Search Results (553)

As the automotive industry continues to evolve rapidly, there is a growing demand for high-throughput reliable communication systems within vehicles. This paper presents the implementation and verification of a fault-tolerant Ethernet-based communication protocol tailored for automotive applications operating at 1 Gbps and above. The proposed system introduces a multi-port Network Interface Controller (NIC) architecture that supports real-time communication and robust fault handling. To ensure adaptability across various in-vehicle network (IVN) scenarios, the system allows for configurable packet sizes and transmission rates and supports diverse data formats. The architecture integrates cyclic redundancy check (CRC)-based error detection, real-time recovery mechanisms, and file-driven data injection techniques. Functional validation is performed using Verilog HDL simulations, demonstrating deterministic timing behavior, modular scalability, and resilience under fault injection. This paper presents a fault-tolerant Network Interface Controller (NIC), architecture incorporating CRC-based error detection, real-time recovery logic, and file-driven data injection. The system is verified through Verilog HDL simulation, demonstrating correct timing behavior, modular scalability, and robustness against injected transmission faults. Compared to conventional dual-port NICs, the proposed quad-port architecture demonstrates superior scalability and error tolerance under injected fault conditions. Experimental results confirm that the proposed NIC architecture achieves stable multi-port communication under embedded automotive environments. This study further introduces a novel quad-port NIC with an integrated fault injection algorithm and evaluates its performance in terms of error tolerance. Full article

IgG Fc binding protein (FcGBP) is a mucin-like protein that binds strongly to IgG and IgG–antigen complexes in intestinal mucus. FcGBP presence and its altered expression levels in meconium accumulating in the fetal intestine and amniotic fluid flowing in the intestine may provide new knowledge of the mechanisms responsible for the immune adaptation of the fetus to extrauterine life. FcGBP concentrations were measured by ELISA in the first-pass meconium and amniotic fluid samples collected from 120 healthy neonates delivered by either vaginal birth (n = 35) or cesarean section (n = 85) at 36 to 41 weeks gestation. The meconium FcGBP concentrations (405.78 ± 145.22 ng/g) decreased (r = −0.241, p = 0.007) over the course of 36 to 41 weeks gestation, but there were no significant changes (p > 0.05) in the amniotic fluid FcGBP (135.70 ± 35.83 ng/mL) in the same period. Both meconium and amniotic fluid FcGBP concentrations were higher (p < 0.05) in neonates delivered by cesarean section. Decreases in the meconium FcGBP concentrations correlated (r = −0.37, p = 0.027) with the gestational age in neonates delivered by vaginal birth but not in those delivered by cesarean section (p > 0.05). No association was found between the FcGBP concentrations in meconium and amniotic fluid and the birth weight (p > 0.05). With the development of the mucosal immune system in the fetal intestine over the course of the third trimester of gestation, the meconium FcGBP concentrations decrease. Increased FcGBP concentrations measured in the meconium and amniotic fluid of neonates delivered by cesarean section may possibly indicate altered intestinal mucosal function. Intrauterine growth is not associated with the intestinal mucosal barrier maturation involving FcGBP. Full article

Interferon (IFN) signaling plays vital roles in host defense against viral infection. However, a variety of observations have been reported in the literature regarding the roles of IFN signaling in COVID-19. Thus, it would be important to reach a clearer picture regarding the activation or suppression of IFN signaling in COVID-19. In this work, regulation of marker genes for IFN signaling was examined in natural infection, viral challenge, and vaccination based on 13 public transcriptome datasets. Three subsets of interferon-stimulated genes (ISGs) were selected for detailed examination, including one set of marker genes for type I IFN signaling (ISGa) and two sets of marker genes for type II IFN signaling (IFN-γ signaling, GBPs for the GBP gene cluster, and HLAd for the HLA-D gene cluster). In natural infection, activation of ISGa and GBPs was accompanied by the suppression of HLAd in hospitalized patients. Suppression of GBPs was also observed in certain critical conditions. The scale of regulation was much greater for ISGa than that of GBPs and HLAd. In addition, the suppression of HLAd was correlated with disease severity, and it took much longer for HLAd to return to the level of healthy controls than that for ISGa and GBPs. Upon viral challenge, the activation of ISGa and GBPs was similar to that of natural infection, while the suppression of HLAd was not observed. Moreover, GBPs’ return to the pre-infection level was at a faster pace than that of ISGa. Upon COVID-19 vaccination, activation was observed for all of these three gene sets, and the scale of activation was comparable for ISGa and GBPs. Notably, it took a much shorter time for GBPs and ISGa to return to the level of healthy controls than that in COVID-19 infection. In addition, the baseline values and transient activation of these gene sets were also associated with subsequent vaccination response. The intricate balance of IFN signaling was demonstrated in mild breakthrough infection, where attenuated response was observed in people with prior vaccination compared to that in vaccine-naïve subjects. Overall, distinctive temporal profiles of IFN signaling were observed in natural infection, viral challenge, and vaccination. The features observed in this work may provide novel insights into the disease management and vaccine development. Full article

