Search Results (86)

The functional genomic mechanisms contributing to aging-associated decline in fertility in men remain insufficiently elucidated. This study investigated age-related alterations in the sperm metabolome of healthy fertile Arab men across three groups: young adult (21–30 years, n = 6), late adult (31–40 years, n = 7), and advanced age (41–51 years, n = 5). Metabolomics was performed using LC-MS/MS. Statistical/functional analyses were performed using MetaboAnalyst-Pro. A total of 380 metabolites were identified, of which 164 showed significant differences (p < 0.05) across age groups. Principal component analysis, partial least squares-discriminate (PLS-DA), and sparse PLS-DA consistently demonstrated distinct metabolomic clustering between young adult and advanced age groups. Notably, in the advanced-age spermatozoa, L-homocysteine was undetectable, while methyloctadecanoyl-CoA was uniquely abundant. Biomarker analysis identified 137 potential aging-sperm biomarkers (AUC = 1), including upregulated (e.g., pentadecanoyl-CoA, (3S)-3-hydroxylinoleoyl-CoA, CDP-DG(LTE4/20:4(8Z11Z14Z17Z)), uracil) and downregulated (e.g., (S)-hydroxyoctanoyl-CoA, DG(22:6/18:4), L-homocysteine, N-myristoyl serine) metabolites. These biomarkers participate in key sperm domains, including motility, energy metabolism, membrane remodeling, oxidative-stress regulation, and fertilization. In conclusion, advancing age disrupts sperm “metabolostasis” (metabolite homeostasis essential for normal function), compromising their physiological integrity and fertilization competence. The identified biomarkers offer promising targets for interventions to preserve sperm health and mitigate age-related fertility decline. Full article

The Cooperative-Intelligent Transport Systems (C-ITS) require emerging Vehicular-to-Everything (V2X) applications, such as Advanced Driving Systems (ADS) and Connected Autonomous Driving (CAD), to support efficient road safety measures. These applications often require high reliability, throughput, and low latency by exchanging a significant amount of data among End-to-End (E2E) vehicles. However, current V2X communication technologies, such as DSRC and C-V2X, are not able to meet these stringent demands. Two or more Radio Access Technologies (RATs) are essential to guarantee the required Quality of Service (QoS) in high-density vehicular environments. To address this critical gap, this survey presents the 3M Framework—a hybrid vehicular architecture approach based on Multi-Radio Access Technology (M-RAT), Mobility Management, and Machine Learning (ML). The manuscript provides a detailed overview of V2X Multi-RAT evolutions, analyzing their state-of-the-art and limitations in heterogeneous scenarios. We specifically highlight that the existing Long Term Evolution (LTE)-based mobility management fails to meet V2X handover requirements for high-speed vehicles, necessitating a comprehensive overview of Vertical Handover (VHO). Furthermore, the survey details how the integration of ML promotes the prediction of network states, enabling optimized context-aware decisions for connectivity and resource allocation, thereby reducing Handover Failures (HoFs) and enhancing reliability using techniques like Deep Reinforcement Learning (DRL). Finally, based on a comprehensive review of existing methods, the paper identifies critical research directions and challenges required to realize intelligent, hyper-fast, and ultra-reliable Beyond 5G (B5G) and Sixth Generation (6G) V2X networks, delivering a more profound understanding for future endeavors. Full article

While BioTRIZ is widely employed in biomimetic design to facilitate creative ideation and standardize workflows, accurately formulating domain conflicts and assessing design schemes during critical stages—such as initial concept development and scheme evaluation—remains a significant challenge. To address these issues, this study proposes an advanced BioTRIZ method. Firstly, the theory of technological evolution is integrated into the domain conflict identification stage, resulting in the development of a prompt framework based on patent analysis to guide large language models (LLMs) in verifying the laws of technological evolution (LTE). Building on these insights, domain conflicts encountered throughout the design process are formulated, and inventive principles with heuristic value, alongside standardized biological knowledge, are derived to generate conceptual solutions. Subsequently, a main parameter of value (MPV) model is constructed through mining user review data, and the evaluation of conceptual designs is systematically performed via the integration of orthogonal design and the fuzzy analytic hierarchy process to identify the optimal combination of component solutions. The optimization case study of a floor scrubber, along with the corresponding experimental results, demonstrates the efficacy and advancement of the proposed method. This study aims to reduce the operational difficulty associated with implementing BioTRIZ in product development processes, while simultaneously enhancing its accuracy. Full article

