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18 pages, 5453 KB  
Article
An Innovative Approach for Direct Identification of Microplastics in Freshwater Samples Using SWIR Hyperspectral Imaging
by Paola Cucuzza, Silvia Serranti, Giuseppe Capobianco and Eleonora Gorga
Sustainability 2026, 18(13), 6450; https://doi.org/10.3390/su18136450 (registering DOI) - 24 Jun 2026
Abstract
Microplastics (MPs) are widely recognized as emerging contaminants in freshwater environments. Their identification often relies on extensive sample preparation and chemical treatments, which increase analysis time, reagent use, and overall resource consumption. Consequently, there is a growing need for sustainable analytical approaches enabling [...] Read more.
Microplastics (MPs) are widely recognized as emerging contaminants in freshwater environments. Their identification often relies on extensive sample preparation and chemical treatments, which increase analysis time, reagent use, and overall resource consumption. Consequently, there is a growing need for sustainable analytical approaches enabling reliable MP detection while minimizing sample handling. This study proposes an analytical workflow based on hyperspectral imaging (HSI) as a proof-of-concept approach for direct identification of MPs in freshwater samples. Water samples collected from three different rivers, containing heterogeneous natural materials, were spiked with MPs (250–1000 μm) of three common polymers, namely high-density polyethylene (HDPE), polystyrene (PS), and polypropylene (PP), to simulate realistic contamination scenarios. HSI acquisitions were performed in the short-wave infrared range (SWIR: 1000–2500 nm). Spectral preprocessing and principal component analysis (PCA) were applied for data exploration, while a hierarchical partial least squares-discriminant analysis (Hi-PLS-DA) model was developed to classify five target classes: natural materials, water, HDPE, PS, and PP. Despite sample complexity, the proposed workflow achieved satisfactory classification results, as demonstrated by the predicted class map and the corresponding statistical metrics (sensitivity, specificity, precision, and F1-score: 0.900–0.999). These results highlight the potential of the SWIR-HSI-based approach as a rapid and sustainable method for direct MP identification in freshwater samples and provide methodological insights for rapid MP screening strategies requiring minimal sample preparation. Full article
(This article belongs to the Special Issue Microplastics, Sustainable Water and Soil Environments)
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50 pages, 3659 KB  
Article
Assessment of River Planform Dynamics in the Amazon Basin Using Sentinel-1 SAR Data (2017–2025)
by Ivar van Rijt, Johannes Balling and Johannes Reiche
Remote Sens. 2026, 18(13), 2075; https://doi.org/10.3390/rs18132075 (registering DOI) - 24 Jun 2026
Abstract
The Amazon Basin and its rivers play a vital role in regional biodiversity, the carbon cycle, and socio-economic security. Through erosion and deposition, river planforms change over time, affecting local infrastructure, food security, and changes to ecosystems. Long-term monitoring is essential for observing [...] Read more.
The Amazon Basin and its rivers play a vital role in regional biodiversity, the carbon cycle, and socio-economic security. Through erosion and deposition, river planforms change over time, affecting local infrastructure, food security, and changes to ecosystems. Long-term monitoring is essential for observing these dynamics. Synthetic Aperture Radar (SAR) provides a method to consistently map river planform dynamics across large areas because it is largely independent of atmospheric conditions. This study presents an approach for deriving river planform metrics across the entire Amazon Basin using Sentinel-1 C-band SAR data. This approach followed three main steps: water mask generation, validation of the data and river metrics extraction. Sentinel-1 imagery from 2017 to 2025 was composited into quarterly mean images, after which Otsu thresholding was applied to derive water classifications. Additional post-processing steps were applied to reduce terrain- and seasonal effects. The final water masks were divided into water-change classes, validated using stratified sampling and achieved an overall accuracy of 98.5%. Quarterly river planform metrics, including sinuosity, mean channel width and migration rate, were derived using channel centerline extraction, but due to a lack of in situ validation data the river metric values have not been validated. The resulting time series provide insights into how river planform changes across all Amazon sub-basins from 2017 to 2025 can be monitored using SAR-based methods. The results reveal spatial differences in river dynamics between tributaries, mostly depending on flow pattern, up- or downstream path and location in the upper, middle or lower Amazon Basin. These findings demonstrate the potential of SAR time series for monitoring large-scale river planform dynamics. Full article
(This article belongs to the Section Environmental Remote Sensing)
28 pages, 1063 KB  
Article
Automatic Oral Cancer Detection Using Improved Honey Badger Algorithm-Based Feature Selection
by Nebras Sobahi, Yagmur Olmez, Osman Fatih Koparır, Muammer Turkoglu, Adalet Çelebi, Yazyd Alghamedi and Abdulkadir Şengür
Diagnostics 2026, 16(13), 1969; https://doi.org/10.3390/diagnostics16131969 (registering DOI) - 24 Jun 2026
Abstract
Background/Objectives: Oral cancer is one of the most common types of cancer, with high mortality rates if not detected early. Traditional diagnostic methods based on clinical examination rely on experience, leading to delays in early and reliable diagnosis. In recent years, medical imaging [...] Read more.
