Antioxidants in Chronic and End Stage Kidney Stage: Defining Biological and Clinical Plausibility

Dear Colleagues,

During recent years, oxidative stress has been at the center of scientific research in both chronic (CKD) and end-stage kidney disease (ESKD) patients. It has emerged as a novel risk factor for cardiovascular disease. These populations exhibit a marked deficiency of various antioxidants due to dietary restrictions, the intestine's incapacity to absorb vitamins and minerals, and the loss of antioxidants through dialysis membranes, which leads to increased oxidative stress.

Although it is known that oxidative stress occurs early in chronic kidney stage and is progressively increased with deterioration of kidney function, several questions remain unanswered regarding the possible clinical role of various exogenous supplemented antioxidants and the biological role of endogenous antioxidants, including Vitamins (B, C, D, E, K), N-acetylcysteine, Superoxide dismutase, catalase and glutathione. The data regarding the potential beneficial effects of antioxidants on diseases and clinical outcomes in these populations are scarce and primarily derived from experimental studies. Large, clinical studies in CKD and ESKD cohorts are still lacking.

We invite research (in vitro, in vivo, and clinical studies) and review articles to this Special Issue, on any of these topics: pathophysiology of antioxidants in CKD and ESKD, regulation, clinical roles of antioxidants in cardiovascular disease, longevity, kidney function, cognitive function, anemia, vascular calcification, and calcium-phosphate balance.

Dr. Stefanos Roumeliotis
Dr. Vassilios Liakopoulos
Guest Editors

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