determine whether preoperative vitamin levels differ in patients who develop cardiac surgery-associated AKI. Methods: Consecutive patients scheduled for cardiac surgery due to coronary artery disease and/or severe aortic stenosis between October 2024 and July 2025 were included. Fourteen patients (16.1%) had preoperative eGFR below 60 mL/min. Preoperative serum levels of vitamin A (retinol), vitamin E (α-tocopherol), and vitamin D (25-hydroxyvitamin D3) were measured. Results: A total of 87 patients (72 males (82.8%) with a median (Q1–Q3) age of 66 (61.5–71) years) were included in the study. Cardiac surgery-associated AKI occurred in 36 (41.4%), as a mild and transient impairment, with only two patients with a more severe stage requiring temporary renal replacement therapy. Patients who developed AKI had significantly higher preoperative retinol levels (p = 0.046). Retinol concentrations correlated positively with preoperative creatinine (Spearman’s rho 0.321, p = 0.002), postoperative day 0 creatinine (Spearman’s rho 0.333, p = 0.002), and postoperative day 1 creatinine (Spearman’s rho 0.268, p = 0.012), and negatively with preoperative eGFR (Spearman’s rho −0.288, p = 0.007). Tocopherol and 25(OH)D3 did not differ significantly between subgroups. No difference in vitamin levels was observed between patients with and without diabetes. Conclusions: Increased preoperative retinol levels were associated with cardiac surgery-associated AKI and correlated with perioperative renal dysfunction. Retinol may reflect impaired kidney handling of retinol and identify increased renal vulnerability in cardiac surgery patients. Retinol may represent a hypothesis-generating biomarker of cardiac surgery-associated AKI risk that warrants confirmation in larger cohorts. Full article

Background/Objectives: Despite the substantial clinical and socioeconomic burden of chronic low back pain (CLBP), objective diagnostic biomarkers remain limited. Structural alterations of the lumbosacral muscles, particularly muscle atrophy and fatty infiltration (FI), have been proposed as imaging correlates of chronic pain. This scoping review aimed to synthesize current evidence on these alterations in CLBP and characterize the imaging and segmentation methods used. Methods: The review was conducted in accordance with PRISMA-ScR guidelines and guided by the Population–Concept–Context framework. Population: adults with CLBP. Concept: MRI segmentation techniques are used to evaluate morphological soft-tissue changes. Context: clinical and research settings using MRI for CLBP evaluation. A comprehensive search of PubMed, Scopus, Embase, and Web of Science was performed for studies published between January 2014 and October 2024. Results: Twelve observational studies met the inclusion criteria. Degenerative alterations were consistently observed in CLBP and were not reported in control groups. Muscle atrophy was reported in ten studies (multifidus [MF]: 9; erector spinae [ES]: 7; psoas major [PM]: 2; paraspinal muscles [PPM]: 1; and increased FI in all studies (MF: 9; ES: 5; PM: 2; PPM: 2). Considerable heterogeneity between studies was noted. Conclusions: Lumbosacral muscles assessment may provide useful objective information for a more objective characterization of CLBP. Degenerative alterations were reported in all examined muscles except QL, with the MF most consistently affected. Changes in ES and PM may be specific for CLBP. The frequent co-occurrence of muscle atrophy and FI suggests that their combined evaluation may provide complementary information. Full article