Search Results (341)

Background: Population aging is driving a convergent rise in three disorders historically managed in isolation: cardiovascular disease, neurocognitive decline, and osteoporotic bone loss. Mechanistic data indicate that these systems are coupled through shared regulators of calcium trafficking, inflammation resolution, vascular integrity, and inflammaging. On this basis, a “Heart–Brain–Bone” axis has been proposed; it should be understood as an integrative conceptual framework that organizes evidence drawn from three separate studies, not as a validated physiological entity with agreed diagnostic criteria or demonstrated modifiability. Three lipid-soluble nutrients—long-chain omega-3 polyunsaturated fatty acids (EPA/DHA), vitamin D3 (cholecalciferol), and vitamin K2 (menaquinone-7 [MK-7])—act on overlapping nodes of this network. Methods: We performed a structured narrative review. PubMed/MEDLINE, Embase, the Cochrane Library, and Web of Science were searched from database inception to 25 June 2026 using predefined term blocks for each nutrient, each organ domain, and each candidate mechanism, and the search was updated on 7 August 2026. Records were screened against prespecified inclusion and exclusion criteria by two authors independently, with disagreements resolved by a third. The strength of evidence for each nutrient–organ relationship was graded with an explicitly defined four-level scheme ((−) to (+++)) applied separately to preclinical, observational, randomized and meta-analytic evidence. Results: Vitamin K2-dependent gamma-carboxylation of matrix Gla protein (MGP) and osteocalcin has been proposed to influence whether calcium is incorporated into the bone matrix or deposited in the arterial wall, offering a candidate mechanistic account of the “calcium paradox” associated with isolated vitamin D3 supplementation; EPA/DHA-derived specialized pro-resolving mediators may support resolution of endothelial and neuronal inflammation; and bone-, vascular- and brain-derived signals (osteocalcin, FGF23, the neurovascular unit) interconnect the three organs. These mechanisms are biologically plausible but remain insufficiently confirmed in humans. The clinical evidence is heterogeneous, formulation- and population-dependent, and comprises positive, neutral and null results: cardiovascular omega-3 trials are discordant (REDUCE-IT, which used icosapent ethyl [an EPA ethyl ester], positive; VITAL/STRENGTH/ASCEND null, predominantly in lower-risk or replete cohorts); cognitive trials are largely null or subgroup-dependent (MAPT, DO-HEALTH, VITAL); and MK-7 improves surrogate bone and calcification biomarkers and slowed coronary artery calcification in one recent randomized imaging trial (VitaK-CAC), whereas combined MK-7 plus vitamin D3 did not slow aortic valve or coronary calcification in AVADEC and MK-7 did not reduce bone loss in early menopausal women. Recognized safety signals include a dose-dependent increase in atrial fibrillation with high-dose omega-3, adverse skeletal effects of high-dose or bolus vitamin D, and clinically relevant interference of even low-dose MK-7 with vitamin K antagonist therapy. Conclusions: No adequately powered randomized trial has demonstrated that the combination of long-chain omega-3, vitamin D3 and MK-7 is superior to its individual components or to placebo for any clinical endpoint. The combined regimen is therefore mechanistically rational and hypothesis-generating rather than clinically established; benefit appears most plausible in individuals with elevated risk or demonstrable nutritional insufficiency, and least in replete, low-risk populations. Findings should be interpreted within a broader healthy-aging context that includes lifestyle and psychosocial factors. Adequately powered factorial randomized controlled trials stratified by baseline Omega-3 index, 25(OH)D and vitamin K status, with prespecified mechanistic biomarkers and hard endpoints, are required. Full article