Background/Objectives: Oral cancer is one of the most common types of cancer, with high mortality rates if not detected early. Traditional diagnostic methods based on clinical examination rely on experience, leading to delays in early and reliable diagnosis. In recent years, medical imaging and AI-based computer-aided diagnostic systems have shown promising results in the automated identification of oral cancer. In particular, the efficient management of high-dimensional feature spaces in machine learning and deep learning approaches directly impacts classification performance. In this context, metaheuristic-based feature selection technics is a critical component because of eliminating redundant and irrelevant features. To address these challenges, this study proposes a metaheuristic-based feature selection method to reduce feature dimensionality and enhance the classification performance of oral cancer detection. Methods: This study proposes an improved Honey Badger Algorithm-based feature selection approach for the automated detection of oral cancer. In the proposed method, the distance vector used in the HBA method has been redefined to improve the balance between exploration and exploitation. Additionally, a new Cauchy mutation-based migration strategy was integrated into the proposed method to increase diversity in the search space and avoid getting stuck in local minima. The continuous-valued iHBA method was discretized with a modified sin–cos transfer function for feature selection. Oral cancer images were filtered using the CLAHE method, and after extracting deep features with the ResNet50 architecture, the proposed metaheuristic-based method was used to select discriminative features. Results: The proposed method was first tested for reliability and limitations through repeated runs on problems with different characteristics, such as unimodal and multimodal classical test functions. Then, the method was applied to extract significant features for oral cancer detection using a Histopathological Imaging Database containing 1224 histopathological oral tissue images at 100× and 400× magnification levels from 230 patients. The proposed approach was assessed in terms of accuracy, precision, recall, F1-score, and convergence curves in comparison with various classical feature selection techniques, such as wrapper-based, filter-based, and embedded-based methods, as well as other metaheuristic-based methods. The experimental results demonstrated that the suggested strategy outperformed both traditional feature selection techniques and alternative metaheuristic approaches. Conclusions: The effectiveness of the proposed method in improving diagnostic accuracy was evaluated through comprehensive experimental analyses. The obtained findings show that the proposed iHBA-based feature selection approach can reduce feature dimensionality, eliminate redundant and irrelevant features, and improve the classification performance of oral cancer detection. Therefore, the proposed method provides an effective and competitive computer-aided diagnostic framework for the automated classification of histopathological oral cancer images. Full article
(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
21 pages, 1784 KB  
Article
Development and Application of an AI Visual Defect Detection System for Warp-Knitted Lace Based on 5G+ Technology
by Taohai Yan, Yongze Wu, Yajing Shi, Chaowang Lin and Li Ji
Information 2026, 17(7), 623; https://doi.org/10.3390/info17070623 (registering DOI) - 24 Jun 2026
Abstract
Conventional defect inspection for warp-knitted lace relies on manual work and negative-sample-based training, resulting in low efficiency, frequent false detections and poor adaptability. This study presents a novel AI visual inspection system centered on positive-sample learning, which is built upon a five-layer 5G [...] Read more.
