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Case Report

11 Citations

3,408 Views

10 Pages

A Diagnostic of Acquired Hemophilia Following PD1/PDL1 Inhibitors in Advanced Melanoma: The Experience of Two Patients and a Literature Review

Antonio Gidaro,
Giuseppe Palmieri,
Mattia Donadoni,
Lucia A. Mameli,
Leyla La Cava,
Giuseppe Sanna,
Dante Castro,
Alessandro P. Delitala,
Roberto Manetti and
Roberto Castelli

Diagnostics2022, 12(10), 2559;https://doi.org/10.3390/diagnostics12102559

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21 October 2022

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the development of specific autoantibodies against factor VIII (FVIII). Immunotherapy is a recent therapeutic option that targets the patient’s self-tolerance against tumor cells...

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Case Report

1 Citations

2,338 Views

8 Pages

Hemoperitoneum as a Life-Threatening Complication of an Acute Cholecystitis in a Patient with Hemophilia A with Inhibitors: A Case Report

Oana Viola Badulescu,
Adelina Papancea,
Nina Filip,
Bogdan Mihnea Ciuntu,
Ciprian Cirdeiu,
Gabriela Bordeianu,
Dan Vintila,
Minerva Codruta Badescu,
Manuela Ciocoiu and
Stefan Octavian Georgescu

Healthcare2022, 10(9), 1652;https://doi.org/10.3390/healthcare10091652

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30 August 2022

We present the case of a 52-year-old male with severe hemophilia A with inhibitors, who was diagnosticated with acute lithiasic cholecystitis that required surgical intervention due to lack of favorable response to conservatory treatment. During surg...

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Article

8 Citations

9,103 Views

16 Pages

Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment

Othman Montacir,
Houda Montacir,
Murat Eravci,
Andreas Springer,
Stephan Hinderlich,
Fereidoun Mahboudi,
Amirhossein Saadati and
Maria Kristina Parr

Bioengineering2018, 5(1), 7;https://doi.org/10.3390/bioengineering5010007

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19 January 2018

Eptacog alfa (NovoSeven^®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amin...

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