The present study was designed to evaluate the structural and biochemical efficacy of Omega-3 fatty acids in preventing renal injury in streptozotocin (STZ)-induced diabetic kidney injury and to correlate systemic oxidative stress parameters with histological and ultrastructural parameters. Twenty-eight male Wistar Albino rats were randomly divided into four groups (n = 7) as follows: Control, Omega-3 (500 mg/kg, orally), Diabetes Mellitus (DM; 50 mg/kg STZ, i.p.), and DM+Omega-3 (STZ, followed by 500 mg/kg Omega-3 for 42 days). Biochemical analysis of renal function (blood urea nitrogen (BUN) and creatinine) and oxidative status (malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)) was measured by ELISA. Histopathological scoring and Caspase-3 staining were performed by Hematoxylin and Eosin (H&E) and immunohistochemically, respectively. Transmission Electron Microscopy (TEM) was used to examine the renal tissues. Our results showed that the DM group presented with severe hyperglycemia, uremia, and a significant oxidative shift, as evidenced by increased MDA/TOS levels and depleted antioxidant defenses. Light microscopy showed extensive glomerular damage, tubular degeneration and inflammatory infiltration in the kidneys of diabetic rats. Immunohistochemical analysis revealed strong Caspase-3 expression in the tubular and glomerular compartments. TEM showed severe podocyte effacement and damage to the glomerular basement membrane (GBM). Notably, Omega-3 supplementation significantly reversed renal dysfunction, restored the pro-oxidant/antioxidant balance and reduced histopathological injury scores. Moreover, Omega-3 treatment efficiently blocked Caspase-3-mediated apoptotic signaling and preserved the ultrastructural integrity of the glomerular filtration barrier (GFB) and tubular mitochondria. Our results demonstrate the potent nephroprotective effects of Omega-3 fatty acids in reducing oxidative stress, preventing programmed cell death and maintaining the stability of the renal parenchyma’s microarchitecture. These findings suggest that Omega-3 fatty acids could be an effective adjuvant therapeutic agent for the management of diabetic nephropathy. Full article

Hemp hurds (HHs), an underutilised lignocellulosic biomass (LB) from agricultural waste, offer potential for bioconversion into high-value bioproducts within a circular bioeconomy. Building on prior work involving magnetic nanoparticle-immobilised cellulase hydrolysis of pretreated HH, this study computationally designed candidate phaCAB expression constructs for cellulolytic hosts toward future polyhdroxybutyrate (PHB) production. The objective was to evaluate, in silico, the feasibility of introducing the phaC1, phaA and phaB1 genes from Cupriavidus necator H16 (C. necator) (assembly GCA_000009285.2; loci H16_A1437–H16_A1439) into the cellulolytic hosts Clostridium thermocellum DSM 1313 (C. thermocellum) and Trichoderma reesei RUT C-30 (T. reesei). Coding sequences were retrieved and translated individually and host-specific expression compatibility was assessed via codon adaptation index, effective number of codons, GC content and rare-codon frequency/clustering. Host-specific architectures were designed: three independent tef1-promoter cassettes with fungal Kozak contexts and cbh1 terminators for T. reesei (TrePHB3 integration construct), and a single groEL-promoter operon with graded ribosome-binding sites for the pIKM1-based C. thermocellum construct (pCtPHB1); Escherichia coli BL21 (DE3) (E. coli)/pET-24a(+) served only as an intermediate assembly platform. Clustal Omega alignment, virtual plasmid assembly and simulated restriction digestion (SnapGene) confirmed preservation of the open reading frames and expected fragment sizes. ProtParam analysis indicated instability indices below 40 and negative GRAVY values for PhaC, PhaA and PhaB, indicating overall hydrophilic character. This computational framework links HH valorisation, cellulolytic Consolidated Bioprocessing (CBP) hosts and PHB pathway design within a conceptual biorefinery, supporting future integrated biomass-valorisation platforms; it is computational only and does not demonstrate transformation, expression, PHB accumulation or biomass conversion, which require experimental validation. Full article