Conventional defect inspection for warp-knitted lace relies on manual work and negative-sample-based training, resulting in low efficiency, frequent false detections and poor adaptability. This study presents a novel AI visual inspection system centered on positive-sample learning, which is built upon a five-layer 5G + Industrial Internet distributed architecture. Supported by modified looms, high-precision imaging devices and an optimized YOLOv5s model, the system accomplishes intelligent defect detection. A positive-sample self-learning paradigm and dual-model collaboration mechanism are proposed to reduce the demand for negative samples and cut labeling expenses. The integration of CBAM, FPN + PAN structure, self-supervised learning and hybrid loss further strengthens the recognition performance for subtle defects under complex patterns. Industrial tests show that the system reaches a grid-level classification accuracy of 95% and a frame-level detection rate over 98%, with a detection speed of 30 m/min. It reduces labor costs and product reject rates by 40% and 30% correspondingly while running stably in real production. This method breaks the constraints of traditional training modes, provides a scalable intelligent solution for the digital upgrading of the warp-knitted lace industry, and promotes the high-quality development of textile manufacturing. Full article
(This article belongs to the Section Information Applications)
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14 pages, 366 KB  
Article
Between Accessibility and Reliability: High Confidence, Low Control in General-Purpose Multimodal Models for Hip Fracture Radiograph Interpretation
by Hadar Gan-Or, Shaked Ankol, Guy Ben Arie, Itay Ashkenazi and Yaniv Warschawski
J. Clin. Med. 2026, 15(13), 4919; https://doi.org/10.3390/jcm15134919 (registering DOI) - 24 Jun 2026
Abstract
Background: Dedicated artificial intelligence (AI) systems for fracture detection already exist, yet general-purpose multimodal models are increasingly accessible to clinicians despite not being developed or formally validated as medical devices. Their behavior in focused orthopedic imaging tasks remains insufficiently characterized. Purpose: [...] Read more.
Background: Dedicated artificial intelligence (AI) systems for fracture detection already exist, yet general-purpose multimodal models are increasingly accessible to clinicians despite not being developed or formally validated as medical devices. Their behavior in focused orthopedic imaging tasks remains insufficiently characterized. Purpose: To characterize how two accessible general-purpose multimodal models interpret AP pelvis radiographs with hip fractures, focusing on context dependence, overconfidence, and complementary error patterns within a surgically confirmed positive-only cohort. This was a behavioral characterization study of a fracture-positive cohort, not a diagnostic accuracy evaluation. Methods: In April 2026, we retrospectively studied 214 surgically confirmed hip fractures on AP pelvis radiographs using two general-purpose multimodal models under six prompting conditions. In runs A–D, the models were explicitly told that a hip fracture was present and were asked to classify it; in runs E–F, they were not told whether a hip fracture was present. Each image was rerun de novo in a separate chat session through vendor APIs using a fixed base prompt and no image preprocessing. We recorded hip-fracture detection, correct laterality, coarse fracture pattern, intracapsular displacement, AO/OTA grading, subtrochanteric identification, and self-reported confidence. Because the cohort contained hip fractures only, we report fracture-detection rates and classification performance within a positive-only cohort rather than full diagnostic-accuracy metrics. Results: Using the more conservative endpoint of hip-fracture detection with correct laterality, GPT-5.4 was correct in 79.0% and 86.4% of cases in runs E and F, whereas Gemini was correct in 80.4% and 93.5%, respectively. When outputs from both models were combined, this endpoint reached 89.7% in run E and 96.7% in run F, indicating complementary rather than redundant error patterns. Incorrect laterality cues markedly degraded performance, from 90.7% to 66.4% in GPT-5.4 and from 97.7% to 57.0% in Gemini. Performance remained limited for treatment-relevant subtyping, particularly AO/OTA grading and subtrochanteric identification. Both models frequently remained highly confident when wrong, and self-reported confidence did not reliably distinguish correct from incorrect outputs. Conclusions: Accessible general-purpose multimodal models showed partial capability for coarse hip-fracture interpretation, but they remained context-sensitive, unreliable for treatment-relevant subtyping, and highly confident even when incorrect. Their complementary error patterns are hypothesis-generating rather than evidence of clinical readiness. On the basis of these findings, we do not support unvalidated or uncontrolled clinical use of such models. As access to these tools expands, explicit usage boundaries, minimum performance expectations, repeated local revalidation, and sustained human oversight become increasingly necessary. Full article
(This article belongs to the Special Issue Acute Trauma and Trauma Care in Orthopedics: 2nd Edition)
20 pages, 20102 KB  
Article
Explainable Glaucoma Screening via Optic Disc Localization and Comparative Class Activation Map-Based Analysis
by Oscar Ramos-Soto, Ezequiel Perez-Zarate, Jorge Ramos-Frutos, Diego Oliva, Marco Pérez-Cisneros, Guillermo Sosa-Gómez and Sandra E. Balderas-Mata
Mach. Learn. Knowl. Extr. 2026, 8(7), 173; https://doi.org/10.3390/make8070173 (registering DOI) - 24 Jun 2026
Abstract
Glaucoma, the leading cause of irreversible vision loss, often goes undetected in early stages due to its asymptomatic behaviour. Early diagnosis typically involves visual analysis of the optic disc (OD) in eye fundus images. Machine and deep learning techniques have emerged as valuable [...] Read more.