Recent advances in non-local thermodynamic equilibrium (non-LTE) plasma simulations, for example in modeling kilonova ejecta, have emphasized the need for consistent and reliable atomic data. Unlike LTE modeling, non-LTE calculations must include a consistent treatment of various photon-induced and collisional processes in order to describe realistic electron and photon distributions in the plasma. However, the available atomic data are often incomplete, inconsistently formatted, or even fail to indicate the main dependencies on the level structure and plasma parameters, thus limiting their practical use. To address these issues, we have extended Jac, the Jena Atomic Calculator (version v0.3.0), to provide direct access to relevant cross sections, plasma rates, and rate coefficients. Emphasis is placed on photoexcitation and ionization processes as well as their time-reversed counterparts—photo-de-excitation and photorecombination. Whereas most of these data are still based on empirical expressions, their dependence on the ionic level structure and plasma temperature is made explicit here. Moreover, the electron and photon distributions can be readily controlled and adjusted by the user. This transparent representation of atomic data for photon-mediated processes, together with a straightforward use, facilitates their integration into existing plasma codes and improves the interpretation of high-energy astrophysical phenomena. It may support also more accurate and flexible non-LTE plasma simulations. Full article

5G technology represents a transformative shift in mobile communications, delivering improved ultra-low latency, data throughput, and the capacity to support huge device connectivity, surpassing the capabilities of LTE systems. As global telecommunication operators shift toward widespread 5G implementation, ensuring optimal network performance and intelligent resource management has become increasingly obvious. To address these challenges, this study explored the role of advanced clustering methods in optimizing cellular networks under heterogeneous and dynamic conditions. A systematic literature review (SLR) was conducted by analyzing 40 peer-reviewed and non-peer-reviewed studies selected from an initial collection of 500 papers retrieved from the Semantic Scholar Open Research Corpus. This review examines a diversity of clustering approaches, including spectral clustering with Bayesian non-parametric models and K-means, density-based clustering such as DBSCAN, and deep representation-based methods like Differential Evolution Memetic Clustering (DEMC) and Domain Adaptive Neighborhood Clustering via Entropy Optimization (DANCE). Key performance outcomes reported across studies include anomaly detection accuracy of up to 98.8%, delivery rate improvements of up to 89.4%, and handover prediction accuracy improvements of approximately 43%, particularly when clustering techniques are combined with machine learning models. In addition to summarizing their effectiveness, this review highlights methodological trends in clustering parameters, mechanisms, experimental setups, and quality metrics. The findings suggest that advanced clustering models play a crucial role in intelligent spectrum sensing, adaptive mobility management, and efficient resource allocation, thereby contributing meaningfully to the development of intelligent 5G/6G mobile network infrastructures. Full article

Subsoil compaction is a major constraint in sugarcane production, limiting yields and reducing resource-use efficiency. This study presents WireDepth, an innovative cloud-connected monitoring system that leverages edge computing and IoT technologies for real-time, spatially aware analysis and visualization of subsoiling depth. The system integrates ultrasonic, laser, inclinometer, and potentiometer sensors mounted on the subsoiler, with on-board microcontroller processing and dual wireless connectivity (LoRaWAN and NB-IoT/LTE-M) for robust data transmission. A cloud platform delivers advanced analytics, including 3D depth maps and operational efficiency metrics. System accuracy was assessed using 300 reference depth measurements, with Root Mean Square Error (RMSE) and Mean Absolute Percentage Error (MAPE) calculated per sensor. The inclinometer and potentiometer achieved the highest accuracy (MAPE of 0.92% and 0.84%, respectively), with no significant deviation from field measurements (paired t-tests, p > 0.05). Ultrasonic and laser sensors exhibited higher errors, particularly at shallow depths, due to soil debris interference. Correlation analysis confirmed a significant effect of depth on sensor accuracy, with laser sensors showing the strongest association (Pearson r = 0.457, p < 0.001). Field validation in commercial sugarcane fields demonstrated that WireDepth improves subsoiling precision, reduces energy waste, and supports sustainable production by enhancing soil structure and root development. These findings advance precision agriculture by offering a scalable, real-time solution for subsoiling management, with broad implications for yield improvement in compaction-affected systems. Full article