Demand for mental health support has exerted unprecedented pressure on statutory services. Innovative solutions such as Green or Nature-Based Social Prescribing (NBSP) programmes may help address unmet need, improve access to personalised treatment, and support the sustainable delivery of primary services within a prevention model of population health. We piloted an innovative health economics-informed Social Return on Investment (SROI) analysis and forecast of a ‘Making Well’ therapeutic craft and horticulture programme for mental health between October 2021 and March 2022. Quantitative and qualitative outcome data were collected from participants with mild-to-moderate mental health conditions at baseline and nine-weeks follow-up using a range of validated measures, including the Short Warwick–Edinburgh Mental Well-being Scale, ICEpop CAPability measure for Adults (ICECAP-A), General Self-Efficacy Scale (GSES), and a bespoke Client Service Receipt Inventory (CSRI). The acceptability and feasibility of these measures were explored. Results indicate that the Making Well programme generated well-being-related social value in the range of British Pound Sterling (GBP) GBP 3.30 to GBP 4.70 for every GBP 1 invested. Our initial pilot forecast suggests that the programme has the potential to generate GBP 5.40 to GBP 7.70 for every GBP 1 invested as the programme is developed and delivered over a 12-month period. Despite the small sample size and lack of a control group, our results contribute to the evidence-base for the effectiveness and social return on investment of NBSP as a therapeutic intervention for improving health and well-being and provides an example of the use of health economic well-being outcome measures such as ICECAP-A and CSRIs in social value analysis. Combining SROI evaluation and forecast methodologies with validated quantitative outcome measures used in the field of health economics can provide valuable social cost–benefit evidence to decision-makers. Full article

Secure communication is critically dependent on high-speed and high-security quantum random number generation (QRNG). In this work, we present a responsive approach to enhance the efficiency and security of QRNG by leveraging polarization-controlled heterodyne detection to simultaneously measure the quadrature amplitude and phase fluctuations of vacuum shot noise. To address the practical non-idealities inherent in QRNG systems, we investigate the critical impacts of imbalanced heterodyne detection, amplitude–phase overlap, finite-size effects, and security parameters on quantum conditional min-entropy derived from the entropy uncertainty principle. It effectively mitigates the overestimation of randomness and fortifies the system against potential eavesdropping attacks. For a high-security parameter of ${10}^{-20}$, QRNG achieves a true random bit extraction ratio of 83.16% with a corresponding real-time speed of 37.25 Gbps following a 16-bit analog-to-digital converter quantization and 1.4 GHz bandwidth extraction. Furthermore, we develop a deep convolutional neural network for rapid and accurate entropy evaluation. The entropy evaluation of 13,473 sets of quadrature data is processed in 68.89 s with a mean absolute percentage error of 0.004, achieving an acceleration of two orders of magnitude in evaluation speed. Extracting the shot noise with full detection bandwidth, the generation rate of QRNG using dual-quadrature heterodyne detection exceeds 85 Gbps. The research contributes to advancing the practical deployment of QRNG and expediting rapid entropy assessment. Full article

