Search Results (43)

Climate change represents one of the main challenges of this century. The hazards generated by this process are various and involve territorial assets all over the globe. Hydrogeological risk represents one of these aspects, and the violence of rain precipitations has led experts to focus their interest on the study of geotechnical assets in relation to these dangerous weather events. At the same time, geospatial representation in 3D WebGIS based on open-source solutions led specialists to employ this kind of technology to remotely analyze and monitor territorial events considering different sources of information. This study considers the construction of a 3D WebGIS framework for the real-time management of geospatial information developed with open-source technologies applied to the dynamic mapping of precipitation in the metropolitan area of Palermo (Italy) based on real-time weather station acquisitions. The structure considered is a WebGIS platform developed with Cesium.js JavaScript libraries, the Postgres database, Geoserver and Mapserver geospatial servers, and the Anaconda Python platform for activating real-time data connections using Python scripts. This framework represents a basic geospatial digital twin structure useful to municipalities, civil protection services, and firefighters for land management and for activating any preventive operations to ensure territorial safety. Furthermore, the open-source nature of the platform favors the free diffusion of this solution, avoiding expensive applications based on property software. The components of the framework are available and shared using GitHub. Full article

The main objective of this work was to develop a viewer with web output, through which the changes experienced by the mangroves of the Gran Humedal del Norte de Ciego de Avila (GHNCA) can be evaluated from remote sensors, contributing to the understanding of the spatiotemporal variability of their vegetative dynamics. The achievement of this objective is supported by the use of open-source technologies such as MapStore, GeoServer and Django, as well as Google Earth Engine, which combine to offer a robust and technologically independent solution to the problem. In this context, it was decided to adopt an action model aimed at automating the workflow steps related to data preprocessing, downloading, and publishing. A visualizer with web output (Geospatial System for Monitoring Mangrove Ecosystems or SIGMEM) is developed for the first time, evaluating changes in an area of central Cuba from different vegetation indices. The evaluation of the machine learning classifiers Random Forest and Naive Bayes for the automated mapping of mangroves highlighted the ability of Random Forest to discriminate between areas occupied by mangroves and other coverages with an Overall Accuracy (OA) of 94.11%, surpassing the 89.85% of Naive Bayes. The estimated net change based on the year 2020 of the areas determined during the classification process showed a decrease of 5138.17 ha in the year 2023 and 2831.76 ha in the year 2022. This tool will be fundamental for researchers, decision makers, and students, contributing to new research proposals and sustainable management of mangroves in Cuba and the Caribbean. Full article

Background: Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration and death of retinal ganglion cells (RGCs), leading to blindness. Current glaucoma interventions reduce intraocular pressure but do not address retinal neurodegeneration. In this effort, to identify new pharmacological targets for glaucoma management, we employed a network pharmacology approach. Methods: We first retrieved transcriptomic data from GEO, an NCBI database, and carried out GEO2R (an interactive web tool aimed at comparing two or more groups of samples in a GEO dataset). The GEO2R statistical analysis aimed at identifying the top differentially expressed genes (DEGs) and used these as input of STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) app within Cytoscape software, which builds networks of proteins starting from input DEGs. Analyses of centrality metrics using Cytoscape were carried out to identify nodes (genes or proteins) involved in network stability. We also employed the web-server software MIRNET 2.0 to build miRNA–target interaction networks for a re-analysis of the GSE105269 dataset, which reports analyses of microRNA expressions. Results: The pharmacological targets, identified in silico through analyses of the centrality metrics carried out with Cytoscape, were rescored based on correlations with entries in the PubMed and clinicaltrials.gov databases. When there was no match (82 out of 135 identified central nodes, in 8 analyzed networks), targets were considered “potential innovative” targets for the treatment of glaucoma, after further validation studies. Conclusions: Several druggable targets, such as GPCRs (e.g., 5-hydroxytryptamine 5A (5-HT5A) and adenosine A_2B receptors) and enzymes (e.g., lactate dehydrogenase A or monoamine oxidase B), were found to be rescored as “potential innovative” pharmacological targets for glaucoma treatment. Full article

