Antioxidants in Chronic and End Stage Kidney Stage: Defining Biological and Clinical Plausibility
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 January 2026
Special Issue Editors
Interests: CKD; hemodialysis; oxidative stress; vitamin K; diabetic nephropathy; vascular calcification; CVD; matrix GLA protein
Special Issues, Collections and Topics in MDPI journals
Interests: chronic kidney disease; cardiovascular disease; vascular calcification; diabetes mellitus; hemodialysis; peritoneal dialysis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
During recent years, oxidative stress has been at the center of scientific research in both chronic (CKD) and end-stage kidney disease (ESKD) patients. It has emerged as a novel risk factor for cardiovascular disease. These populations exhibit a marked deficiency of various antioxidants due to dietary restrictions, the intestine's incapacity to absorb vitamins and minerals, and the loss of antioxidants through dialysis membranes, which leads to increased oxidative stress.
Although it is known that oxidative stress occurs early in chronic kidney stage and is progressively increased with deterioration of kidney function, several questions remain unanswered regarding the possible clinical role of various exogenous supplemented antioxidants and the biological role of endogenous antioxidants, including Vitamins (B, C, D, E, K), N-acetylcysteine, Superoxide dismutase, catalase and glutathione. The data regarding the potential beneficial effects of antioxidants on diseases and clinical outcomes in these populations are scarce and primarily derived from experimental studies. Large, clinical studies in CKD and ESKD cohorts are still lacking.
We invite research (in vitro, in vivo, and clinical studies) and review articles to this Special Issue, on any of these topics: pathophysiology of antioxidants in CKD and ESKD, regulation, clinical roles of antioxidants in cardiovascular disease, longevity, kidney function, cognitive function, anemia, vascular calcification, and calcium-phosphate balance.
Dr. Stefanos Roumeliotis
Dr. Vassilios Liakopoulos
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CKD
- ESKD
- Cardiovascular Disease
- Catalase
- Chronic Kidney Disease
- End Stage Kidney Disease
- N- acetylcysteine
- Superoxide Dismutase
- Vascular Calcification
- Vitamin C
- Vitamin E
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