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are critical modulators of cardiovascular physiology, acting through anti-inflammatory signaling, membrane remodeling, and transcriptional regulation. Despite strong biological plausibility, clinical evidence remains heterogeneous. This narrative review evaluates the complexities of ω-3 supplementation, moving beyond standardized dosing to discuss the emerging role of biomarker-based assessments. While traditional low-dose mixed formulations often failed to show significant benefits, high-dose purified EPA (icosapent ethyl, 4 g/day) has demonstrated a substantial reduction in residual cardiovascular risk in specific populations. However, this clinical success is accompanied by a modest but consistent increase in atrial fibrillation risk at pharmacological doses, suggesting a need for better risk stratification. We highlight that therapeutic efficacy is closely tied to bioavailability—driven by chemical form and dietary context. In this setting, objective metrics such as the ω-3 Index or EPA/arachidonic acid (AA) ratio are discussed as validated biomarkers of ω-3 status that, although not yet incorporated into clinical guidelines as routine treatment targets, may help account for inter-individual variability. Furthermore, we address the environmental burden of marine-derived oils, considering microalgae-based alternatives as sustainable solutions. Ultimately, this review advocates for a more nuanced approach that integrates clinical evidence, the potential of biomarker monitoring, and global environmental responsibility. Full article

Biological research relies on the use of taxa, with species expressed in the form of a Latin binomial. Although taxa are commonly regarded as established entities, they actually represent hypotheses on the distribution of natural biological variation and may change their status as new systematic knowledge becomes available. A long-standing problem affecting systematics and taxonomy, with important consequences for other biological disciplines, is that a binomial itself conveys no information about the strength of the taxonomic hypothesis it represents. Here, we introduce the concept of a standardized heuristic index, named Turrill’s Omega Index (TOI), to estimate the degree of support for a taxonomic hypothesis. Turrill’s Omega Index is a single numerical value calculated by integrating four macro-categories of comparative data: Phenotype, Genealogy, Isolation, and Geography-Ecology. Turrill’s Omega Index provides a practical and reliable framework for quantifying the support for a taxonomic hypothesis, without requiring resolution of the long-standing debate surrounding species delimitation and species concepts. Accordingly, it has the potential to represent a valuable and transformative advance in systematics and taxonomy. In addition, TOI can support conservation decision-making by helping prioritize funding allocation among equally threatened taxa according to their degree of support. Full article

Background/Objectives: Post-COVID follow-up may provide an opportunity to reassess persistent and modifiable cardiometabolic risk. We characterized six-month cardiometabolic and vascular trajectories after COVID-19 hospitalization and explored associations with routinely documented dietary counseling and omega-3 recommendations. Methods: This single-center retrospective longitudinal cohort included 238 adults hospitalized with COVID-19 between March 2020 and December 2024. Patients were classified according to recorded post-discharge management as usual care (n = 64), dietary management (n = 60), omega-3 supplementation (n = 59), or combined management (n = 55). Outcomes were assessed at the index visit and at visits labeled approximately three and six months later. Longitudinal changes were estimated using generalized estimating equations; six-month associations were evaluated using baseline-adjusted ANCOVA with robust standard errors and Benjamini–Hochberg correction. Results: Mean age was 54.0 ± 10.6 years, 54.6% were women, 82.4% had hypertension, 40.8% had diabetes, and mean body mass index was 33.8 ± 4.6 kg/m². At six months, endpoint-specific data were available for 182 participants for blood pressure, total cholesterol, triglycerides, and HDL-C; 180 for waist circumference; 179 for SCORE; 177 for LDL-C and bilateral carotid IMT analyses; 173 for HOMA-IR; and 164 for IL-6. Across the cohort, systolic and diastolic blood pressure decreased by 7.91 and 4.75 mmHg; several lipid, anthropometric, and insulin-resistance markers also improved. No omnibus group-by-time interaction was significant. After false-discovery-rate correction, only higher six-month HDL-C in the dietary and combined-management groups versus usual care remained statistically significant; all other between-group findings were nonsignificant after correction. Conclusions: Several cardiometabolic risk markers improved during follow-up, but no recorded management category showed consistent trajectory-level superiority. Because intervention content and adherence, time-updated medication use, acute COVID-19 severity, and lifestyle changes were not captured, the comparative findings are exploratory and noncausal. The isolated HDL-C associations should not be interpreted as evidence of cardiovascular benefit. No cardiac biomarkers, echocardiographic measures, incident heart failure, or cardiovascular events were assessed. Full article