With the rapid development of geo-positioning technologies, location-based services have become increasingly widespread. In the field of location-based services, range queries on geographical data have emerged as an important research topic, attracting significant attention from academia and industry. In many applications, data owners choose to outsource their geographical data and range query tasks to cloud servers to alleviate the burden of local data storage and computation. However, this outsourcing presents many security challenges. These challenges include adversaries analyzing outsourced geographical data and query requests to obtain privacy information, untrusted cloud servers selectively querying a portion of the outsourced data to conserve computational resources, returning incorrect search results to data users, and even illegally modifying the outsourced geographical data, etc. To address these security concerns and provide reliable services to data owners and data users, this paper proposes an efficient and verifiable range query scheme (EVRQ) for encrypted geographical information in untrusted cloud environments. EVRQ is constructed based on a map region tree, 0–1 encoding, hash function, Bloom filter, and cryptographic multiset accumulator. Extensive experimental evaluations demonstrate the efficiency of EVRQ, and a comprehensive analysis confirms the security of EVRQ. Full article

Understanding breast cancer drug response mechanisms can play a crucial role in improving treatment outcomes and survival rates. Existing bioinformatics-based approaches are far from perfect and do not adopt computational methods based on advanced artificial intelligence concepts. Therefore, we introduce a novel computational framework based on an efficient support vector machine (esvm) working as follows: First, we downloaded and processed three gene expression datasets related to breast cancer responding and non-responding to treatments from the gene expression omnibus (GEO) according to the following GEO accession numbers: GSE130787, GSE140494, and GSE196093. Our method esvm is formulated as a constrained optimization problem in its dual form as a function of λ. We recover the importance of each gene as a function of λ, y, and x. Then, we select p genes out of n, which are provided as input to enrichment analysis tools, Enrichr and Metascape. Compared to existing baseline methods, including deep learning, results demonstrate the superiority and efficiency of esvm, achieving high-performance results and having more expressed genes in well-established breast cancer cell lines, including MD-MB231, MCF7, and HS578T. Moreover, esvm is able to identify (1) various drugs, including clinically approved ones (e.g., tamoxifen and erlotinib); (2) seventy-four unique genes (including tumor suppression genes such as TP53 and BRCA1); and (3) thirty-six unique TFs (including SP1 and RELA). These results have been reported to be linked to breast cancer drug response mechanisms, progression, and metastasizing. Our method is available publicly on the maGENEgerZ web server. Full article

Traditional treatments of cancer have faced various challenges, including toxicity, medication resistance, and financial burdens. On the other hand, bioactive phytochemicals employed in complementary alternative medicine have recently gained interest due to their ability to control a wide range of molecular pathways while being less harmful. As a result, we used a network pharmacology approach to study the possible regulatory mechanisms of active constituents of Cordia myxa for the treatment of liver cancer (LC). Active constituents were retrieved from the IMPPAT database and the literature review, and their targets were retrieved from the STITCH and Swiss Target Prediction databases. LC-related targets were retrieved from expression datasets (GSE39791, GSE76427, GSE22058, GSE87630, and GSE112790) through gene expression omnibus (GEO). The DAVID Gene Ontology (GO) database was used to annotate target proteins, while the Kyoto Encyclopedia and Genome Database (KEGG) was used to analyze signaling pathway enrichment. STRING and Cytoscape were used to create protein–protein interaction networks (PPI), while the degree scoring algorithm of CytoHubba was used to identify hub genes. The GEPIA2 server was used for survival analysis, and PyRx was used for molecular docking analysis. Survival and network analysis revealed that five genes named heat shot protein 90 AA1 (HSP90AA1), estrogen receptor 1 (ESR1), cytochrome P450 3A4 (CYP3A4), cyclin-dependent kinase 1 (CDK1), and matrix metalloproteinase-9 (MMP9) are linked with the survival of LC patients. Finally, we conclude that four extremely active ingredients, namely cosmosiin, rosmarinic acid, quercetin, and rubinin influence the expression of HSP90AA1, which may serve as a potential therapeutic target for LC. These results were further validated by molecular dynamics simulation analysis, which predicted the complexes with highly stable dynamics. The residues of the targeted protein showed a highly stable nature except for the N-terminal domain without affecting the drug binding. An integrated network pharmacology and docking study demonstrated that C. myxa had a promising preventative effect on LC by working on cancer-related signaling pathways. Full article