Accurate and continuous tracking of athletes is essential to meet the infotainment demands and health and safety requirements of major marathon events. However, the current ability to track individual athletes or groups at mass sporting events is severely limited by the weight, size and cost of the equipment required. In marathons, Radio Frequency Identification (RFID) technology is typically used for timing but can only provide accurate tracking at widely spaced intervals, relying on heuristic and interpolation algorithms to estimate runners’ positions between measurement points. Alternative IOT solutions, such as Low Power Wide Area Network (LWPAN), have limitations in terms of range and require dedicated infrastructure and regulation. Therefore, we analyzed the potential use of smartwatches as accurate and continuous tracking devices for athletes, assessing battery consumption during tracking and standby drain, achievable GPS tracking accuracy and the update rate of data transfer from the device in urban environments. The 4G LTE battery drain is different from non-urban areas. Analysis of standby usage is necessary as devices need to conserve power for tracking. We programmed an application that allowed us to control the modalities of acquisition and transmission intervals, integrating advanced logging and statistics at runtime, and evaluated the achievable results in major marathon events. Our empirical evaluation at the Frankfurt, Athens and Vienna marathons with three different types of smartwatch tracking platforms showed the validity of this approach, while respecting some necessary limitations of the tracking settings. Median battery drain was 5.3%/h in standby before race start (σ 1.5) and 16.5%/h in tracking mode (σ 3.29), with an actual update rate varying between 19 and 57 s on Wear OS devices. The average GPS offset to the track was 4.5 m (σ 8.7). Future work will focus on integrating these consumer devices with existing time and tracking infrastructure. Full article

The increasing need for high-resolution, real-time radiative transfer (RT) modeling in climate science, remote sensing, and planetary exploration has exposed limitations of traditional solvers such as the Discrete Ordinate Radiative Transfer (DISORT) and Rapid Radiative Transfer Model for General Circulation Models (RRTMG), particularly in handling spectral complexity, non-local thermodynamic equilibrium (non-LTE) conditions, and computational scalability. Quantum-Inspired Neural Radiative Transfer (QINRT) frameworks, combining tensor-network parameterizations and quantum neural operators (QNOs), offer efficient approximation of high-dimensional radiative fields while preserving key physical correlations. This review highlights the advances of QINRT in enhancing spectral fidelity and computational efficiency, enabling energy-efficient, real-time RT inference suitable for satellite constellations and unmanned aerial vehicle (UAV) platforms. By integrating physics-informed modeling with scalable neural architectures, QINRT represents a transformative approach for next-generation Earth-system digital twins and autonomous climate intelligence. Full article

The television white space (TVWS) spectrum presents a promising opportunity to extend wireless broadband access, particularly in rural, underserved, and hard-to-reach communities. To leverage this potential, low-power radio communication equipment must efficiently utilise the TVWS spectrum on a secondary basis while ensuring strict compliance with regulatory requirements to prevent harmful interference to primary services. This paper presents a comparative performance analysis of TVWS radio equipment from three original equipment manufacturers (OEMs). The equipment under test was identified to reflect each OEM, as follows: OEM 1 and OEM 2 from South Korea and OEM 3 from the USA. We evaluated their performance in two real-world field scenarios, namely outdoor short-distance and outdoor long-distance. The evaluation was based on the following key metrics: (i) spectrum utilisation efficiency (SUE), (ii) received signal strength (RSS), (iii) downlink throughput, and (iv) connectivity to the Geo-Location Spectrum Database (GLSD) in compliance with the South African TVWS regulatory framework. The overall preliminary experimental results indicate that in both scenarios, white space devices (WSDs) based on the Institute of Electrical and Electronics Engineers (IEEE) 802.11af Standard demonstrated better performance than those based on the 3rd Generation Partnership Project Long-Term Evolution-Advanced (3GPP LTE-A) Standard in terms of the SUE, downlink throughput, and RSS metrics. All WSDs under test demonstrated sufficient compliance with the regulatory requirement metric. Full article