THz communication stands as a pivotal technology for 6G networks, designed to address the critical challenge of data demands surpassing current microwave and millimeter-wave (mmWave) capabilities. However, realizing Tbps and kilometer-range transmission confronts the “dual attenuation dilemma” comprising severe free-space path loss (FSPL) (>120 dB/km) and atmospheric absorption. This review comprehensively summarizes our group′s advancements in overcoming fundamental challenges of long-distance THz communication. Through systematic photonic–electronic co-optimization, we report key enabling technologies including photonically assisted THz signal generation, polarization-multiplexed multiple-input multiple-output (MIMO) systems with maximal ratio combining (MRC), high-gain antenna–lens configurations, and InP amplifier systems for complex weather resilience. Critical experimental milestones encompass record-breaking 1.0488 Tbps throughput using probabilistically shaped 64QAM (PS-64QAM) in the 330–500 GHz band; 30.2 km D-band transmission (18 Gbps with 543.6 Gbps·km capacity–distance product); a 3 km fog-penetrating link at 312 GHz; and high-sensitivity SIMO-validated 100 Gbps satellite-terrestrial communication beyond 36,000 km. These findings demonstrate THz communication′s viability for 6G networks requiring extreme-capacity backhaul and ultra-long-haul connectivity. Full article

Modern industrial ecosystems, particularly those embracing Industry 4.0, increasingly depend on coherent optical networks operating at 400 Gbps and beyond. These high-capacity infrastructures, coupled with advanced digital signal processing and phase-sensitive detection, enable real-time data exchange for automated manufacturing, robotics, and interconnected factory systems. However, they introduce multilayer security challenges—ranging from hardware synchronization gaps to protocol overhead manipulation. Moreover, the rise of large-scale quantum computing intensifies these threats by potentially breaking classical key exchange protocols and enabling the future decryption of stored ciphertext. In this paper, we present a systematic vulnerability analysis of coherent optical networks that use OTU4 framing, Media Access Control Security (MACsec), and 400G ZR+ transceivers. Guided by established risk assessment methodologies, we uncover critical weaknesses affecting management plane interfaces (e.g., MDIO and I²C) and overhead fields (e.g., Trail Trace Identifier, Bit Interleaved Parity). To mitigate these risks while preserving the robust data throughput and low-latency demands of industrial automation, we propose a post-quantum security framework that merges spectral phase masking with multi-homodyne coherent detection, strengthened by quantum key distribution for key management. This layered approach maintains backward compatibility with existing infrastructure and ensures forward secrecy against quantum-enabled adversaries. The evaluation results show a substantial reduction in exposure to timing-based exploits, overhead field abuses, and cryptographic compromise. By integrating quantum-safe measures at the optical layer, our solution provides a future-proof roadmap for network operators, hardware vendors, and Industry 4.0 stakeholders tasked with safeguarding next-generation manufacturing and engineering processes. Full article

In response to the increasing demands for reliable, fast, and secure communications beyond 5G scenarios, the high-capacity networks have become a focal point. Quantum communication is at the forefront of this research, offering unmatched throughput and security. A free space optics (FSO) communication system integrated with fiber-end is designed and investigated using the Bennett–Brassard 1984 quantum key distribution (BB84-QKD) protocol. Simulation results show that reliable transmission can be achieved over a 10–15 km fiber length with a signal power of −19.54 dBm and high optical-to-signal noise of 72.28–95.30 dB over a 550 m FSO range under clear air, haze, fog, and rain conditions at a data rate of 1 Gbps. Also, the system using rectilinearly and circularly polarized signals exhibits a Stokes parameter intensity of −4.69 to −35.65 dBm and −7.7 to −35.66 dBm Stokes parameter intensity, respectively, over 100–700 m FSO range under diverse weather conditions. Likewise, for the same scenario, an FSO range of 100 m incorporating 2.5–4 mrad beam divergence provides the Stokes power intensity of −6.03 to −11.1 dBm and −9.04 to −14.12 dBm for rectilinearly and circularly polarized signals, respectively. Moreover, compared to existing works, this work allows faithful and secure signal transmission in free space, considering FSO–fiber link losses. Full article

This study presents a comprehensive economic valuation of UK saltmarsh habitats, utilising a benefit transfer approach. The core of this research underscored the necessity for consistency in the selection of primary studies for meta-regression models (MRMs) to mitigate potential inaccuracies. A commodity-consistent, methodology-consistent meta-regression model was established based on the existing literature that only used the stated preference methods for saltmarsh valuation in the UK. This research is distinct in its concentration on UK-based studies, aiming to provide a valuation that is not only more reflective of the region-specific importance of these habitats but also contributes to the formulation of more informed policies. The results from the unweighted Ordinary Least Squares (OLS) model, which accounted for approximately 61% of the variance in LnWTPHA (logarithm of per hectare willingness to pay), were particularly revealing. These findings suggest a higher valuation for saltmarshes when a spectrum of benefits is presented for valuation purposes. Incorporating the economic valuation derived from this research, the estimated existence value of saltmarsh habitats in the UK stands at GBP 991 per hectare per year. These findings offer region-specific insights critical for formulating effective conservation strategies, emphasising balanced approaches that consider diverse saltmarsh sizes and socio-economic factors. The study’s UK-focused, consistent methodology and commodity and variable analysis provide policymakers and environmental managers with robust tools to ensure sustainable preservation of saltmarsh habitats. Full article