Glaucoma, the leading cause of irreversible vision loss, often goes undetected in early stages due to its asymptomatic behaviour. Early diagnosis typically involves visual analysis of the optic disc (OD) in eye fundus images. Machine and deep learning techniques have emerged as valuable tools for automating this process; however, their integration into clinical practice still faces limitations. These challenges include the presence of image regions that are not directly related to glaucoma assessment, such as retinal vasculature, the macula, and background structures, which may introduce irrelevant information and negatively affect classification performance, as well as a general lack of transparency in the decision-making process. This article proposes a methodology that enhances both the accuracy and interpretability of glaucoma detection by focusing solely on the OD region. First, a metaheuristic-based strategy is employed for precise OD detection and cropping, generating an OD-centric dataset with glaucoma-labeled images, which is composed of different public datasets. Four convolutional neural networks (CNNs), namely VGG-19, MobileNet-V2, ResNet-50, and DenseNet-161, are trained on this dataset using transfer learning. To address the need for model explainability, Grad-CAM, Score-CAM, and Eigen-CAM are applied to the trained models to generate post hoc visual explanations of their predictions. The experimental results showed that DenseNet-161 achieved the best overall performance on the assembled public dataset, using an 80%-10%-10% training, validation, and testing split, with a test accuracy of 0.9369 and an AUC of 0.9831. By isolating the OD region and incorporating explainability techniques, the methodology provides a robust and interpretable second opinion, supporting more accurate and efficient glaucoma screening. Full article
19 pages, 2696 KB  
Article
Improving the Identification of the Preclinical Stages of Spinocerebellar Ataxia Type 2
by Camilo Mora-Batista, Cruz Vargas-De-León, Ramón Reyes-Carreto, Frank J. Carrillo-Rodes and José Alberto Álvarez-Cuesta
Tomography 2026, 12(7), 92; https://doi.org/10.3390/tomography12070092 (registering DOI) - 24 Jun 2026
Abstract
Background: Spinocerebellar ataxia type 2 (SCA2) is an inherited neurodegenerative disorder characterized by progressive cerebellar degeneration. One difficulty in treating this disease lies in identifying preclinical carriers: individuals who carry the pathogenic ATXN2 mutation but remain asymptomatic with respect to motor manifestations. Though [...] Read more.
Background: Spinocerebellar ataxia type 2 (SCA2) is an inherited neurodegenerative disorder characterized by progressive cerebellar degeneration. One difficulty in treating this disease lies in identifying preclinical carriers: individuals who carry the pathogenic ATXN2 mutation but remain asymptomatic with respect to motor manifestations. Though magnetic resonance imaging (MRI) has proven valuable in supporting the diagnosis of ataxia, traditional univariate approaches using linear measurements have shown limited ability to capture the complex anatomical changes that occur across the disease spectrum, particularly during the preclinical phase. Methods: This study employed a comprehensive multivariate approach to improve the classification of individuals across the SCA2 spectrum. We developed a multinomial logistic regression model incorporating multiple linear measurements derived from magnetic resonance imaging to discriminate between healthy controls (n = 72), preclinical carriers (n = 17), and patients with manifest SCA2 (n = 61). To mitigate inherent class imbalance, particularly in the smaller preclinical subgroup, we implemented the Synthetic Minority Over-sampling Technique (SMOTE), generating a balanced dataset that enhances the model’s ability to discern the distinctive anatomical features. This was compared to the model applied to the unbalanced data. An improvement was observed when applying SMOTE. Results: The multivariate model demonstrated discriminatory performance, achieving an overall accuracy of 80.7%. The ability to identify healthy controls (AUC: 0.96), preclinical individuals (AUC: 0.75), and clinical individuals (AUC: 95%). This represents an advance over previous univariate approaches, which have had difficulty capturing the neurodegenerative changes characteristic of the preclinical stage. Conclusions: By integrating multiple neuroimaging biomarkers into a multivariable model, this study provides a tool for early identification of preclinical SCA2 carriers. The ability to accurately classify these individuals opens an opportunity for early therapeutic intervention before irreversible neurological deterioration occurs. This approach shows promise for optimizing clinical trial design and personalized care in SCA2. Full article
(This article belongs to the Section Neuroimaging)
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18 pages, 3207 KB  
Article
Meta-Learning-Based Multi-Task Framework for Joint Modulation Format Identification and ESNR Estimation in Coherent Optical Communication Systems
by Qifan Zhang, Shi Jia, Tianhao Zhang, Zhuangzhuang Zang, Shiqian Jia, Lianmeng Wu, Hao Luo and Jinlong Yu
Photonics 2026, 13(7), 607; https://doi.org/10.3390/photonics13070607 (registering DOI) - 24 Jun 2026
Abstract
Optical performance monitoring is essential for adaptive and intelligent coherent optical communication systems. In this paper, a Transformer-based multi-task meta-learning framework is proposed for joint modulation format identification and electrical signal-to-noise ratio (ESNR) estimation from original received waveforms. A simulated coherent optical communication [...] Read more.