Heating, ventilation, and air-conditioning (HVAC) systems account for the largest share of energy consumption in European Union (EU) buildings, representing approximately 40% of the final energy use and contributing significantly to carbon emissions. Latent thermal energy storage (LTES) using phase change materials (PCMs) has emerged as a promising strategy to enhance HVAC efficiency. This review systematically examines the role of latent thermal energy storage using phase change materials (PCMs) in optimizing HVAC performance to align with EU climate targets, including the Energy Performance of Buildings Directive (EPBD) and the Energy Efficiency Directive (EED). By analyzing advancements in PCM-enhanced HVAC systems across residential and commercial sectors, this study identifies critical pathways for reducing energy demand, enhancing grid flexibility, and accelerating the transition to nearly zero-energy buildings (NZEBs). The review categorizes PCM technologies into organic, inorganic, and eutectic systems, evaluating their integration into thermal storage tanks, airside free cooling units, heat pumps, and building envelopes. Empirical data from case studies demonstrate consistent energy savings of 10–30% and peak load reductions of 20–50%, with Mediterranean climates achieving superior cooling load management through paraffin-based PCMs (melting range: 18–28 °C) compared to continental regions. Policy-driven initiatives, such as Germany’s renewable integration mandates for public buildings, are shown to amplify PCM adoption rates by 40% compared to regions lacking regulatory incentives. Despite these benefits, barriers persist, including fragmented EU standards, life cycle cost uncertainties, and insufficient training. This work bridges critical gaps between PCM research and EU policy implementation, offering a roadmap for scalable deployment. By contextualizing technical improvement within regulatory and economic landscapes, the review provides strategic recommendations to achieve the EU’s 2030 emissions reduction targets and 2050 climate neutrality goals. Full article

This article presents the decision feedback equalizer (DFE), the maximum likelihood detection (MLD), and the radius-directed equalization (RDE) algorithms designed in MATLAB-R2018a to equalize the received signal in a dispersive optical link up to 120 km. DFE is essential for improving signal quality in several communication systems, including WiFi networks, cable modems, and long-term evolution (LTE) systems. Its capacity to mitigate inter-symbol interference (ISI) and rapidly adjust to channel variations renders it a flexible option for high-speed data transfer and wireless communications. Conversely, MLD is utilized in applications that require great precision and dependability, including multi-input–multi-output (MIMO) systems, satellite communications, and radar technology. The ability of MLD to optimize the probability of accurate symbol detection in complex, high-dimensional environments renders it crucial for systems where signal integrity and precision are critical. Lastly, RDE is implemented as an alternative algorithm to the CMA-based equalizer, utilizing the idea of adjusting the amplitude of the received distorted symbol so that its modulus is closer to the ideal value for that symbol. The algorithms are tested using a converged 5G mm-wave analog radio-over-fiber (A-RoF) system at 60 GHz. Their performance is measured regarding error vector magnitude (EVM) values before and after equalization for different optical fiber lengths and modulation formats (QPSK, 16-QAM, 64-QAM, and 128-QAM) and shows a clear performance improvement of the output signal. Moreover, the performance of the proposed algorithms is compared to three commonly used algorithms: the simple least mean square (LMS) algorithm, the constant modulus algorithm (CMA), and the adaptive median filtering (AMF), demonstrating superior results in both QPSK and 16-QAM and extending the transmission distance up to 120 km. DFE has a significant advantage over LMS and AMF in reducing the inter-symbol interference (ISI) in a dispersive channel by using previous decision feedback, resulting in quicker convergence and more precise equalization. MLD, on the other hand, is highly effective in improving detection accuracy by taking into account the probability of various symbol sequences achieving lower error rates and enhancing performance in advanced modulation schemes. RDE performs best for QPSK and 16-QAM constellations among all the other algorithms. Furthermore, DFE and MLD are particularly suitable for higher-order modulation formats like 64-QAM and 128-QAM, where accurate equalization and error detection are of utmost importance. The enhanced functionalities of DFE, RDE, and MLD in managing greater modulation orders and expanding transmission range highlight their efficacy in improving the performance and dependability of our system. Full article