The low-chirp operation of distributed feedback lasers is highly desirable in high-speed and high-bit rate optical transmission. In this article, we address this issue by theoretically investigating the possibility of further a reduction in the linewidth enhancement factor (LEF) of a quantum well (QW). The energy band structure of AlGaInAs quantum-well DFB lasers grown with a (110) crystal orientation in the active region of the L-band has been theoretically analyzed using multi-band k.p perturbation theory, by reducing the asymmetry of conduction bands and valence bands and thus the linewidth enhancement factor parameter, which is related to the frequency chirp. Simulation results show that the LEF of the directly modulated DFB laser is reduced from 2.434 to 1.408 by designing the (110)-oriented compression-strained Al_0.06Ga_0.24InAs multiple-quantum-well structure, and the eye diagram of the (110)-oriented quantum-well DFB laser with a digital signal transmission of 20 km is significantly better than the (001) crystal-oriented quantum-well DFB laser for the 10Gbps optical fiber communication system, thus achieving a longer distance and higher-quality optical signal transmission. Full article

Free space optics (FSO) aims to perform as one of the best optical wireless channels to design a reliable, flexible, and cost-effective communication system. In FSO systems, mode-division multiplexing (MDM) transmission is a proven technique to expand transmission capacity per communication link. Thus, a 16 × 10 Gbps MDM-FSO system using fiber Bragg grating (FBG) sensors for the coexistence of communication and sensing, exploiting FSO links to transmit distinct Laguerre-Gaussian (LG) beams at a 1000–1900 m range, is proposed. The results illustrate that the system can transmit higher-order LG beams with sensor temperatures of 20–120 °C over a 1500 m range under clear air, drizzle, and moderate haze weather. Also, an improved performance is achieved in gamma–gamma compared to the log-normal distribution model for 10⁻⁶–10^−2.5 index modulation under weak-to-strong turbulence. The proposed system is capable of offering a high optical signal-to-noise ratio (OSNR) and gain of 113.39 and 15.43 dB, respectively, at an aggregate data rate of 160 Gbps under different atmospheric scenarios. Moreover, the proposed system achieves better system performance compared to existing works. Full article

Glycans on the surface of all immune cells are the product of diverse post-translational modifications (glycosylation) that affect almost all proteins and possess enormous structural heterogeneity. Their bioinformational content is decoded by glycan-binding proteins (lectins, GBPs), such as C-type lectins, including selectins, galectins, and Siglecs. Glycans located on the surface of immune cells are involved in many immunological processes through interactions with GBPs. Lectins recognize changes in the glycan epitopes; distinguish among host (self), microbial (non-self), and tumor (modified self) antigens; and consequently regulate immune responses. Understanding GBP–glycan interactions accelerates the development of glycan-targeted therapeutics in severe diseases, including inflammatory and autoimmune diseases and cancer. This review will discuss N- and O-glycosylations and glycosyltransferases involved in the biosynthesis of carbohydrate epitopes and address how interactions between glycan epitopes and GBPs are crucial in immune responses. The pivotal role of the glycan antigen tetrasaccharide sialyl Lewis x in mediating immune and tumor cell trafficking into the extravascular site will be discussed. Next, the role of glycans in modulating bacterial, fungal, viral, and parasitic infections and cancer will be surveyed. Finally, the role of glycosylation in antibodies and carbohydrate vaccines will be analyzed. Full article