Optical performance monitoring is essential for adaptive and intelligent coherent optical communication systems. In this paper, a Transformer-based multi-task meta-learning framework is proposed for joint modulation format identification and electrical signal-to-noise ratio (ESNR) estimation from original received waveforms. A simulated coherent optical communication system is established to generate QPSK, 16QAM, and 32QAM signals under different launch-power conditions. The received I/Q waveforms are directly used as model inputs, avoiding handcrafted feature extraction or constellation-image conversion. The proposed model employs a shared one-dimensional Transformer encoder to extract temporal waveform representations. A prototypical classification branch is used for few-shot modulation format identification, while an ESNR regression branch is introduced for continuous signal-quality estimation. The two tasks are jointly optimized under an episodic support-query training mechanism. Experimental results show that the proposed method achieves 99.99% modulation identification accuracy on the test episodes. For ESNR estimation, the model obtains an MAE of 0.1194 dB, an RMSE of 0.1738 dB, and an R2 value of 99.83%. These results demonstrate that the proposed framework can simultaneously provide accurate modulation decisions and reliable ESNR estimation, showing its potential for waveform-based optical performance monitoring. Full article
(This article belongs to the Special Issue Microwave Photonics: Advances and Applications)
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19 pages, 309 KB  
Article
Ultrasound-Based Staging and Its Impact on Clinical Management of Hepatic Hydatid Cysts in an Endemic Setting: A Cross-Sectional Study in Eastern Afghanistan
by Samiullah Sajjad, Parnpen Viriyavejakul, Dorn Watthanakulpanich, Sant Muangnoicharoen, Paron Dekumyoy, Wirongrong Chierakul, Chayasin Mansaguan and Prakaykaew Charunwatthana
Trop. Med. Infect. Dis. 2026, 11(7), 172; https://doi.org/10.3390/tropicalmed11070172 (registering DOI) - 24 Jun 2026
Abstract
Background: Hydatid disease, caused by Echinococcus granulosus, remains a significant public health concern in endemic regions. This study aimed to evaluate the role of ultrasound in the diagnosis, staging, and clinical management of liver hydatid cysts in the eastern city of Jalalabad, [...] Read more.
Background: Hydatid disease, caused by Echinococcus granulosus, remains a significant public health concern in endemic regions. This study aimed to evaluate the role of ultrasound in the diagnosis, staging, and clinical management of liver hydatid cysts in the eastern city of Jalalabad, Afghanistan. Method: A cross-sectional study was conducted between February and November 2024 among 159 patients diagnosed with liver hydatid cysts. Demographic, clinical, laboratory, and imaging data were collected. Cysts were classified according to the WHO Informal Working Group on Echinococcosis (WHO-IWGE) and Gharbi systems. Ultrasound findings were compared with computed tomography (CT), and their association with treatment decisions was assessed. Result: A total of 159 patients with liver hydatid cysts were included in the study. Among them, 91 (57.2%) were female, 80 (50.3%) were aged 20–39 years, and 128 (80.5%) resided in rural areas. Most patients presented with a single cyst (144/159, 90.6%), while multiple cysts were observed in 15 (9.4%). The majority of cysts measured 5–9.9 cm in diameter (43.4%), followed by 1–4.9 cm (42.1%) and ≥10 cm (14.5%). According to the WHO-IWGE classification, CE1 (25.8%) and CE4 (24.5%) were the most common stages, followed by CE2 (17.6%), CE3a (13.8%), CE3b (11.3%), and CE5 (7.0%). Common exposure-related factors included dog ownership, poor hygiene practices, and consumption of raw vegetables. Ultrasound accurately identified cyst stages and demonstrated a significant association between WHO-IWGE staging and treatment modality (χ2 = 63.56, p < 0.001). Almost perfect agreement was observed between ultrasound and CT for cyst classification (Cohen’s κ > 0.90), although CT provided additional anatomical information in selected complex cases. Conclusions: Ultrasound is an accessible, accurate, and reliable imaging modality for the diagnosis, staging, and management of liver hydatid cysts. In resource-limited settings, it serves as the primary imaging modality for guiding clinical decision-making, with CT reserved for complex or uncertain cases. Full article
19 pages, 1470 KB  
Article
Automatic Interpretation of RPR Tests Using Lightweight Hybrid Architectures for Binary and Ternary Classification: A Preliminary, Single-Device Proof-of-Concept Study
by Enmanuel Abilheira, Bruno Silva, Ljiljana Dukanovic, Afonso Pinheiro and Vitor Carvalho
BioMedInformatics 2026, 6(4), 39; https://doi.org/10.3390/biomedinformatics6040039 (registering DOI) - 24 Jun 2026
Abstract
This study evaluates a lightweight, edge-deployable artificial intelligence pipeline to assist, not replace, trained human readers in the classification of RPR test reactions. Two separate and non-directly comparable experimental configurations were investigated: a binary task (Reactive vs. Non-Reactive) using 243 original images and [...] Read more.