The requirements for low latency and high stability in large-scale geo-distributed training simulations have made cloud-edge collaborative simulation an emerging trend. However, there is currently limited research on how to deploy simulation run-time resources (SRR), including edge servers, simulation services, and simulation members. On one hand, the deployment schemes of these resources are coupled and have mutual impacts. It is difficult to ensure overall optimum by deploying these resources separately. On the other hand, the pursuit of low latency and high system stability is often challenging to achieve simultaneously because high stability implies low server load, while a small number of simulation services implies high response latency. We formulate this problem as a multi-objective optimization problem for the joint deployment of SRR, considering the complex combinatorial relationship between simulation services. Our objective is to minimize the system time cost and resource usage rate of edge servers under constraints such as server resource capacity and the relationship between edge servers and base stations. To address this problem, we propose a learnable genetic algorithm for SRR deployment (LGASRD) where the population can learn from elites and adaptively select evolution operators performing well. Extensive experiments with different settings based on real-world data sets demonstrate that LGASRD outperforms the baseline policies in terms of optimality, feasibility, and convergence rate, verifying the effectiveness and excellence of LGASRD when deploying SRR. Full article

Gastric cancer (GC) is a highly heterogeneous, complex disease and the fifth most common cancer worldwide (about 1 million cases and 784,000 deaths worldwide in 2018). GC has a poor prognosis (the 5-year survival rate is less than 20%), but there is an effort to find genes highly expressed during tumor establishment and use the related proteins as targets to find new anticancer molecules. Data were collected from the Gene Expression Omnibus (GEO) bank to obtain three dataset matrices analyzing gastric tumor tissue versus normal gastric tissue and involving microarray analysis performed using the GPL570 platform and different sources. The data were analyzed using the GEPIA tool for differential expression and KMPlot for survival analysis. For more robustness, GC data from the TCGA database were used to corroborate the analysis of data from GEO. The genes found in in silico analysis in both GEO and TCGA were confirmed in several lines of GC cells by RT-qPCR. The AlphaFold Protein Structure Database was used to find the corresponding proteins. Then, a structure-based virtual screening was performed to find molecules, and docking analysis was performed using the DockThor server. Our in silico and RT-qPCR analysis results confirmed the high expression of the AJUBA, CD80 and NOLC1 genes in GC lines. Thus, the corresponding proteins were used in SBVS analysis. There were three molecules, one molecule for each target, MCULE-2386589557-0-6, MCULE-9178344200-0-1 and MCULE-5881513100-0-29. All molecules had favorable pharmacokinetic, pharmacodynamic and toxicological properties. Molecular docking analysis revealed that the molecules interact with proteins in critical sites for their activity. Using a virtual screening approach, a molecular docking study was performed for proteins encoded by genes that play important roles in cellular functions for carcinogenesis. Combining a systematic collection of public microarray data with a comparative meta-profiling, RT-qPCR, SBVS and molecular docking analysis provided a suitable approach for finding genes involved in GC and working with the corresponding proteins to search for new molecules with anticancer properties. Full article