This paper presents a comparative analysis of a long-term evolution advanced (LTE-A) and fifth-generation new radio (5G-NR), focusing on the effects of transient electromagnetic interference (EMI) caused by catenary–pantograph contact in a railway environment.A software-defined radio (SDR)-based prototype was developed to evaluate the performance of LTE-A and 5G-NR links under the influence of transient interference. The results show that both links experience considerable degradation due to interference at different centre frequencies. Performance degradation is proportional to the gain of interference. The measurement results show that both links experience considerable performance degradation in the presence of transient EMI. Full article

The evolution from 5G to 6G networks is driven by the need to meet the stringent requirements, i.e., ultra-reliable, low-latency, and high-throughput communication. The new services are called Further-Enhanced Mobile Broadband (feMBB), Extremely Reliable and Low-Latency Communications (ERLLCs), Ultra-Massive Machine-Type Communications (umMTCs), Massive Ultra-Reliable Low-Latency Communications (mURLLCs), and Mobile Broadband Reliable Low-Latency Communications (MBRLLCs). Network slicing emerges as a critical enabler in 6G, providing virtualized, end-to-end network segments tailored to diverse application needs. Despite its significance, existing datasets for slice selection are limited to 5G or LTE-A contexts, lacking relevance to the enhanced requirements. In this work, we present a novel synthetic dataset tailored to 6G network slicing. By analyzing the emerging service requirements, we generated traffic parameters, including latency, packet loss, jitter, and transfer rates. Machine Learning (ML) models like Random Forest (RF), Decision Tree (DT), XGBoost, Support Vector Machine (SVM), and Feedforward Neural Network (FNN) were trained on this dataset, achieving over 99% accuracy in both slice classification and handover prediction. Our results highlight the potential of this dataset as a valuable tool for developing AI-assisted 6G network slicing mechanisms. While still in its early stages, the dataset lays a foundation for future research. As the 6G standardization advances, we aim to refine the dataset and models, ultimately enabling real-time, intelligent slicing solutions for next-generation networks. Full article

The way we connect with the physical world has completely changed because of the advancement of the Internet of Things (IoT). However, there are several difficulties associated with this change. A significant advancement has been the emergence of intelligent machines that are able to gather data for analysis and decision-making. In terms of IoT security, we are seeing a sharp increase in hacker activities worldwide. Botnets are more common now in many countries, and such attacks are very difficult to counter. In this context, Distributed Denial of Service (DDoS) attacks pose a significant threat to the availability and integrity of online services. In this paper, we developed a predictive model called Markov Detection and Prediction (MDP) using a Continuous-Time Markov Chain (CTMC) to identify and preemptively mitigate DDoS attacks. The MDP model helps in studying, analyzing, and predicting DDoS attacks in Long-Term Evolution for Machine (LTE-M) networks and IoT environments. The results show that using our MDP model, the system is able to differentiate between Authentic, Suspicious, and Malicious traffic. Additionally, we are able to predict the system behavior when facing different DDoS attacks. Full article

As autonomous driving may be the most important application scenario of the next generation, the development of wireless access technologies enabling reliable and low-latency vehicle communication becomes crucial. To address this, 3GPP has developed Vehicle-to-Everything (V2X) specifications based on 5G New Radio (NR) technology, where Mode 2 Side-Link (SL) communication resembles Mode 4 in LTE-V2X, allowing direct communication between vehicles. This supplements SL communication in LTE-V2X and represents the latest advancements in cellular V2X (C-V2X) with the improved performance of NR-V2X. However, in NR-V2X Mode 2, resource collisions still occur and thus degrade the age of information (AOI). Therefore, an interference cancellation method is employed to mitigate this impact by combining NR-V2X with Non-Orthogonal multiple access (NOMA) technology. In NR-V2X, when vehicles select smaller resource reservation intervals (RRIs), higher-frequency transmissions use more energy to reduce AoI. Hence, it is important to jointly considerAoI and communication energy consumption based on NR-V2X communication. Then, we formulate such an optimization problem and employ the Deep Reinforcement Learning (DRL) algorithm to compute the optimal transmission RRI and transmission power for each transmitting vehicle to reduce the energy consumption of each transmitting vehicle and the AoI of each receiving vehicle. Extensive simulations demonstrate the performance of our proposed algorithm. Full article