This study evaluates a lightweight, edge-deployable artificial intelligence pipeline to assist, not replace, trained human readers in the classification of RPR test reactions. Two separate and non-directly comparable experimental configurations were investigated: a binary task (Reactive vs. Non-Reactive) using 243 original images and a ternary task (Reactive, Minimally Reactive, Non-Reactive) using a distinct dataset of 293 original images. Because the datasets were acquired using a single device and laboratory protocol, and because deterministic augmentation generates highly correlated transformations rather than independent clinical samples, the reported results should be interpreted as preliminary internal evidence of feasibility rather than proof of clinical generalizability. In the augmented internal test evaluation, the binary model achieved 99.98% accuracy (25,137/25,200), while the ternary model achieved 91.12% accuracy (14,417/15,822). In the original-image deployment evaluation, binary performance remained 100% (58/58) across FP32, FP16, and INT8; ternary performance was preserved under FP32/FP16 at 95.24% (80/84) but decreased to 76.19% (64/84) after INT8 quantization. An additional stochastic augmentation experiment for ternary INT8 deployment restored performance to 95.24% (80/84) and 0.9444 Macro-F1, but external validation remains mandatory before any clinical adoption. Full article
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28 pages, 1299 KB  
Review
Multimodal Deep Learning Approaches for Lung Disease Detection: A Review
by Bastian Estay Zamorano, Ali Dehghan Firoozabadi, Pablo Adasme, Wanda Montiel Piña, Mauricio Chávez Muñoz, David Zabala-Blanco, Pablo Palacios Játiva and Cesar A. Azurdia-Meza
Medicina 2026, 62(7), 1223; https://doi.org/10.3390/medicina62071223 (registering DOI) - 24 Jun 2026
Abstract
Lung diseases are among the leading global causes of morbidity and mortality, and existing reviews on deep learning (DL) for pulmonary diagnosis rarely integrate imaging, acoustic, and electronic health record (EHR) modalities within a single framework. We aimed to synthesize the state of [...] Read more.
Lung diseases are among the leading global causes of morbidity and mortality, and existing reviews on deep learning (DL) for pulmonary diagnosis rarely integrate imaging, acoustic, and electronic health record (EHR) modalities within a single framework. We aimed to synthesize the state of the art (2019–2024) in multimodal DL for lung disease detection and classification, identifying dominant architectures, performance benchmarks, and translational barriers across chest X-rays, CT scans, respiratory sounds, and EHRs. A structured narrative review was conducted using PubMed, Scopus, IEEE Xplore, and Web of Science, applying explicit inclusion criteria for peer-reviewed studies; performance metrics, dataset characteristics, and reported limitations were extracted. Research involving convolutional neural networks (CNNs) and more recent models such as Transformers have reported high performance in chest X-ray classification, whereas acoustic approaches based on spectrograms and self-supervised representations (e.g., Wav2Vec 2.0) show promising but dataset-dependent results. Full article
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13 pages, 1290 KB  
Article
[18F]FDG PET/CT Radiomics for Predicting Pathological Risk Subtypes of Thymic Epithelial Tumors: A Bicentric Study
by Antonio Sarubbi, Luca Frasca, Fatih Aksu, Guido Maria Meduri, Valerio Guarrasi, Gaetano Romano, Carmelina Cristina Zirafa, Filippo Longo, Gaetano Russo, Rosario Francesco Grasso, Paolo Soda, Franca Melfi and Pierfilippo Crucitti
Cancers 2026, 18(13), 2038; https://doi.org/10.3390/cancers18132038 (registering DOI) - 24 Jun 2026
Abstract
Background: Thymic epithelial tumors (TETs) are rare mediastinal malignancies whose prognosis is largely determined by histology. Current predictive models rely on clinical variables and subjective imaging interpretation, with unsatisfied performance. Non-invasive pre-treatment risk stratification could guide surgical planning and perioperative management in patients [...] Read more.