Benefiting from advanced satellite payload technologies, edge computing servers can be deployed on satellites to achieve orbital computing and reduce the mission processing delay. However, geostationary Earth orbit (GEO) satellites are hindered by long-distance communication, whereas low Earth orbit (LEO) satellites are restricted by time windows. Relying solely on GEO or LEO satellites cannot meet the strict quality of service (QoS) requirements of on-board missions while conserving energy consumption. In this paper, we propose a computation offloading strategy for GEO/LEO hybrid satellite networks that minimizes total energy consumption while guaranteeing the QoS requirements of multiple missions. We first innovatively transform the on-board partial computation offloading problem, which is a mixed-integer nonlinear programming (MINLP) problem, into a minimum cost maximum flow (MCMF) problem. Then, the successive shortest path-based computation offloading (SSPCO) method is introduced to obtain the offloading decision in polynomial time. To evaluate the effectiveness and performance of SSPCO, we conduct a series of numerical experiments and compare SSPCO with other offloading methods. The experimental results demonstrate that our proposed SSPCO outperforms the reference methods in terms of total energy consumption, QoS violation degree, and algorithm running time. Full article

The centralization of the global DNS ecosystem may accelerate the creation of an oligopoly market, thereby, increasing the risk of a single point of failure and network traffic manipulation. Earlier studies have revealed the level of centralization in terms of the market share of public DNS services and DNS traffic seen by major CDN providers. However, the level of centralization in the infrastructure of the DNS Ecosystem is not well understood. In this paper, we present a novel and lightweight measurement approach that effectively discovers resolver pools from a single probing point. We conduct an Internet-wide active measurement on the client-side as well as the server-side DNS infrastructure to assess the level of DNS centralization in terms of the supporting infrastructure. Our measurement results show that the DNS infrastructure is much more centralized than previously believed. Over 90% of forwarding resolvers are backed by less than 5% (4071) of indirect resolvers. Merely 0.45% (12,679) of all name servers across 1138 gTLDs, operated by just 10 DNS providers, provide authoritative domain resolution service for 48.5% (more than 100 million) of domain names. We also investigated several leading DNS providers in IP infrastructure, load distribution, and service geo-distribution. The findings of our measurements provide novel insights into the centrality of the DNS infrastructure, which will help the Internet community promote the understanding of the DNS ecosystem. Full article

The framework for aqua farming database collection and the real-time monitoring of different working functions of aqua farming are essential to enhance and digitalize aqua farming. Data collection and real-time monitoring are attained using cutting-edge technologies, and these cutting-edge technologies are useful for the conservation and advancement of traditional aquatic farming, particularly in hilly areas with sustainable development goals (SDGs). Geo-tagging and geo-mapping of the aqua resources will play an important role in monitoring the species in the aquatic environment and can track the real-time health status, movement, and location, and monitor the foraging behaviors, of aquatic species. This study proposed an architecture with the IoT to manage the aqua resource for eco-sustainability with geospatial data. This study also discussed the geo information systems (GIS)- and geo positioning system (GPS)-based web-based framework for the fisheries sector and the creation of a database for aqua resource management. In the study, the results of database generation for the aqua resource management and the results of the fishpond in the cloud server are presented in detail. Machine learning (ML) is integrated with the framework to analyze the sensor data and geo-spatial data for the identification of any degradation in the water quality. This will provide real-time information to the policymakers for their critical decisions for the further development of aquatic species for enhancing the economy of the state as well as aqua farmers. Full article

Quickly obtaining accurate soil quality information is the premise for accurate agricultural production and increased crop yield. With the development of the digital information industry, smart agriculture has become a new trend in agricultural development and there is increasing demand for efficiently and intelligently acquiring good soil quality information. Scientists worldwide have developed many remote sensing quantitative inversion models, which need to be systematized and intelligent for agricultural personnel to enjoy the dividends of information technology such as 3S (remote sensing, geographic information system, and global navigation satellite system) techniques. Accordingly, to meet the need of farmers, agricultural managers, and agricultural researchers to acquire timely information on regional soil quality, in this paper, we designed a cloud platform for inversion analysis of moisture, nutrient, salinity, and other important soil quality indicators. The platform was developed using ArcGIS (The software is produced by the Environmental Systems Research Institute, Inc. of America in Redlands, CL, USA) and GeoScene (The software is produced by GeoScene Information Technology Co.,Ltd., Beijing, China) software, with Java and JavaScript as programing languages and SQL Server as the database management system with a PC client, a web client, and a mobile app. On the basis of the existing quantitative remote sensing models, the platform realizes mapping functions, intelligent inversion of soil moisture–nutrient–salinity (SMNS) content, data analysis mining, soil knowledge base, platform management, and so on. It can help different users acquire, manage, and analyze data and make decisions based on the data. In addition, the platform can customize model parameters according to regional characteristics, improving analysis accuracy and expanding the application area. Overall, the platform employs 3S techniques, Internet technology, and mobile communication technology synthetically and realizes intelligent inversion and decision analysis of significant soil quality information, such as moisture–nutrient–salinity content. This platform has been applied to the analysis of soil indicators in several areas and has produced good operational results and benefits. This study will enable rapid data analysis and provide technical support for regional agriculture production, contributing to the development of smart agriculture. Full article

