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Keywords = Lactobacillus helveticus postbiotics (LHPs)

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17 pages, 2387 KB  
Article
Application of Lactobacillus helveticus KLDS 1.1105 Postbiotics for Resisting Pathogenic Bacteria Infection in the Intestine
by Peng Du, Jiaying Liu, Chengwen Hu, Jianing Zhang, Miao Li, Yu Xin, Libo Liu, Aili Li and Chun Li
Foods 2025, 14(15), 2659; https://doi.org/10.3390/foods14152659 - 29 Jul 2025
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Abstract
Postbiotics, defined as metabolites produced by probiotics, encompass both bacterial cells and their metabolic byproducts, and offer significant health benefits to the host. However, there are relatively few reports on their effects on intestinal microbiota. In this study, we investigated the components, total [...] Read more.
Postbiotics, defined as metabolites produced by probiotics, encompass both bacterial cells and their metabolic byproducts, and offer significant health benefits to the host. However, there are relatively few reports on their effects on intestinal microbiota. In this study, we investigated the components, total antioxidant capacity of Lactobacillus helveticus postbiotics (LHPs) and their impact on intestinal flora using the Simulator for Human Intestinal Microecology Simulation (SHIME). The results indicate that the primary components of postbiotics include polysaccharides, proteins, and organic acids. Furthermore, LHPs have a strong ability to inhibit the growth of harmful bacteria while promoting the growth of probiotics. Additionally, LHPs significantly increased the total antioxidant capacity in the intestine and regulated the balance of intestinal microbiota. Notably, there was also a significant increase in the content of short-chain fatty acids (SCFAs) in the intestine. Overall, LHPs have the potential to aid in the prevention and treatment of diseases by enhancing gut microbiology. Full article
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