Background: Thymic epithelial tumors (TETs) are rare mediastinal malignancies whose prognosis is largely determined by histology. Current predictive models rely on clinical variables and subjective imaging interpretation, with unsatisfied performance. Non-invasive pre-treatment risk stratification could guide surgical planning and perioperative management in patients with TETs. The role of fluorine-18 (18F) fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (CT) in identifying aggressive disease is increasingly recognized. In this bicentric study, we aimed to evaluate a machine learning-based radiomics model using PET and CT images to differentiate between low-risk and high-risk TETs. Methods: Seventy-five patients who underwent PET/CT to evaluate the suspected anterior mediastinal mass and histopathologically diagnosed with TETs were included. On PET/CT images, the tumor was manually segmented by two experienced clinicians. First-order, shape, and texture features were extracted using the PyRadiomics library, resulting in 200 radiomics features (186 intensity/texture features and 14 shape features). In addition, rPET (i.e., tumor SUVmax/Liver SUVmax) parameter was included, yielding a grand total of 201 features. The feature set was reduced to 20 variables using ANOVA, with both selection and model evaluation performed via stratified 5-fold cross-validation. Results: The proposed approach achieved an average balanced accuracy of 0.58 ± 0.07 and an average AUC of 0.71 ± 0.04. Average sensitivity and specificity were 0.48 and 0.68, respectively. The model obtained an average Gmean of 0.57, indicating balanced and stable classification performance. Conclusions: Our ML models trained on PET/CT radiomic features showed moderate discriminatory performance for TET risk stratification. Full article
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14 pages, 636 KB  
Review
Absent Septum Pellucidum in Fetal Development: Diagnostic Challenges, Associated Anomalies, and Prognostic Uncertainty—A Structured Narrative Review
by Agnieszka Helena Czapska, Beata Rebizant and Katarzyna Kosińska-Kaczyńska
J. Clin. Med. 2026, 15(13), 4889; https://doi.org/10.3390/jcm15134889 (registering DOI) - 23 Jun 2026
Abstract
Background/Objectives: Absent septum pellucidum (ASP) is a rare fetal midline brain finding that may occur in isolation or alongside broader central nervous system (CNS) malformations, genetic disorders, or septo-optic dysplasia (SOD). Accurate prenatal diagnosis and counseling remain challenging because apparently isolated ASP [...] Read more.
Background/Objectives: Absent septum pellucidum (ASP) is a rare fetal midline brain finding that may occur in isolation or alongside broader central nervous system (CNS) malformations, genetic disorders, or septo-optic dysplasia (SOD). Accurate prenatal diagnosis and counseling remain challenging because apparently isolated ASP may be reclassified following fetal magnetic resonance imaging (MRI), postnatal neuroimaging, or specialist assessment. This structured narrative review aimed to synthesize current evidence on prenatal imaging findings, associated anomalies, genetic evaluation, and postnatal outcomes in fetuses with ASP. Methods: This structured narrative review used PRISMA-informed reporting. PubMed and Google Scholar were searched for full-text English-language studies published from 2014 through the updated search date (8 June 2026). Data on gestational age at diagnosis, imaging classification, associated anomalies, genetic testing, postnatal assessment, and neurodevelopmental, ophthalmological, and endocrine outcomes were extracted. Study methodological quality was appraised using Joanna Briggs Institute tools. Results: Seven studies comprising 342 fetal ASP cases were included. Of these, 94 cases (27.5%) were classified as isolated ASP prenatally, but only 57 remained isolated postnatally when follow-up data were available. SOD was confirmed after birth in 11 of 94 (11.7%) fetuses with prenatally isolated ASP. As definitions, imaging protocols, genetic testing strategies, and follow-up duration differed substantially across studies, these pooled values are descriptive observations rather than formal quantitative estimates. Conclusions: ASP is a heterogeneous prenatal finding. The prognosis is most favorable when ASP remains isolated following a detailed prenatal and postnatal evaluation. Multidisciplinary follow-up involving fetal medicine, neuroradiology, genetics, ophthalmology, endocrinology, and neurology is essential for risk stratification and counseling. Full article
(This article belongs to the Special Issue Challenges and Opportunities in Prenatal Diagnosis)
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21 pages, 3219 KB  
Article
A New Condition Diagnosis Method for Ball Bearings Using Ultrasonic Visualization and Light CNN
by Hangyeol Jo, Sung-Ho Hong, Choon-Su Park, Moonsuk Kim, Miao Dai and Sang-Woo Ban
Lubricants 2026, 14(7), 249; https://doi.org/10.3390/lubricants14070249 (registering DOI) - 23 Jun 2026
Abstract
Early fault diagnosis of ball bearings is essential for maintaining the reliability of rotating machinery and preventing unexpected downtime. This study proposes a fault diagnosis framework that combines non-contact ultrasonic visualization with a lightweight convolutional neural network (Light CNN). Seven bearing conditions, including [...] Read more.