The quality of edible oils is determined not only by the raw material, but also by the applied processing technology. Rapeseed oil is widely valued for its favorable fatty acid profile, however, the effects of combined pressing conditions and low-temperature bleaching on its lipid profile and calculated nutritional quality indices remain insufficiently characterized. This study aimed to evaluate the effects of oil production method and bleaching earth addition on the fatty acid profile, nutritional quality indices, and oxidizability-related indices of rapeseed oil from an applied food processing perspective. Rapeseed oil samples were obtained from a commercial producer using cold pressing, hot pressing, and mixed two-stage pressing. The oils were subjected to low-temperature bleaching with 1–5% bleaching earth. The fatty acid profile was determined by gas chromatography, and selected fatty acid-based indices were calculated and grouped into three categories: fatty acid class ratios, nutritional quality indices, and oxidizability-related indices. These included ratios describing the balance between omega-6 s omega-3 polyunsaturated fatty acids (Σ PUFA n-6/n-3), unsaturated and saturated fatty acids (Σ UFA/Σ SFA), and polyunsaturated and saturated fatty acids (Σ PUFA/Σ SFA). Health-oriented indices such as the Desirable Fatty Acids/Undesirable Fatty Acids ratio (Σ DFA/Σ OFA), hypocholesterolemic/hypercholesterolemic ratio (h/H), Nutritive Value Index (NVI), Atherogenic Index (AI), and Thrombogenic Index (TI), and oxidizability-related indices including the Unsaturation Index (UI), Peroxidizability Index (PI), Oxidizability Index (OI), calculated Oxidizability Value (Cox), and Oxidative Stability Index (OS). The results showed that the production method significantly influenced saturated fatty acid content and selected fatty acid-based nutritional quality indices. Cold-pressed oil was characterized by the lowest saturated fatty acid content and the most beneficial values of selected nutritional quality indices. Hot-pressed oil showed higher saturated fatty acid content and less favorable values for selected indices, whereas mixed oil generally showed values between those of cold-pressed and hot-pressed oils. However, differences in the main unsaturated fatty acid fractions were limited and, for most monounsaturated and polyunsaturated fatty acid parameters, were not statistically significant. Across all processing variants, the nutritional quality indices remained advantageous, with omega-6/omega-3 polyunsaturated fatty acid ratio values of 2.1–2.4, atherogenic index values of approximately 0.04–0.05, and thrombogenic index values of approximately 0.08–0.09. Although significant interactions between production method and bleaching earth addition were observed for selected oxidizability-related indices, the magnitude of bleaching-induced changes was limited. Overall, the findings indicate that low-temperature bleaching may be applied as a mild processing step without substantially compromising the fatty acid-based quality characteristics of rapeseed oil. The study provides practical insight into the relationship between pressing technology, bleaching conditions, and lipid quality assessment in industrial rapeseed oil production. Full article

Background: This study investigated the relationship between erythrocyte membrane fatty acids, omega-3 index, and zinc protoporphyrin (ZnPP) levels in hemodialysis (HD) patients across hemoglobin-defined anemia severities. Methods: This prospective cross-sectional study included 117 chronic HD patients and 28 healthy controls. ZnPP was measured by high-performance liquid chromatography, and erythrocyte membrane fatty acids by gas chromatography–mass spectrometry. Results: HD patients showed a significantly lower omega-3 index than controls (p < 0.0001), although it did not differ across hemoglobin-defined groups (p = 0.589). Palmitic and erucic acid were higher, whereas oleic acid was lower, in patients with lower hemoglobin. In unadjusted analyses, hemoglobin correlated inversely with palmitic acid (r = −0.220, p = 0.017) and erucic acid (r = −0.183, p = 0.048), whereas the positive association with oleic acid (r = 0.451, p < 0.0001) remained significant after false discovery rate (FDR) correction. ZnPP increased as hemoglobin decreased (p = 0.013) and was negatively associated with hemoglobin (r = −0.406, p < 0.0001). Conclusions: HD patients with lower hemoglobin showed altered erythrocyte membrane fatty acid composition; among fatty acids, only the oleic acid–hemoglobin association remained significant after FDR correction. ZnPP rose as hemoglobin declined and was independently inversely associated with hemoglobin after multivariable adjustment (β = −0.051, p < 0.0001), independent of any dichotomous reference definition, supporting ZnPP as a continuous marker of anemia severity and iron-restricted erythropoiesis in HD patients. Full article