This work utilizes the anthraquinone (AQ) database to identify potential inhibitors of the RIPK1 protein for developing medicines targeting AP-associated necroptosis. Screening for necroptosis-related genes that play a crucial role in AP is based on the GEO and GSEA databases. An optimum AQ for receptor-interacting protein kinase 1 (RIPK1) inhibition was virtually screened using the Discovery Studio 2019 tool, with a previously described RIPK1 inhibitor (necrostatin-1) as a reference ligand. Using LibDock and CDOCKER molecular docking, an AQ that robustly binds to RIPK1 was identified. The DOCKTHOR web server was used to calculate the ligand–receptor binding energy. The pharmacological properties and toxicity of potential AQ were evaluated using the ADME module and ProTox-II web server. The stability of ligand–receptor complexes was examined using molecular dynamics (MD) simulation. All 12 AQs showed solid binding activity to RIPK1, 5 of which were superior to necrostatin-1. Rheochrysin and Aloe-Emodin-8-O-Beta-D-Glucopyranoside (A8G) were safe RIPK1 inhibitors based on pharmacological characterization and toxicity studies. Additionally, the potential energy of the candidate AQs with RIPK1 was greater than that of the reference ligand, necrostatin-1. MD simulations also showed that the candidate AQs could bind stably to RIPK1 in the natural environment. Rheochrysin and A8G are safe and effective anthraquinones that inhibit the RIPK1 protein. This research takes a first step toward developing RIPK1 inhibitors by screening AQs that have the potential to be more effective than the reference ligand necrostatin-1. Full article

We not only present an alternative and simpler approach to find steady-state distributions of the number of jobs for the finite-space queueing model $Geo/G^{a,Y}/1/N$ using roots of the inherent characteristic equation, but also correct errors in some published papers. The server has a random service capacity Y, and it processes the jobs only when the number of jobs in the system is at least ‘a’, a threshold value. The main advantage of this alternative process is that it gives a unified approach in dealing with both finite- and infinite-buffer systems. The queue-length distribution is obtained both at departure and random epochs. We derive the relation between the discrete-time Geo/$G^{a,Y}$/1/N queue and its continuous-time analogue. Finally, we deal with performance measures and numerical results. Full article

Background: Although emerging studies support the relationship between S100 calcium binding protein A7 (S100A7) and various cancers, no pancancer analysis of S100A7 is available thus far. Methods: We investigated the potential oncogenic roles of S100A7 across 33 tumors based on datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Moreover, a survival prognosis analysis was performed with the gene expression profiling interactive analysis (GEPIA) web server and Kaplan–Meier plotter, followed by the genetic alteration analysis of S100A7 and enrichment analysis of S100A7-related genes. Results: S100A7 was highly expressed in most types of cancers, and remarkable associations were found between S100A7 expression and the prognosis of cancer patients. S100A7 expression was associated with the expression of DNA methyltransferase and mismatch repair genes in head and neck squamous cell carcinoma, the infiltration of CD8⁺ T cells and cancer-associated fibroblasts in different tumors. Moreover, glycosaminoglycan degradation and lysosome-associated functions were involved in the functional mechanisms of S100A7. Conclusions: The current pancancer study shows a relatively integrative understanding of the carcinogenic involvement of S100A7 in numerous types of cancers. Full article