The error correction capability of the RS(255,223) code has been significantly enhanced compared to that of the RS(256,252) code, making it the preferred choice for the next generation of onboard solid-state recorders (O-SSRs). With the application of non-volatile double data rate (NV-DDR) interface technology in O-SSRs, instantaneous transmission rates of up to 1 Gbps per data I/O interface can be achieved. This development imposes higher requirements on the encoding throughput of RS encoders. For RS(255,223) encoders, throughput improvement is limited by the structures of serial architectures. The algorithm’s inherent characteristics restrict the depth of pipelining. In contrast, parallel solutions face bottlenecks in resource efficiency. To address these challenges, an interleaved pipelined architecture is proposed. By integrating interleaving technology within the pipeline, the structure overcomes the limitations of serial architectures. Using this architecture, a 36-stage pipelined RS(255,223) encoder is implemented. The throughput is greatly enhanced, and the radiation tolerance is also improved due to the application of interleaving techniques. The RS(255,223) encoder performance was evaluated on the Xilinx XC7K325T platform. The results confirm that the proposed architecture can support high data rates and provide effective error correction. With an 8-bit symbol size, a single encoder achieved throughput of 3.043 Gbps, making it highly suitable for deployment in future space exploration missions. Full article

The increasing demand for high-capacity, energy-efficient wireless networks poses significant challenges in maintaining spectral efficiency, minimizing interference, and ensuring sustainability. Traditional direct-link communication suffers from signal degradation due to path loss, multipath fading, and interference, limiting overall performance. To mitigate these challenges, this paper proposes a unified RIS framework that integrates passive and active Reconfigurable Intelligent Surfaces (RISs) for enhanced communication and ambient RF energy harvesting. Our methodology optimizes RIS-assisted beamforming using successive convex approximation (SCA) and adaptive phase shift tuning, maximizing desired signal reception while reducing interference. Passive RIS efficiently reflects signals without external power, whereas active RIS employs amplification-assisted reflection for superior performance. Evaluations using realistic urban macrocell and mmWave channel models reveal that, compared to direct links, passive RIS boosts SNR from 3.0 dB to 7.1 dB, and throughput from 2.6 Gbps to 4.6 Gbps, while active RIS further enhances the SNR to 10.0 dB and throughput to 6.8 Gbps. Energy efficiency increases from 0.44 to 0.67 (passive) and 0.82 (active), with latency reduced from 80 ms to 35 ms. These performance metrics validate the proposed approach and highlight its potential applications in urban 5G networks, IoT systems, high-mobility scenarios, and other next-generation wireless environments. Full article

Background: Colon capsule endoscopy (CCE) or panenteric capsule endoscopy (PCE) offers a promising, non-invasive diagnostic approach for patients with iron deficiency anaemia (IDA). However, high rates of conversion to conventional colonoscopy (CCC) following capsule procedures reduce cost-effectiveness and patient satisfaction. Optimising the faecal immunochemical test (FIT) threshold may improve patient stratification and reduce unnecessary conversions in future applications within the IDA diagnostic pathway. Methods: The CLEAR IDA study was a multicentre, retrospective observational study conducted across four UK hospitals. Data were collected over a six-month study period and included patients referred via the two-week-wait (2WW) cancer pathway for iron deficiency, with or without anaemia, over a 12-month timeframe. Colonoscopy findings were analysed and extrapolated using NHS England’s CCE-to-colonoscopy referral criteria to assess the predictive value of FIT for colorectal cancer (CRC), polyp burden, and CCC using ROC curve analysis. The optimal FIT threshold was identified through three complementary approaches: threshold-based analysis, decision curve analysis, and cost–benefit modelling. Results: A total of 1531 patients were analysed; only 1.6% underwent small bowel capsule endoscopy. The diagnostic accuracy (AUC) of FIT for predicting CRC, polypoidal lesions, and CCC was 0.78, 0.58, and 0.69, respectively. Threshold-based analysis identified FIT = 15 µg/g as the lowest level at which CCC rates significantly increased (p = 0.02; OR = 1.87; 95% CI: 1.07–3.14). Decision curve analysis showed a maximum net benefit at FIT = 17.6 µg/g, while cost–benefit modelling identified 9 µg/g as the most cost-effective. Raising the threshold to 10 µg/g resulted in a net loss of GBP –294.4 per patient. An optimal cost-effective FIT threshold range was identified between 10 and 17.6 µg/g. The threshold selection should be tailored to local service capacity and resource availability. Conclusions: While FIT alone is an imperfect triage tool, optimising thresholds between 10 and 17 µg/g may enhance cost-effectiveness and guide appropriate PCE use in IDA. Full article