Background: Psychosocial well-being at work is a multidimensional construct associated with employee health, organizational functioning, sustainable workforce development, and population mental health. However, few theoretically integrated instruments simultaneously assess work-related resources, job demands, psychosocial risks, and employee subjective well-being. This study aimed to develop and conduct the initial validation of the Multidimensional Psychosocial Work Environment Scale for Employed Persons (MPWES), grounded in the OECD well-being framework, the WHO-5 conceptual approach, and the Job Demands–Resources model. Methods: Scale development involved theory-driven identification of psychosocial dimensions, item generation, content and face validity assessment, and stepwise psychometric evaluation. Content validity was assessed using the Content Validity Index, and face validity using the Face Validity Index. The hypothesized structure was examined using confirmatory factor analysis. Internal consistency was evaluated using Cronbach’s alpha and McDonald’s omega, while convergent and discriminant validity were assessed using Average Variance Extracted, Composite Reliability, and inter-factor correlations. Results: The proposed measurement model comprised ten dimensions: Subjective Well-Being, Inclusion, Social Support, Workplace Harassment, Work Intensity, Work-related Psychosomatic Strain, Professional Development, Health Risks, Financial Safety, and Autonomy. CFA results provided preliminary and partial support for the proposed ten-factor structure, with borderline-to-acceptable absolute fit indices but limited-to-moderate incremental fit indices. Most dimensions demonstrated acceptable internal consistency; however, convergent and discriminant validity findings should be interpreted cautiously, particularly for dimensions with few items, Financial Safety, and the high correlation between Inclusion and Social Support. Conclusions: The findings provide preliminary empirical support for the MPWES as an initial integrated assessment framework. Further longitudinal, cross-cultural, and independent validation is required. Full article

Background/Objectives: The obesity epidemic coexists with the phenomenon of “hidden hunger” (Type B malnutrition)—a micronutrient deficiency amidst a caloric excess. Traditional dietary assessment methods often distort the actual picture by ignoring technological losses during cooking, which necessitates the use of digital tools. Methods: A cross-sectional study (N = 3267) was conducted using the digital platform “NIAP”. The analysis was based on valid 3–7-day dietary records with algorithmic accounting for nutrient retention factors during thermal processing. The nutrient profiles of individuals with a normal body mass index (BMI) and obesity (BMI ≥ 30 kg/m²) were compared. Results: The epidemiology of intake shortfalls was highly prevalent and pronounced: 99.9% of the cohort had ≥1 inadequacy (with a mean negative deviation of −77.3% for vitamin D and −59.2% for Omega-3), and 61.5% exhibited ≥10 simultaneous multiple intake shortfalls. These inadequacy rates remained robust in a sensitivity analysis excluding under-reporters. The obesity group consumed significantly more energy, saturated fatty acids, added sugars, cholesterol, and sodium, but demonstrated a lower relative macronutrient intake (g/kg of body weight). Absolute fiber intake did not differ between the groups, indicating a decrease in its density per 1000 kcal in the diet of individuals with obesity; the intake of Omega-3 polyunsaturated fatty acids (PUFAs) showed a downward trend. The Na:K ratio was significantly higher in the obesity group (1.19 vs. 1.04, p < 0.001). Correlation analysis confirmed an inverse relationship between BMI and the overall nutrient density of the diet. Conclusions: A high-energy diet does not compensate for systemic micronutrient inadequacy among the evaluated cohort. Obesity is associated with a dietary imbalance favoring “empty calories” and pro-inflammatory components against a background of severe multiple dietary inadequacies. The integration of algorithmic dietary assessment that accounts for cooking losses is critical for objective diagnosis and personalized nutritional intervention. Full article