Early fault diagnosis of ball bearings is essential for maintaining the reliability of rotating machinery and preventing unexpected downtime. This study proposes a fault diagnosis framework that combines non-contact ultrasonic visualization with a lightweight convolutional neural network (Light CNN). Seven bearing conditions, including ferrous particle contamination and grease starvation, were investigated using ultrasonic, vibration, and acoustic emission (AE) sensors under identical experimental conditions. Sa-liency-map extraction and two-dimensional histogram analysis were applied to ultrasonic RGB images to generate compact feature representations, which were compressed into 20 × 20 feature maps and used as inputs to a three-layer Light CNN. The proposed method achieved an average classification accuracy of 99.98% and an F1-score of 99.98%. In addition, an average inference throughput of 11.47 IPS was obtained, representing approximately ten times higher computational efficiency than vibration- and AE-based approach-es. Stable diagnostic performance was also maintained under a low-speed operating condition of 500 rpm. These results demonstrate the effectiveness of combining ultrasonic visualization and a lightweight CNN for accurate and computationally efficient bearing fault diagnosis. Full article
(This article belongs to the Special Issue Multiphysics Modelling in Bearing Lubrication)
17 pages, 2785 KB  
Article
Mechanized Ground Roughness Mapping by Remotely Piloted Aircraft
by Lucas Gabryel Maciel dos Santos, Lucas Santos Santana, Marcos David dos Santos Lopes, Josiane Maria da Silva, Carmem Lúcia da Silva Surmani, Celine Russo, Daniele Sarri, Giuseppe Rossi and Andrea Pagliai
AgriEngineering 2026, 8(7), 256; https://doi.org/10.3390/agriengineering8070256 (registering DOI) - 23 Jun 2026
Abstract
Digital Elevation Models (DEMs) provide essential information for decision-making in precision agriculture. This study evaluated the altimetric quality of DEMs generated by Remotely Piloted Aircraft (RPA) platforms, the influence of flight direction, and the effect of mechanically disturbed soil surface conditions. We obtained [...] Read more.
Digital Elevation Models (DEMs) provide essential information for decision-making in precision agriculture. This study evaluated the altimetric quality of DEMs generated by Remotely Piloted Aircraft (RPA) platforms, the influence of flight direction, and the effect of mechanically disturbed soil surface conditions. We obtained data from a 900 m2 area. Flights were conducted under pre- and post-mechanization conditions using a reversible plow, with flights in both longitudinal and transverse directions. We processed images using Structure-from-Motion (SfM) techniques to generate dense point clouds and DEMs. Statistical analyses relied on raster statistics and elevation cross-section transects of microtopography, were evaluated via descriptive statistics, ANOVA, Tukey’s HSD tests, and spatialization with micro-variation classification. Significant differences emerged among the evaluated models (p < 0.001), with Phantom-derived DEMs showing systematically higher elevations than Mavic models (617.31 ± 0.16 m vs. 605.41 ± 0.23 m, respectively). Post-plowing longitudinal flights showed the least variation, indicating greater altimetric consistency after secondary soil preparation. Conversely, the pre-plowing transverse flight (Mavic Flight 2) produced the largest errors. Quantitative assessment of topographic profiles revealed high morphological correspondence between platforms, with Pearson correlation coefficients ranging from 0.84 to 0.96 after vertical normalization, confirming that terrain morphology was preserved despite systematic vertical offsets. The effect of flight direction was more pronounced before soil preparation; after harrowing (a homogeneous surface), the difference between directions decreased, but longitudinal flights maintained an advantage, while transverse flights (especially Mavic) tended to overestimate elevations spatially. Full article
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