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Identification of a Novel Inhibitor of TfR1 from Designed and Synthesized Muriceidine A Derivatives
- Yu Wu,
- Zongchen Ma,
- Xiaoyuan Mai,
- Xiaoling Liu,
- Pinglin Li,
- Xin Qi,
- Guoqiang Li and
- Jing Li
The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed in malignant cells, and this increase may be associated with poor prognosis in different...