Anisotropic, Tellegen, chiral, moving-medium-type, omega, gyrotropic, hyperbolic, and multi-hyperbolic materials form an important class of isotropy-broken photonic media in which wave propagation can no longer be characterized by the Fresnel wave surface alone. Here we show that Fresnel wave surfaces can be converted into propagation maps that organize positive- and negative-phase-velocity propagation together with attenuation and amplification. In Hermitian media, the boundary between forward and backward propagation forms the orthogonal-phase-velocity separatrix. This separatrix is also a continuous locus of orthogonal-phase-velocity exceptional points, where the index-of-refraction operator becomes defective even though the material medium remains Hermitian. In non-Hermitian media, the attenuation–amplification boundary forms the loss–gain separatrix. The associated loss–gain singularities occur where the handedness remains continuous while the gain–loss character changes sign. Their physical importance is revealed by the momentum-resolved density of states: at these points, the Lorentzian linewidth of the non-Hermitian momentum-resolved density of states (DOS) collapses, producing sharp DOS peaks whose sign reverses across the separatrix. Thus, loss–gain singularities are threshold-like singularities of the Fresnel wave-surface propagation map, generated by non-Hermitian linewidth collapse. The result is a compact geometric language for describing how handedness, degeneracy, loss, gain, and momentum-resolved DOS are organized in isotropy-broken electromagnetic materials. Full article

Critically ill obese patients with gynecological cancer represent a high-risk population with complex nutritional needs. Although excess adiposity may suggest adequate energy reserves, it often conceals sarcopenia, micronutrient deficiencies, and functional malnutrition, contributing to impaired wound healing, immune dysfunction, prolonged mechanical ventilation, increased susceptibility to infections, and adverse oncologic outcomes. Obesity-associated inflammation, insulin resistance, and tumor-driven catabolism further exacerbate metabolic stress and complicate nutritional management in the intensive care setting. Accurate nutritional assessment requires a multimodal approach incorporating body composition analysis, functional measures, and laboratory parameters, as conventional indices such as body mass index may underestimate nutritional risk. Nutritional support should be individualized and may include early enteral nutrition to preserve gut integrity, supplemental or total parenteral nutrition when gastrointestinal function is compromised, high-protein regimens, and targeted micronutrient replacement. Immunonutrition, including arginine, glutamine, omega-3 fatty acids, and nucleotides, has emerged as a promising strategy to modulate inflammation, enhance immune function, and support tissue repair. This narrative review summarizes current evidence regarding obesity-related metabolic dysfunction, nutritional assessment, enteral and parenteral nutrition, and immunonutrition in obese critically ill patients with gynecological cancer. It highlights the challenges associated with sarcopenic obesity and hidden malnutrition while providing a clinically relevant overview for intensivists, gynecologic oncologists, surgeons, and nutrition specialists. Early recognition of nutritional risk and implementation of individualized multimodal nutritional strategies may improve recovery and clinical outcomes. However, high-quality ICU-specific studies remain limited, and further prospective research is needed to establish evidence-based nutritional protocols and evaluate their impact on survival, treatment tolerance, and quality of life in this vulnerable population. Full article

