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Article

2 Citations

3,073 Views

31 Pages

Roadmap for HCC Surveillance and Management in the Asia Pacific

Masatoshi Kudo,
Bui Thi Oanh,
Chien-Jen Chen,
Do Thi Ngat,
Jacob George,
Do Young Kim,
Luckxawan Pimsawadi,
Pisit Tangkijvanich,
Raoh-Fang Pwu and
Roberta Sarno
+ 7 authors

Cancers2025, 17(12), 1928;https://doi.org/10.3390/cancers17121928

10 June 2025

Background/Objectives: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with the Asia-Pacific (APAC) region bearing a disproportionate burden. This paper examines HCC challenges within seven APAC health systems, identifi...

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Article

524 Views

13 Pages

Assessment of Hepatocellular Carcinoma Awareness and Understanding Among Health Science Students: A Cross-Sectional Study

Zaki H. Hakami

Healthcare2025, 13(21), 2669;https://doi.org/10.3390/healthcare13212669

23 October 2025

Background: Hepatocellular carcinoma (HCC) is a prominent contributor to global cancer-related mortality and is characterized by unfavorable prognosis despite regional discrepancies in its occurrence. Understanding and awareness of HCC among health s...

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Article

3 Citations

2,737 Views

12 Pages

Effects of Achieving SVR on Clinical Characteristics and Surgical Outcomes in Patients Who Developed Early-Stage HCV-Related Hepatocellular Carcinoma and Received Curative Resection: Preoperative versus Postoperative SVR

Po-Yao Hsu,
Po-Cheng Liang,
Ching-I Huang,
Meng-Hsuan Hsieh,
Yi-Shan Tsai,
Tzu-Chun Lin,
Ming-Lun Yeh,
Chung-Feng Huang,
Chih-Wen Wang and
Chia-Yen Dai
+ 4 authors

Viruses2022, 14(11), 2412;https://doi.org/10.3390/v14112412

31 October 2022

The high accessibility to healthcare and increasing awareness of hepatocellular carcinoma (HCC) surveillance after sustained virologic response (SVR) to HCV treatment allow early detection of operable HCC in Taiwan. However, the effects of achieving...

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Review

18 Citations

5,311 Views

21 Pages

Hepatocellular Carcinoma: Surveillance, Diagnosis, Evaluation and Management

Jessica Elderkin,
Najeeb Al Hallak,
Asfar S. Azmi,
Hussein Aoun,
Jeffrey Critchfield,
Miguel Tobon and
Eliza W. Beal

Cancers2023, 15(21), 5118;https://doi.org/10.3390/cancers15215118

24 October 2023

Hepatocellular carcinoma (HCC) ranks fourth in cancer-related deaths worldwide. Semiannual surveillance of the disease for patients with cirrhosis or hepatitis B virus allows for early detection with more favorable outcomes. The current underuse of s...

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Feature Paper
Article

8 Citations

4,417 Views

5 Pages

Rising Rates of Hepatocellular Carcinoma Leading to Liver Transplantation in Baby Boomer Generation with Chronic Hepatitis C, Alcohol Liver Disease, and Nonalcoholic Steatohepatitis-Related Liver Disease

George Cholankeril,
Eric R. Yoo,
Ryan B. Perumpail,
Andy Liu,
Jeevin S. Sandhu,
Satheesh Nair,
Menghan Hu and
Aijaz Ahmed

Diseases2017, 5(4), 20;https://doi.org/10.3390/diseases5040020

26 September 2017

We aim to study the impact of the baby boomer (BB) generation, a birth-specific cohort (born 1945–1965) on hepatocellular carcinoma (HCC)-related liver transplantation (LT) in patients with chronic hepatitis C virus (HCV), alcoholic liver disease (AL...

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Article

4 Citations

2,441 Views

11 Pages

Clinician Perspectives on Palliative Care for People with Hepatocellular Carcinoma: Facilitators of and Barriers to Referral

Christopher D. Woodrell,
Christie N. Mulholland,
Nathan E. Goldstein,
Carole L. Hutchinson,
Thomas D. Schiano and
Lissi Hansen

Cancers2023, 15(14), 3617;https://doi.org/10.3390/cancers15143617

14 July 2023

(1) Background: Little is known about facilitators of and barriers to palliative care referral for people with hepatocellular carcinoma (HCC). The objective of this study is to identify facilitators and barriers of palliative care referral described...

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Article

2 Citations

3,235 Views

19 Pages

Effect of the COVID-19 Pandemic on the Psychological Health of Patients Who Underwent Liver Transplantation Due to Hepatocellular Carcinoma

Sami Akbulut,
Zeynep Kucukakcali,
Hasan Saritas,
Cigdem Bozkir,
Murat Tamer,
Musap Akyuz,
Nazlican Bagci,
Selver Unsal,
Mehmet Serdar Akbulut and
Sezai Yilmaz
+ 2 authors

Diagnostics2023, 13(8), 1410;https://doi.org/10.3390/diagnostics13081410

13 April 2023

Background: The primary aim of this study was to compare liver transplant (LT) recipients with and without hepatocellular carcinoma (HCC) in terms of COVID-19-related depression, anxiety, and stress. Method: A total of 504 LT recipients with (HCC gro...

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Article

13 Citations

3,421 Views

17 Pages

Diagnostic Performance of an Artificial Intelligence Model Based on Contrast-Enhanced Ultrasound in Patients with Liver Lesions: A Comparative Study with Clinicians

Marinela-Cristiana Urhuț,
Larisa Daniela Săndulescu,
Costin Teodor Streba,
Mădălin Mămuleanu,
Adriana Ciocâlteu,
Sergiu Marian Cazacu and
Suzana Dănoiu

Diagnostics2023, 13(21), 3387;https://doi.org/10.3390/diagnostics13213387

5 November 2023

Contrast-enhanced ultrasound (CEUS) is widely used in the characterization of liver tumors; however, the evaluation of perfusion patterns using CEUS has a subjective character. This study aims to evaluate the accuracy of an automated method based on...

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Case Report

984 Views

13 Pages

Hepatic Focal Lesion Suspicious for Hepatocellular Carcinoma in a Patient with a History of Post-Traumatic Splenectomy: The Challenge of Differential Diagnosis with Intrahepatic Splenosis—Literature Review and Case Report

Andrea Lanzafame,
Giulio Perrone,
Andrea Campisi,
Francesco Razionale,
Elena Panettieri,
Enza Genco,
Maria Cristina Giustiniani,
Alessandro Coppola,
Felice Giuliante and
Francesco Ardito

Diagnostics2025, 15(19), 2442;https://doi.org/10.3390/diagnostics15192442

25 September 2025

Background: Hepatic splenosis (HS) is a rare para-physiological condition resulting from the ectopic implantation of splenic tissue, most commonly following traumatic or surgical splenectomy. Its radiological features can mimic those of hepatocellula...

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Article

1,044 Views

36 Pages

NLE-ANSNet: A Multilevel Noise Estimation and Adaptive Scaling Framework for Hybrid Noise Suppression in Contrast-Enhanced Magnetic Resonance Imaging for Hepatocellular Carcinoma

Jasem Almotiri

Mathematics2025, 13(11), 1768;https://doi.org/10.3390/math13111768

26 May 2025

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, so its detection and monitoring are critical. However, contrast-enhanced magnetic resonance imaging (CE-MRI) is particularly vulnerable to complex, unstructured...

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Article

1 Citations

613 Views

17 Pages

DuXplore: A Dual-Hierarchical Deep Learning Model for Prognostic Prediction of Hepatocellular Carcinoma in Digital Pathology

Haotian Zhang,
Mengling Liu,
Xinshen Zhao,
Yichen Zhang and
Li Sui

Diagnostics2025, 15(23), 2981;https://doi.org/10.3390/diagnostics15232981

24 November 2025

Background: Spatial heterogeneity in tumor tissue has been linked to patient prognosis. To exploit both structural and semantic cues in whole slide images (WSIs), we propose Dual eXplanatory Framework (DuXplore), a dual-branch deep learning framework...

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Article

17 Citations

4,296 Views

19 Pages

Circulating Tumor DNA Profiling in Liver Transplant for Hepatocellular Carcinoma, Cholangiocarcinoma, and Colorectal Liver Metastases: A Programmatic Proof of Concept

Hanna Hong,
Chase J. Wehrle,
Mingyi Zhang,
Sami Fares,
Henry Stitzel,
David Garib,
Bassam Estfan,
Suneel Kamath,
Smitha Krishnamurthi and
Federico Aucejo
+ 14 authors

Cancers2024, 16(5), 927;https://doi.org/10.3390/cancers16050927

25 February 2024

Introduction: Circulating tumor DNA (ctDNA) is emerging as a promising, non-invasive diagnostic and surveillance biomarker in solid organ malignancy. However, its utility before and after liver transplant (LT) for patients with primary and secondary...

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12 Results Found

Roadmap for HCC Surveillance and Management in the Asia Pacific

Assessment of Hepatocellular Carcinoma Awareness and Understanding Among Health Science Students: A Cross-Sectional Study

Effects of Achieving SVR on Clinical Characteristics and Surgical Outcomes in Patients Who Developed Early-Stage HCV-Related Hepatocellular Carcinoma and Received Curative Resection: Preoperative versus Postoperative SVR

Hepatocellular Carcinoma: Surveillance, Diagnosis, Evaluation and Management

Rising Rates of Hepatocellular Carcinoma Leading to Liver Transplantation in Baby Boomer Generation with Chronic Hepatitis C, Alcohol Liver Disease, and Nonalcoholic Steatohepatitis-Related Liver Disease

Clinician Perspectives on Palliative Care for People with Hepatocellular Carcinoma: Facilitators of and Barriers to Referral

Effect of the COVID-19 Pandemic on the Psychological Health of Patients Who Underwent Liver Transplantation Due to Hepatocellular Carcinoma

Diagnostic Performance of an Artificial Intelligence Model Based on Contrast-Enhanced Ultrasound in Patients with Liver Lesions: A Comparative Study with Clinicians

Hepatic Focal Lesion Suspicious for Hepatocellular Carcinoma in a Patient with a History of Post-Traumatic Splenectomy: The Challenge of Differential Diagnosis with Intrahepatic Splenosis—Literature Review and Case Report

NLE-ANSNet: A Multilevel Noise Estimation and Adaptive Scaling Framework for Hybrid Noise Suppression in Contrast-Enhanced Magnetic Resonance Imaging for Hepatocellular Carcinoma

DuXplore: A Dual-Hierarchical Deep Learning Model for Prognostic Prediction of Hepatocellular Carcinoma in Digital Pathology

Circulating Tumor DNA Profiling in Liver Transplant for Hepatocellular Carcinoma, Cholangiocarcinoma, and Colorectal Liver Metastases: A Programmatic Proof of Concept