Background/Objective: Low back pain (LBP) is a leading cause of disability worldwide, and patient-reported outcome measures such as the Roland–Morris Disability Questionnaire (RMDQ) are essential for assessing LBP-related disability. While the Modern Standard Arabic version of the RMDQ has demonstrated preliminary reliability, its structural validity has not been thoroughly evaluated. This study aimed to assess the structural validity of the Modern Standard Arabic RMDQ using confirmatory factor analysis (CFA). Methods: A cross-sectional study was conducted for 113 patients with LBP recruited from outpatient physical therapy clinics in Saudi Arabia. Participants completed the Modern Standard Arabic RMDQ, a 24-item instrument scored dichotomously. CFA was performed using the Weighted Least Squares Mean and Variance adjusted estimator to test a unidimensional model. Model fit was assessed using Root Mean Square Error of Approximation (RMSEA), Standardized Root Mean Square Residual (SRMR), Tucker–Lewis Index (TLI), and Comparative Fit Index (CFI). Reliability was evaluated using McDonald’s omega (ω). Results: The initial one-factor CFA model showed close to acceptable fit (RMSEA = 0.044; SRMR = 0.149; TLI = 0.94; CFI = 0.93). After accounting for significant residual correlations between item pairs (items 4 & 21; 13 & 18), model fit improved (Δχ² = 22.33; Δdf = 2; p < 0.001) (RMSEA = 0.038; SRMR = 0.145; TLI = 0.95; CFI = 0.95). Most items had significant loadings on the latent construct, except item 2. McDonald’s ω was 0.91, indicating excellent internal consistency. Conclusions: The findings of this study provide supportive evidence for the structural validity and internal consistency of the Modern Standard Arabic version of the RMDQ and suggest the presence of a dominant unidimensional structure. The Arabic RMDQ may be useful for assessing LBP-related disability in Arabic-speaking patients with LBP, although further validation studies are warranted. Full article

In this study, a new approach to improving the fire resistance of flexible polyurethane (PUR) foams is presented, based on the incorporation of cotton chemically modified with boron compounds into the polyurethane matrix. The developed system was additionally modified with melamine polyphosphate (MPP). The effects of the applied modifications on the morphology and chemical structure of the PUR composites were investigated using scanning electron microscopy and infrared spectroscopy. Thermal stability was evaluated by thermogravimetric analysis, whereas fire hazard was assessed using cone calorimetry and a smoke optical density chamber. The toxicometric index (WLC_50SM) was determined using a coupled TG-Omega 5 gas analyzer system. The results provide insight into the mechanism responsible for reducing flammability and limiting the emission of toxic combustion and thermal decomposition products through the modification of PUR foams with chemically modified cotton in combination with MPP. It was observed that, during the combustion of the developed PUR composites, the addition of cotton promotes the formation of a three-dimensional spatial network, which substantially limits heat release and the emission of toxic combustion products. Consequently, the composites exhibited a reduction in heat release of up to 67% in terms of HRR_MAX, together with decreased production of HCN and CO. Nevertheless, the formation of a protective carbon layer contributed to an increase in smoke optical density, which was associated with increased CO₂ emission. Overall, this work demonstrates the development of a new synergistic system capable of reducing both the flammability and toxicity of flexible PUR foams. Full article

Background: Ageism is a global public health concern associated with poorer health outcomes and inequities in care. Culturally adapted instruments are needed to assess ageist attitudes among healthcare professionals in Spain. This study aimed to cross-culturally adapt and evaluate the preliminary psychometric properties of the Spanish version of the Fraboni Scale of Ageism (FSA-SV). Methods: A methodological study was conducted, including translation and back-translation, expert review, and a pilot test. Content validity was assessed using the content validity index (CVI), the modified kappa coefficient, and Aiken’s V. A descriptive cross-sectional pilot study was conducted with 101 healthcare professionals from a single health department in Valencia to evaluate comprehension and reliability. Internal consistency was examined using Cronbach’s alpha and McDonald’s omega. Results: Content validity indices indicated acceptable agreement among experts (S-CVI = 0.745; Aiken’s V = 0.770). All items were retained to preserve conceptual and structural equivalence with the original instrument. The FSA-SV demonstrated high internal consistency (Cronbach’s alpha = 0.903; McDonald’s omega = 0.915). The mean total score was 51.2 (SD = 9.62), with no significant associations observed between ageism and participants’ sociodemographic or professional variables. Conclusions: This pilot study represents a first step in the cross-cultural adaptation and preliminary psychometric evaluation of the FSA-SV for use among healthcare professionals in Spain. The results suggest that the instrument shows promising initial properties for the preliminary assessment of ageism, supporting its potential utility in future research and in evaluating educational and organizational interventions aimed at reducing ageism and improving the quality and safety of care for older adults. Further studies with larger, more diverse samples are required to evaluate additional psychometric properties, including the factorial structure. Full article